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It induces a significant inhibition of bacterial viability at a concentration of NPs as low as 1 mg l\n                    <jats:sup>\u22121<\/jats:sup>\n                    . After intravenous administration, the particles showed high tropism for lung accumulation reaching concentration of almost 300%\/g of tissue, more than 10 times higher than concentrations in other tissues. This study demonstrates the effectiveness of using MIL-101 (Cr) MOFs for pulmonary drug delivery and holds significant promise for developing antibacterial therapies.\n                  <\/jats:p>","DOI":"10.1088\/1748-605x\/ae32d9","type":"journal-article","created":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T22:53:52Z","timestamp":1767394432000},"page":"015021","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["MIL-101 (Cr) metal\u2013organic frameworks for systemic delivery of rifampicin antibiotic to lungs"],"prefix":"10.1088","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1275-8535","authenticated-orcid":false,"given":"Aziz","family":"Mirkasymov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5684-0977","authenticated-orcid":false,"given":"Danila","family":"Pokhorukov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6371-7517","authenticated-orcid":true,"given":"Iaroslav","family":"Belyaev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6570-8147","authenticated-orcid":true,"given":"Polina","family":"Kotelnikova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6180-7444","authenticated-orcid":false,"given":"Olga","family":"Griaznova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9871-8050","authenticated-orcid":false,"given":"Daria","family":"Trushina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0209-2116","authenticated-orcid":true,"given":"Ivan","family":"Zelepukin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3952-0631","authenticated-orcid":false,"given":"Sergey","family":"Deyev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2026,1,22]]},"reference":[{"key":"bmmae32d9bib1","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.mpaic.2017.11.002","type":"journal-article","volume":"19","author":"Barker","year":"2018","journal-title":"Anaesth. 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