{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T11:49:05Z","timestamp":1775130545461,"version":"3.50.1"},"reference-count":133,"publisher":"IOP Publishing","issue":"2","license":[{"start":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000},"content-version":"tdm","delay-in-days":1,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"funder":[{"name":"USF Microbiome Research Award"}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Biomed. Mater."],"published-print":{"date-parts":[[2026,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Human intestine is a complex organ that performs critical roles in nutrient absorption, immune regulation, and host\u2013microbiome interactions. Traditional two-dimensional and three-dimensional\n                    <jats:italic>in vitro<\/jats:italic>\n                    models, while useful for some applications, fall short in replicating the dynamic and multifaceted environment of the small intestine. In recent years, intestine-on-chip (IoC) technologies have emerged as promising platforms that integrate microfluidics, biomechanical cues, and tissue engineering to better simulate intestinal structure and function. This review provides a comprehensive overview of IoC devices, covering their underlying principles, historical development, design elements, and key functional capabilities, with special emphasis on the incorporation of mechanical strain and peristalsis-like motion. We also discuss the limitations of current models, including application of constant uniaxial strain, scale constraints, material challenges, biological complexity, and lack of standardization as well as prospective directions for advancing this field. By addressing these gaps, next-generation IoC systems can pave the way for more predictive disease models, advanced drug testing platforms, and personalized medicine applications.\n                  <\/jats:p>","DOI":"10.1088\/1748-605x\/ae5437","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T22:54:02Z","timestamp":1773874442000},"page":"022006","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Biomechanical design principles of intestine-on-chip models: past, present and future directions"],"prefix":"10.1088","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-0097-9861","authenticated-orcid":true,"given":"Rafsan Ahmed","family":"Rashik","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivia","family":"Guanella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenbin","family":"Mao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6454-7660","authenticated-orcid":true,"given":"Nathan D","family":"Gallant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"266","published-online":{"date-parts":[[2026,4,2]]},"reference":[{"key":"bmmae5437bib1","doi-asserted-by":"publisher","first-page":"1677","DOI":"10.1017\/S1751731114001645","type":"journal-article","article-title":"The in ovo administration of l-trans pyrrolidine-2,4-dicarboxylic acid regulates small intestinal growth in chicks","volume":"8","author":"Li","year":"2014","journal-title":"Animal"},{"key":"bmmae5437bib2","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1186\/scrt362","type":"journal-article","article-title":"Building additional complexity to in vitro-derived intestinal tissues","volume":"4","author":"Brugmann","year":"2013","journal-title":"Stem Cell Res. 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