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The outcomes showed that ethyl cellulose (EC) NP containing MES has particles size of 142 \u00b1 2.8 nm, zeta potential (ZP) of \u221224.8 \u00b1 2.3 mV, % EE of 87.9 \u00b1 1.6%, and PDI of 0.226 \u00b1 0.15. Scanning electron microscopy revealed NPs has a uniform and spherical shape. The <jats:italic>in-vitro<\/jats:italic> release data disclosed that the EC NPs containing MES showed bursts release of 52% \u00b1 1.6% in simulated stomach media within 2 h, followed by a steady release of 93% \u00b1 2.9% in simulated intestinal fluid that lasted for 48 h. The MES release from NP best match with the Korsmeyer\u2013Peppas model (<jats:italic>R<\/jats:italic>\n                  <jats:sup>2<\/jats:sup> = 0.962) and it followed Fickian diffusion case I release mechanism. The formulation stability over six-months at 25 \u00b0C \u00b1 2 \u00b0C with 65% \u00b1 5% relative humidity, and 40 \u00b0C \u00b1 2 \u00b0C with 75% \u00b1 5% relative humidity showed no significant changes in colour, EE, particle sizes and ZP. As per <jats:italic>in vivo<\/jats:italic> results, MES-NP effectively increased glutathione, SOD level and reduces the LPO level as compared to other treatment groups. The findings hold promise that the developed formulation can suitably give in ulcerative colitis.<\/jats:p>","DOI":"10.1088\/1748-605x\/ad920e","type":"journal-article","created":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T22:58:47Z","timestamp":1731538727000},"page":"015008","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Mesalamine loaded ethyl cellulose nanoparticles: optimization and in vivo evaluation of antioxidant potential in ulcerative colitis"],"prefix":"10.1088","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-7071-2552","authenticated-orcid":true,"given":"Preety","family":"Gautam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6278-0370","authenticated-orcid":true,"given":"Md Habban","family":"Akhter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anubhav","family":"Anand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Safia Obaidur","family":"Rab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariusz","family":"Jaremko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul-Hamid","family":"Emwas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2024,11,22]]},"reference":[{"key":"bmmad920ebib1","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1093\/ibd\/izz268","article-title":"Dining with inflammatory bowel disease: a review of the literature on diet in the pathogenesis and management of IBD","volume":"26","author":"Gu","year":"2020","journal-title":"Inflamm. 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