{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T12:11:34Z","timestamp":1791807094206,"version":"4.3.4"},"reference-count":94,"publisher":"IOP Publishing","issue":"5","license":[{"start":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T00:00:00Z","timestamp":1721174400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/page\/copyright"},{"start":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T00:00:00Z","timestamp":1721174400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100018729","name":"Materials and Energy Research Center","doi-asserted-by":"crossref","award":["791400006"],"award-info":[{"award-number":["791400006"]}],"id":[{"id":"10.13039\/501100018729","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Biomed. Mater."],"published-print":{"date-parts":[[2024,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The performance and long-term durability of dental implants hinge on the quality of bone integration and their resistance to bacteria. This research aims to introduce a surface modification strategy for zirconia implants utilizing femtosecond laser ablation techniques, exploring their impact on osteoblast cell behavior and bacterial performance, as well as the integral factors influencing the soft tissue quality surrounding dental implants. Ultrafast lasers were employed to craft nanoscale groove geometries on zirconia surfaces, with thorough analyses conducted using x-ray diffraction, scanning electron microscopy, atomic force microscopy, and water contact angle measurements. The study evaluated the response of human fetal osteoblastic cell lines to textured zirconia ceramics by assessing alkaline phosphatase activity, collagen I, and interleukin 1<jats:italic>\u03b2<\/jats:italic> secretion over a 7 day period. Additionally, the antibacterial behavior of the textured surfaces was investigated using <jats:italic>Fusobacterium nucleatum<\/jats:italic>, a common culprit in infections associated with dental implants. Ciprofloxacin (CIP), a widely used antibacterial antibiotic, was loaded onto zirconia ceramic surfaces. The results of this study unveiled a substantial reduction in bacterial adhesion on textured zirconia surfaces. The fine biocompatibility of these surfaces was confirmed through the MTT assay and observations of cell morphology. Moreover, the human fetal osteoblastic cell line exhibited extensive spreading and secreted elevated levels of collagen I and interleukin 1<jats:italic>\u03b2<\/jats:italic> in the modified samples. Drug release evaluations demonstrated sustained CIP release through a diffusion mechanism, showcasing excellent antibacterial activity against pathogenic bacteria, including <jats:italic>Streptococcus mutans, Pseudomonas aeruginosa<\/jats:italic>, and <jats:italic>Escherichia coli<\/jats:italic>.<\/jats:p>","DOI":"10.1088\/1748-605x\/ad606f","type":"journal-article","created":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T10:18:28Z","timestamp":1721211508000},"page":"055017","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":17,"title":["Tailoring zirconia surface topography via femtosecond laser-induced nanoscale features: effects on osteoblast cells and antibacterial properties"],"prefix":"10.1088","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6514-6754","authenticated-orcid":true,"given":"Arash","family":"Ghalandarzadeh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1988-4534","authenticated-orcid":true,"given":"Monireh","family":"Ganjali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milad","family":"Hosseini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2024,7,17]]},"reference":[{"key":"bmmad606fbib1","first-page":"696","article-title":"The efficacy of various bone augmentation procedures for dental implants: a Cochrane systematic review of randomized controlled clinical trials","volume":"21","author":"Esposito","year":"2006","journal-title":"Int. J. Oral Maxillofac. Implants"},{"key":"bmmad606fbib2","doi-asserted-by":"publisher","first-page":"S96","DOI":"10.1007\/s005860100282","article-title":"Osteoinduction, osteoconduction and osseointegration","volume":"10","author":"Albrektsson","year":"2001","journal-title":"Eur. Spine J."},{"key":"bmmad606fbib3","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1111\/j.1532-849X.1999.tb00006.x","article-title":"Dental implant materials: commercially pure titanium and titanium alloys","volume":"8","author":"McCracken","year":"1999","journal-title":"J. Prosthodont."},{"key":"bmmad606fbib4","doi-asserted-by":"publisher","DOI":"10.1016\/j.matchemphys.2022.126899","article-title":"Tackling the challenges facing the clinical applications of pure PEO hydroxyapatite layers: co-deposition of YSZ nanoparticles","volume":"293","author":"Hosseini","year":"2023","journal-title":"Mater. Chem. Phys."},{"key":"bmmad606fbib5","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1016\/j.jeurceramsoc.2008.08.025","article-title":"Ceramics for medical applications: a picture for the next 20 years","volume":"29","author":"Chevalier","year":"2009","journal-title":"J. Eur. Ceram. Soc."},{"key":"bmmad606fbib6","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1016\/j.jdent.2007.07.008","article-title":"An overview of zirconia ceramics: basic properties and clinical applications","volume":"35","author":"Manicone","year":"2007","journal-title":"J. Dent."},{"key":"bmmad606fbib7","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1097\/ID.0000000000000368","article-title":"Implant-supported immediately loaded full-arch rehabilitations: comparison of resin and zirconia clinical outcomes in a 5-year retrospective follow-up study","volume":"25","author":"Tartaglia","year":"2016","journal-title":"Implant Dent."},{"key":"bmmad606fbib8","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1007\/s40496-020-00289-9","article-title":"Clinical longevity of zirconia implants with the focus on biomechanical and biological outcome","volume":"7","author":"Kohal","year":"2020","journal-title":"Curr. Oral Health Rep."},{"key":"bmmad606fbib9","first-page":"27","article-title":"Osseointegration and clinical success of zirconia dental implants: a systematic review","volume":"21","author":"Wenz","year":"2008","journal-title":"Int. J. Prosthodont."},{"key":"bmmad606fbib10","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1902\/jop.2004.75.2.292","article-title":"Bacterial adhesion on commercially pure titanium and zirconium oxide disks: an in vivo human study","volume":"75","author":"Scarano","year":"2004","journal-title":"J. Periodontol."},{"key":"bmmad606fbib11","doi-asserted-by":"publisher","first-page":"4872","DOI":"10.1073\/pnas.0903269107","article-title":"Geometric cues for directing the differentiation of mesenchymal stem cells","volume":"107","author":"Kilian","year":"2010","journal-title":"Proc. Natl Acad. Sci."},{"key":"bmmad606fbib12","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.tibtech.2009.12.003","article-title":"Classification of osseointegrated implant surfaces: materials, chemistry and topography","volume":"28","author":"Ehrenfest","year":"2010","journal-title":"Trends Biotechnol."},{"key":"bmmad606fbib13","doi-asserted-by":"publisher","first-page":"4304","DOI":"10.1016\/j.jeurceramsoc.2020.03.049","article-title":"Influence of grinding\/polishing on the mechanical, phase stability and cell adhesion properties of yttria-stabilized zirconia","volume":"40","author":"Minguela","year":"2020","journal-title":"J. Eur. Ceram. Soc."},{"key":"bmmad606fbib14","doi-asserted-by":"publisher","first-page":"2246","DOI":"10.1016\/j.actbio.2009.01.024","article-title":"Influence of a zirconia sandblasting treated surface on peri-implant bone healing: an experimental study in sheep","volume":"5","author":"Bacchelli","year":"2009","journal-title":"Acta Biomater."},{"key":"bmmad606fbib15","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/S0022-3913(07)60123-1","article-title":"Selective infiltration-etching technique for a strong and durable bond of resin cements to zirconia-based materials","volume":"98","author":"Aboushelib","year":"2007","journal-title":"J. Prosthet. Dent."},{"key":"bmmad606fbib16","doi-asserted-by":"publisher","first-page":"6200","DOI":"10.1039\/C9RA08575K","article-title":"Biofunctionalization of zirconia with cell-adhesion peptides via polydopamine crosslinking for soft tissue engineering: effects on the biological behaviors of human gingival fibroblasts and oral bacteria","volume":"10","author":"Yang","year":"2020","journal-title":"RSC Adv."},{"key":"bmmad606fbib17","doi-asserted-by":"publisher","first-page":"110","DOI":"10.4047\/jap.2016.8.2.110","article-title":"Comparison of removal torques of SLActive\u00ae implant and blasted, laser-treated titanium implant in rabbit tibia bone healed with concentrated growth factor application","volume":"8","author":"Park","year":"2016","journal-title":"J. Adv. Prosthodont."},{"key":"bmmad606fbib18","doi-asserted-by":"publisher","DOI":"10.1088\/2051-672X\/acd076","article-title":"Effects of surface topography through laser texturing on the surface characteristics of zirconia-based dental materials: surface hydrophobicity, antibacterial behavior, and cellular response","volume":"11","author":"Ghalandarzadeh","year":"2023","journal-title":"Surf. Topogr.: Metrol. Prop."},{"key":"bmmad606fbib19","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.1016\/j.biomaterials.2008.11.024","article-title":"Enhanced osteoblast function on ultraviolet light-treated zirconia","volume":"30","author":"Att","year":"2009","journal-title":"Biomaterials"},{"key":"bmmad606fbib20","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1016\/B978-0-12-381422-7.10036-7","article-title":"Surface modification of biomaterials","author":"Garc\u00eda","year":"2009","edition":"2nd edn"},{"key":"bmmad606fbib21","first-page":"558","author":"Ganjali","year":"2024"},{"key":"bmmad606fbib22","first-page":"92","author":"Vorobyev","year":"2009"},{"key":"bmmad606fbib23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00339-018-1628-z","article-title":"Selective cell response on natural polymer bio-interfaces textured by femtosecond laser","volume":"124","author":"Daskalova","year":"2018","journal-title":"Appl. Phys. A"},{"key":"bmmad606fbib24","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1007\/s00339-010-5816-8","article-title":"Femtosecond laser drilling of alumina ceramic substrates","volume":"101","author":"Wang","year":"2010","journal-title":"Appl. Phys. A"},{"key":"bmmad606fbib25","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1016\/j.apsusc.2017.11.206","article-title":"Femtosecond laser microstructured Alumina toughened Zirconia: a new strategy to improve osteogenic differentiation of hMSCs","volume":"435","author":"Carvalho","year":"2018","journal-title":"Appl. Surf. Sci."},{"key":"bmmad606fbib26","doi-asserted-by":"publisher","first-page":"5694","DOI":"10.1364\/OE.23.005694","article-title":"Femtosecond laser induced periodic surface structure on poly-L-lactic acid","volume":"23","author":"Yada","year":"2015","journal-title":"Opt. Express"},{"key":"bmmad606fbib27","doi-asserted-by":"publisher","first-page":"2472","DOI":"10.1111\/ijac.14109","article-title":"The influence of particle size distribution on rheological properties of fused silica pastes for direct ink writing","volume":"19","author":"Khecho","year":"2022","journal-title":"Int. J. Appl. Ceram. Technol."},{"key":"bmmad606fbib28","doi-asserted-by":"publisher","first-page":"23","DOI":"10.30501\/ACP.2021.287468.1062","article-title":"Preparation of high-solid filled alumina inks for stereolithography 3D printing process","volume":"7","author":"Khecho","year":"2021","journal-title":"Adv. Ceram. Prog."},{"key":"bmmad606fbib29","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1016\/j.cirp.2021.05.007","article-title":"Ultrafast laser manufacturing: from physics to industrial applications","volume":"70","author":"Orazi","year":"2021","journal-title":"CIRP Ann."},{"key":"bmmad606fbib30","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.triboint.2016.05.047","article-title":"Tribological behaviour of glass-ceramics reinforced by Yttria stabilized Zirconia","volume":"102","author":"Santos","year":"2016","journal-title":"Tribol. Int."},{"key":"bmmad606fbib31","doi-asserted-by":"publisher","DOI":"10.1016\/j.surfcoat.2021.127296","article-title":"Corrosion resistance and antibacterial activity of Ti-NO coatings deposited on dental titanium alloy","volume":"419","author":"Bao","year":"2021","journal-title":"Surf. Coat. Technol."},{"key":"bmmad606fbib32","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1016\/j.ijpharm.2014.10.026","article-title":"Evaluation of sorption capacity of antibiotics and antibacterial properties of a cyclodextrin-polymer functionalized hydroxyapatite-coated titanium hip prosthesis","volume":"477","author":"Taha","year":"2014","journal-title":"Int. J. Pharm."},{"key":"bmmad606fbib33","doi-asserted-by":"publisher","first-page":"15227","DOI":"10.1016\/j.ceramint.2017.08.058","article-title":"Effect of laser surface texturing on primary stability and surface properties of zirconia implants","volume":"43","author":"Moura","year":"2017","journal-title":"Ceram. Int."},{"key":"bmmad606fbib34","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1364\/AO.16.000027","article-title":"Laser applications in medicine and biology: a bibliography","volume":"16","author":"Eichler","year":"1977","journal-title":"Appl. Opt."},{"key":"bmmad606fbib35","doi-asserted-by":"publisher","DOI":"10.1063\/1.3275868","article-title":"Laser ablation characteristics of yttria-doped zirconia in the nanosecond and femtosecond regimes","volume":"107","author":"Heiroth","year":"2010","journal-title":"J. Appl. Phys."},{"key":"bmmad606fbib36","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfa.2022.130198","article-title":"Wettability and frictional properties on zirconia surfaces irradiated by femtosecond laser","volume":"654","author":"Jing","year":"2022","journal-title":"Colloids Surf. A"},{"key":"bmmad606fbib37","doi-asserted-by":"publisher","first-page":"24173","DOI":"10.1016\/j.ceramint.2020.06.197","article-title":"Nanosecond laser induced microstructure features and effects thereof on the wettability in zirconia","volume":"46","author":"Jing","year":"2020","journal-title":"Ceram. Int."},{"key":"bmmad606fbib38","doi-asserted-by":"publisher","DOI":"10.1016\/j.optlastec.2022.108209","article-title":"Combined pulse laser: reliable tool for high-quality, high-efficiency material processing","volume":"153","author":"Jia","year":"2022","journal-title":"Opt. Laser Technol."},{"key":"bmmad606fbib39","doi-asserted-by":"publisher","first-page":"1901","DOI":"10.1111\/j.1551-2916.2009.03278.x","article-title":"The tetragonal\u2010monoclinic transformation in zirconia: lessons learned and future trends","volume":"92","author":"Chevalier","year":"2009","journal-title":"J. Am. Ceram. Soc."},{"key":"bmmad606fbib40","doi-asserted-by":"publisher","first-page":"2485","DOI":"10.1007\/s11431-021-1813-0","article-title":"The influence of pore size distribution on thermal conductivity, permeability, and phase change behavior of hierarchical porous materials","volume":"64","author":"Liu","year":"2021","journal-title":"Sci. China Technol. Sci."},{"key":"bmmad606fbib41","author":"Adamson","year":"1967"},{"key":"bmmad606fbib42","doi-asserted-by":"publisher","DOI":"10.1007\/s10266-023-00853-6","article-title":"Influence of laser intensity and BaTiO3 content on the surface properties of 3YSZ","volume":"112","author":"Majidian","year":"2024","journal-title":"Odontology"},{"key":"bmmad606fbib43","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1002\/jbm.a.30518","article-title":"Enhancing surface free energy and hydrophilicity through chemical modification of microstructured titanium implant surfaces","volume":"76","author":"Rupp","year":"2006","journal-title":"J. Biomed. Mater. Res. A"},{"key":"bmmad606fbib44","doi-asserted-by":"publisher","first-page":"7161","DOI":"10.1016\/j.ceramint.2019.11.210","article-title":"Enhanced hydrophilicity and tribological behavior of dental zirconia ceramics based on picosecond laser surface texturing","volume":"46","author":"Ji","year":"2020","journal-title":"Ceram. Int."},{"key":"bmmad606fbib45","doi-asserted-by":"publisher","first-page":"107","DOI":"10.2351\/1.1471560","article-title":"On the mechanisms of wetting characteristics modification for selected metallic materials by means of high power diode laser radiation","volume":"14","author":"Lawrence","year":"2002","journal-title":"J. Laser Appl."},{"key":"bmmad606fbib46","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1016\/j.surfcoat.2018.05.032","article-title":"Topographical effects of laser surface texturing on various time-dependent wetting regimes in Ti6Al4V","volume":"349","author":"Patel","year":"2018","journal-title":"Surf. Coat. Technol."},{"key":"bmmad606fbib47","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsusc.2021.149842","article-title":"Fabrication of super hydrophilic surface on alumina ceramic by ultrafast laser microprocessing","volume":"557","author":"Cao","year":"2021","journal-title":"Appl. Surf. Sci."},{"key":"bmmad606fbib48","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1007\/s10266-022-00781-x","article-title":"The evaluation of prepared microstructure pattern by carbon-dioxide laser on zirconia-based ceramics for dental implant application: an in vitro study","volume":"111","author":"Ghalandarzadeh","year":"2022","journal-title":"Odontology"},{"key":"bmmad606fbib49","doi-asserted-by":"publisher","first-page":"9023","DOI":"10.1016\/j.biomaterials.2014.07.015","article-title":"Differential regulation of osteogenic differentiation of stem cells on surface roughness gradients","volume":"35","author":"Faia-Torres","year":"2014","journal-title":"Biomaterials"},{"key":"bmmad606fbib50","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/j.msec.2014.12.011","article-title":"Cytocompatibility and early osseointegration of nanoTiO2-modified Ti-24 Nb-4 Zr-7.9 Sn surfaces","volume":"48","author":"Liu","year":"2015","journal-title":"Mater. Sci. Eng. C"},{"key":"bmmad606fbib51","doi-asserted-by":"publisher","DOI":"10.1016\/j.wear.2021.203845","article-title":"Toward the mechanisms of surface texturing on the wear behavior of dental zirconia ceramics under dry and saliva lubricated conditions","volume":"484\u2013485","author":"Ji","year":"2021","journal-title":"Wear"},{"key":"bmmad606fbib52","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1128\/mr.54.1.75-87.1990","article-title":"Influence of interfaces on microbial activity","volume":"54","author":"van Loosdrecht","year":"1990","journal-title":"Microbiol. Rev."},{"key":"bmmad606fbib53","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1038\/nrmicro2415","article-title":"The biofilm matrix","volume":"8","author":"Flemming","year":"2010","journal-title":"Nat. Rev. Microbiol."},{"key":"bmmad606fbib54","doi-asserted-by":"publisher","first-page":"17915","DOI":"10.1007\/s10853-021-06404-0","article-title":"Antimicrobial surfaces: a review of synthetic approaches, applicability and outlook","volume":"56","author":"Mahanta","year":"2021","journal-title":"J. Mater. Sci."},{"key":"bmmad606fbib55","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1016\/j.desal.2007.01.042","article-title":"Adhesion of microorganisms to polymer membranes: a photobactericidal effect of surface treatment with TiO2","volume":"220","author":"Kochkodan","year":"2008","journal-title":"Desalination"},{"key":"bmmad606fbib56","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1038\/s41579-018-0129-6","article-title":"Fusobacterium nucleatum\u2014symbiont, opportunist and oncobacterium","volume":"17","author":"Brennan","year":"2019","journal-title":"Nat. Rev. Microbiol."},{"key":"bmmad606fbib57","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1111\/j.1365-2958.2008.06503.x","article-title":"The Fusobacterium nucleatum outer membrane protein RadD is an arginine\u2010inhibitable adhesin required for inter\u2010species adherence and the structured architecture of multispecies biofilm","volume":"71","author":"Kaplan","year":"2009","journal-title":"Mol. Microbiol."},{"key":"bmmad606fbib58","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.chom.2013.07.012","article-title":"Fusobacterium nucleatum promotes colorectal carcinogenesis by modulating E-cadherin\/\u03b2-catenin signaling via its FadA adhesin","volume":"14","author":"Rubinstein","year":"2013","journal-title":"Cell Host Microbe"},{"key":"bmmad606fbib59","doi-asserted-by":"publisher","first-page":"2005","DOI":"10.1128\/JB.184.7.2005-2018.2002","article-title":"Genome sequence and analysis of the oral bacterium Fusobacterium nucleatum strain ATCC 25586","volume":"184","author":"Kapatral","year":"2002","journal-title":"J. Bacteriol."},{"key":"bmmad606fbib60","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/0021-9797(88)90244-5","article-title":"Relationship of substratum wettability measurements and initial Staphylococcus aureau adhesion to films and fabrics","volume":"123","author":"Hsieh","year":"1988","journal-title":"J. Colloid Interface Sci."},{"key":"bmmad606fbib61","doi-asserted-by":"publisher","first-page":"3462","DOI":"10.1016\/j.surfcoat.2006.07.236","article-title":"A study on bacterial attachment on titanium and hydroxyapatite based films","volume":"201","author":"Jeyachandran","year":"2006","journal-title":"Surf. Coat. Technol."},{"key":"bmmad606fbib62","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/j.apsusc.2015.10.102","article-title":"Femtosecond laser surface texturing of titanium as a method to reduce the adhesion of Staphylococcus aureus and biofilm formation","volume":"360","author":"Cunha","year":"2016","journal-title":"Appl. Surf. Sci."},{"key":"bmmad606fbib63","doi-asserted-by":"publisher","first-page":"6550","DOI":"10.1016\/j.ceramint.2019.11.139","article-title":"Effects of surface roughness and texture on the bacterial adhesion on the bearing surface of bio-ceramic joint implants: an in vitro study","volume":"46","author":"Lu","year":"2020","journal-title":"Ceram. Int."},{"key":"bmmad606fbib64","doi-asserted-by":"publisher","first-page":"3363","DOI":"10.1016\/j.actbio.2014.03.037","article-title":"Implant osseointegration and the role of microroughness and nanostructures: lessons for spine implants","volume":"10","author":"Gittens","year":"2014","journal-title":"Acta Biomater."},{"key":"bmmad606fbib65","doi-asserted-by":"publisher","first-page":"4856","DOI":"10.1016\/j.biomaterials.2006.05.037","article-title":"The effect of silica nanoparticulate coatings on serum protein adsorption and cellular response","volume":"27","author":"Lord","year":"2006","journal-title":"Biomaterials"},{"key":"bmmad606fbib66","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.job.2022.02.002","article-title":"Peri-implant cell response on groove and pore-textured zirconia surfaces","volume":"64","author":"da Cruz","year":"2022","journal-title":"J. Oral Biosci."},{"key":"bmmad606fbib67","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1177\/0885328204043546","article-title":"Effects of CO2 laser irradiation on the surface properties of magnesia-partially stabilised zirconia (MgO-PSZ) bioceramic and the subsequent improvements in human osteoblast cell adhesion","volume":"19","author":"Hao","year":"2004","journal-title":"J. Biomater. Appl."},{"key":"bmmad606fbib68","first-page":"27","article-title":"The influence of microgrooved surfaces on the behavior and celluar function of osteoblasts","author":"Li","year":"2003"},{"key":"bmmad606fbib69","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1007\/s10856-005-2608-3","article-title":"Osteoblast cell adhesion on a laser modified zirconia based bioceramic","volume":"16","author":"Hao","year":"2005","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"bmmad606fbib70","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1038\/nrm2593","article-title":"Environmental sensing through focal adhesions","volume":"10","author":"Geiger","year":"2009","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"bmmad606fbib71","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1002\/jbm.a.10537","article-title":"Surface chemistry modulates fibronectin conformation and directs integrin binding and specificity to control cell adhesion","volume":"66","author":"Keselowsky","year":"2003","journal-title":"J. Biomed. Mater. Res. A"},{"key":"bmmad606fbib72","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1016\/S0092-8674(02)00971-6","article-title":"Integrins: bidirectional, allosteric signaling machines","volume":"110","author":"Hynes","year":"2002","journal-title":"Cell"},{"key":"bmmad606fbib73","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1038\/nmat2013","article-title":"The control of human mesenchymal cell differentiation using nanoscale symmetry and disorder","volume":"6","author":"Dalby","year":"2007","journal-title":"Nat. Mater."},{"key":"bmmad606fbib74","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1002\/smll.200901158","article-title":"Effect of surface properties on nanoparticle\u2013cell interactions","volume":"6","author":"Verma","year":"2010","journal-title":"Small"},{"key":"bmmad606fbib75","doi-asserted-by":"publisher","first-page":"5406","DOI":"10.1002\/anie.200805179","article-title":"Engineering substrate topography at the micro\u2010and nanoscale to control cell function","volume":"48","author":"Bettinger","year":"2009","journal-title":"Angew. Chem., Int. Ed."},{"key":"bmmad606fbib76","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1089\/107632702320934191","article-title":"Polymer-demixed nanotopography: control of fibroblast spreading and proliferation","volume":"8","author":"Dalby","year":"2002","journal-title":"Tissue Eng."},{"key":"bmmad606fbib77","doi-asserted-by":"publisher","first-page":"1803","DOI":"10.1016\/S0142-9612(00)00075-2","article-title":"Enhanced functions of osteoblasts on nanophase ceramics","volume":"21","author":"Webster","year":"2000","journal-title":"Biomaterials"},{"key":"bmmad606fbib78","doi-asserted-by":"publisher","first-page":"5405","DOI":"10.1016\/j.biomaterials.2005.01.058","article-title":"Nanopattern-induced changes in morphology and motility of smooth muscle cells","volume":"26","author":"Yim","year":"2005","journal-title":"Biomaterials"},{"key":"bmmad606fbib79","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.optlaseng.2018.07.008","article-title":"In vitro response of bone marrow mesenchymal stem cells (hBMSCs) on laser-induced periodic surface structures for hard tissue replacement: comparison between tantalum and titanium","volume":"111","author":"Jorge-Mora","year":"2018","journal-title":"Opt. Lasers Eng."},{"key":"bmmad606fbib80","doi-asserted-by":"publisher","first-page":"2210","DOI":"10.3390\/ma12132210","article-title":"Femtosecond laser nano\/micro textured Ti6Al4V surfaces\u2014effect on wetting and MG-63 cell adhesion","volume":"12","author":"Schnell","year":"2019","journal-title":"Materials"},{"key":"bmmad606fbib81","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1002\/jcb.20958","article-title":"Regulation of osteoblast differentiation by transcription factors","volume":"99","author":"Komori","year":"2006","journal-title":"J. Cell Biochem."},{"key":"bmmad606fbib82","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1023\/a:1024907615244","article-title":"Poly (vinyl alcohol) as versatile biomaterial for potential biomedical applications","volume":"14","author":"Paradossi","year":"2003","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"bmmad606fbib83","article-title":"A review of polyvinyl alcohol derivatives: promising materials for pharmaceutical & biomedical applications","author":"Mar\u00edn Cardona","year":"2014"},{"key":"bmmad606fbib84","first-page":"401","author":"Jaffe","year":"1990"},{"key":"bmmad606fbib85","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.ijpharm.2018.05.060","article-title":"Development of ciprofloxacin-loaded poly(vinyl alcohol) dry powder formulations for lung delivery","volume":"547","author":"Silva","year":"2018","journal-title":"Int. J. Pharm."},{"key":"bmmad606fbib86","doi-asserted-by":"publisher","DOI":"10.1016\/j.reactfunctpolym.2022.105339","article-title":"Genipin cross-linked chitosan\u2013PVA composite films: an investigation on the impact of cross-linking on accelerating wound healing","volume":"178","author":"Panchal","year":"2022","journal-title":"React. Funct. Polym."},{"key":"bmmad606fbib87","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1515\/epoly-2020-0071","article-title":"Seawater degradation of PLA accelerated by water-soluble PVA","volume":"20","author":"Huang","year":"2020","journal-title":"e-Polymers"},{"key":"bmmad606fbib88","author":"Bruschi","year":"2015"},{"key":"bmmad606fbib89","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1016\/S1473-3099(13)70318-9","article-title":"Antibiotic resistance-the need for global solutions","volume":"13","author":"Laxminarayan","year":"2013","journal-title":"Lancet Infect. Dis."},{"key":"bmmad606fbib90","doi-asserted-by":"publisher","first-page":"3167","DOI":"10.3390\/ma14123167","article-title":"Recent advances in the development of antimicrobial and antifouling biocompatible materials for dental applications","volume":"14","author":"Ramburrun","year":"2021","journal-title":"Materials"},{"key":"bmmad606fbib91","doi-asserted-by":"publisher","first-page":"7064","DOI":"10.1021\/acsnano.2c12488","article-title":"Review of antimicrobial nanocoatings in medicine and dentistry: mechanisms of action, biocompatibility performance, safety, and benefits compared to antibiotics","volume":"17","author":"Butler","year":"2023","journal-title":"ACS nano"},{"key":"bmmad606fbib92","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/S0924-8579(03)00085-2","article-title":"Berberis aetnensis C.Presl. extracts: antimicrobial properties and interaction with ciprofloxacin","volume":"22","author":"Musumeci","year":"2003","journal-title":"Int. J. Antimicrob. Agents"},{"key":"bmmad606fbib93","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2019.100017","article-title":"Adaptive antibacterial biomaterial surfaces and their applications","volume":"2","author":"Ahmed","year":"2019","journal-title":"Mater. Today"},{"key":"bmmad606fbib94","doi-asserted-by":"publisher","first-page":"5287","DOI":"10.1039\/C4TB00236A","article-title":"Hernia-repair prosthetic devices functionalised with chitosan and ciprofloxacin coating: controlled release and antibacterial activity","volume":"2","author":"Avetta","year":"2014","journal-title":"J. Mater. Chem. B"}],"container-title":["Biomedical Materials"],"original-title":[],"link":[{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ad606f","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ad606f\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ad606f\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ad606f\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T14:15:43Z","timestamp":1749910543000},"score":1,"resource":{"primary":{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ad606f"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,17]]},"references-count":94,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2024,7,17]]},"published-print":{"date-parts":[[2024,9,1]]}},"URL":"https:\/\/doi.org\/10.1088\/1748-605x\/ad606f","relation":{},"ISSN":["1748-6041","1748-605X"],"issn-type":[{"value":"1748-6041","type":"print"},{"value":"1748-605X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,17]]},"assertion":[{"value":"Tailoring zirconia surface topography via femtosecond laser-induced nanoscale features: effects on osteoblast cells and antibacterial properties","name":"article_title","label":"Article Title"},{"value":"Biomedical Materials","name":"journal_title","label":"Journal Title"},{"value":"paper","name":"article_type","label":"Article Type"},{"value":"\u00a9 2024 IOP Publishing Ltd. All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2023-12-29","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2024-07-08","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2024-07-17","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}