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The electrospun PLA\/Gel-CS-IBU membrane showed good antioxidant and anti-inflammatory activity as evidenced by suppressing M1 polarization and promoting M2 polarization of macrophages\n                    <jats:italic>in vitro<\/jats:italic>\n                    . Similarly, it induced significantly milder chronic inflammatory responses\n                    <jats:italic>in vivo<\/jats:italic>\n                    than unmodified electrospun membranes. Given the good anti-inflammatory and antibacterial effects, this strategy might improve the biological performance of electrospun membranes as implants in clinics.\n                  <\/jats:p>","DOI":"10.1088\/1748-605x\/adae48","type":"journal-article","created":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T17:55:01Z","timestamp":1737741301000},"page":"025024","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Chitosan and ibuprofen grafted electrospun polylactic acid\/gelatin membrane mitigates inflammatory response"],"prefix":"10.1088","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-0113-8296","authenticated-orcid":true,"given":"Qiaolin","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anlin","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinjian","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binbin","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongsheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4265-0701","authenticated-orcid":true,"given":"Mohamed","family":"El-Newehy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meera Moydeen","family":"Abdulhameed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiumei","family":"Mo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9549-3992","authenticated-orcid":true,"given":"Jinglei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8231-0210","authenticated-orcid":false,"given":"Tian","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2025,2,13]]},"reference":[{"key":"bmmadae48bib1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.progpolymsci.2014.12.001","article-title":"Electrospinning of polymer nanofibers for tissue regeneration","volume":"46","author":"Jiang","year":"2015","journal-title":"Prog. 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