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Mater."],"published-print":{"date-parts":[[2025,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The growing interest in peripheral nerve regeneration and developing post-traumatic repair methods under diabetes was the impetus for this study, which aims to investigate the effect of curcumin and <jats:italic>Garcinia kola<\/jats:italic> (GK) on the transected and diabetic sciatic nerves. Thirty-five male Wistar albino rats were used. The animals were divided into five groups; each consisted of seven rats. The sciatic nerve was transected in all groups of rats except the control (Cont) group, which underwent no treatment. In the transected animals, a 10 mm nerve stump was removed from the 2 cm distal to the sciatic notch. The external jugular vein was used as a conduit to repair the gap between the two ends of the sciatic nerve. Diabetes was induced in the transected + diabetes mellitus (T + DM), the transected + diabetes mellitus + GK (T + DM + GK), and the transected + diabetes mellitus + Curcumin (T + DM + Cur) groups except for the sham group. A dose of 300 mg kg<jats:sup>\u22121<\/jats:sup> d<jats:sup>\u22121<\/jats:sup> of curcumin dissolved in olive oil was administered to the T + DM + Cur group (via oral gavage every day for 28 d) and 200 mg kg<jats:sup>\u22121<\/jats:sup> d<jats:sup>\u22121<\/jats:sup> of GK to the T + DM + GK group (via oral gavage every day for 7 d). All animals were sacrificed after three months. Stereological analysis and functional and microscopic evaluations were done to evaluate the sciatic nerve regeneration and function. In the T + DM + GK and the sham groups, the number of axons increased. A slight improvement in the axonal area in the T + DM + Cur and the sham groups was also observed, and an increase in the myelin sheath thickness was found in the T + DM + GK and the sham group. When the SFI test results were evaluated, it was seen that GK had a stronger effect than curcumin in terms of functional regeneration. Additionally, no significant difference was observed between T + DM and Cont groups when the electrophysiological results were examined. The study showed GK\u2019s efficiency in treating diabetic peripheral nerve regeneration.<\/jats:p>","DOI":"10.1088\/1748-605x\/adcfe3","type":"journal-article","created":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T22:53:27Z","timestamp":1745448807000},"page":"035025","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Neuroprotective effects of <i>Garcinia kola<\/i> and curcumin on diabetic transected sciatic nerve"],"prefix":"10.1088","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1463-2757","authenticated-orcid":true,"given":"Hala Mahgoub","family":"Hamour","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6183-8427","authenticated-orcid":false,"given":"Abdullah Hilmi","family":"Marangoz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3959-9893","authenticated-orcid":false,"given":"Gamze","family":"Altun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1477-5002","authenticated-orcid":true,"given":"S\u00fcleyman","family":"Kaplan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2025,5,6]]},"reference":[{"key":"bmmadcfe3bib1","doi-asserted-by":"publisher","first-page":"65","DOI":"10.4103\/1673-5374.224370","article-title":"Diabetes, its impact on peripheral nerve regeneration: lessons from pre-clinical rat models towards nerve repair and reconstruction","volume":"13","author":"Haastert-Talini","year":"2018","journal-title":"Neural Regen. 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