{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T04:18:55Z","timestamp":1742962735437,"version":"3.40.3"},"reference-count":59,"publisher":"IOP Publishing","issue":"3","license":[{"start":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T00:00:00Z","timestamp":1742860800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/page\/copyright"},{"start":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T00:00:00Z","timestamp":1742860800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100012046","name":"Vietnam Academy of Science and Technology","doi-asserted-by":"crossref","award":["NCXS.01.01\/23-25"],"award-info":[{"award-number":["NCXS.01.01\/23-25"]}],"id":[{"id":"10.13039\/100012046","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Biomed. Mater."],"published-print":{"date-parts":[[2025,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>A paclitaxel (PTX) nano-delivery system using modified heparin and polyethylene glycol hexadecyl ether (Brij 58) was developed in this study. Brij 58 was conjugated to the heparin backbone via the cystamine bridge, denoted as Hep-Brij 58, to facilitate self-assembly into stable nanoparticles in an aqueous environment. The self-assembled formation of Hep-Brij nanoparticles was demonstrated through dynamic light scattering and TEM, while the iodine method identified the critical concentration for the self-assembled process. PTX was incorporated into Hep-Brij nanoparticles through physical entrapment. The PTX-loaded Hep-Brij nanoparticles were then characterized according to particle size and size distribution, drug-loading content, and efficiency. Compared to Brij 58, Hep-Brij 58 was more effective in terms of the amount of PTX loaded. Hep-Brij 58\/PTX was stable over two weeks of storage in distilled water. <jats:italic>In vitro<\/jats:italic> release of PTX from Hep-Brij 58 exhibited a controlled drug release effect following the diffusion kinetics. Furthermore, Hep-Brij 58 was non-toxic to primary healthy cells and cancer cells. The <jats:italic>in vitro<\/jats:italic> anticancer test with Hela cells indicated remarkable anticancer activity of PTX-loaded Hep-Brij 58 nanoparticles compared to free PTX. In summary, Hep-Brij 58 nanoparticles hold considerable potential for use as a delivery system for managing PTX therapy.<\/jats:p>","DOI":"10.1088\/1748-605x\/adbaa1","type":"journal-article","created":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T22:53:49Z","timestamp":1740610429000},"page":"035004","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Polyethylene glycol hexadecyl ether modified heparin for paclitaxel nano-delivery system"],"prefix":"10.1088","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7981-1847","authenticated-orcid":false,"given":"Van Toan","family":"Nguyen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5766-6300","authenticated-orcid":true,"given":"Thi Le Hang","family":"Dang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0737-2531","authenticated-orcid":false,"given":"Minh -Thanh","family":"Vu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5258-531X","authenticated-orcid":false,"given":"Thi Phuong","family":"Le","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thi Loan","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2716-936X","authenticated-orcid":true,"given":"Thi Huong","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2899-5452","authenticated-orcid":false,"given":"Ngoc Quyen","family":"Tran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"266","published-online":{"date-parts":[[2025,3,25]]},"reference":[{"key":"bmmadbaa1bib1","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/S0731-7085(03)00632-0","article-title":"A HPLC validated assay of paclitaxel\u2019s related impurities in pharmaceutical forms containing Cremophor EL","volume":"34","author":"Ciutaru","year":"2004","journal-title":"J. Pharm. Biomed. Anal."},{"key":"bmmadbaa1bib2","doi-asserted-by":"publisher","first-page":"63","DOI":"10.3390\/ph17010063","article-title":"Paclitaxel and therapeutic drug monitoring with microsampling in clinical practice","volume":"17","author":"Radovanovic","year":"2023","journal-title":"Pharmaceuticals"},{"key":"bmmadbaa1bib3","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1111\/ajco.12035","article-title":"A multicenter phase II randomized study of Cremophor-free polymeric nanoparticle formulation of paclitaxel in women with locally advanced and\/or metastatic breast cancer after failure of anthracycline","volume":"9","author":"Ranade","year":"2013","journal-title":"Asia Pac. J. Clin. Oncol."},{"key":"bmmadbaa1bib4","doi-asserted-by":"publisher","first-page":"1590","DOI":"10.1016\/S0959-8049(01)00171-X","article-title":"Cremophor EL: the drawbacks and advantages of vehicle selection for drug formulation","volume":"37","author":"Gelderblom","year":"2001","journal-title":"Eur. J. Cancer"},{"key":"bmmadbaa1bib5","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.fct.2014.03.013","article-title":"Systemic toxicity induced by paclitaxel in vivo is associated with the solvent cremophor EL through oxidative stress-driven mechanisms","volume":"68","author":"Campos","year":"2014","journal-title":"Food Chem. Toxicol."},{"key":"bmmadbaa1bib6","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.addr.2017.02.003","article-title":"The battle of \u201cnano\u201d paclitaxel","volume":"122","author":"Sofias","year":"2017","journal-title":"Adv. Drug Deliv. Rev."},{"key":"bmmadbaa1bib7","doi-asserted-by":"publisher","first-page":"408","DOI":"10.3928\/23258160-20240227-01","article-title":"Case report: macula structural and functional assessment in nab-paclitaxel-related cystoid macular edema","volume":"55","author":"Kwok","year":"2024","journal-title":"Ophthalmic Surg. Lasers Imaging Retina"},{"key":"bmmadbaa1bib8","doi-asserted-by":"publisher","first-page":"377","DOI":"10.7417\/CT.2022.2449","article-title":"Nab-Paclitaxel related cystoid macular edema","volume":"173","author":"Di Pippo","year":"2022","journal-title":"Clin. Ther."},{"key":"bmmadbaa1bib9","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1007\/s11882-011-0214-7","article-title":"Role of sensitization to mammalian serum albumin in allergic disease","volume":"11","author":"Liccardi","year":"2011","journal-title":"Curr. Allergy Asthma Rep."},{"key":"bmmadbaa1bib10","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.jconrel.2007.11.008","article-title":"A new hydrotropic block copolymer micelle system for aqueous solubilization of paclitaxel","volume":"126","author":"Huh","year":"2008","journal-title":"J. Control. Release"},{"key":"bmmadbaa1bib11","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1007\/s13233-023-00240-8","article-title":"Efficient and controllable co-delivery of paclitaxel and curcumin from fucoidan-pluronic F127 nanogel for synergistic breast cancer treatment","volume":"32","author":"Nguyen","year":"2024","journal-title":"Macromol. Res."},{"key":"bmmadbaa1bib12","doi-asserted-by":"publisher","first-page":"5317","DOI":"10.1158\/0008-5472.CAN-04-3921","article-title":"Nanoparticle targeting of anticancer drug improves therapeutic response in animal model of human epithelial cancer","volume":"65","author":"Kukowska-Latallo","year":"2005","journal-title":"Cancer Res."},{"key":"bmmadbaa1bib13","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/S0168-3659(01)00309-1","article-title":"Mechanism of tumor-targeted delivery of macromolecular drugs, including the EPR effect in solid tumor and clinical overview of the prototype polymeric drug SMANCS","volume":"74","author":"Maeda","year":"2001","journal-title":"J. Control. Release"},{"key":"bmmadbaa1bib14","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2022.119496","article-title":"Molecular dynamics simulation reveals the reliability of Brij-58 nanomicellar drug delivery systems for flurbiprofen","volume":"360","author":"Seif","year":"2022","journal-title":"J. Mol. Liq."},{"key":"bmmadbaa1bib15","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1080\/10837450.2016.1221431","article-title":"Nonionic surfactant structure on the drug release, formulation and physical properties of ethylcellulose microspheres","volume":"22","author":"Thakare","year":"2017","journal-title":"Pharm. Dev. Technol."},{"key":"bmmadbaa1bib16","doi-asserted-by":"publisher","first-page":"4521","DOI":"10.1021\/acs.langmuir.1c02996","article-title":"Brij niosomes as carriers for sustained drug delivery horizontal line a fluorescence-based approach to probe the niosomal microenvironment","volume":"38","author":"Sarkar","year":"2022","journal-title":"Langmuir"},{"key":"bmmadbaa1bib17","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.3390\/pharmaceutics15051403","article-title":"A versatile Brij-linker for one-step preparation of targeted nanoparticles","volume":"15","author":"Anzengruber","year":"2023","journal-title":"Pharmaceutics"},{"key":"bmmadbaa1bib18","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2021.111647","article-title":"Brij-stabilized zein nanoparticles as potential drug carriers","volume":"201","author":"Gagliardi","year":"2021","journal-title":"Colloids Surf. B"},{"key":"bmmadbaa1bib19","doi-asserted-by":"publisher","first-page":"33","DOI":"10.31351\/vol32iss3pp105-117","article-title":"Preparation, in-vitro characterization and pharmacokinetic evaluation of Brij decorated doxorubicin liposomes as a potential nanocarrier for cancer therapy","volume":"17","author":"Fazel","year":"2018","journal-title":"Iran. J. Pharm. Res."},{"key":"bmmadbaa1bib20","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.ejpb.2019.12.001","article-title":"Brij-58, a potential injectable protein-stabilizer used in therapeutic protein formulation","volume":"146","author":"Yue","year":"2020","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"bmmadbaa1bib21","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2021.118112","article-title":"Brij-functionalized chitosan nanocarrier system enhances the intestinal permeability of P-glycoprotein substrate-like drugs","volume":"266","author":"Xiong","year":"2021","journal-title":"Carbohydrate Polym."},{"key":"bmmadbaa1bib22","doi-asserted-by":"publisher","first-page":"1110","DOI":"10.3390\/ph15091110","article-title":"Phosphatidylcholine-based nanoemulsions for paclitaxel and a P-glycoprotein inhibitor delivery and breast cancer intraductal treatment","volume":"15","author":"Salata","year":"2022","journal-title":"Pharmaceuticals"},{"key":"bmmadbaa1bib23","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2024.149855","article-title":"Cryo-EM structure of P-glycoprotein bound to triple elacridar inhibitor molecules","volume":"709","author":"Hamaguchi-Suzuki","year":"2024","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"bmmadbaa1bib24","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1021\/bm301661w","article-title":"Key structure of Brij for overcoming multidrug resistance in cancer","volume":"14","author":"Tang","year":"2013","journal-title":"Biomacromolecules"},{"key":"bmmadbaa1bib25","doi-asserted-by":"publisher","first-page":"5051","DOI":"10.1007\/s00253-023-12640-y","article-title":"Brij-58 supplementation enhances menaquinone-7 biosynthesis and secretion in Bacillus natto","volume":"107","author":"Yi","year":"2023","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"bmmadbaa1bib26","first-page":"151","article-title":"Importance of the HLB-value in drug technology","volume":"81","author":"Niczinger","year":"2011","journal-title":"Acta Pharm. Hung."},{"key":"bmmadbaa1bib27","doi-asserted-by":"publisher","first-page":"4985","DOI":"10.1007\/s12274-018-2152-3","article-title":"Strategies to improve micelle stability for drug delivery","volume":"11","author":"Lu","year":"2018","journal-title":"Nano Res."},{"key":"bmmadbaa1bib28","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1080\/19336918.2020.1767489","article-title":"The anti-cancer properties of heparin and its derivatives: a review and prospect","volume":"14","author":"Ma","year":"2020","journal-title":"Cell Adhes. Migration"},{"key":"bmmadbaa1bib29","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1517\/13543784.17.7.1029","article-title":"Heparin as an anticancer therapeutic","volume":"17","author":"Zacharski","year":"2008","journal-title":"Expert Opin. Investig. Drugs"},{"key":"bmmadbaa1bib30","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1016\/j.thromres.2006.10.026","article-title":"The anti-inflammatory effects of heparin and related compounds","volume":"122","author":"Young","year":"2008","journal-title":"Thromb. Res."},{"key":"bmmadbaa1bib31","doi-asserted-by":"publisher","first-page":"1588","DOI":"10.1016\/j.actbio.2013.07.031","article-title":"Heparin-functionalized polymeric biomaterials in tissue engineering and drug delivery applications","volume":"10","author":"Liang","year":"2014","journal-title":"Acta Biomater."},{"key":"bmmadbaa1bib32","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1021\/mp300480v","article-title":"Heparin-conjugated pluronic nanogels as multi-drug nanocarriers for combination chemotherapy","volume":"10","author":"Joung","year":"2013","journal-title":"Mol. Pharm."},{"key":"bmmadbaa1bib33","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1038\/nrc842","article-title":"Roles of heparan-sulphate glycosaminoglycans in cancer","volume":"2","author":"Sasisekharan","year":"2002","journal-title":"Nat. Rev. Cancer"},{"key":"bmmadbaa1bib34","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1159\/000179145","article-title":"Basic-fibroblast-growth-factor-mediated de novo angiogenesis is more effectively suppressed by low-molecular-weight than by high-molecular-weight heparin","volume":"16","author":"Norrby","year":"1996","journal-title":"Int. J. Microcirc. Clin. Exp."},{"key":"bmmadbaa1bib35","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1016\/0955-0674(90)90084-R","article-title":"The affinity of fibroblast growth factors (FGFs) for heparin; FGF-heparan sulfate interactions in cells and extracellular matrix","volume":"2","author":"Klagsbrun","year":"1990","journal-title":"Curr. Opin. Cell Biol."},{"key":"bmmadbaa1bib36","doi-asserted-by":"publisher","first-page":"7335","DOI":"10.1039\/c3cs60040h","article-title":"Designing degradable hydrogels for orthogonal control of cell microenvironments","volume":"42","author":"Kharkar","year":"2013","journal-title":"Chem. Soc. Rev."},{"key":"bmmadbaa1bib37","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1016\/j.ijpharm.2016.07.020","article-title":"Heparin modification enhances the delivery and tumor targeting of paclitaxel-loaded N-octyl-N-trimethyl chitosan micelles","volume":"511","author":"Zhang","year":"2016","journal-title":"Int. J. Pharm."},{"key":"bmmadbaa1bib38","doi-asserted-by":"publisher","first-page":"2023","DOI":"10.1007\/s11051-023-05841-z","article-title":"A redox-responsive delivery system for paclitaxel based on heparin\u2014pluronic F127 nanogel","volume":"25","author":"Huong","year":"2023","journal-title":"J. Nanopart. Res."},{"key":"bmmadbaa1bib39","doi-asserted-by":"publisher","first-page":"24531","DOI":"10.1021\/acsami.9b22495","article-title":"Think beyond the core: impact of the hydrophilic corona on drug solubilization using polymer micelles","volume":"12","author":"Haider","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"bmmadbaa1bib40","doi-asserted-by":"publisher","first-page":"1855","DOI":"10.3390\/cancers11121855","article-title":"Thirty years of cancer nanomedicine: success, frustration, and hope","volume":"11","author":"Salvioni","year":"2019","journal-title":"Cancers"},{"key":"bmmadbaa1bib41","doi-asserted-by":"publisher","first-page":"2202","DOI":"10.1002\/anie.202010934","article-title":"The Trojan horse goes wild: the effect of drug loading on the behavior of nanoparticles","volume":"60","author":"Stenzel","year":"2021","journal-title":"Angew. Chem., Int. Ed. Engl."},{"key":"bmmadbaa1bib42","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.125248","article-title":"Potential from synergistic effect of quercetin and paclitaxel co-encapsulated in the targeted folic-gelatin-pluronic P123 nanogels for chemotherapy","volume":"243","author":"Nguyen","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"bmmadbaa1bib43","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2021.102807","article-title":"An in vitro investigation into targeted paclitaxel delivery nanomaterials based on chitosan-Pluronic P123-biotin copolymer for inhibiting human breast cancer cells","volume":"66","author":"Nguyen","year":"2021","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"bmmadbaa1bib44","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1080\/10837450701563277","article-title":"In vitro controlled release of alfuzosin hydrochloride using HPMC-based matrix tablets and its comparison with marketed product","volume":"12","author":"Nair","year":"2007","journal-title":"Pharm. Dev. Technol."},{"key":"bmmadbaa1bib45","doi-asserted-by":"publisher","first-page":"E1","DOI":"10.1208\/pt070101","article-title":"Formulation and in vitro, in vivo evaluation of extended- release matrix tablet of zidovudine: influence of combination of hydrophilic and hydrophobic matrix formers","volume":"7","author":"Kuksal","year":"2006","journal-title":"AAPS Pharm. Sci. Tech."},{"key":"bmmadbaa1bib46","doi-asserted-by":"publisher","first-page":"10504","DOI":"10.1021\/acs.analchem.2c02913","article-title":"Enhanced copolymer characterization for polyethers using gel permeation chromatography combined with artificial neural networks","volume":"95","author":"Nagy","year":"2023","journal-title":"Anal. Chem."},{"key":"bmmadbaa1bib47","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.carbpol.2018.08.037","article-title":"Cytotoxicity against cancer cells of chitosan oligosaccharides prepared from chitosan powder degraded by electrical discharge plasma","volume":"201","author":"Chokradjaroen","year":"2018","journal-title":"Carbohydrate Polym."},{"key":"bmmadbaa1bib48","doi-asserted-by":"publisher","first-page":"59","DOI":"10.3390\/gels8010059","article-title":"Curcuminoid co-loading platinum heparin-poloxamer P403 nanogel increasing effectiveness in antitumor activity","volume":"8","author":"Nguyen","year":"2022","journal-title":"Gels"},{"key":"bmmadbaa1bib49","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1080\/09205063.2016.1154239","article-title":"Aquated cisplatin and heparin-pluronic nanocomplexes exhibiting sustainable release of active platinum compound and NCI-H460 lung cancer cell antiproliferation","volume":"27","author":"Tong","year":"2016","journal-title":"J. Biomater. Sci. Polym. Ed."},{"key":"bmmadbaa1bib50","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/j.jcis.2017.02.033","article-title":"Redox-sensitive self-assembled nanoparticles based on alpha-tocopherol succinate-modified heparin for intracellular delivery of paclitaxel","volume":"496","author":"Yang","year":"2017","journal-title":"J. Colloid Interface Sci."},{"key":"bmmadbaa1bib51","doi-asserted-by":"publisher","first-page":"2120","DOI":"10.1016\/j.carbpol.2011.10.030","article-title":"Targeted delivery of paclitaxel using folate-conjugated heparin-poly(\u03b2-benzyl-l-aspartate) self-assembled nanoparticles","volume":"87","author":"Li","year":"2012","journal-title":"Carbohydrate Polym."},{"key":"bmmadbaa1bib52","doi-asserted-by":"publisher","first-page":"1675","DOI":"10.1021\/acsapm.1c01515","article-title":"Metal (Au)-decorated chitosan-l-arginine polymeric vector for codelivery of gefitinib and miR125b for lung cancer therapy","volume":"4","author":"Amgoth","year":"2022","journal-title":"ACS Appl. Polym. Mater."},{"key":"bmmadbaa1bib53","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1002\/bit.21301","article-title":"Microparticles and nanoparticles for drug delivery","volume":"96","author":"Kohane","year":"2007","journal-title":"Biotechnol. Bioeng."},{"key":"bmmadbaa1bib54","doi-asserted-by":"publisher","first-page":"2663","DOI":"10.1016\/j.biomaterials.2008.02.020","article-title":"Targeted delivery of paclitaxel using folate-decorated poly(lactide)-vitamin E TPGS nanoparticles","volume":"29","author":"Pan","year":"2008","journal-title":"Biomaterials"},{"key":"bmmadbaa1bib55","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2023.123576","article-title":"Injectable thermogel incorporating reactive oxygen species scavenger and nitric oxide donor to accelerate the healing process of diabetic wounds","volume":"648","author":"Dang","year":"2023","journal-title":"Int. J. Pharm."},{"key":"bmmadbaa1bib56","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1007\/s13233-011-0214-4","article-title":"Self assembled nanogel of pluronic conjugated heparin as a versatile drug nanocarrier","volume":"19","author":"Choi","year":"2011","journal-title":"Macromol. Res."},{"key":"bmmadbaa1bib57","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1016\/j.jconrel.2010.07.118","article-title":"Intracellular delivery and anti-cancer effect of self-assembled heparin-pluronic nanogels with RNase A","volume":"147","author":"Choi","year":"2010","journal-title":"J. Control. Release"},{"key":"bmmadbaa1bib58","doi-asserted-by":"publisher","first-page":"2397","DOI":"10.1016\/j.drudis.2021.04.012","article-title":"Stimuli-responsive hydrogels for intratumoral drug delivery","volume":"26","author":"Marques","year":"2021","journal-title":"Drug Discovery Today"},{"key":"bmmadbaa1bib59","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1016\/j.msec.2018.07.033","article-title":"Self-assembled block copolymer [(BenzA)-b-(PCL)] micelles to orient randomly distributed AuNPs into hollow core-shell morphology and its role as payload for nanomedicines","volume":"91","author":"Amgoth","year":"2018","journal-title":"Mater. Sci. Eng. C"}],"container-title":["Biomedical Materials"],"original-title":[],"link":[{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/adbaa1","content-type":"text\/html","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/adbaa1\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/adbaa1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/adbaa1\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/adbaa1\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/adbaa1\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/adbaa1\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"similarity-checking"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/adbaa1\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T19:20:30Z","timestamp":1742930430000},"score":1,"resource":{"primary":{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/adbaa1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,25]]},"references-count":59,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,3,25]]},"published-print":{"date-parts":[[2025,5,1]]}},"URL":"https:\/\/doi.org\/10.1088\/1748-605x\/adbaa1","relation":{},"ISSN":["1748-6041","1748-605X"],"issn-type":[{"type":"print","value":"1748-6041"},{"type":"electronic","value":"1748-605X"}],"subject":[],"published":{"date-parts":[[2025,3,25]]},"assertion":[{"value":"Polyethylene glycol hexadecyl ether modified heparin for paclitaxel nano-delivery system","name":"article_title","label":"Article Title"},{"value":"Biomedical Materials","name":"journal_title","label":"Journal Title"},{"value":"paper","name":"article_type","label":"Article Type"},{"value":"\u00a9 2025 IOP Publishing Ltd. All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2024-06-18","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2025-02-26","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2025-03-25","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}