{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T13:27:25Z","timestamp":1740144445165,"version":"3.37.3"},"reference-count":30,"publisher":"IOP Publishing","issue":"3","license":[{"start":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T00:00:00Z","timestamp":1709510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T00:00:00Z","timestamp":1709510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100002260","name":"North Carolina Textile Foundation","doi-asserted-by":"crossref","award":["762150-46411"],"award-info":[{"award-number":["762150-46411"]}],"id":[{"id":"10.13039\/100002260","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Biomed. Mater."],"published-print":{"date-parts":[[2024,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Bioresorbable polymeric sutures are gaining interest from surgeons and patients as they reduce surgical stress and trauma. This study involves two bioresorbable polymers, namely, catgut and poly(4-hyrdorxybutyrate) (P4HB) that are used widely in cosmetic procedures. P4HB barbed sutures are favorably used in rhytidectomy (micro-facelifts) procedures while catgut sutures are widely used for external wound closure after surgical interventions. This study involves the mechanical fabrication of catgut and P4HB barbed sutures and compares their mechanical and anchoring properties. Barbed sutures were fabricated with two different barb geometries namely, straight and curved barbs. The mechanical properties were evaluated via tensile testing, and the anchoring performance was studied by means of a suture-tissue pull-out protocol using porcine dermis tissue which was harvested from the medial dorsal site. The fabricated barbed sutures of both materials showed a similar trend compared to non-barbed sutures of decreases in failure stress, strain at failure, and work to rupture or toughness which was reduced by about 70%. At the same time there was a 15% increase in the initial modulus or stiffness of the barbed sutures. The pull-out force for the barbed sutures with straight barbs was similar for both P4HB (5.04 \u00b1 0.8 N) and catgut (4.47 \u00b1 3.8 N), and as expected, were higher than that of non-barbed sutures of the same size. It was also observed that barbed sutures with curved barbs also required a higher pull-out force than those sutures with straight barbs. It was concluded that by barbing sutures with different barb shapes and geometries, a range of barbed suture products could be fabricated, each meeting the closure requirements for different types of tissue and therefore being suitable for different surgical procedures.<\/jats:p>","DOI":"10.1088\/1748-605x\/ad2c1e","type":"journal-article","created":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T22:23:00Z","timestamp":1708640580000},"page":"035002","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Mechanical fabrication and evaluation of bioresorbable barbed sutures with different barb geometries"],"prefix":"10.1088","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9795-1595","authenticated-orcid":true,"given":"Karuna","family":"Nambi Gowri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7092-0732","authenticated-orcid":false,"given":"Martin W","family":"King","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"266","published-online":{"date-parts":[[2024,3,4]]},"reference":[{"key":"bmmad2c1ebib1","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1615\/JEnvironPatholToxicolOncol.v29.i4.60","article-title":"Wound closure sutures and needles: a new perspective","volume":"29","author":"Edich","year":"2010","journal-title":"J. Environ. Pathol. Toxicol. Oncol."},{"article-title":"Knotless bi-directional barbed absorbable surgical suture","year":"2002","author":"Dattilo","key":"bmmad2c1ebib2"},{"key":"bmmad2c1ebib3","doi-asserted-by":"publisher","first-page":"419","DOI":"10.3390\/bioengineering10040419","article-title":"A review of barbed sutures\u2014evolution, applications and clinical significance","volume":"10","author":"Nambi Gowri","year":"2023","journal-title":"Bioengineering"},{"article-title":"Studies of barbed surgical sutures associated with materials, anchoring performance and histology","year":"2018","author":"Cong","key":"bmmad2c1ebib4"},{"key":"bmmad2c1ebib5","doi-asserted-by":"publisher","first-page":"1544","DOI":"10.1002\/jbm.a.35683","article-title":"Suture materials\u2014current and emerging trends: suture materials","volume":"104","author":"Dennis","year":"2016","journal-title":"J. Biomed. Mater. Res. A"},{"key":"bmmad2c1ebib6","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1533\/9781845694104.7.395","article-title":"Barbed, BI-directional surgical sutures","author":"Leung","year":"2006"},{"article-title":"Inserting device for a barbed tissue connector","year":"1994","author":"Ruff","key":"bmmad2c1ebib7"},{"key":"bmmad2c1ebib8","doi-asserted-by":"publisher","first-page":"17S","DOI":"10.1177\/1090820X13499343","article-title":"Barbed sutures in aesthetic plastic surgery: evolution of thought and process","volume":"33","author":"Matarasso","year":"2013","journal-title":"Aesthetic Surg. J."},{"key":"bmmad2c1ebib9","doi-asserted-by":"publisher","DOI":"10.1177\/2309499020965681","article-title":"A symmetric anchor designed barbed suture versus conventional interrupted sutures in total knee arthroplasty: a multicenter, randomized controlled trial","volume":"28","author":"Wang","year":"2020","journal-title":"J. Orthop. Surg."},{"key":"bmmad2c1ebib10","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1007\/s00266-007-9012-y","article-title":"Complications of Barbed Sutures","volume":"32","author":"Paul","year":"2008","journal-title":"Aesthetic Plast. Surg."},{"key":"bmmad2c1ebib11","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1016\/j.asj.2006.08.011","article-title":"Technique and uses for absorbable barbed sutures","volume":"26","author":"Ruff","year":"2006","journal-title":"Aesthetic Surg. J."},{"article-title":"Evolution of Barbed sutures (Power point presentation)","year":"2008","author":"Ruff","key":"bmmad2c1ebib12"},{"author":"Ruff","key":"bmmad2c1ebib13","article-title":"Barbed bodily tissue connector"},{"article-title":"Fabrication and tissue anchoring performance of nylon and polypropylene barbed surgical sutures","year":"2013","author":"Cong","key":"bmmad2c1ebib14"},{"key":"bmmad2c1ebib15","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1016\/j.jbiomech.2009.11.012","article-title":"Finite element analysis of barbed sutures in skin and tendon tissues","volume":"43","author":"Ingle","year":"2010","journal-title":"J. Biomech."},{"key":"bmmad2c1ebib16","doi-asserted-by":"publisher","first-page":"2258","DOI":"10.1002\/jbm.b.35074","article-title":"Comparison of the mechanical properties and anchoring performance of polyvinylidene fluoride and polypropylene barbed sutures for tendon repair","volume":"110","author":"Huang","year":"2022","journal-title":"J. Biomed. Mater. Res. B"},{"key":"bmmad2c1ebib17","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1016\/j.jbiomech.2009.08.033","article-title":"Optimizing the tissue anchoring performance of barbed sutures in skin and tendon tissues","volume":"43","author":"Ingle","year":"2010","journal-title":"J. Biomech."},{"key":"bmmad2c1ebib18","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1136\/pgmj.25.287.427","article-title":"The Story of Catgut","volume":"25","author":"Holder","year":"1949","journal-title":"Postgrad. Med. J."},{"key":"bmmad2c1ebib19","first-page":"432","article-title":"Surgical sutures: the largest textile implant material","author":"Ajmeri","year":"2006"},{"key":"bmmad2c1ebib20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2012\/216137","article-title":"MonoMax suture: a new long-term absorbable monofilament suture made from Poly-4-Hydroxybutyrate","volume":"2012","author":"Odermatt","year":"2012","journal-title":"Int. J. Polym. Sci."},{"key":"bmmad2c1ebib21","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1515\/bmt-2013-0009","article-title":"Poly-4-hydroxybutyrate (P4HB): a new generation of resorbable medical devices for tissue repair and regeneration","volume":"58","author":"Williams","year":"2013","journal-title":"Biomed. Technol. Eng."},{"key":"bmmad2c1ebib22","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1016\/j.jmbbm.2017.08.021","article-title":"The suture retention test, revisited and revised","volume":"77","author":"Pensalfini","year":"2018","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"bmmad2c1ebib23","first-page":"2123","article-title":"Commonly used suture materials in skin surgery","volume":"44","author":"Moy","year":"1991","journal-title":"Am. Fam. Phys."},{"author":"Genova","key":"bmmad2c1ebib24","article-title":"Method of forming barbs on a suture and apparatus for performing same"},{"article-title":"A comparison of the properties and performance of polyvinylidene fluoride and polypropylene barbed sutures in tendon repair","year":"2017","author":"Huang","key":"bmmad2c1ebib25"},{"key":"bmmad2c1ebib26","first-page":"48","article-title":"Catgut: a historically revered and gold standard suture for toughness and tenacity","volume":"10","author":"Gupta","year":"2020","journal-title":"Indian Obstet. Gynecol."},{"key":"bmmad2c1ebib27","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1002\/bjs.18004620020","article-title":"The absorption of surgical catgut","volume":"46","author":"Lawrie","year":"2005","journal-title":"Br. J. Surg."},{"key":"bmmad2c1ebib28","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1002\/jbm.820130312","article-title":"A comparative study of poly(glycolic acid) and catgut as suture materials. Histomorphology and mechanical properties","volume":"13","author":"Pavan","year":"1979","journal-title":"J. Biomed. Mater. Res."},{"key":"bmmad2c1ebib29","doi-asserted-by":"publisher","DOI":"10.1016\/j.polymdegradstab.2020.109451","article-title":"Hydrolytic and enzymatic degradation of biobased poly(4-hydroxybutyrate) films. Selective etching of spherulites","volume":"183","author":"Keridou","year":"2021","journal-title":"Polym. Degrad. Stab."},{"key":"bmmad2c1ebib30","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/0142-9612(92)90165-K","article-title":"Degradation of collagen suture in vitro and in viva","volume":"13","author":"Okada","year":"1992","journal-title":"Biomater."}],"container-title":["Biomedical Materials"],"original-title":[],"link":[{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ad2c1e","content-type":"text\/html","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ad2c1e\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ad2c1e","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ad2c1e\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ad2c1e\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ad2c1e\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ad2c1e\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"similarity-checking"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ad2c1e\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T11:41:16Z","timestamp":1709552476000},"score":1,"resource":{"primary":{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ad2c1e"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,4]]},"references-count":30,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,3,4]]},"published-print":{"date-parts":[[2024,5,1]]}},"URL":"https:\/\/doi.org\/10.1088\/1748-605x\/ad2c1e","relation":{},"ISSN":["1748-6041","1748-605X"],"issn-type":[{"type":"print","value":"1748-6041"},{"type":"electronic","value":"1748-605X"}],"subject":[],"published":{"date-parts":[[2024,3,4]]},"assertion":[{"value":"Mechanical fabrication and evaluation of bioresorbable barbed sutures with different barb geometries","name":"article_title","label":"Article Title"},{"value":"Biomedical Materials","name":"journal_title","label":"Journal Title"},{"value":"paper","name":"article_type","label":"Article Type"},{"value":"\u00a9 2024 The Author(s). Published by IOP Publishing Ltd","name":"copyright_information","label":"Copyright Information"},{"value":"2023-10-05","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2024-02-22","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2024-03-04","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}