{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T16:12:47Z","timestamp":1784563967125,"version":"3.55.0"},"reference-count":31,"publisher":"IOP Publishing","issue":"2","license":[{"start":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:00:00Z","timestamp":1772582400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/iop-standard\/v1"},{"start":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:00:00Z","timestamp":1772582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"crossref","award":["17441904200"],"award-info":[{"award-number":["17441904200"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"crossref","award":["2018M642039"],"award-info":[{"award-number":["2018M642039"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Shanghai Ninth People\u2019s Hospital MDT Program","award":["2017-1-019"],"award-info":[{"award-number":["2017-1-019"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81470990"],"award-info":[{"award-number":["81470990"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Shanghai Ninth People\u2019s Hospital Clinical Research Program","award":["JYLJ007"],"award-info":[{"award-number":["JYLJ007"]}]}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Biomed. Mater."],"published-print":{"date-parts":[[2026,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Indoxyl sulfate (IS), one of protein bound uremic toxins, is associated with various complications in chronic kidney disease patients and could partially be removed through hemodialysis and hemoperfusion due to its high affinity to human serum albumin. Many studies have demonstrated the potential for blood purification applications, such as poly-\n                    <jats:italic>\u03b2<\/jats:italic>\n                    -cyclodextrin (PCD) and metal\u2013organic frameworks, providing new possibilities for the efficient removal of IS. Here, we utilized\n                    <jats:italic>\u03b2<\/jats:italic>\n                    -cyclodextrin (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    -CD)-grafted polyethyleneimine (PEI), which is referred to as\n                    <jats:italic>\u03b2<\/jats:italic>\n                    P, as a scavenger for IS and sodium alginate (SA) as the matrix material to prepare alginate-based hybrid macrospheres (MS). The surface polydopamine (PD) and argatroban (AG) modification resulted in enhanced biocompatibility and anticoagulation. The results indicated that the hybrid MS demonstrated effective adsorption and removal capacity (79.96%) of IS. Moreover, the lower hemolysis rate (0.36%) and longer anticoagulation-related factors (APTT: 161.5 s; TT, 35.6 s) also revealed favorable biocompatibility and anticoagulation. This study presents a new way to designate blood purification materials and highlights their potential in clinical hemoperfusion treatment.\n                  <\/jats:p>","DOI":"10.1088\/1748-605x\/ae3ec3","type":"journal-article","created":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T22:51:26Z","timestamp":1769640686000},"page":"025008","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["<i>\u03b2<\/i>\n                    -CD-polyethyleneimine hybrid alginate macrospheres for the efficient removal of indoxyl sulfate"],"prefix":"10.1088","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-7061-5019","authenticated-orcid":true,"given":"Yukuan","family":"Lou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaolun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenkai","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3639-4940","authenticated-orcid":true,"given":"Yifeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suhua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2026,3,4]]},"reference":[{"key":"bmmae3ec3bib1","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1681\/ASN.2016121374","type":"journal-article","article-title":"Update on the Burden of CKD","volume":"28","author":"Coresh","year":"2017","journal-title":"J. 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All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2025-06-11","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2026-01-28","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2026-03-04","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}