{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T03:21:56Z","timestamp":1793762516528,"version":"4.6.1"},"reference-count":30,"publisher":"IOP Publishing","issue":"3","license":[{"start":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:00:00Z","timestamp":1747180800000},"content-version":"vor","delay-in-days":13,"URL":"https:\/\/iopscience.iop.org\/page\/copyright"},{"start":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:00:00Z","timestamp":1747180800000},"content-version":"tdm","delay-in-days":13,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"funder":[{"name":"Key R&D Program of China","award":["2016YFC1101000"],"award-info":[{"award-number":["2016YFC1101000"]}]}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Biomed. Mater."],"published-print":{"date-parts":[[2025,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Heart valve replacement surgery has been the most effective treatment for severe valvular heart disease. Bioprosthetic heart valves (BHVs) crosslinked by glutaraldehyde (GA) have non-negligible advantages in clinical applications. However, structural valve degeneration, calcification, insufficient re-endothelialization and other factors lead to a shortened service life of BHVs. In this study, GA-crosslinked decellularized heart valves (GADHVs) were grafted with zwitterionic copolymer (PSBG) of [2-(methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl) ammonium hydroxide and glycidyl methacrylate, and further treated with Arg-Glu-Asp-Val (REDV) peptide to obtain REDV-PSBG-GADHVs with anti-fouling ability and endothelial cell affinity. REDV-PSBG-GADHVs exhibited good collagen stability, reliable mechanical property and excellent hemocompatibility. Moreover,\n                    <jats:italic>in vitro<\/jats:italic>\n                    and\n                    <jats:italic>in vivo<\/jats:italic>\n                    experiments demonstrated that REDV-PSBG-GADHVs exhibited better endothelialization property, lower immune responses and reduced calcification than GADHVs. This modified strategy for heart valve fabrication, which can improve the effect of anti-calcification and endothelialization while maintaining the original advantages of BHVs, shows great potential for application in heart valve replacement.\n                  <\/jats:p>","DOI":"10.1088\/1748-605x\/add3e7","type":"journal-article","created":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T19:01:56Z","timestamp":1746212516000},"page":"035033","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Bioprosthetic heart valves with zwitterionic copolymer grafting to improve the properties of endothelialization and anti-calcification"],"prefix":"10.1088","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-6635-2896","authenticated-orcid":true,"given":"Daoyang","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7335-020X","authenticated-orcid":true,"given":"Yu","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenyu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6496-7064","authenticated-orcid":true,"given":"Lie","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2025,5,14]]},"reference":[{"key":"bmmadd3e7bib1","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1097\/MOP.0000000000000137","article-title":"Advances in the treatment of aortic valve disease","volume":"26","author":"Hinton","year":"2014","journal-title":"Curr. Opin. Pediatr."},{"key":"bmmadd3e7bib2","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1093\/ehjci\/jeae146","article-title":"Valvular heart disease: the oncoming tsunami","volume":"25","author":"Chan","year":"2024","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"bmmadd3e7bib3","doi-asserted-by":"publisher","first-page":"e323","DOI":"10.1002\/term.2326","article-title":"The future of heart valve replacement: recent developments and translational challenges for heart valve tissue engineering","volume":"12","author":"Fioretta","year":"2018","journal-title":"J. Tissue Eng. Regen. Med."},{"key":"bmmadd3e7bib4","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/j.biomaterials.2007.09.033","article-title":"Prosthetic heart valves: catering for the few","volume":"29","author":"Zilla","year":"2008","journal-title":"Biomaterials"},{"key":"bmmadd3e7bib5","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1146\/annurev-bioeng-061008-124903","article-title":"Bioengineering challenges for heart valve tissue engineering","volume":"11","author":"Sacks","year":"2009","journal-title":"Annu. Rev. Biomed. Eng."},{"key":"bmmadd3e7bib6","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.actbio.2020.10.029","article-title":"A method for simultaneously crosslinking and functionalizing extracellular matrix-based biomaterials as bioprosthetic heart valves with enhanced endothelialization and reduced inflammation","volume":"119","author":"Guo","year":"2021","journal-title":"Acta Biomater."},{"key":"bmmadd3e7bib7","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202309844","article-title":"Recent advances in the modification and improvement of bioprosthetic heart valves","volume":"20","author":"Tong","year":"2024","journal-title":"Small"},{"key":"bmmadd3e7bib8","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.actbio.2015.01.028","article-title":"Procyanidins-crosslinked aortic elastin scaffolds with distinctive anti-calcification and biological properties","volume":"16","author":"Wang","year":"2015","journal-title":"Acta Biomater."},{"key":"bmmadd3e7bib9","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1016\/j.athoracsur.2004.06.033","article-title":"Calcification of tissue heart valve substitutes: progress toward understanding and prevention","volume":"79","author":"Schoen","year":"2005","journal-title":"Ann. Thorac. Surg."},{"key":"bmmadd3e7bib10","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2022.121675","article-title":"Strategies for development of decellularized heart valve scaffolds for tissue engineering","volume":"288","author":"Snyder","year":"2022","journal-title":"Biomaterials"},{"key":"bmmadd3e7bib11","doi-asserted-by":"publisher","first-page":"1728","DOI":"10.1016\/j.actbio.2010.11.030","article-title":"First quantitative assay of alpha-Gal in soft tissues: presence and distribution of the epitope before and after cell removal from xenogeneic heart valves","volume":"7","author":"Naso","year":"2011","journal-title":"Acta Biomater."},{"key":"bmmadd3e7bib12","doi-asserted-by":"publisher","DOI":"10.1088\/1748-605X\/abaabf","article-title":"Bioprosthetic heart valves with reduced immunogenic residuals using vacuum-assisted decellularization treatment","volume":"15","author":"Luo","year":"2020","journal-title":"Biomed. Mater."},{"key":"bmmadd3e7bib13","doi-asserted-by":"publisher","DOI":"10.1088\/1748-605X\/ac0088","article-title":"A novel detergent-based decellularization combined with carbodiimide crosslinking for improving anti-calcification of bioprosthetic heart valve","volume":"16","author":"Luo","year":"2021","journal-title":"Biomed. Mater."},{"key":"bmmadd3e7bib14","doi-asserted-by":"publisher","first-page":"3684","DOI":"10.1016\/j.biomaterials.2006.02.008","article-title":"Crosslinking of decellularized porcine heart valve matrix by procyanidins","volume":"27","author":"Zhai","year":"2006","journal-title":"Biomaterials"},{"key":"bmmadd3e7bib15","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202303737","article-title":"Functional oxidized hyaluronic acid cross\u2010linked decellularized heart valves for improved immunomodulation, anti\u2010calcification, and recellularization","volume":"13","author":"Wu","year":"2024","journal-title":"Adv. Healthcare Mater."},{"key":"bmmadd3e7bib16","doi-asserted-by":"publisher","first-page":"17073","DOI":"10.1021\/acs.chemrev.2c00344","article-title":"Zwitterionic biomaterials","volume":"122","author":"Li","year":"2022","journal-title":"Chem. Rev."},{"key":"bmmadd3e7bib17","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1021\/acsabm.9b00902","article-title":"Artificial heart valves with balanced charged networks exhibiting anti-calcification properties","volume":"3","author":"Guo","year":"2020","journal-title":"ACS Appl. Bio Mater."},{"key":"bmmadd3e7bib18","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2021.131803","article-title":"Chemical bonding of biological valve leaflets with an aminated zwitterionic copolymer for long-term anticoagulation and improved anti-calcification","volume":"426","author":"Liu","year":"2021","journal-title":"Chem. Eng. J."},{"key":"bmmadd3e7bib19","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2020.128244","article-title":"Polyzwitterion-crosslinked hybrid tissue with antithrombogenicity, endothelialization, anticalcification properties","volume":"410","author":"Yang","year":"2021","journal-title":"Chem. Eng. J."},{"key":"bmmadd3e7bib20","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.actbio.2016.03.044","article-title":"Zwitterionic polymer functionalization of polysulfone membrane with improved antifouling property and blood compatibility by combination of ATRP and click chemistry","volume":"40","author":"Xiang","year":"2016","journal-title":"Acta Biomater."},{"key":"bmmadd3e7bib21","doi-asserted-by":"publisher","first-page":"11763","DOI":"10.1021\/acs.langmuir.6b03016","article-title":"Antifouling zwitterionic coating via electrochemically mediated atom transfer radical polymerization on enzyme-based glucose sensors for long-time stability in 37 \u00b0C serum","volume":"32","author":"Hu","year":"2016","journal-title":"Langmuir"},{"key":"bmmadd3e7bib22","doi-asserted-by":"publisher","first-page":"6024","DOI":"10.1039\/C9TB01337G","article-title":"Layer-by-layer zwitterionic modification of diverse substrates with durable anti-corrosion and anti-fouling properties","volume":"7","author":"Li","year":"2019","journal-title":"J. Mater. Chem. B"},{"key":"bmmadd3e7bib23","doi-asserted-by":"publisher","first-page":"239","DOI":"10.21470\/1678-9741-2020-0635","article-title":"Bioprosthetic aortic valve degeneration: a review from a basic science perspective","volume":"37","author":"Velho","year":"2022","journal-title":"Braz. J. Cardiovasc. Surg."},{"key":"bmmadd3e7bib24","doi-asserted-by":"publisher","DOI":"10.1088\/1748-6041\/10\/6\/065014","article-title":"Promoting endothelialization on decellularized porcine aortic valve by immobilizing branched polyethylene glycolmodified with cyclic-RGD peptide: an in vitro study","volume":"10","author":"Zhou","year":"2015","journal-title":"Biomed. Mater."},{"key":"bmmadd3e7bib25","doi-asserted-by":"publisher","first-page":"2327","DOI":"10.1007\/s10856-009-3791-4","article-title":"RGD-modified acellular bovine pericardium as a bioprosthetic scaffold for tissue engineering","volume":"20","author":"Dong","year":"2009","journal-title":"J. Mater. Sci., Mater. Med."},{"key":"bmmadd3e7bib26","doi-asserted-by":"publisher","first-page":"1628","DOI":"10.1016\/j.bioactmat.2020.10.028","article-title":"Coaxial-printed small-diameter polyelectrolyte-based tubes with an electrostatic self-assembly of heparin and YIGSR peptide for antithrombogenicity and endothelialization","volume":"6","author":"Zeng","year":"2021","journal-title":"Bioact. Mater."},{"key":"bmmadd3e7bib27","doi-asserted-by":"publisher","first-page":"4602","DOI":"10.1039\/D3BM00458A","article-title":"Functionalization of 3D printed polymeric bioresorbable stents with a dual cell-adhesive peptidic platform combining RGDS and YIGSR sequences","volume":"11","author":"Chausse","year":"2023","journal-title":"Biomater. Sci."},{"key":"bmmadd3e7bib28","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2022.121478","article-title":"A nitric oxide-eluting and REDV peptide-conjugated coating promotes vascular healing","volume":"284","author":"Zhang","year":"2022","journal-title":"Biomaterials"},{"key":"bmmadd3e7bib29","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.actbio.2018.07.046","article-title":"Improving functional re-endothelialization of acellular liver scaffold using REDV cell-binding domain","volume":"78","author":"Devalliere","year":"2018","journal-title":"Acta Biomater."},{"key":"bmmadd3e7bib30","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2021.112329","article-title":"Zwitterionic hydrogel-coated heart valves with improved endothelialization and anti-calcification properties","volume":"128","author":"Luo","year":"2021","journal-title":"Mater. Sci. Eng. C"}],"container-title":["Biomedical Materials"],"original-title":[],"link":[{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/add3e7","content-type":"text\/html","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/add3e7\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/add3e7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/add3e7\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/add3e7\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/add3e7\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/add3e7\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"similarity-checking"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/add3e7\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T06:46:09Z","timestamp":1747205169000},"score":1,"resource":{"primary":{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/add3e7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,1]]},"references-count":30,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,5,14]]},"published-print":{"date-parts":[[2025,5,1]]}},"URL":"https:\/\/doi.org\/10.1088\/1748-605x\/add3e7","relation":{},"ISSN":["1748-6041","1748-605X"],"issn-type":[{"value":"1748-6041","type":"print"},{"value":"1748-605X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,1]]},"assertion":[{"value":"Bioprosthetic heart valves with zwitterionic copolymer grafting to improve the properties of endothelialization and anti-calcification","name":"article_title","label":"Article Title"},{"value":"Biomedical Materials","name":"journal_title","label":"Journal Title"},{"value":"paper","name":"article_type","label":"Article Type"},{"value":"\u00a9 2025 IOP Publishing Ltd. All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2024-12-19","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2025-05-02","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2025-05-14","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}