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Mater."],"published-print":{"date-parts":[[2021,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The use of alloplastic materials in periodontal regenerative therapies is limited by their incapacity to establish a dynamic dialog with the surrounding milieu. The aim of the present study was to control biomaterial surface bioactivity by introducing aptamers to induce the selective adsorption of fibronectin from blood, thus promoting platelets activation\n                    <jats:italic>in vitro<\/jats:italic>\n                    and bone regeneration\n                    <jats:italic>in vivo<\/jats:italic>\n                    . A hyaluronic acid\/polyethyleneglycole-based hydrogel was enriched with aptamers selected for recognizing and binding fibronectin.\n                    <jats:italic>In vitro<\/jats:italic>\n                    , the capacity of constructs to support osteoblast adhesion, as well as platelets aggregation and activation was assessed by chemiluminescence within 24 h. Matrices were then evaluated in a rat periodontal defect to assess their regenerative potential by microcomputed tomography (\n                    <jats:italic>\u00b5<\/jats:italic>\n                    CT) and their osteogenic capacity by Luminex assay 5, 15 and 30 d postoperatively. Aptamers were found to confer matrices the capacity of sustaining firm cell adhesion (p = 0.0377) and to promote platelets activation (p = 0.0442).\n                    <jats:italic>In vivo<\/jats:italic>\n                    , aptamers promoted new bone formation 30 d post-operatively (p &lt; 0.001) by enhancing osteoblastic lineage commitment maturation. Aptamers are a viable surface modification, which confers alloplastic materials the potential capacity to orchestrate blood clot formation, thus controlling bone healing.\n                  <\/jats:p>","DOI":"10.1088\/1748-605x\/abb6b2","type":"journal-article","created":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T18:32:01Z","timestamp":1599676321000},"page":"015016","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Aptamers recognizing fibronectin confer improved bioactivity to biomaterials and promote new bone formation in a periodontal defect in rats"],"prefix":"10.1088","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4673-3176","authenticated-orcid":false,"given":"Ludovica","family":"Parisi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Rivara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camila A","family":"Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodriguo PF","family":"Abuna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela B","family":"Palioto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2203-3092","authenticated-orcid":false,"given":"Guido M","family":"Macaluso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"266","published-online":{"date-parts":[[2020,12,11]]},"reference":[{"key":"bmmabb6b2bib1","doi-asserted-by":"publisher","first-page":"1809","DOI":"10.1016\/S0140-6736(05)67728-8","type":"journal-article","article-title":"Periodontal diseases","volume":"366","author":"Pihlstrom","year":"2005","journal-title":"Lancet"},{"key":"bmmabb6b2bib2","doi-asserted-by":"publisher","first-page":"1368","DOI":"10.1111\/clr.12996","type":"journal-article","article-title":"The influence of collagen membrane and autogenous bone chips on bone augmentation in the anterior maxilla: a preclinical study","volume":"28","author":"Janner","year":"2017","journal-title":"Clin. 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All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2019-11-01","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2020-09-09","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2020-12-11","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}