{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T23:23:03Z","timestamp":1788909783886,"version":"build-2803163510"},"reference-count":63,"publisher":"IOP Publishing","issue":"2","license":[{"start":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:00:00Z","timestamp":1773273600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/iop-standard\/v1"},{"start":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:00:00Z","timestamp":1773273600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"funder":[{"name":"ARG","award":["ARG\/2025\/8857\/LS"],"award-info":[{"award-number":["ARG\/2025\/8857\/LS"]}]},{"name":"MoE","award":["MoE\/STARS-2\/2023-0640"],"award-info":[{"award-number":["MoE\/STARS-2\/2023-0640"]}]},{"DOI":"10.13039\/501100001411","name":"ICMR","doi-asserted-by":"crossref","award":["ICMR\/FIW-2024-01-00000208"],"award-info":[{"award-number":["ICMR\/FIW-2024-01-00000208"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"crossref"}]},{"name":"ANRF","award":["ANRF\/SPR\/2022\/000230"],"award-info":[{"award-number":["ANRF\/SPR\/2022\/000230"]}]},{"DOI":"10.13039\/501100019550","name":"SPARC","doi-asserted-by":"crossref","award":["SPARC\/P2082\/SL"],"award-info":[{"award-number":["SPARC\/P2082\/SL"]}],"id":[{"id":"10.13039\/501100019550","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Biomed. Mater."],"published-print":{"date-parts":[[2026,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Breast cancer is the most often diagnosed malignancy in women, exceeding lung cancer with almost 2.3 million new cases per year. Triple-negative breast cancer (TNBC), comprising 10%\u201315% of cases, is distinguished by its aggressive development, high invasiveness, and restricted treatment alternatives. Patients with malignancies often exhibit impaired immune function, predisposing them to opportunistic infections, particularly those caused by\n                    <jats:italic>S. aureus (S. aureus)<\/jats:italic>\n                    . In this study, the development and characterization of a multifunctional liposomal nanosystem co-delivering betanin and IR806 dye (Bet-IR806-LPs) for the dual management of TNBC and bacterial infections was reported. The liposomes were formulated using soybean phosphatidylcholine (Soya PC), which enhanced drug encapsulation, stability, and biocompatibility. Bet-IR806-LPs exhibited strong photothermal (PTT) conversion efficiency under near-infrared (NIR) irradiation, enabling effective PTT and photodynamic therapy (PDT). Antibacterial assessment against\n                    <jats:italic>S. aureus<\/jats:italic>\n                    revealed potent inhibitory activity, with an IC\n                    <jats:sub>50<\/jats:sub>\n                    of 5 \u03bcg ml\n                    <jats:sup>\u22121<\/jats:sup>\n                    . Biocompatibility was confirmed in fibroblast cell models, while zebrafish assays provided further insights into nanomaterial safety through analyses of reactive oxygen species and apoptosis. Cytotoxicity studies in 4T1 TNBC cells demonstrated significant anti-proliferative and anti-migratory effects, with enhanced tumor cell ablation upon NIR irradiation mediated by combined PTT-PDT mechanisms. Collectively, Bet-IR806-LPs demonstrate promising dual functionality, integrating antibacterial and anticancer activities within a single nanosystem. These findings suggest their potential as a versatile therapeutic platform with clinical relevance for improving treatment outcomes in TNBC while simultaneously addressing bacterial co-infections.\n                  <\/jats:p>","DOI":"10.1088\/1748-605x\/ae49cd","type":"journal-article","created":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T22:53:26Z","timestamp":1771973606000},"page":"025012","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Synergistic anticancer and antimicrobial efficacy of betanin and IR806 co-encapsulated liposomes against triple-negative breast cancer"],"prefix":"10.1088","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0570-1087","authenticated-orcid":false,"given":"Chandra Lekha","family":"Putta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5054-1356","authenticated-orcid":false,"given":"Srujana","family":"T L","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3994-6760","authenticated-orcid":true,"given":"Aravind Kumar","family":"Rengan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2026,3,12]]},"reference":[{"key":"bmmae49cdbib1","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/1475-2867-10-11","type":"journal-article","article-title":"From \u201comics\u201d to complex disease: a systems biology approach to gene-environment interactions in cancer","volume":"10","author":"Knox","year":"2010","journal-title":"Cancer Cell Int."},{"key":"bmmae49cdbib2","doi-asserted-by":"publisher","first-page":"4287","DOI":"10.3390\/cancers13174287","type":"journal-article","article-title":"Breast cancer\u2014epidemiology, risk factors, classification, prognostic markers, and current treatment strategies\u2014an updated review","volume":"13","author":"\u0141ukasiewicz","year":"2021","journal-title":"Cancers"},{"key":"bmmae49cdbib3","doi-asserted-by":"publisher","first-page":"3749","DOI":"10.3390\/cancers13153749","type":"journal-article","article-title":"Targeted liposomal chemotherapies to treat triple-negative breast cancer","volume":"13","author":"Margaret","year":"2021","journal-title":"Cancers"},{"key":"bmmae49cdbib4","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2024.1405491","type":"journal-article","article-title":"Advancements and challenges in triple-negative breast cancer: a comprehensive review of therapeutic and diagnostic strategies","volume":"14","author":"Xiong","year":"2024","journal-title":"Front. Oncol."},{"key":"bmmae49cdbib5","doi-asserted-by":"publisher","first-page":"106","DOI":"10.7497\/j.issn.2095-3941.2015.0030","type":"journal-article","article-title":"Current approaches in treatment of triple-negative breast cancer","volume":"12","author":"Wahba","year":"2015","journal-title":"Cancer Biol. Med."},{"key":"bmmae49cdbib6","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.3892\/ijo.2020.5135","type":"journal-article","article-title":"Triple-negative breast cancer therapy: current and future perspectives (review)","volume":"57","author":"Won","year":"2020","journal-title":"Int. J. Oncol."},{"key":"bmmae49cdbib7","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1186\/s13045-023-01497-3","type":"journal-article","article-title":"Recent advances in targeted strategies for triple-negative breast cancer","volume":"16","author":"Zhu","year":"2023","journal-title":"J. Hematol. Oncol."},{"key":"bmmae49cdbib8","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1186\/s13045-022-01341-0","type":"journal-article","article-title":"Recent advances in therapeutic strategies for triple-negative breast cancer","volume":"15","author":"Li","year":"2022","journal-title":"J. Hematol. Oncol."},{"key":"bmmae49cdbib9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2021\/8883700","type":"journal-article","article-title":"Bacterial infection among cancer patients: analysis of isolates and antibiotic sensitivity pattern","volume":"2021","author":"Bhat","year":"2021","journal-title":"Int. J. Microbiol."},{"key":"bmmae49cdbib10","doi-asserted-by":"publisher","first-page":"195","DOI":"10.14740\/wjon1410","type":"journal-article","article-title":"Infections in hospitalized cancer patients","volume":"12","author":"Delgado","year":"2021","journal-title":"World J. Oncol."},{"key":"bmmae49cdbib11","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1080\/21505594.2016.1156821","type":"journal-article","article-title":"Bloodstream infections in neutropenic cancer patients: a practical update","volume":"7","author":"Gustinetti","year":"2016","journal-title":"Virulence"},{"key":"bmmae49cdbib12","doi-asserted-by":"publisher","first-page":"10099","DOI":"10.1007\/s00520-022-07392-w","type":"journal-article","article-title":"All-cause mortality in cancer patients treated for sepsis in intensive care units: a systematic review and meta-analysis","volume":"30","author":"Nazer","year":"2022","journal-title":"Supportive Care Cancer"},{"key":"bmmae49cdbib13","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1007\/978-3-319-66432-3_15","type":"book","article-title":"Bacterial infections","volume":"vol 647","author":"Ison","year":"2018"},{"key":"bmmae49cdbib14","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1016\/j.jmii.2010.08.004","type":"journal-article","article-title":"Clinical manifestations and prognostic factors in cancer patients with bacteremia due to extended-spectrum \u03b2-lactamase-producing Escherichia coli or Klebsiella pneumoniae","volume":"44","author":"Wang","year":"2011","journal-title":"J. Microbiol. Immunol. Infection"},{"key":"bmmae49cdbib15","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1182\/asheducation-2003.1.438","type":"journal-article","article-title":"Infections in patients with hematological cancer: recent developments","volume":"2003","author":"O\u2019Brien","year":"2003","journal-title":"Hematology"},{"key":"bmmae49cdbib16","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1128\/CMR.00020-18","type":"journal-article","article-title":"Methicillin-resistant staphylococcus aureus: molecular characterization, evolution, and epidemiology","volume":"31","author":"Lakhundi","year":"2018","journal-title":"Clin. Microbiol. Rev."},{"key":"bmmae49cdbib17","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1128\/CMR.00134-14","type":"journal-article","article-title":"Staphylococcus aureus infections: epidemiology, pathophysiology, clinical manifestations, and management","volume":"28","author":"Tong","year":"2015","journal-title":"Clin. Microbiol. Rev."},{"key":"bmmae49cdbib18","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1126\/science.aay9189","type":"journal-article","article-title":"The human tumor microbiome is composed of tumor type\u2013specific intracellular bacteria","volume":"368","author":"Nejman","year":"2020","journal-title":"Science"},{"key":"bmmae49cdbib19","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1038\/s41523-025-00721-2","type":"journal-article","article-title":"Triple-negative breast cancer modifies the systemic immune landscape and alters neutrophil functionality","volume":"11","author":"Bakker","year":"2025","journal-title":"npj Breast Cancer"},{"key":"bmmae49cdbib20","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2025.1582382","type":"journal-article","article-title":"Microbial infection and treatment strategies in cancer patients","volume":"16","author":"Zhu","year":"2025","journal-title":"Front. Microbiol."},{"key":"bmmae49cdbib21","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.866014","type":"journal-article","article-title":"IL-6\/JAK\/STAT3 signaling in breast cancer metastasis: biology and treatment","volume":"12","author":"Manore","year":"2022","journal-title":"Front. Oncol."},{"key":"bmmae49cdbib22","doi-asserted-by":"publisher","first-page":"445","DOI":"10.4161\/viru.2.5.17724","type":"journal-article","article-title":"Staphylococcus aureus biofilms","volume":"2","author":"Archer","year":"2011","journal-title":"Virulence"},{"key":"bmmae49cdbib23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fimmu.2020.01048","type":"journal-article","article-title":"Vaccines against antimicrobial resistance","volume":"11","author":"Rosini","year":"2020","journal-title":"Front. Immunol."},{"key":"bmmae49cdbib24","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.1016\/S1359-6446(02)02498-4","type":"journal-article","article-title":"New ways to treat bacterial infections","volume":"7","author":"Taylor","year":"2002","journal-title":"Drug Discovery Today"},{"key":"bmmae49cdbib25","doi-asserted-by":"publisher","first-page":"1926","DOI":"10.3390\/ijms25031926","type":"journal-article","article-title":"Zebrafish insights into nanomaterial toxicity: a focused exploration on metallic, metal oxide, semiconductor, and mixed-metal nanoparticles","volume":"25","author":"Mutalik","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"bmmae49cdbib26","doi-asserted-by":"publisher","first-page":"177","DOI":"10.5599\/admet.2102","type":"journal-article","article-title":"Beneficial effects of bioinspired silver nanoparticles on zebrafish embryos including a gene expression study","volume":"12","author":"Sakthi Devi","year":"2024","journal-title":"ADMET DMPK"},{"key":"bmmae49cdbib27","doi-asserted-by":"publisher","DOI":"10.1038\/srep37145","type":"journal-article","article-title":"Use of zebrafish larvae as a multi-endpoint platform to characterize the toxicity profile of silica nanoparticles","volume":"6","author":"Pham","year":"2016","journal-title":"Sci. Rep."},{"key":"bmmae49cdbib28","doi-asserted-by":"publisher","first-page":"2238","DOI":"10.3390\/cancers14092238","type":"journal-article","article-title":"What zebrafish and nanotechnology can offer for cancer treatments in the age of personalized medicine","volume":"14","author":"Cascallar","year":"2022","journal-title":"Cancers"},{"key":"bmmae49cdbib29","doi-asserted-by":"publisher","first-page":"9873","DOI":"10.1038\/s41598-021-87968-4","type":"journal-article","article-title":"Edelfosine nanoemulsions inhibit tumor growth of triple negative breast cancer in zebrafish xenograft model","volume":"11","author":"Saraiva","year":"2021","journal-title":"Sci. Rep."},{"key":"bmmae49cdbib30","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.049147","type":"journal-article","article-title":"The zebrafish embryo as an in vivo model for screening nanoparticle-formulated lipophilic anti-tuberculosis compounds","volume":"15","author":"Knudsen Dal","year":"2022","journal-title":"Dis. Model Mech."},{"key":"bmmae49cdbib31","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.1007018","type":"journal-article","article-title":"Zebrafish as a platform to evaluate the potential of lipidic nanoemulsions for gene therapy in cancer","volume":"13","author":"Cascallar","year":"2022","journal-title":"Front. Pharmacol."},{"key":"bmmae49cdbib32","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1016\/j.ijbiomac.2022.07.018","type":"journal-article","article-title":"Chitosan IR806 dye-based polyelectrolyte complex nanoparticles with mitoxantrone combination for effective chemo-photothermal therapy of metastatic triple-negative breast cancer","volume":"216","author":"Alvi","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"bmmae49cdbib33","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2020.111901","type":"journal-article","article-title":"NIR-dye based mucoadhesive nanosystem for photothermal therapy in breast cancer cells","volume":"208","author":"Jogdand","year":"2020","journal-title":"J. Photochem. Photobiol. B"},{"key":"bmmae49cdbib34","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1007\/s12010-021-03744-0","type":"journal-article","article-title":"Inhibition of proliferation in ovarian cancer cell line (PA-1) by the action of green compound \u201cbetanin\u201d","volume":"194","author":"Rakshanaa","year":"2022","journal-title":"Appl. Biochem. Biotechnol."},{"key":"bmmae49cdbib35","doi-asserted-by":"publisher","first-page":"280","DOI":"10.2174\/187152011795347504","type":"journal-article","article-title":"Cytotoxic effect of the red beetroot (beta vulgaris L.) extract compared to doxorubicin (adriamycin) in the human prostate (PC-3) and breast (MCF-7) cancer cell lines","volume":"11","author":"Kapadia","year":"2011","journal-title":"Anti Cancer Agents Med. Chem."},{"key":"bmmae49cdbib36","doi-asserted-by":"publisher","first-page":"11522","DOI":"10.1002\/anie.201805138","type":"journal-article","article-title":"Innovative strategies for hypoxic\u2010tumor photodynamic therapy","volume":"57","author":"Li","year":"2018","journal-title":"Angew. Chem., Int. Ed."},{"key":"bmmae49cdbib37","doi-asserted-by":"publisher","first-page":"13911","DOI":"10.2147\/IJN.S542880","type":"journal-article","article-title":"Recent advances in near-infrared cyanine dye-based fluorescent nanoprobes for tumor imaging and therapy","volume":"20","author":"Gao","year":"2025","journal-title":"Int. J. Nanomed."},{"key":"bmmae49cdbib38","doi-asserted-by":"publisher","first-page":"2801","DOI":"10.3390\/nu7042801","type":"journal-article","article-title":"The potential benefits of red beetroot supplementation in health and disease","volume":"7","author":"Clifford","year":"2015","journal-title":"Nutrients"},{"key":"bmmae49cdbib39","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2022.111556","type":"journal-article","article-title":"Bioactive potential of beetroot (beta vulgaris)","volume":"158","author":"Punia Bangar","year":"2022","journal-title":"Food Res. Int."},{"key":"bmmae49cdbib40","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1016\/j.phymed.2007.03.017","type":"journal-article","article-title":"Betanin a betacyanin pigment purified from fruits of opuntia ficus-indica induces apoptosis in human chronic myeloid leukemia cell line-K562","volume":"14","author":"Sreekanth","year":"2007","journal-title":"Phytomedicine"},{"key":"bmmae49cdbib41","doi-asserted-by":"publisher","first-page":"9268","DOI":"10.1021\/jf051399j","type":"journal-article","article-title":"Relative inhibition of lipid peroxidation, cyclooxygenase enzymes, and human tumor cell proliferation by natural food colors","volume":"53","author":"Reddy","year":"2005","journal-title":"J. Agric. Food Chem."},{"key":"bmmae49cdbib42","doi-asserted-by":"publisher","first-page":"928","DOI":"10.1039\/D4PM00176A","type":"journal-article","article-title":"Advances in liposomal nanotechnology: from concept to clinics","volume":"1","author":"Senjab","year":"2024","journal-title":"RSC Pharm."},{"key":"bmmae49cdbib43","doi-asserted-by":"publisher","first-page":"653","DOI":"10.3390\/pharmaceutics11120653","type":"journal-article","article-title":"The impact of solvent selection: strategies to guide the manufacturing of liposomes using microfluidics","volume":"11","author":"Webb","year":"2019","journal-title":"Pharmaceutics"},{"key":"bmmae49cdbib44","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222413643","type":"journal-article","article-title":"Advances in lipid extraction methods\u2014a review","volume":"22","author":"Saini","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"bmmae49cdbib45","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtnano.2023.100348","type":"journal-article","article-title":"Bioinspired gold coated phage nanosomes for anti-microbial and anti-cancer theranostics","volume":"23","author":"Yadav","year":"2023","journal-title":"Mater. Today Nano"},{"key":"bmmae49cdbib46","author":"Monte Westerfield","year":"2000","type":"book"},{"key":"bmmae49cdbib47","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.reprotox.2011.06.121","type":"journal-article","article-title":"Zebrafish embryos as an alternative to animal experiments\u2014a commentary on the definition of the onset of protected life stages in animal welfare regulations","volume":"33","author":"Str\u00e4hle","year":"2012","journal-title":"Reprod. Toxicol."},{"key":"bmmae49cdbib48","doi-asserted-by":"publisher","first-page":"1688","DOI":"10.15252\/embr.201643153","type":"journal-article","article-title":"Euthanizing zebrafish legally in Europe","volume":"17","author":"Valentim","year":"2016","journal-title":"EMBO Rep."},{"key":"bmmae49cdbib49","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222413417","type":"journal-article","article-title":"Zebrafish embryos and larvae as alternative animal models for toxicity testing","volume":"22","author":"Bauer","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"bmmae49cdbib50","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1177\/0023677219869037","type":"journal-article","article-title":"Zebrafish: housing and husbandry recommendations","volume":"54","author":"Alestr\u00f6m","year":"2020","journal-title":"Lab. Anim."},{"key":"bmmae49cdbib51","doi-asserted-by":"publisher","DOI":"10.1002\/ppap.202000188","type":"journal-article","article-title":"Zebrafish larvae as a toxicity model in plasma medicine","volume":"18","author":"Gandhirajan","year":"2021","journal-title":"Plasma Process. Polym."},{"key":"bmmae49cdbib52","doi-asserted-by":"publisher","first-page":"1332","DOI":"10.3389\/fphar.2019.01332","type":"journal-article","article-title":"Liang-Ge-San, a classic traditional chinese medicine formula, attenuates lipopolysaccharide-induced acute lung injury through up-regulating miR-21","volume":"10","author":"Yang","year":"2019","journal-title":"Front. Pharmacol."},{"key":"bmmae49cdbib53","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2021.119864","type":"journal-article","article-title":"Oxidative stress induced antioxidant and neurotoxicity demonstrated in vivo zebrafish embryo or larval model and their normalization due to morin showing therapeutic implications","volume":"283","author":"Issac","year":"2021","journal-title":"Life Sci."},{"key":"bmmae49cdbib54","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1016\/j.foodchem.2012.11.005","type":"journal-article","article-title":"Protective effect of marine algae phlorotannins against AAPH-induced oxidative stress in zebrafish embryo","volume":"138","author":"Kang","year":"2013","journal-title":"Food Chem."},{"key":"bmmae49cdbib55","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1038\/nature12111","type":"journal-article","article-title":"The zebrafish reference genome sequence and its relationship to the human genome","volume":"496","author":"Howe","year":"2013","journal-title":"Nature"},{"key":"bmmae49cdbib56","doi-asserted-by":"publisher","first-page":"4954","DOI":"10.1007\/s12010-023-04791-5","type":"journal-article","article-title":"Evaluation of developmental toxicity and oxidative stress caused by zinc oxide nanoparticles in zebra fish embryos\/ larvae","volume":"196","author":"Deenathayalan","year":"2024","journal-title":"Appl. Biochem. Biotechnol."},{"key":"bmmae49cdbib57","doi-asserted-by":"publisher","first-page":"9112","DOI":"10.1039\/D2NR01378A","type":"journal-article","article-title":"A plasmon-enhanced fluorescent gold coated novel lipo-polymeric hybrid nanosystem: synthesis, characterization and application for imaging and photothermal therapy of breast cancer","volume":"14","author":"Appidi","year":"2022","journal-title":"Nanoscale"},{"key":"bmmae49cdbib58","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1021\/acsabm.4c01533","type":"journal-article","article-title":"Baicalein and IR780 coloaded liposomes for antifungal and anticancer therapy","volume":"8","author":"Putta","year":"2025","journal-title":"ACS Appl. Bio Mater."},{"key":"bmmae49cdbib59","doi-asserted-by":"publisher","first-page":"5333","DOI":"10.1021\/acsabm.2c00724","type":"journal-article","article-title":"Terminalia chebula polyphenol and near-infrared dye-loaded poly(lactic acid) nanoparticles for imaging and photothermal therapy of cancer cells","volume":"5","author":"Pebam","year":"2022","journal-title":"ACS Appl. Bio Mater."},{"key":"bmmae49cdbib60","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202203669","type":"journal-article","article-title":"Multifunctional superparticles for magnetically targeted NIR\u2010II imaging and photodynamic therapy","volume":"10","author":"Liu","year":"2023","journal-title":"Adv. Sci"},{"key":"bmmae49cdbib61","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202104100","type":"journal-article","article-title":"A bionanozyme with ultrahigh activity enables spatiotemporally controlled reactive oxygen species generation for cancer therapy","volume":"31","author":"Xu","year":"2021","journal-title":"Adv. Funct. Mater."},{"key":"bmmae49cdbib62","doi-asserted-by":"publisher","first-page":"29901","DOI":"10.18632\/oncotarget.4898","type":"journal-article","article-title":"NZ51, a ring-expanded nucleoside analog, inhibits motility and viability of breast cancer cells by targeting the RNA helicase DDX3","volume":"6","author":"Xie","year":"2015","journal-title":"Oncotarget"},{"key":"bmmae49cdbib63","doi-asserted-by":"publisher","first-page":"2518","DOI":"10.1039\/D2BM01814D","type":"journal-article","article-title":"Camptothecin loaded casein nanosystem for tuning the therapeutic efficacy against highly metastatic triple-negative breast cancer cells","volume":"11","author":"Khatun","year":"2023","journal-title":"Biomater. Sci."}],"container-title":["Biomedical Materials"],"original-title":[],"link":[{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ae49cd","content-type":"text\/html","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ae49cd\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ae49cd","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ae49cd\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ae49cd\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ae49cd\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ae49cd\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"similarity-checking"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ae49cd\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T09:56:52Z","timestamp":1773309412000},"score":1,"resource":{"primary":{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ae49cd"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,12]]},"references-count":63,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,3,12]]},"published-print":{"date-parts":[[2026,4,1]]}},"URL":"https:\/\/doi.org\/10.1088\/1748-605x\/ae49cd","relation":{},"ISSN":["1748-6041","1748-605X"],"issn-type":[{"value":"1748-6041","type":"print"},{"value":"1748-605X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,12]]},"assertion":[{"value":"Synergistic anticancer and antimicrobial efficacy of betanin and IR806 co-encapsulated liposomes against triple-negative breast cancer","name":"article_title","label":"Article Title"},{"value":"Biomedical Materials","name":"journal_title","label":"Journal Title"},{"value":"paper","name":"article_type","label":"Article Type"},{"value":"\u00a9 2026 IOP Publishing Ltd. All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2025-10-08","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2026-02-24","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2026-03-12","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}