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The PS, PDI, zeta potential, and pH of the optimized formulation were found 451 \u00b1 82.0995 nm, 0.3807 \u00b1 0.1862, +20.33 \u00b1 1.04 mV and 6.8367 \u00b1 0.0737 respectively. The %EE and drug loading of formulation were 61.66 \u00b1 4.2914% and 21.442 \u00b1 1.814% respectively. <jats:italic>In vitro<\/jats:italic> drug release studies of optimized formulation showed the prolonged release up to 12 h whereas, the marketed formulation showed the burst release 85.625 \u00b1 4.3062% in 1 h and 98.1462 \u00b1 3.0921% at 6 h, respectively. Fourier transform infrared studies suggested the effective incorporation of the drug into the PEC-NPs formulation whereas differential scanning calorimetry and x-ray diffraction studies showed the amorphized nature of the drug in the formulation. Transmission electron microscopy study showed self-assembled, nearly spherical, core\u2013shell nanostructures. The corneal permeation study showed higher permeation of the drug from PEC-NPs compared to the marketed formulation. Hen\u2019s Eggs test-Chorioallantoic Membrane test of the optimized formulation revealed non-irritant and safe for ocular administration. Therefore, DSP-loaded PEC-NPs are an effective substitute for conventional eye drops due to their ability to increase bioavailability through longer precorneal retention duration and sustained drug release.<\/jats:p>","DOI":"10.1088\/1748-605x\/ad7e6b","type":"journal-article","created":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T13:29:44Z","timestamp":1727184584000},"page":"065016","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["Development of chitosan\/sodium carboxymethyl cellulose-based polyelectrolyte complex of dexamethasone for treatment of anterior uveitis"],"prefix":"10.1088","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6372-890X","authenticated-orcid":false,"given":"Md Ali","family":"Mujtaba","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9860-066X","authenticated-orcid":true,"given":"Harita","family":"Desai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6481-6314","authenticated-orcid":false,"given":"Anju","family":"Ambekar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1898-2957","authenticated-orcid":true,"given":"Ritesh","family":"Fule","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3327-8727","authenticated-orcid":false,"given":"Shriya","family":"Pande","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9071-8889","authenticated-orcid":false,"given":"Musarrat Husain","family":"Warsi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gamal Osman","family":"Elhassan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9405-5245","authenticated-orcid":false,"given":"Murtada","family":"Taha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5227-3954","authenticated-orcid":false,"given":"Khalid","family":"Anwer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarkeshwar devidas","family":"Golghate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2024,10,3]]},"reference":[{"key":"bmmad7e6bbib1","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.colcom.2018.03.008","article-title":"Recent developments in ophthalmic drug delivery systems for therapy of both anterior and posterior segment diseases","volume":"24","author":"Chen","year":"2018","journal-title":"Colloid Interface Sci."},{"key":"bmmad7e6bbib2","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1016\/j.addr.2006.07.027","article-title":"Challenges and obstacles of ocular pharmacokinetics and drug delivery","volume":"58","author":"Urti","year":"2006","journal-title":"Adv. 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