{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T20:50:19Z","timestamp":1785703819602,"version":"3.56.0"},"reference-count":32,"publisher":"IOP Publishing","issue":"4","license":[{"start":{"date-parts":[[2021,5,11]],"date-time":"2021-05-11T00:00:00Z","timestamp":1620691200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/iop-standard\/v1"},{"start":{"date-parts":[[2021,5,11]],"date-time":"2021-05-11T00:00:00Z","timestamp":1620691200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001852","name":"Indo-French Centre for the Promotion of Advanced Research","doi-asserted-by":"crossref","award":["IFCPAR PROJECT No. 2603-2"],"award-info":[{"award-number":["IFCPAR PROJECT No. 2603-2"]}],"id":[{"id":"10.13039\/501100001852","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Biomed. Mater."],"published-print":{"date-parts":[[2021,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>In situ<\/jats:italic>\n                    forming tissue adhesives based on biopolymers offer advantages over conventional sutures and staples in terms of biocompatibility, biodegradability, ease of application and improved patient compliance and comfort. Here, we describe the evaluation of\n                    <jats:italic>in situ<\/jats:italic>\n                    gelling hydrogel system based on dextran dialdehyde (DDA) obtained by periodate oxidization of dextran and chitosan hydrochloride (CH) as tissue adhesive. The hydrogel was prepared by reacting aldehyde functions in DDA with the amino functions in CH via Schiff\u2019s reaction. The gelation reaction was instantaneous and took just 4 s. The DDA-CH hydrogel as tissue adhesive was evaluated on a sheep lung parenchymal injury model and a pig aortic model and was compared with the commercially available tissue sealant, Bioglue\u00ae. The DDA-CH glue could completely seal the sheep lung incision site even at inflation with air way pressure of 30 cm of H\n                    <jats:sub>2<\/jats:sub>\n                    O with no air leak observed in the incision sites (\n                    <jats:italic>n<\/jats:italic>\n                    = 8) in any of the animals. Histological analyses showed mild inflammation after 2 weeks, comparable to Bioglue\u00ae. Resorption of test material by giant cells with no adverse effect on lung parenchyma was seen after 3 months. The DDA-CH glue was also very effective in sealing aortic incisions in a pig model (\n                    <jats:italic>n<\/jats:italic>\n                    = 4) with no failures and aneurisms. The endoluminal surface of the sealed incision in all cases showed intact apposition with adequate healing across the incision. No tissue necrosis or inflammation of endothelial surface could be seen grossly. Our studies show that the DDA-CH hydrogel could function as an effective sealant for the prevention of air and blood leaks following lung and vascular surgery.\n                  <\/jats:p>","DOI":"10.1088\/1748-605x\/abfbbf","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T21:14:25Z","timestamp":1619471665000},"page":"044106","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["Efficacy evaluation of an\n                    <i>in situ<\/i>\n                    forming tissue adhesive hydrogel as sealant for lung and vascular injury"],"prefix":"10.1088","volume":"16","author":[{"given":"Biji","family":"Balakrishnan","sequence":"first","affiliation":[{"name":"Bhabha Atomic Research Centre"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umashanker","family":"Payanam","sequence":"additional","affiliation":[{"name":"Sree Chitra Tirunal Institute for Medical Sciences & Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Laurent","sequence":"additional","affiliation":[{"name":"APHP, H\u00f4pital Lariboisi\u00e8re"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Wassef","sequence":"additional","affiliation":[{"name":"APHP, H\u00f4pital Lariboisi\u00e8re"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2738-6161","authenticated-orcid":false,"given":"Athipettah","family":"Jayakrishnan","sequence":"additional","affiliation":[{"name":"Rajiv Gandhi Centre for Biotechnology"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2021,5,11]]},"reference":[{"key":"bmmabfbbfbib1","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1007\/s00268-014-2516-0","type":"journal-article","article-title":"Charitable platforms in global surgery: a systematic review of their effectiveness, cost-effectiveness, sustainability, and role training","volume":"39","author":"Shrime","year":"2015","journal-title":"World J. 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All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2020-12-15","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2021-04-26","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2021-05-11","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}