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Mater."],"published-print":{"date-parts":[[2021,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Stent-related granulation tissue hyperplasia is a major complication that limits the application of stents in airways. In this study, an arsenic trioxide-eluting electrospun nanofiber-covered self-expandable metallic stent (ATO-NFCS) was developed. Poly-L-lactide-caprolactone (PLCL) was selected as the drug-carrying polymer. Stents with two different ATO contents (0.4% ATO\/PLCL and 1.2% ATO\/PLCL) were fabricated. The <jats:italic>in vitro<\/jats:italic> release in simulated airway fluid suggested that the total ATO release time was 1 d. The growth of human embryonic pulmonary fibroblasts (CCC-HPF-1), normal human bronchial epithelial cells and airway smooth muscle cells was inhibited by ATO. When embedded in paravertebral muscle, the nanofiber membrane showed good short-term and long-term biological effects. In an animal study, placement of the ATO-NFCS in the trachea through a delivery system under fluoroscopy was feasible. The changes in liver and kidney function 1 and 7 d after ATO-NFCS placement were within the normal range. On pathological examination, the heart, liver, spleen, lungs and kidneys were normal. The effectiveness of the ATO-NFCS in reducing granulation tissue hyperplasia and collagen deposition was demonstrated in the rabbit airway (n = 18) at 4 weeks. The present study preliminarily investigated the efficacy of the ATO-NFCS in reducing granulation tissue formation in the trachea of rabbits. The results suggest that the ATO-NFCS is safe <jats:italic>in vivo<\/jats:italic>, easy to place, and effective for the suppression of granulation tissue formation.<\/jats:p>","DOI":"10.1088\/1748-605x\/abb25a","type":"journal-article","created":{"date-parts":[[2020,8,25]],"date-time":"2020-08-25T22:15:43Z","timestamp":1598393743000},"page":"015013","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["Arsenic trioxide-eluting electrospun nanofiber-covered self-expandable metallic stent reduces granulation tissue hyperplasia in rabbit trachea"],"prefix":"10.1088","volume":"16","author":[{"given":"Yahua","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengde","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8916-5404","authenticated-orcid":false,"given":"Xiaofeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaonan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kewei","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuhua","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianzhuang","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4407-4864","authenticated-orcid":false,"given":"Xinwei","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2020,12,11]]},"reference":[{"key":"bmmabb25abib1","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1111\/resp.13801","article-title":"Airway stenting: technological advancements and its role in interventional pulmonology","volume":"25","author":"Guibert","year":"2020","journal-title":"Respirology"},{"key":"bmmabb25abib2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000020498","article-title":"Single Y-shaped tracheal self-expandable metallic stent for emergent carinal stenosis combined with stenosis of the right main and intermediate bronchi","volume":"99","author":"Li","year":"2020","journal-title":"Medicine (Baltimore)"},{"key":"bmmabb25abib3","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.1016\/j.chest.2018.12.001","article-title":"Metallic endobronchial stents: a contemporary resurrection","volume":"155","author":"Avasarala","year":"2019","journal-title":"Chest"},{"key":"bmmabb25abib4","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1007\/s00270-016-1353-y","article-title":"Outcomes of temporary partially covered stent placement for benign tracheobronchial stenosis","volume":"39","author":"Ma","year":"2016","journal-title":"Cardiovasc. 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