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Mater."],"published-print":{"date-parts":[[2023,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>In this proof-of-concept, bone neoformation beyond the skeletal envelope is explored by using a collagen pouch (<jats:italic>n<\/jats:italic> = 6) packed with calcium phosphate (CaP) granules placed over the frontal bone in sheep (<jats:italic>n<\/jats:italic> = 3). At 13 weeks, macroscopic examination showed specimens covered by an adherent fibrinous envelope with slight vascularization. Histology revealed colonization of the implant by newly formed woven bone and fibrous connective tissue. Surface osteoblasts as well as material-filled macrophages, lymphocytes, polymorphonuclear cells and giant cells were also found in large quantities surrounding the newly formed bone tissue inside the collagen pouch. On the side facing the recipient bone, the collagen membrane had to a large extent been resorbed and bridging bone formation was clearly visible between the test article and recipient bone. On the other side facing soft tissue, the collagen pouch remained intact with a visible fibrous capsule. This study demonstrated that the use of a collagen sleeve as a container for CaP granules allows for good neoformation beyond the skeletal envelope with bridging bone formation clearly visible between the test article and recipient bone. Additionally, in this model, macrophages rather than osteoclasts appear to modulate CaP granule resorption and remodeling into new bone. This construct opens new perspectives for treatment methods that could be used for bone augmentation and restoration of cranio-maxillofacial defects and malformations.<\/jats:p>","DOI":"10.1088\/1748-605x\/acc55e","type":"journal-article","created":{"date-parts":[[2023,3,17]],"date-time":"2023-03-17T22:30:52Z","timestamp":1679092252000},"page":"035007","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Bone formation beyond the skeletal envelope using calcium phosphate granules packed into a collagen pouch\u2014a pilot study"],"prefix":"10.1088","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9773-1747","authenticated-orcid":true,"given":"Claire","family":"Guillet","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7983-925X","authenticated-orcid":true,"given":"Ulrik","family":"Birgersson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Engstrand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2232-7226","authenticated-orcid":true,"given":"Jonas","family":"\u00c5berg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2079-4170","authenticated-orcid":true,"given":"Viviana R","family":"Lopes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Thor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e5kan","family":"Engqvist","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franck","family":"Forterre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"266","published-online":{"date-parts":[[2023,3,28]]},"reference":[{"key":"bmmacc55ebib1","doi-asserted-by":"publisher","first-page":"276","DOI":"10.3390\/app7030276","article-title":"Cranioplasty and craniofacial reconstruction: a review of implant material, manufacturing method and infection risk","volume":"7","author":"Kwarcinski","year":"2017","journal-title":"Appl. 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