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The biological performance of the scaffolds was evaluated through osteoblast cell culturing, assessing cell viability, proliferation, alkaline phosphatase (ALP) activity, calcium content, and calcium deposition. The results demonstrate that the scaffolds with both SF and SPI had greater molecular mobility of \u2013OH, amide I, II, and III groups, compared to the scaffold with only SF or SPI. These scaffolds also displayed larger pore sizes. Scaffolds with both SF and SPI showed higher swelling and degradation rates than those with only SF or SPI. Additionally, they exhibited better cell viability and calcium deposition, along with increased cell proliferation, ALP activity, and calcium content. Notably, the scaffold with a higher amount of SPI, PVA10SF20SPI, exhibited the most suitable performance for enhancing cell response, thereby promoting bone formation. This scaffold is proposed as a supportive biomaterial to be incorporated with plates and screws for bone fixation at defect sites in osteoporosis.<\/jats:p>","DOI":"10.1088\/1748-605x\/adb66f","type":"journal-article","created":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T22:56:21Z","timestamp":1739573781000},"page":"025046","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Mimicking bone remodeling scaffolds of polyvinylalcohol\/silk fibroin with phytoactive compound of soy protein isolate as surgical supporting biomaterials for tissue formation at defect area in osteoporosis; characterization, morphology, and <i>in-vitro<\/i> testing"],"prefix":"10.1088","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5002-4487","authenticated-orcid":true,"given":"Nattawat","family":"Watcharajittanont","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9301-8941","authenticated-orcid":true,"given":"Kanon","family":"Jatuworapruk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Worasak","family":"Prarokijjak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prawichaya","family":"Sangsuwan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6242-818X","authenticated-orcid":true,"given":"Jirut","family":"Meesane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"266","published-online":{"date-parts":[[2025,3,13]]},"reference":[{"key":"bmmadb66fbib1","doi-asserted-by":"publisher","DOI":"10.1177\/17455057231176655","article-title":"An overview of the management of osteoporosis in the aging female population","volume":"19","author":"Amin","year":"2023","journal-title":"Womens Health"},{"key":"bmmadb66fbib2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41413-019-0058-7","article-title":"Autophagy in bone homeostasis and the onset of osteoporosis","volume":"7","author":"Yin","year":"2019","journal-title":"Bone Res."},{"key":"bmmadb66fbib3","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2024.100943","article-title":"Dual-functional 3D-printed porous bioactive scaffold enhanced bone repair by promoting osteogenesis and angiogenesis","volume":"24","author":"Li","year":"2024","journal-title":"Mater. 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