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Mater."],"published-print":{"date-parts":[[2026,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Magnetic fluid hyperthermia (MFH) is emerging as a promising cancer therapeutic modality due to its minimal side effects and targeted approach. This study presents the synthesis and characterization of temperature-sensitive biocompatible MF containing citric acid-coated Mn\n                    <jats:sub>0.9<\/jats:sub>\n                    Zn\n                    <jats:sub>0.1<\/jats:sub>\n                    Fe\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    nanoparticles, along with\n                    <jats:italic>in vitro<\/jats:italic>\n                    investigations on the prostate cancer cells LNCaP, to demonstrate the potential of these nanoparticles as a hyperthermic agent for MFH. The biocompatibility of MF was assessed using the MTT assay, which demonstrated no cytotoxic effects at concentrations up to 3 mg ml\n                    <jats:sup>\u22121<\/jats:sup>\n                    . Furthermore, rapid internalization of nanoparticles into LNCaP prostate cancer cells was observed within 10 min, as determined by a Prussian blue assay and quantified by inductively coupled plasma mass spectrometry. Upon exposure to an alternating magnetic field of 10 kA m\n                    <jats:sup>\u22121<\/jats:sup>\n                    and 332 kHz frequency, the nanoparticles achieved the therapeutic temperature of 42 \u00b0C within 27 min, while sustaining a hyperthermic range of 42 \u00b0C\u201345 \u00b0C for one hour. Notably, three MFH treatment sessions were identified as requisite for the elimination of LNCaP cells. Apoptosis was detected using Hoechst-Propidium iodide (PI) staining and further quantified by Annexin-V\/PI flow cytometry. These findings underscore the potential of citric acid-coated Mn\u2013Zn ferrite nanoparticles as effective biocompatible agents for MFH-based cancer therapy, warranting further detailed investigations to elucidate their therapeutic efficacy.\n                  <\/jats:p>","DOI":"10.1088\/1748-605x\/ae30be","type":"journal-article","created":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T22:52:11Z","timestamp":1766530331000},"page":"015014","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Multiple sessions magnetic fluid hyperthermia: a requisite for apoptosis in prostate cancer cells LNCaP"],"prefix":"10.1088","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-0506-5356","authenticated-orcid":true,"given":"Uma","family":"Iyer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hima","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1566-2846","authenticated-orcid":true,"given":"Kinnari","family":"Parekh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1415-3652","authenticated-orcid":true,"given":"Neeraj","family":"Jain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2026,1,8]]},"reference":[{"key":"bmmae30bebib1","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.3390\/pharmaceutics12111020","type":"journal-article","article-title":"Systemically delivered magnetic hyperthermia for prostate cancer treatment","volume":"12","author":"Albarqi","year":"2020","journal-title":"Pharmaceutics"},{"key":"bmmae30bebib2","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1007\/s11095-012-0710-z","type":"journal-article","article-title":"Controlled cell death by magnetic hyperthermia: effects of exposure time, field amplitude, and nanoparticle concentration","volume":"29","author":"As\u00edn","year":"2012","journal-title":"Pharm. 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