{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T13:56:07Z","timestamp":1790085367571,"version":"4.0.1"},"reference-count":136,"publisher":"IOP Publishing","issue":"4","license":[{"start":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T00:00:00Z","timestamp":1716422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T00:00:00Z","timestamp":1716422400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81873919"],"award-info":[{"award-number":["81873919"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Biomed. Mater."],"published-print":{"date-parts":[[2024,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In the field of medicine, we often brave the unknown like interstellar explorers, especially when confronting the formidable opponent of hepatocellular carcinoma (HCC). The global burden of HCC remains significant, with suboptimal treatment outcomes necessitating the urgent development of novel drugs and treatments. While various treatments for liver cancer, such as immunotherapy and targeted therapy, have emerged in recent years, improving their transport and therapeutic efficiency, controlling their targeting and release, and mitigating their adverse effects remains challenging. However, just as we grope through the darkness, a glimmer of light emerges\u2014nanotechnology. Recently, nanotechnology has attracted attention because it can increase the local drug concentration in tumors, reduce systemic toxicity, and has the potential to enhance the effectiveness of precision therapy for HCC. However, there are also some challenges hindering the clinical translation of drug-loaded nanoparticles (NPs). Just as interstellar explorers must overcome interstellar dust, we too must overcome various obstacles. In future researches, the design and development of nanodelivery systems for novel drugs treating HCC should be the first attention. Moreover, researchers should focus on the active targeting design of various NPs. The combination of the interventional therapies and drug-loaded NPs will greatly advance the process of precision HCC therapy.<\/jats:p>","DOI":"10.1088\/1748-605x\/ad46d3","type":"journal-article","created":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T19:06:43Z","timestamp":1714676803000},"page":"042004","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Recent advances in hepatocellular carcinoma-targeted nanoparticles"],"prefix":"10.1088","volume":"19","author":[{"given":"Xiaoming","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2360-1445","authenticated-orcid":true,"given":"Yaowei","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binqian","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songlin","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiacheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuansheng","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2024,5,23]]},"reference":[{"key":"bmmad46d3bib1","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1016\/S0140-6736(22)01200-4","article-title":"Hepatocellular carcinoma","volume":"400","author":"Vogel","year":"2022","journal-title":"Lancet"},{"key":"bmmad46d3bib2","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"bmmad46d3bib3","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.230527","article-title":"Development of a model including MRI features for predicting advanced-stage recurrence of hepatocellular carcinoma after liver resection","volume":"309","author":"Jiang","year":"2023","journal-title":"Radiology"},{"key":"bmmad46d3bib4","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1016\/j.jhep.2021.11.018","article-title":"BCLC strategy for prognosis prediction and treatment recommendation: the 2022 update","volume":"76","author":"Reig","year":"2022","journal-title":"J. Hepatol."},{"key":"bmmad46d3bib5","doi-asserted-by":"publisher","first-page":"e312","DOI":"10.1016\/S1470-2045(23)00186-9","article-title":"Personalised management of patients with hepatocellular carcinoma: a multiparametric therapeutic hierarchy concept","volume":"24","author":"Vitale","year":"2023","journal-title":"Lancet Oncol."},{"key":"bmmad46d3bib6","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1016\/j.jhep.2021.11.030","article-title":"Updated efficacy and safety data from IMbrave150: atezolizumab plus bevacizumab vs. sorafenib for unresectable hepatocellular carcinoma","volume":"76","author":"Cheng","year":"2022","journal-title":"J. Hepatol."},{"key":"bmmad46d3bib7","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1053\/j.gastro.2021.12.276","article-title":"AGA clinical practice guideline on systemic therapy for hepatocellular carcinoma","volume":"162","author":"Su","year":"2022","journal-title":"Gastroenterology"},{"key":"bmmad46d3bib8","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1038\/s41392-020-0187-x","article-title":"The mechanisms of sorafenib resistance in hepatocellular carcinoma: theoretical basis and therapeutic aspects","volume":"5","author":"Tang","year":"2020","journal-title":"Signal Transduct. Target. Ther."},{"key":"bmmad46d3bib9","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1016\/j.jhep.2022.03.039","article-title":"Uncoupling immune trajectories of response and adverse events from anti-PD-1 immunotherapy in hepatocellular carcinoma","volume":"77","author":"Chuah","year":"2022","journal-title":"J. Hepatol."},{"key":"bmmad46d3bib10","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1038\/s41392-023-01663-6","article-title":"Camrelizumab (a PD-1 inhibitor) plus apatinib (an VEGFR-2 inhibitor) and hepatic artery infusion chemotherapy for hepatocellular carcinoma in Barcelona clinic liver cancer stage C (TRIPLET): a phase II study","volume":"8","author":"Zhang","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"bmmad46d3bib11","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1186\/s12951-023-01990-4","article-title":"Multifunctional nanocarriers for targeted drug delivery and diagnostic applications of lymph nodes metastasis: a review of recent trends and future perspectives","volume":"21","author":"Lan","year":"2023","journal-title":"J. Nanobiotechnol."},{"key":"bmmad46d3bib12","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.3390\/polym14061188","article-title":"Nanocluster-based drug delivery and theranostic systems: towards cancer therapy","volume":"14","author":"Villela Zumaya","year":"2022","journal-title":"Polymers"},{"key":"bmmad46d3bib13","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1016\/j.jconrel.2016.01.020","article-title":"Nanoparticle-liver interactions: cellular uptake and hepatobiliary elimination","volume":"240","author":"Zhang","year":"2016","journal-title":"J Control. Release"},{"key":"bmmad46d3bib14","doi-asserted-by":"publisher","first-page":"3475","DOI":"10.1016\/j.apsb.2022.05.026","article-title":"Combination therapy using microwave ablation and d-mannose-chelated iron oxide nanoparticles inhibits hepatocellular carcinoma progression","volume":"12","author":"Cui","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"key":"bmmad46d3bib15","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202308780","article-title":"NIR-II photoacoustic imaging-guided oxygen delivery and controlled release improves photodynamic therapy for hepatocellular carcinoma","volume":"36","author":"Zeng","year":"2024","journal-title":"Adv. Mater."},{"key":"bmmad46d3bib16","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1016\/j.ajps.2020.01.001","article-title":"Regorafenib-loaded poly (lactide-co-glycolide) microspheres designed to improve transarterial chemoembolization therapy for hepatocellular carcinoma","volume":"15","author":"Li","year":"2020","journal-title":"Asian J. Pharm. Sci."},{"key":"bmmad46d3bib17","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1148\/radiol.2016150361","article-title":"Antitumoral effect of sunitinib-eluting beads in the rabbit VX2 tumor model","volume":"280","author":"Bize","year":"2016","journal-title":"Radiology"},{"key":"bmmad46d3bib18","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.22721","article-title":"Toxicity profiles of systemic therapies for advanced hepatocellular carcinoma: a systematic review and meta-analysis","volume":"5","author":"Griffiths","year":"2022","journal-title":"JAMA Netw. Open"},{"key":"bmmad46d3bib19","doi-asserted-by":"publisher","first-page":"3893","DOI":"10.3390\/ma15113893","article-title":"Nanotechnology in the diagnostic and therapy of hepatocellular carcinoma","volume":"15","author":"Graur","year":"2022","journal-title":"Materials"},{"key":"bmmad46d3bib20","doi-asserted-by":"publisher","first-page":"2798","DOI":"10.3390\/cancers14112798","article-title":"Emerging therapies for hepatocellular carcinoma (HCC)","volume":"14","author":"Chakraborty","year":"2022","journal-title":"Cancers"},{"key":"bmmad46d3bib21","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.2217\/nnm.12.87","article-title":"Nanotechnology in therapeutics: a focus on nanoparticles as a drug delivery system","volume":"7","author":"Bamrungsap","year":"2012","journal-title":"Nanomedicine"},{"key":"bmmad46d3bib22","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201901223","article-title":"Size-dependent EPR effect of polymeric nanoparticles on tumor targeting","volume":"9","author":"Kang","year":"2020","journal-title":"Adv. Healthcare Mater."},{"key":"bmmad46d3bib23","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1038\/nnano.2011.166","article-title":"Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size","volume":"6","author":"Cabral","year":"2011","journal-title":"Nat. Nanotechnol."},{"key":"bmmad46d3bib24","doi-asserted-by":"publisher","first-page":"1919","DOI":"10.3390\/pharmaceutics14091919","article-title":"\u201cTargeting design\u201d of nanoparticles in tumor therapy","volume":"14","author":"Yang","year":"2022","journal-title":"Pharmaceutics"},{"key":"bmmad46d3bib25","doi-asserted-by":"publisher","first-page":"2914","DOI":"10.1021\/acs.nanolett.8b05202","article-title":"Microwave responsive nanoplatform via P-selectin mediated drug delivery for treatment of hepatocellular carcinoma with distant metastasis","volume":"19","author":"Xu","year":"2019","journal-title":"Nano Lett."},{"key":"bmmad46d3bib26","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/j.ijbiomac.2021.12.197","article-title":"Co-delivery of siRNA and lycopene encapsulated hybrid lipid nanoparticles for dual silencing of insulin-like growth factor 1 receptor in MCF-7 breast cancer cell line","volume":"200","author":"Mennati","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"bmmad46d3bib27","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1080\/10717544.2016.1225856","article-title":"Asialoglycoprotein receptor targeted delivery of doxorubicin nanoparticles for hepatocellular carcinoma","volume":"24","author":"Pranatharthiharan","year":"2017","journal-title":"Drug Deliv."},{"key":"bmmad46d3bib28","doi-asserted-by":"publisher","first-page":"3223","DOI":"10.1021\/acs.molpharmaceut.0c00327","article-title":"Facile fabrication of nanoparticles with dual-targeting ligands for precise hepatocellular carcinoma therapy in vitro and in vivo","volume":"17","author":"Xiang","year":"2020","journal-title":"Mol. Pharm."},{"key":"bmmad46d3bib29","doi-asserted-by":"publisher","first-page":"643","DOI":"10.3109\/13880209.2012.761245","article-title":"Dual ligands modified double targeted nano-system for liver targeted gene delivery","volume":"51","author":"Jing","year":"2013","journal-title":"Pharm. Biol."},{"key":"bmmad46d3bib30","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2019.110498","article-title":"Sorafenib encapsulated in nanocarrier functionalized with glypican-3 specific peptide for targeted therapy of hepatocellular carcinoma","volume":"184","author":"Feng","year":"2019","journal-title":"Colloids Surf. B"},{"key":"bmmad46d3bib31","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1517\/17425247.2014.950564","article-title":"The importance of nanoparticle shape in cancer drug delivery","volume":"12","author":"Truong","year":"2015","journal-title":"Expert Opin. Drug Deliv."},{"key":"bmmad46d3bib32","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.addr.2013.11.009","article-title":"Cancer nanotechnology: the impact of passive and active targeting in the era of modern cancer biology","volume":"66","author":"Bertrand","year":"2014","journal-title":"Adv. Drug Deliv. Rev."},{"key":"bmmad46d3bib33","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1016\/j.talanta.2018.02.088","article-title":"Recent biomedical applications of gold nanoparticles: a review","volume":"184","author":"Elahi","year":"2018","journal-title":"Talanta"},{"key":"bmmad46d3bib34","doi-asserted-by":"publisher","first-page":"3490","DOI":"10.1021\/ic202197g","article-title":"Cisplatin-tethered gold nanoparticles that exhibit enhanced reproducibility, drug loading, and stability: a step closer to pharmaceutical approval?","volume":"51","author":"Craig","year":"2012","journal-title":"Inorg. Chem."},{"key":"bmmad46d3bib35","doi-asserted-by":"publisher","first-page":"7643","DOI":"10.2147\/IJN.S223941","article-title":"Gold nanoparticles and angiogenesis: molecular mechanisms and biomedical applications","volume":"14","author":"Darweesh","year":"2019","journal-title":"Int. J. Nanomed."},{"key":"bmmad46d3bib36","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/j.pdpdt.2019.01.027","article-title":"Gold nanoparticles application in liver cancer","volume":"25","author":"Taghizadeh","year":"2019","journal-title":"Photodiagnosis Photodyn. Ther."},{"key":"bmmad46d3bib37","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1007\/s10103-018-2467-z","article-title":"In vitro outlook of gold nanoparticles in photo-thermal therapy: a literature review","volume":"33","author":"Norouzi","year":"2018","journal-title":"Lasers Med. Sci."},{"key":"bmmad46d3bib38","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/s12645-016-0021-x","article-title":"Gold nanoparticles for cancer radiotherapy: a review","volume":"7","author":"Haume","year":"2016","journal-title":"Cancer Nanotechnol."},{"key":"bmmad46d3bib39","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1080\/21691401.2017.1374282","article-title":"Nanomedicines: a theranostic approach for hepatocellular carcinoma","volume":"46","author":"Usmani","year":"2017","journal-title":"Artif Cells Nanomed Biotechnol."},{"key":"bmmad46d3bib40","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1148\/radiol.2016152510","article-title":"Hepatocellular carcinoma: intra-arterial delivery of doxorubicin-loaded hollow gold nanospheres for photothermal ablation-chemoembolization therapy in rats","volume":"281","author":"Li","year":"2016","journal-title":"Radiology"},{"key":"bmmad46d3bib41","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1053\/j.gastro.2012.04.009","article-title":"miR-375 inhibits autophagy and reduces viability of hepatocellular carcinoma cells under hypoxic conditions","volume":"143","author":"Chang","year":"2012","journal-title":"Gastroenterology"},{"key":"bmmad46d3bib42","doi-asserted-by":"publisher","first-page":"86675","DOI":"10.18632\/oncotarget.13431","article-title":"Gold nanoparticles delivered miR-375 for treatment of hepatocellular carcinoma","volume":"7","author":"Xue","year":"2016","journal-title":"Oncotarget"},{"key":"bmmad46d3bib43","doi-asserted-by":"publisher","first-page":"2830","DOI":"10.1080\/21691401.2018.1489266","article-title":"Gold nano-particles (AuNPs) carrying miR-326 targets PDK1\/AKT\/c-myc axis in hepatocellular carcinoma","volume":"47","author":"Mo","year":"2019","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"bmmad46d3bib44","doi-asserted-by":"publisher","first-page":"1990","DOI":"10.1021\/cr5004198","article-title":"Nanoparticles in photodynamic therapy","volume":"115","author":"Lucky","year":"2015","journal-title":"Chem. Rev."},{"key":"bmmad46d3bib45","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.jphotobiol.2018.03.024","article-title":"Improved chemo-photothermal therapy of hepatocellular carcinoma using chitosan-coated gold nanoparticles","volume":"182","author":"Salem","year":"2018","journal-title":"J. Photochem. Photobiol. B"},{"key":"bmmad46d3bib46","doi-asserted-by":"publisher","first-page":"164","DOI":"10.7150\/thno.17099","article-title":"Smart Cu(II)-aptamer complexes based gold nanoplatform for tumor micro-environment triggered programmable intracellular prodrug release, photodynamic treatment and aggregation induced photothermal therapy of hepatocellular carcinoma","volume":"7","author":"Zhang","year":"2017","journal-title":"Theranostics"},{"key":"bmmad46d3bib47","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1016\/j.bmcl.2013.11.045","article-title":"Inhibition effects of gold nanoparticles on proliferation and migration in hepatic carcinoma-conditioned HUVECs","volume":"24","author":"Pan","year":"2014","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"bmmad46d3bib48","doi-asserted-by":"publisher","first-page":"1865","DOI":"10.1016\/j.biomaterials.2010.11.030","article-title":"The inhibition of retinal neovascularization by gold nanoparticles via suppression of VEGFR-2 activation","volume":"32","author":"Kim","year":"2011","journal-title":"Biomaterials"},{"key":"bmmad46d3bib49","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/418624","article-title":"Gold nanoparticles inhibit VEGF165-induced migration and tube formation of endothelial cells via the Akt pathway","volume":"2014","author":"Pan","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"bmmad46d3bib50","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1016\/j.nano.2011.01.011","article-title":"Mechanism of anti-angiogenic property of gold nanoparticles: role of nanoparticle size and surface charge","volume":"7","author":"Arvizo","year":"2011","journal-title":"Nanomedicine"},{"key":"bmmad46d3bib51","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1016\/j.nano.2018.01.007","article-title":"Metallic gold and bioactive quinacrine hybrid nanoparticles inhibit oral cancer stem cell and angiogenesis by deregulating inflammatory cytokines in p53 dependent manner","volume":"14","author":"Satapathy","year":"2018","journal-title":"Nanomedicine"},{"key":"bmmad46d3bib52","doi-asserted-by":"publisher","first-page":"43","DOI":"10.3109\/17435390.2010.489207","article-title":"Comparison of the toxicity of silver, gold and platinum nanoparticles in developing zebrafish embryos","volume":"5","author":"Asharani","year":"2011","journal-title":"Nanotoxicology"},{"key":"bmmad46d3bib53","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1080\/21691401.2017.1337031","article-title":"Exploiting antidiabetic activity of silver nanoparticles synthesized using Punica granatum leaves and anticancer potential against human liver cancer cells (HepG2)","volume":"46","author":"Saratale","year":"2018","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"bmmad46d3bib54","doi-asserted-by":"publisher","first-page":"1402","DOI":"10.1016\/j.ijbiomac.2020.10.032","article-title":"Shrimp shells extracted chitin in silver nanoparticle synthesis: expanding its prophecy towards anticancer activity in human hepatocellular carcinoma HepG2 cells","volume":"165","author":"Vijayakumar","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"bmmad46d3bib55","doi-asserted-by":"publisher","first-page":"3890","DOI":"10.1016\/j.sjbs.2022.02.054","article-title":"Subacute toxic effects of silver nanoparticles oral administration and withdrawal on the structure and function of adult Albino Rats\u2019 hepatic tissue","volume":"29","author":"Mohammad Yousof","year":"2022","journal-title":"Saudi J. Biol. Sci."},{"key":"bmmad46d3bib56","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/j.molmed.2017.03.004","article-title":"ROS in cancer: the burning question","volume":"23","author":"Chio","year":"2017","journal-title":"Trends Mol. Med."},{"key":"bmmad46d3bib57","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1007\/s00280-016-2976-z","article-title":"Platinum-based drugs: past, present and future","volume":"77","author":"Dilruba","year":"2016","journal-title":"Cancer Chemother. Pharmacol."},{"key":"bmmad46d3bib58","doi-asserted-by":"publisher","first-page":"3436","DOI":"10.1021\/acs.chemrev.5b00597","article-title":"The next generation of platinum drugs: targeted Pt(II) agents, nanoparticle delivery, and Pt(IV) prodrugs","volume":"116","author":"Johnstone","year":"2016","journal-title":"Chem. Rev."},{"key":"bmmad46d3bib59","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1111\/j.1478-3231.2008.01963.x","article-title":"Oxidative stress may enhance the malignant potential of human hepatocellular carcinoma by telomerase activation","volume":"29","author":"Nishikawa","year":"2009","journal-title":"Liver Int."},{"key":"bmmad46d3bib60","doi-asserted-by":"publisher","DOI":"10.1177\/1010428317717259","article-title":"Evaluation of the antitumor activity of platinum nanoparticles in the treatment of hepatocellular carcinoma induced in rats","volume":"39","author":"Medhat","year":"2017","journal-title":"Tumour Biol."},{"key":"bmmad46d3bib61","doi-asserted-by":"publisher","first-page":"4901","DOI":"10.1002\/anie.201813149","article-title":"Peptide-coated platinum nanoparticles with selective toxicity against liver cancer cells","volume":"58","author":"Shoshan","year":"2019","journal-title":"Angew. Chem., Int. Ed. Engl."},{"key":"bmmad46d3bib62","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.bioactmat.2021.10.014","article-title":"Recent advances in engineering iron oxide nanoparticles for effective magnetic resonance imaging","volume":"12","author":"Zhao","year":"2022","journal-title":"Bioact. Mater."},{"key":"bmmad46d3bib63","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.addr.2010.05.006","article-title":"Superparamagnetic iron oxide nanoparticles (SPIONs): development, surface modification and applications in chemotherapy","volume":"63","author":"Mahmoudi","year":"2011","journal-title":"Adv. Drug Deliv. Rev."},{"key":"bmmad46d3bib64","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1021\/ar200085c","article-title":"Theranostic magnetic nanoparticles","volume":"44","author":"Yoo","year":"2011","journal-title":"Acc. Chem. Res."},{"key":"bmmad46d3bib65","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1016\/j.jcmg.2020.06.038","article-title":"Diagnostic applications of ultrasmall superparamagnetic particles of iron oxide for imaging myocardial and vascular inflammation","volume":"14","author":"Merinopoulos","year":"2021","journal-title":"JACC Cardiovascular Imaging"},{"key":"bmmad46d3bib66","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1148\/radiol.2015141624","article-title":"Multimodality imaging of ethiodized oil-loaded radiopaque microspheres during transarterial embolization of rabbits with VX2 liver tumors","volume":"279","author":"Tacher","year":"2016","journal-title":"Radiology"},{"key":"bmmad46d3bib67","doi-asserted-by":"publisher","first-page":"1280","DOI":"10.1016\/j.jvir.2007.07.008","article-title":"Comparison of transcatheter intraarterial perfusion MR imaging and fluorescent microsphere perfusion measurements during transcatheter arterial embolization of rabbit liver tumors","volume":"18","author":"Virmani","year":"2007","journal-title":"JVIR"},{"key":"bmmad46d3bib68","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1186\/s40644-019-0257-x","article-title":"Local application of doxorubicin- loaded iron oxid nanoparticles and the vascular disrupting agent via the hepatic artery: chemoembolization-photothermal ablation treatment of hepatocellular carcinoma in rats","volume":"19","author":"Yuan","year":"2019","journal-title":"Cancer Imaging"},{"key":"bmmad46d3bib69","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1097\/RLI.0b013e31827994e5","article-title":"MRI-monitored transcatheter intra-arterial delivery of SPIO-labeled natural killer cells to hepatocellular carcinoma: preclinical studies in a rodent model","volume":"48","author":"Sheu","year":"2013","journal-title":"Invest. Radiol."},{"key":"bmmad46d3bib70","doi-asserted-by":"publisher","first-page":"2891","DOI":"10.1021\/acs.molpharmaceut.0c00336","article-title":"Multipotent miRNA sponge-loaded magnetic nanodroplets with ultrasound\/magnet-assisted delivery for hepatocellular carcinoma therapy","volume":"17","author":"Dong","year":"2020","journal-title":"Mol. Pharm."},{"key":"bmmad46d3bib71","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1007\/s13346-022-01237-z","article-title":"Magnetically responsive nanoplatform targeting circRNA circ_0058051 inhibits hepatocellular carcinoma progression","volume":"13","author":"You","year":"2023","journal-title":"Drug Deliv. Transl. Res."},{"key":"bmmad46d3bib72","doi-asserted-by":"publisher","first-page":"28","DOI":"10.7150\/thno.13137","article-title":"A novel inherently radiopaque bead for transarterial embolization to treat liver cancer\u2014a pre-clinical study","volume":"6","author":"Duran","year":"2016","journal-title":"Theranostics"},{"key":"bmmad46d3bib73","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.jconrel.2017.02.001","article-title":"Characterization of a novel intrinsically radiopaque drug-eluting bead for image-guided therapy: DC bead LUMI\u2122","volume":"250","author":"Ashrafi","year":"2017","journal-title":"J. Control. Release"},{"key":"bmmad46d3bib74","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1016\/j.actbio.2021.07.006","article-title":"Fabrication of Fe3O4@PVA microspheres by one-step electrospray for magnetic resonance imaging during transcatheter arterial embolization","volume":"131","author":"Li","year":"2021","journal-title":"Acta Biomater."},{"key":"bmmad46d3bib75","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1016\/j.actbio.2021.05.031","article-title":"Magnetic mesoporous embolic microspheres in transcatheter arterial chemoembolization for liver cancer","volume":"130","author":"Liu","year":"2021","journal-title":"Acta Biomater."},{"key":"bmmad46d3bib76","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/j.biomaterials.2015.05.010","article-title":"Poly(lactide-co-glycolide) microspheres for MRI-monitored delivery of sorafenib in a rabbit VX2 model","volume":"61","author":"Chen","year":"2015","journal-title":"Biomaterials"},{"key":"bmmad46d3bib77","doi-asserted-by":"publisher","first-page":"3793","DOI":"10.7150\/thno.40805","article-title":"Comprehensive understanding of magnetic hyperthermia for improving antitumor therapeutic efficacy","volume":"10","author":"Liu","year":"2020","journal-title":"Theranostics"},{"key":"bmmad46d3bib78","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/s13046-014-0057-x","article-title":"The intratumoral administration of ferucarbotran conjugated with doxorubicin improved therapeutic effect by magnetic hyperthermia combined with pharmacotherapy in a hepatocellular carcinoma model","volume":"33","author":"Jeon","year":"2014","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"bmmad46d3bib79","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1016\/j.addr.2011.03.008","article-title":"Magnetic nanomaterials for hyperthermia-based therapy and controlled drug delivery","volume":"63","author":"Kumar","year":"2011","journal-title":"Adv. Drug Deliv. Rev."},{"key":"bmmad46d3bib80","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2020.103741","article-title":"Optimization of power used in liver cancer microwave therapy by injection of magnetic nanoparticles (MNPs)","volume":"120","author":"Minbashi","year":"2020","journal-title":"Comput. Biol. Med."},{"key":"bmmad46d3bib81","doi-asserted-by":"publisher","first-page":"6764","DOI":"10.1021\/acs.nanolett.1c01313","article-title":"Magnetostrictive-piezoelectric-triggered nanocatalytic tumor therapy","volume":"21","author":"Ge","year":"2021","journal-title":"Nano Lett."},{"key":"bmmad46d3bib82","doi-asserted-by":"publisher","first-page":"24958","DOI":"10.1039\/d2ra03429h","article-title":"Magnetoelectric core-shell CoFe2O4@BaTiO3 nanorods: their role in drug delivery and effect on multidrug resistance pump activity in vitro","volume":"12","author":"Mushtaq","year":"2022","journal-title":"RSC Adv."},{"key":"bmmad46d3bib83","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2020.111444","article-title":"Field-controlled magnetoelectric core-shell CoFe2O4@BaTiO3 nanoparticles as effective drug carriers and drug release in vitro","volume":"119","author":"Shahzad","year":"2021","journal-title":"Mater. Sci. Eng. C"},{"key":"bmmad46d3bib84","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1177\/1091581816659661","article-title":"Cytotoxicity of manganese (III) complex in human breast adenocarcinoma cell line is mediated by the generation of reactive oxygen species followed by mitochondrial damage","volume":"35","author":"Al-Anbaky","year":"2016","journal-title":"Int. J. Toxicol."},{"key":"bmmad46d3bib85","doi-asserted-by":"publisher","first-page":"65474","DOI":"10.1007\/s11356-021-15571-1","article-title":"Ameliorative potential of manganese nanoparticles with low-level ionizing radiation against experimentally induced hepatocarcinogenesis","volume":"28","author":"Abdel-Aziz","year":"2021","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"bmmad46d3bib86","doi-asserted-by":"publisher","first-page":"2705","DOI":"10.1016\/j.biomaterials.2008.03.014","article-title":"The role of cerium redox state in the SOD mimetic activity of nanoceria","volume":"29","author":"Heckert","year":"2008","journal-title":"Biomaterials"},{"key":"bmmad46d3bib87","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1002\/hep.31139","article-title":"Bespoken nanoceria: an effective treatment in experimental hepatocellular carcinoma","volume":"72","author":"Fern\u00e1ndez-Varo","year":"2020","journal-title":"Hepatology"},{"key":"bmmad46d3bib88","doi-asserted-by":"publisher","first-page":"1820","DOI":"10.1039\/c4nr05843g","article-title":"Enhanced reactive oxygen species overexpression by CuO nanoparticles in poorly differentiated hepatocellular carcinoma cells","volume":"7","author":"Kung","year":"2015","journal-title":"Nanoscale"},{"key":"bmmad46d3bib89","doi-asserted-by":"publisher","first-page":"10688","DOI":"10.1021\/acsnano.0c05332","article-title":"Bortezomib-encapsulated CuS\/carbon dot nanocomposites for enhanced photothermal therapy via stabilization of polyubiquitinated substrates in the proteasomal degradation pathway","volume":"14","author":"Yu","year":"2020","journal-title":"ACS Nano"},{"key":"bmmad46d3bib90","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/j.actbio.2021.03.051","article-title":"Ataxia telangiectasia mutated inhibitor-loaded copper sulfide nanoparticles for low-temperature photothermal therapy of hepatocellular carcinoma","volume":"127","author":"Cai","year":"2021","journal-title":"Acta Biomater."},{"key":"bmmad46d3bib91","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.ijpharm.2005.10.010","article-title":"Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles","volume":"307","author":"Owens","year":"2006","journal-title":"Int. J. Pharm."},{"key":"bmmad46d3bib92","doi-asserted-by":"publisher","first-page":"1980","DOI":"10.1002\/anie.201002969","article-title":"PEGylated inorganic nanoparticles","volume":"50","author":"Karakoti","year":"2011","journal-title":"Angew. Chem., Int. Ed. Engl."},{"key":"bmmad46d3bib93","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.colsurfb.2017.07.038","article-title":"Recent applications of PLGA based nanostructures in drug delivery","volume":"159","author":"Mir","year":"2017","journal-title":"Colloids Surf. B"},{"key":"bmmad46d3bib94","doi-asserted-by":"publisher","first-page":"4874","DOI":"10.1002\/jps.22200","article-title":"Development of PLGA nanoparticles simultaneously loaded with vincristine and verapamil for treatment of hepatocellular carcinoma","volume":"99","author":"Song","year":"2010","journal-title":"J. Pharm. Sci."},{"key":"bmmad46d3bib95","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/j.jconrel.2012.01.043","article-title":"PLGA-based nanoparticles: an overview of biomedical applications","volume":"161","author":"Danhier","year":"2012","journal-title":"J. Control. Release"},{"key":"bmmad46d3bib96","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.drudis.2014.09.018","article-title":"Hybrid poly(lactic-co-glycolic acid) nanoparticles: design and delivery prospectives","volume":"20","author":"Pandita","year":"2015","journal-title":"Drug. Discov. Today"},{"key":"bmmad46d3bib97","doi-asserted-by":"publisher","first-page":"33412","DOI":"10.1021\/acsami.6b08153","article-title":"Gemcitabine and antisense-microRNA co-encapsulated PLGA-PEG polymer nanoparticles for hepatocellular carcinoma therapy","volume":"8","author":"Devulapally","year":"2016","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"bmmad46d3bib98","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1186\/s13046-019-1216-x","article-title":"Co-delivery of sorafenib and metapristone encapsulated by CXCR4-targeted PLGA-PEG nanoparticles overcomes hepatocellular carcinoma resistance to sorafenib","volume":"38","author":"Zheng","year":"2019","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"bmmad46d3bib99","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201600327","article-title":"Laser-triggered small interfering RNA releasing gold nanoshells against heat shock protein for sensitized photothermal therapy","volume":"4","author":"Wang","year":"2017","journal-title":"Adv. Sci."},{"key":"bmmad46d3bib100","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2022.1022330","article-title":"A smart nanoplatform for enhanced photo-ferrotherapy of hepatocellular carcinoma","volume":"10","author":"Tang","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"key":"bmmad46d3bib101","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.actbio.2022.07.019","article-title":"Embolization therapy with microspheres for the treatment of liver cancer: state-of-the-art of clinical translation","volume":"149","author":"P\u00e9rez-L\u00f3pez","year":"2022","journal-title":"Acta Biomater."},{"key":"bmmad46d3bib102","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/j.colsurfb.2015.05.037","article-title":"Doxorubicin-loaded poly(lactic-co-glycolic acid) microspheres prepared using the solid-in-oil-in-water method for the transarterial chemoembolization of a liver tumor","volume":"132","author":"Choi","year":"2015","journal-title":"Colloids Surf. B"},{"key":"bmmad46d3bib103","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110512","article-title":"Preparation of microspheres encapsulating sorafenib and catalase and their application in rabbit VX2 liver tumor","volume":"129","author":"Li","year":"2020","journal-title":"Biomed. Pharm."},{"key":"bmmad46d3bib104","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.jconrel.2018.06.026","article-title":"Saccharides, oligosaccharides, and polysaccharides nanoparticles for biomedical applications","volume":"284","author":"Seidi","year":"2018","journal-title":"J. Control. Release"},{"key":"bmmad46d3bib105","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.jconrel.2015.02.022","article-title":"Asialoglycoprotein receptor mediated hepatocyte targeting\u2014strategies and applications","volume":"203","author":"D\u2019Souza","year":"2015","journal-title":"J. Control. Release"},{"key":"bmmad46d3bib106","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.carbpol.2019.04.041","article-title":"Angelica sinensis polysaccharide nanoparticles as a targeted drug delivery system for enhanced therapy of liver cancer","volume":"219","author":"Zhang","year":"2019","journal-title":"Carbohydr. Polym."},{"key":"bmmad46d3bib107","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1016\/j.nano.2011.11.002","article-title":"Self-assembly and liver targeting of sulfated chitosan nanoparticles functionalized with glycyrrhetinic acid","volume":"8","author":"Tian","year":"2012","journal-title":"Nanomedicine"},{"key":"bmmad46d3bib108","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.ijpharm.2010.05.001","article-title":"Synthesis and characterization of low-toxic amphiphilic chitosan derivatives and their application as micelle carrier for antitumor drug","volume":"394","author":"Huo","year":"2010","journal-title":"Int. J. Pharm."},{"key":"bmmad46d3bib109","doi-asserted-by":"publisher","first-page":"10578","DOI":"10.1021\/acsami.9b00634","article-title":"Delivery of liver-specific miRNA-122 using a targeted macromolecular prodrug toward synergistic therapy for hepatocellular carcinoma","volume":"11","author":"Ning","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"bmmad46d3bib110","doi-asserted-by":"publisher","first-page":"3218","DOI":"10.2174\/1381612826666200622133407","article-title":"Recent advances in lipid-based nanodrug delivery systems in cancer therapy","volume":"26","author":"Layek","year":"2020","journal-title":"Curr. Pharm. Des."},{"key":"bmmad46d3bib111","doi-asserted-by":"publisher","first-page":"5123","DOI":"10.2147\/IJN.S87011","article-title":"Lactoferrin-modified PEGylated liposomes loaded with doxorubicin for targeting delivery to hepatocellular carcinoma","volume":"10","author":"Wei","year":"2015","journal-title":"Int. J. Nanomed."},{"key":"bmmad46d3bib112","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.ijpharm.2014.10.014","article-title":"Liposomes for targeting hepatocellular carcinoma: use of conjugated arabinogalactan as targeting ligand","volume":"477","author":"Shah","year":"2014","journal-title":"Int. J. Pharm."},{"key":"bmmad46d3bib113","doi-asserted-by":"publisher","first-page":"1374","DOI":"10.1080\/21691401.2019.1596943","article-title":"Co-delivery of sorafenib and VEGF-siRNA via pH-sensitive liposomes for the synergistic treatment of hepatocellular carcinoma","volume":"47","author":"Yao","year":"2019","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"bmmad46d3bib114","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.bioactmat.2022.01.003","article-title":"CXCR4-guided liposomes regulating hypoxic and immunosuppressive microenvironment for sorafenib-resistant tumor treatment","volume":"17","author":"Wang","year":"2022","journal-title":"Bioact. Mater."},{"key":"bmmad46d3bib115","doi-asserted-by":"publisher","first-page":"2004","DOI":"10.1016\/j.apsb.2021.02.001","article-title":"Synergetic delivery of triptolide and Ce6 with light-activatable liposomes for efficient hepatocellular carcinoma therapy","volume":"11","author":"Yu","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"key":"bmmad46d3bib116","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1016\/j.jconrel.2009.11.008","article-title":"Biodegradable calcium phosphate nanoparticle with lipid coating for systemic siRNA delivery","volume":"142","author":"Li","year":"2010","journal-title":"J. Control. Release"},{"key":"bmmad46d3bib117","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.2147\/IJN.S156328","article-title":"Targeted co-delivery of Beclin 1 siRNA and FTY720 to hepatocellular carcinoma by calcium phosphate nanoparticles for enhanced anticancer efficacy","volume":"13","author":"Wu","year":"2018","journal-title":"Int. J. Nanomed."},{"key":"bmmad46d3bib118","doi-asserted-by":"publisher","first-page":"eaax5032","DOI":"10.1126\/sciadv.aax5032","article-title":"Highly efficient and tumor-selective nanoparticles for dual-targeted immunogene therapy against cancer","volume":"6","author":"Huang","year":"2020","journal-title":"Sci. Adv."},{"key":"bmmad46d3bib119","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/j.canlet.2012.07.011","article-title":"Targeted delivery of EV peptide to tumor cell cytoplasm using lipid coated calcium carbonate nanoparticles","volume":"334","author":"Kim","year":"2013","journal-title":"Cancer Lett."},{"key":"bmmad46d3bib120","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.actbio.2018.03.022","article-title":"Enhancing anti-tumor efficiency in hepatocellular carcinoma through the autophagy inhibition by miR-375\/sorafenib in lipid-coated calcium carbonate nanoparticles","volume":"72","author":"Zhao","year":"2018","journal-title":"Acta Biomater."},{"key":"bmmad46d3bib121","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1016\/j.actbio.2022.09.074","article-title":"Nanoscale CaO2 materials for synergistic transarterial chemoembolization in a VX2 orthotopic rabbit liver cancer model","volume":"154","author":"Wang","year":"2022","journal-title":"Acta Biomater."},{"key":"bmmad46d3bib122","doi-asserted-by":"publisher","first-page":"3862","DOI":"10.1039\/c3cs35405a","article-title":"Synthesis of mesoporous silica nanoparticles","volume":"42","author":"Wu","year":"2013","journal-title":"Chem. Soc. Rev."},{"key":"bmmad46d3bib123","doi-asserted-by":"publisher","first-page":"184","DOI":"10.3389\/fbioe.2020.00184","article-title":"Emerging and innovative theranostic approaches for mesoporous silica nanoparticles in hepatocellular carcinoma: current status and advances","volume":"8","author":"Tao","year":"2020","journal-title":"Front. Bioeng. Biotechnol."},{"key":"bmmad46d3bib124","doi-asserted-by":"publisher","first-page":"2767","DOI":"10.2147\/IJN.S60171","article-title":"Liver cancer cells: targeting and prolonged-release drug carriers consisting of mesoporous silica nanoparticles and alginate microspheres","volume":"9","author":"Liao","year":"2014","journal-title":"Int. J. Nanomed."},{"key":"bmmad46d3bib125","doi-asserted-by":"publisher","first-page":"5271","DOI":"10.2147\/IJN.S135306","article-title":"Delivery of miR-375 and doxorubicin hydrochloride by lipid-coated hollow mesoporous silica nanoparticles to overcome multiple drug resistance in hepatocellular carcinoma","volume":"12","author":"Xue","year":"2017","journal-title":"Int. J. Nanomed."},{"key":"bmmad46d3bib126","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/CAD.0000000000000572","article-title":"Autophagy and doxorubicin resistance in cancer","volume":"29","author":"Chen","year":"2018","journal-title":"Anticancer Drugs"},{"key":"bmmad46d3bib127","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1016\/j.actbio.2022.09.035","article-title":"Isoginkgetin synergizes with doxorubicin for robust co-delivery to induce autophagic cell death in hepatocellular carcinoma","volume":"153","author":"Wang","year":"2022","journal-title":"Acta Biomater."},{"key":"bmmad46d3bib128","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.7150\/thno.14471","article-title":"Safe and immunocompatible nanocarriers cloaked in RBC membranes for drug delivery to treat solid tumors","volume":"6","author":"Luk","year":"2016","journal-title":"Theranostics"},{"key":"bmmad46d3bib129","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1038\/nature15373","article-title":"Nanoparticle biointerfacing by platelet membrane cloaking","volume":"526","author":"Hu","year":"2015","journal-title":"Nature"},{"key":"bmmad46d3bib130","doi-asserted-by":"publisher","first-page":"3248","DOI":"10.1021\/nl401376w","article-title":"Reconstructed stem cell nanoghosts: a natural tumor targeting platform","volume":"13","author":"Toledano Furman","year":"2013","journal-title":"Nano Lett."},{"key":"bmmad46d3bib131","doi-asserted-by":"publisher","first-page":"10049","DOI":"10.1021\/acsnano.6b04695","article-title":"Cancer cell membrane-biomimetic nanoparticles for homologous-targeting dual-modal imaging and photothermal therapy","volume":"10","author":"Chen","year":"2016","journal-title":"ACS Nano"},{"key":"bmmad46d3bib132","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/j.apsb.2019.01.011","article-title":"Red blood cell membrane-camouflaged nanoparticles: a novel drug delivery system for antitumor application","volume":"9","author":"Xia","year":"2019","journal-title":"Acta Pharm. Sin. B"},{"key":"bmmad46d3bib133","doi-asserted-by":"publisher","first-page":"21","DOI":"10.3390\/pharmaceutics12010021","article-title":"Erythrocyte membrane-coated arsenic trioxide-loaded sodium alginate nanoparticles for tumor therapy","volume":"12","author":"Lian","year":"2019","journal-title":"Pharmaceutics"},{"key":"bmmad46d3bib134","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201706245","article-title":"Neutrophil-based drug delivery systems","volume":"30","author":"Chu","year":"2018","journal-title":"Adv. Mater."},{"key":"bmmad46d3bib135","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2021.107624","article-title":"Biodegradable hypocrellin B nanoparticles coated with neutrophil membranes for hepatocellular carcinoma photodynamics therapy effectively via JUNB\/ROS signaling","volume":"99","author":"Zhang","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"bmmad46d3bib136","doi-asserted-by":"publisher","first-page":"5828","DOI":"10.7150\/thno.34837","article-title":"Homotypic cell membrane-cloaked biomimetic nanocarrier for the targeted chemotherapy of hepatocellular carcinoma","volume":"9","author":"Liu","year":"2019","journal-title":"Theranostics"}],"container-title":["Biomedical Materials"],"original-title":[],"link":[{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ad46d3","content-type":"text\/html","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ad46d3\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ad46d3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ad46d3\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ad46d3\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ad46d3\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ad46d3\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"similarity-checking"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ad46d3\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T04:11:40Z","timestamp":1716437500000},"score":1,"resource":{"primary":{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ad46d3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,23]]},"references-count":136,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,5,23]]},"published-print":{"date-parts":[[2024,7,1]]}},"URL":"https:\/\/doi.org\/10.1088\/1748-605x\/ad46d3","relation":{"has-review":[{"id-type":"doi","id":"10.1088\/1748-605X\/AD46D3\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1088\/1748-605X\/AD46D3\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1088\/1748-605X\/AD46D3\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1088\/1748-605X\/AD46D3\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1088\/1748-605X\/AD46D3\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1088\/1748-605X\/AD46D3\/v1\/decision1","asserted-by":"object"}]},"ISSN":["1748-6041","1748-605X"],"issn-type":[{"value":"1748-6041","type":"print"},{"value":"1748-605X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,23]]},"assertion":[{"value":"Recent advances in hepatocellular carcinoma-targeted nanoparticles","name":"article_title","label":"Article Title"},{"value":"Biomedical Materials","name":"journal_title","label":"Journal Title"},{"value":"paper","name":"article_type","label":"Article Type"},{"value":"\u00a9 2024 The Author(s). Published by IOP Publishing Ltd","name":"copyright_information","label":"Copyright Information"},{"value":"2024-02-03","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2024-05-01","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2024-05-23","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}