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Mater."],"published-print":{"date-parts":[[2024,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>This study aimed to synthesize bioactive glass (BG) and phosphorylated chitosan (PCS), and fabricate a BG\/PCS composite scaffold. The physical properties (mechanical strength, swelling degree, and degradation rate) of the BG\/PCS scaffold were tested. The <jats:italic>in vitro<\/jats:italic> mineralization properties of composite scaffolds in simulated body fluid were investigated. MC3T3-E1 cell responses with the BG\/PCS scaffold were investigated using live\/dead cell staining, actin staining, alkaline phosphatase (ALP) activity, and Alizarin red staining. Our results showed that the scaffold had an inner porous structure, good swelling properties, and good degradation rate. After immersion in SBF, the scaffolds demonstrated high properties in inducing mineralization. Leaching solutions of the composite scaffolds exhibited good cytocompatibility. MC3T3-E1 cells adhered, spread, and proliferated on the scaffold. The BG\/PCS composite scaffold showed osteo-inductive activity by increasing ALP activity and calcium deposition. Our results indicated that the BG\/PCS scaffold had potential applications as a bone-defect repair biomaterial.<\/jats:p>","DOI":"10.1088\/1748-605x\/ad1bb0","type":"journal-article","created":{"date-parts":[[2024,1,5]],"date-time":"2024-01-05T22:40:38Z","timestamp":1704494438000},"page":"025002","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Fabrication of bioactive glass\/phosphorylated chitosan composite scaffold and its effects on MC3T3-E1 cells"],"prefix":"10.1088","volume":"19","author":[{"given":"Liu","family":"Wenxiu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han","family":"Guojiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin","family":"Liying","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong","family":"Wenli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han","family":"Baoqin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Liming","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9922-1126","authenticated-orcid":true,"given":"Yang","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"266","published-online":{"date-parts":[[2024,1,16]]},"reference":[{"key":"bmmad1bb0bib1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2020.117598","article-title":"Reduced polydopamine nanoparticles incorporated oxidized dextran\/chitosan hybrid hydrogels with enhanced antioxidative and antibacterial properties for accelerated wound healing","volume":"257","author":"Fu","year":"2021","journal-title":"Carbohydrate Polym."},{"key":"bmmad1bb0bib2","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1016\/j.ijbiomac.2020.05.016","article-title":"A novel synthetic chitosan selenate (CS) induces apoptosis in A549 lung cancer cells via the Fas\/FasL pathway","volume":"158","author":"Gao","year":"2020","journal-title":"Int. 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