{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T11:57:42Z","timestamp":1774958262348,"version":"3.50.1"},"reference-count":55,"publisher":"IOP Publishing","issue":"2","license":[{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/iop-standard\/v1"},{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"funder":[{"name":"Suqian Guided Science and Technology Program Project","award":["Z2024109"],"award-info":[{"award-number":["Z2024109"]}]},{"name":"China University Innovation Fund for Industry-Academia-Research Collaboration \u2013 Wound Repair and Tissue Regeneration Special Project","award":["2024hr008"],"award-info":[{"award-number":["2024hr008"]}]}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Biomed. Mater."],"published-print":{"date-parts":[[2026,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Burn is a common form of trauma, and the treatment of burn wounds remains the focus of clinical research. Dihydromyricetin (DMY) exhibits biological activities including antioxidant, anti-inflammatory, and wound-healing promotion, On the other hand, cerium oxide (CeO\n                    <jats:sub>\u2082<\/jats:sub>\n                    ) demonstrates excellent redox properties. This study developed dihydromyricetin-loaded cerium oxide nanoparticles (CeO\n                    <jats:sub>\u2082<\/jats:sub>\n                    @DMY) to investigate their impact on deep burn wound healing. CeO\n                    <jats:sub>\u2082<\/jats:sub>\n                    @APTES was synthesized by a hydrothermal method, followed by covalent modification to load DMY, forming the CeO\n                    <jats:sub>\u2082<\/jats:sub>\n                    @DMY complexes.\n                    <jats:italic>In vitro<\/jats:italic>\n                    experiments assessed the antioxidant capacity, antibacterial efficacy, cytotoxicity, and anti-inflammatory activity of CeO\n                    <jats:sub>\u2082<\/jats:sub>\n                    @DMY.\n                    <jats:italic>In vivo<\/jats:italic>\n                    experiments involved subcutaneous injection of CeO\n                    <jats:sub>\u2082<\/jats:sub>\n                    @DMY into rat burn wounds to evaluate its effects on wound healing. CeO\n                    <jats:sub>\u2082<\/jats:sub>\n                    @DMY exhibited potent antioxidant and antibacterial capabilities\n                    <jats:italic>in vitro<\/jats:italic>\n                    . It enhanced fibroblast viability and effectively scavenged reactive oxygen species.\n                    <jats:italic>In vivo<\/jats:italic>\n                    , CeO\n                    <jats:sub>\u2082<\/jats:sub>\n                    @DMY accelerated wound closure. Histological analysis revealed reduced inflammatory infiltration, increased connective tissue and neovascularization, elevated collagen deposition, and improved collagen alignment in the CeO\n                    <jats:sub>\u2082<\/jats:sub>\n                    @DMY group. Immunohistochemistry confirmed significantly upregulated expression of CD31 and\n                    <jats:italic>\u03b1<\/jats:italic>\n                    -SMA. CeO\n                    <jats:sub>\u2082<\/jats:sub>\n                    @DMY integrates antioxidant, antibacterial, and anti-inflammatory functions, enables sustained drug release, and promotes burn wound healing. It presents a promising therapeutic strategy for deep burn injuries.\n                  <\/jats:p>","DOI":"10.1088\/1748-605x\/ae5565","type":"journal-article","created":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T22:51:43Z","timestamp":1774047103000},"page":"025021","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Dihydromyricetin-loaded cerium oxide nanoparticles promote deep burn wound healing"],"prefix":"10.1088","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1111-0278","authenticated-orcid":true,"given":"Zhaonan","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaozheng","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengwang","family":"Ge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yekai","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueshan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deguang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"266","published-online":{"date-parts":[[2026,3,31]]},"reference":[{"key":"bmmae5565bib1","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1177\/1534734620924857","type":"journal-article","article-title":"A systematic review on classification, identification, and healing process of burn wound healing","volume":"21","author":"Abazari","year":"2022","journal-title":"Int. J. Low Extrem. Wounds"},{"key":"bmmae5565bib2","first-page":"54","type":"journal-article","article-title":"Antibacterial activity of cerium colloids against opportunistic microorganisms in vitro","volume":"74","author":"Babenko","year":"2012","journal-title":"Mikrobiol. z"},{"key":"bmmae5565bib3","doi-asserted-by":"publisher","first-page":"3073","DOI":"10.3390\/cells11193073","type":"journal-article","article-title":"The immune and regenerative response to burn injury","volume":"11","author":"Burgess","year":"2022","journal-title":"Cells"},{"key":"bmmae5565bib4","doi-asserted-by":"publisher","first-page":"4537","DOI":"10.1021\/nn200126a","type":"journal-article","article-title":"Ce3+ ions determine redox-dependent anti-apoptotic effect of cerium oxide nanoparticles","volume":"5","author":"Celardo","year":"2011","journal-title":"ACS Nano"},{"key":"bmmae5565bib5","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1111\/imm.13152","type":"journal-article","article-title":"Skin barrier immunity and ageing","volume":"160","author":"Chambers","year":"2020","journal-title":"Immunology"},{"key":"bmmae5565bib6","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2024.1404651","type":"journal-article","article-title":"Cerium oxide nanoparticles in wound care: a review of mechanisms and therapeutic applications","volume":"12","author":"Chen","year":"2024","journal-title":"Front. Bioeng. Biotechnol."},{"key":"bmmae5565bib7","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.actbio.2021.02.002","type":"journal-article","article-title":"Sprayable hydrogel dressing accelerates wound healing with combined reactive oxygen species-scavenging and antibacterial abilities","volume":"124","author":"Cheng","year":"2021","journal-title":"Acta Biomater."},{"key":"bmmae5565bib8","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1111\/srt.12424","type":"journal-article","article-title":"The relationship between skin function, barrier properties, and body-dependent factors","volume":"24","author":"D\u0105browska","year":"2018","journal-title":"Skin Res. Technol."},{"key":"bmmae5565bib9","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.1002\/jbm.a.36669","type":"journal-article","article-title":"Effects of cerium oxide nanoparticles on hemostasis: coagulation, platelets, and vascular endothelial cells","volume":"107","author":"Del Turco","year":"2019","journal-title":"J. Biomed. Mater. Res. A"},{"key":"bmmae5565bib10","doi-asserted-by":"publisher","first-page":"2296","DOI":"10.3390\/pharmaceutics15092296","type":"journal-article","article-title":"Preparation of dihydromyricetin-loaded self-emulsifying drug delivery system and its anti-alcoholism effect","volume":"15","author":"Dong","year":"2023","journal-title":"Pharmaceutics"},{"key":"bmmae5565bib11","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.actbio.2020.03.040","type":"journal-article","article-title":"Conformable hyaluronic acid hydrogel delivers adipose-derived stem cells and promotes regeneration of burn injury","volume":"108","author":"Dong","year":"2020","journal-title":"Acta Biomater."},{"key":"bmmae5565bib12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0301036","type":"journal-article","article-title":"Protective effect and pharmacokinetics of dihydromyricetin nanoparticles on oxidative damage of myocardium","volume":"19","author":"Du","year":"2024","journal-title":"PLoS One"},{"key":"bmmae5565bib13","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1111\/iwj.12557","type":"journal-article","article-title":"Reactive oxygen species (ROS) and wound healing: the functional role of ROS and emerging ROS-modulating technologies for augmentation of the healing process","volume":"14","author":"Dunnill","year":"2017","journal-title":"Int. Wound J."},{"key":"bmmae5565bib14","doi-asserted-by":"publisher","first-page":"4536","DOI":"10.3390\/molecules30234536","type":"journal-article","article-title":"The effectiveness of cerium oxide nanoparticle-based drugs in wound healing in animal models","volume":"30","author":"Erokhina","year":"2025","journal-title":"Molecules"},{"key":"bmmae5565bib15","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1111\/j.1600-0625.2010.01105.x","type":"journal-article","article-title":"The biology of burn injury","volume":"19","author":"Evers","year":"2010","journal-title":"Exp. Dermatol."},{"key":"bmmae5565bib16","doi-asserted-by":"publisher","first-page":"20492","DOI":"10.3390\/ijms160920492","type":"journal-article","article-title":"Influence of parathyroid hormone-loaded PLGA nanoparticles in porous scaffolds for bone regeneration","volume":"16","author":"Gentile","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"bmmae5565bib17","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.jphotobiol.2016.05.002","type":"journal-article","article-title":"Apoptosis inhibition effect of dihydromyricetin against UVA-exposed human keratinocyte cell line","volume":"161","author":"He","year":"2016","journal-title":"J. Photochem. Photobiol. B"},{"key":"bmmae5565bib18","doi-asserted-by":"publisher","first-page":"766","DOI":"10.2174\/1389201023666220821161737","type":"journal-article","article-title":"Biosynthesized cerium oxide nanoparticles CeO2NPs: recent progress and medical applications","volume":"24","author":"Humaira","year":"2023","journal-title":"Curr. Pharm. Biotechnol."},{"key":"bmmae5565bib19","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/s41572-020-0145-5","type":"journal-article","article-title":"Burn injury","volume":"6","author":"Jeschke","year":"2020","journal-title":"Nat. Rev. Dis. Primers"},{"key":"bmmae5565bib20","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a041222","type":"journal-article","article-title":"Diversity of fibroblasts and their roles in wound healing","volume":"15","author":"Jiang","year":"2023","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"bmmae5565bib21","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1233800","type":"journal-article","article-title":"Fibroblasts\u2014the cellular choreographers of wound healing","volume":"14","author":"Knoedler","year":"2023","journal-title":"Front. Immunol."},{"key":"bmmae5565bib22","doi-asserted-by":"publisher","first-page":"C58","DOI":"10.1152\/ajpcell.00106.2021","type":"journal-article","article-title":"Burn-induced hypermetabolism and skeletal muscle dysfunction","volume":"321","author":"Knuth","year":"2021","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"bmmae5565bib23","doi-asserted-by":"publisher","first-page":"tkaf024","DOI":"10.1093\/burnst\/tkaf024","type":"journal-article","article-title":"A multifunctional dihydromyricetin-loaded hydrogel for the sequential modulation of diabetic wound healing and glycemic control","volume":"13","author":"Li","year":"2025","journal-title":"Burns Trauma"},{"key":"bmmae5565bib24","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2022.121904","type":"journal-article","article-title":"Cerium oxide nanoparticles with antioxidative neurorestoration for ischemic stroke","volume":"291","author":"Li","year":"2022","journal-title":"Biomaterials"},{"key":"bmmae5565bib25","doi-asserted-by":"publisher","first-page":"481","DOI":"10.2147\/ijn.S283677","type":"journal-article","article-title":"Eco-friendly and facile synthesis of antioxidant, antibacterial and anticancer dihydromyricetin-mediated silver nanoparticles","volume":"16","author":"Li","year":"2021","journal-title":"Int. J. Nanomed."},{"key":"bmmae5565bib26","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1111\/jcmm.13403","type":"journal-article","article-title":"Dihydromyricetin enhances glucose uptake by inhibition of MEK\/ERK pathway and consequent down-regulation of phosphorylation of PPAR\u03b3 in 3T3-L1 cells","volume":"22","author":"Liu","year":"2018","journal-title":"J. Cell Mol. Med."},{"key":"bmmae5565bib27","doi-asserted-by":"publisher","first-page":"8658","DOI":"10.7150\/thno.111874","type":"journal-article","article-title":"Fe-flavonoid nanozyme as dual modulator of oxidative stress and autophagy for acute kidney injury repair","volume":"15","author":"Luo","year":"2025","journal-title":"Theranostics"},{"key":"bmmae5565bib28","doi-asserted-by":"publisher","first-page":"2176","DOI":"10.3390\/ma12132176","type":"journal-article","article-title":"Nanomaterials for wound healing and infection control","volume":"12","author":"Mihai","year":"2019","journal-title":"Materials"},{"key":"bmmae5565bib29","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1111\/wrr.12937","type":"journal-article","article-title":"Myofibroblast progeny in wound biology and wound healing studies","volume":"29","author":"Monika","year":"2021","journal-title":"Wound Repair Regen."},{"key":"bmmae5565bib30","doi-asserted-by":"publisher","first-page":"5951","DOI":"10.2147\/ijn.S255784","type":"journal-article","article-title":"Green synthesis of cerium oxide nanoparticles (CeO2 NPs) and their antimicrobial applications: a review","volume":"15","author":"Nadeem","year":"2020","journal-title":"Int. J. Nanomed."},{"key":"bmmae5565bib31","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.2741\/4632","type":"journal-article","article-title":"Nanoparticles in wound healing; from hope to promise, from promise to routine","volume":"23","author":"Naderi","year":"2018","journal-title":"Front. Biosci."},{"key":"bmmae5565bib32","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.ymeth.2021.04.018","type":"journal-article","article-title":"Magnetite nanoparticles: synthesis methods\u2014a comparative review","volume":"199","author":"Niculescu","year":"2022","journal-title":"Methods"},{"key":"bmmae5565bib33","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2023.100823","type":"journal-article","article-title":"Cerium oxide nanoparticles: synthesis methods and applications in wound healing","volume":"23","author":"Nosrati","year":"2023","journal-title":"Mater. Today Bio"},{"key":"bmmae5565bib34","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1016\/j.ijbiomac.2021.10.013","type":"journal-article","article-title":"Cationic, anionic and neutral polysaccharides for skin tissue engineering and wound healing applications","volume":"192","author":"Nosrati","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"bmmae5565bib35","doi-asserted-by":"publisher","first-page":"5","DOI":"10.12968\/jowc.2017.26.1.5","type":"journal-article","article-title":"Burn wound healing: present concepts, treatment strategies and future directions","volume":"26","author":"Oryan","year":"2017","journal-title":"J. Wound Care"},{"key":"bmmae5565bib36","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.119919","type":"journal-article","article-title":"Revascularization and limb salvage following critical limb ischemia by nanoceria-induced Ref-1\/APE1-dependent angiogenesis","volume":"242","author":"Park","year":"2020","journal-title":"Biomaterials"},{"key":"bmmae5565bib37","doi-asserted-by":"publisher","first-page":"4559","DOI":"10.3390\/molecules25194559","type":"journal-article","article-title":"Cerium oxide nanoparticles (nanoceria): hopes in soft tissue engineering","volume":"25","author":"Sadidi","year":"2020","journal-title":"Molecules"},{"key":"bmmae5565bib38","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-43413-2","type":"journal-article","article-title":"Fabrication and evaluation of vitamin doped Zno\/AgNPs nanocomposite based wheat gluten films: a promising findings for burn wound treatment","volume":"13","author":"Sajjad","year":"2023","journal-title":"Sci. Rep."},{"key":"bmmae5565bib39","doi-asserted-by":"publisher","first-page":"296","DOI":"10.3390\/pathogens9040296","type":"journal-article","article-title":"In vivo antimicrobial and wound-healing activity of resveratrol, dihydroquercetin, and dihydromyricetin against staphylococcus aureus, pseudomonas aeruginosa, and Candida albicans","volume":"9","author":"Shevelev","year":"2020","journal-title":"Pathogens"},{"key":"bmmae5565bib40","doi-asserted-by":"publisher","first-page":"11213","DOI":"10.2147\/ijn.S490027","type":"journal-article","article-title":"Nanoparticle-based therapeutics for enhanced burn wound healing: a comprehensive review","volume":"19","author":"Shi","year":"2024","journal-title":"Int. J. Nanomed."},{"key":"bmmae5565bib41","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/146764","type":"journal-article","article-title":"Complements and the wound healing cascade: an updated review","volume":"2013","author":"Sinno","year":"2013","journal-title":"Plast Surg. Int."},{"key":"bmmae5565bib42","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.794563","type":"journal-article","article-title":"Mechanism of dihydromyricetin on inflammatory diseases","volume":"12","author":"Sun","year":"2021","journal-title":"Front. Pharmacol."},{"key":"bmmae5565bib43","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1089\/wound.2014.0561","type":"journal-article","article-title":"Extracellular matrix and dermal fibroblast function in the healing wound","volume":"5","author":"Tracy","year":"2016","journal-title":"Adv. Wound Care"},{"key":"bmmae5565bib44","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.medin.2015.11.010","type":"journal-article","article-title":"Initial evaluation and management of the critical burn patient","volume":"40","author":"Viv\u00f3","year":"2016","journal-title":"Med. Intensiva"},{"key":"bmmae5565bib45","doi-asserted-by":"publisher","first-page":"454","DOI":"10.12659\/msm.897076","type":"journal-article","article-title":"Protective effect of dihydromyricetin against lipopolysaccharide-induced acute kidney injury in a rat model","volume":"22","author":"Wang","year":"2016","journal-title":"Med. Sci. Monit."},{"key":"bmmae5565bib46","doi-asserted-by":"publisher","first-page":"10806","DOI":"10.3390\/ijerph120910806","type":"journal-article","article-title":"Effects of Nano-CeO\u2082 with different nanocrystal morphologies on cytotoxicity in HepG2 cells","volume":"12","author":"Wang","year":"2015","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"bmmae5565bib47","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1093\/jbcr\/irae003","type":"journal-article","article-title":"Effects of nanoparticle-mediated dihydromyricetin to diabetic wounds: an in vivo study","volume":"45","author":"Wang","year":"2024","journal-title":"J. Burn. Care Res."},{"key":"bmmae5565bib48","doi-asserted-by":"publisher","first-page":"1473","DOI":"10.1016\/j.jvs.2018.01.060","type":"journal-article","article-title":"The Society for Vascular Surgery Wound, Ischemia, and foot Infection (WIfI) classification system predicts wound healing better than direct angiosome perfusion in diabetic foot wounds","volume":"68","author":"Weaver","year":"2018","journal-title":"J. Vasc. Surg."},{"key":"bmmae5565bib49","article-title":"Burns","author":"World Health Organization","year":"2023","type":"web-resource"},{"key":"bmmae5565bib50","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/j.foodchem.2016.07.090","type":"journal-article","article-title":"A dual antibacterial mechanism involved in membrane disruption and DNA binding of 2R,3R-dihydromyricetin from pine needles of cedrus deodara against staphylococcus aureus","volume":"218","author":"Wu","year":"2017","journal-title":"Food Chem."},{"key":"bmmae5565bib51","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202302858","type":"journal-article","article-title":"CeO2 nanoparticles to promote wound healing: a systematic review","volume":"13","author":"Xue","year":"2024","journal-title":"Adv. Healthcare Mater."},{"key":"bmmae5565bib52","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.ejphar.2019.02.039","type":"journal-article","article-title":"Dihydromyricetin attenuates hypertrophic scar formation by targeting activin receptor-like kinase 5","volume":"852","author":"Ye","year":"2019","journal-title":"Eur. J. Pharmacol."},{"key":"bmmae5565bib53","doi-asserted-by":"publisher","first-page":"401","DOI":"10.2217\/rme-2022-0029","type":"journal-article","article-title":"Cellular and biological factors involved in healing wounds and burns and treatment options in tissue engineering","volume":"17","author":"Yeganeh","year":"2022","journal-title":"Regen. Med."},{"key":"bmmae5565bib54","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1439960","type":"journal-article","article-title":"The regulatory mechanisms of cerium oxide nanoparticles in oxidative stress and emerging applications in refractory wound care","volume":"15","author":"Yi","year":"2024","journal-title":"Front. Pharmacol."},{"key":"bmmae5565bib55","doi-asserted-by":"publisher","DOI":"10.1016\/j.carpta.2024.100532","type":"journal-article","article-title":"Chitosan-derivative nanoparticles loaded with dihydromyricetin: characterization, antibacterial and antioxidant activities","volume":"8","author":"Zhang","year":"2024","journal-title":"Carbohydr. Polym. Technol. Appl."}],"container-title":["Biomedical Materials"],"original-title":[],"link":[{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ae5565","content-type":"text\/html","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ae5565\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ae5565","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ae5565\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ae5565\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ae5565\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ae5565\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"similarity-checking"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ae5565\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T11:11:43Z","timestamp":1774955503000},"score":1,"resource":{"primary":{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ae5565"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,31]]},"references-count":55,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,3,31]]},"published-print":{"date-parts":[[2026,4,1]]}},"URL":"https:\/\/doi.org\/10.1088\/1748-605x\/ae5565","relation":{},"ISSN":["1748-6041","1748-605X"],"issn-type":[{"value":"1748-6041","type":"print"},{"value":"1748-605X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,31]]},"assertion":[{"value":"Dihydromyricetin-loaded cerium oxide nanoparticles promote deep burn wound healing","name":"article_title","label":"Article Title"},{"value":"Biomedical Materials","name":"journal_title","label":"Journal Title"},{"value":"paper","name":"article_type","label":"Article Type"},{"value":"\u00a9 2026 IOP Publishing Ltd. All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2025-12-18","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2026-03-20","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2026-03-31","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}