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Mater."],"published-print":{"date-parts":[[2020,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Zirconia-containing wollastonite (CaSiO\n                    <jats:sub>3<\/jats:sub>\n                    ) ceramics with partial substitution of zirconia (1, 3 and 5 mol%) were prepared using eggshells and rice husk ash as source materials for calcium oxide and silica, respectively, through a sol\u2013gel technique. The effect of incorporation of zirconia on\n                    <jats:italic>in vitro<\/jats:italic>\n                    bioactivity, mechanical properties, degradability and cytocompatibility of wollastonite was studied. Bioactivity was evaluated by\n                    <jats:italic>in vitro<\/jats:italic>\n                    assay using simulated body fluid while degradability was tested in Tris-HCl buffer solution for different time periods (1, 3, 7, 14 and 21 d) according to the ISO 10\u2009993-14 standard. Human osteosarcoma (MG-63) cells were used to assess cytocompatibility with the MTT assay. X-ray diffractometry, Fourier transform infrared spectroscopy and scanning electron microscopy\u2013energy dispersive spectroscopy were used to characterize the ceramics before and after\n                    <jats:italic>in vitro<\/jats:italic>\n                    studies. The results obtained showed that increasing the zirconia content in the wollastonite phase increases microhardness, compressive strength, bending strength and the elasticity modulus, while slightly decreasing the rate of formation of the hydroxyapatite layer. Moreover, the samples doped with zirconia had a lower degradation rate and it was noticed that cell viability is unaffected by the incorporation of zirconia.\n                  <\/jats:p>","DOI":"10.1088\/1748-605x\/ab975d","type":"journal-article","created":{"date-parts":[[2020,5,28]],"date-time":"2020-05-28T18:15:37Z","timestamp":1590689737000},"page":"055025","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Zirconia-containing wollastonite ceramics derived from biowaste resources for bone tissue engineering"],"prefix":"10.1088","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6591-8969","authenticated-orcid":false,"given":"Palakurthy","family":"Srinath","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8269-4322","authenticated-orcid":false,"given":"P Abdul","family":"Azeem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Venugopal Reddy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4742-8867","authenticated-orcid":false,"given":"Vasudevarao","family":"Penugurti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1797-398X","authenticated-orcid":false,"given":"Bramanandam","family":"Manavathi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"266","published-online":{"date-parts":[[2020,7,31]]},"reference":[{"key":"bmmab975dbib1","doi-asserted-by":"publisher","first-page":"349","DOI":"10.3390\/ma11030349","type":"journal-article","article-title":"Bioactive glass-ceramic foam scaffolds from \u2018inorganic gel casting\u2019 and sinter-crystallization","volume":"11","author":"Elsayed","year":"2018","journal-title":"Materials"},{"key":"bmmab975dbib2","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1016\/j.joen.2011.05.009","type":"journal-article","article-title":"Biomimetic calcium-silicate cements support differentiation of human orofacial mesenchymal stem cells","volume":"37","author":"Gandolfi","year":"2011","journal-title":"J. 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