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Mater."],"published-print":{"date-parts":[[2026,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Bone related problems due to numerous reasons are global concerns and increasing recently. Although bone tissues have an ability to regenerate, they cannot completely heal without external intervention when severe defects occur. It is required to develop new biomaterials, termed scaffolds, that can support and induce bone tissue regeneration. A biomaterial scaffold for bone repair possesses the requirements of non-toxicity, biocompatibility, osteoconductivity, and non-immunogenicity. Among natural osteogenic compounds, tamarind seed polysaccharide (TSP) is a desirable agent for fabrication of scaffolds for bone tissue engineering due to its suitable bio-chemical properties. In the previous study, sulfated derivative of TSP was synthesized and characterized. It is proven that this TSP sulfate (TSPS) is an osteogenic compound by inducing osteoblastic cell differentiation and bone mineralization\n                    <jats:italic>in vitro<\/jats:italic>\n                    . In the current study, osteogenic activities of TSPS were further investigated\n                    <jats:italic>in vivo<\/jats:italic>\n                    . Our data showed that TSPS supplemented orally at a dose of 62.5 mg kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    rescued bone loss in osteoporotic mice. Furthermore, histological images of the solid and spongy bone areas indicated that TSPS treated group improved the density and cell morphology of osteocytes and osteoblasts. From positive results observed\n                    <jats:italic>in vivo<\/jats:italic>\n                    , we further continued to study effects of TSPS on HA\/Collagen\/TSPS composite on bone formation by evaluating alkaline phosphatase (ALP) activity, and bone mineralization. It is shown that TSPS induced cell adherence and proliferation in HA\/Collagen (HA\/Col) composite. TSPS 100 \u00b5g ml\n                    <jats:sup>\u22121<\/jats:sup>\n                    supplemented onto the culture medium and coated onto HA\/Col composites resulted in increased of ALP activity to 258 \u00b1 13% and 539 \u00b1 38%, respectively; and of bone mineralization to 135 \u00b1 28.8% and 119 \u00b1 23.5%, respectively. Overall, TSPS proved to be a good osteogenic agent for bone formation and could be a highly potential candidate in pharmaceutical industry or biomaterial scaffold for bone tissue engineering.\n                  <\/jats:p>","DOI":"10.1088\/1748-605x\/ae56a7","type":"journal-article","created":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T22:54:06Z","timestamp":1774392846000},"page":"025025","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Osteogenic potential of tamarind seed polysaccharide sulfate in tissue engineering"],"prefix":"10.1088","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4384-1673","authenticated-orcid":true,"given":"Thi Trang Huyen","family":"Nguyen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hoang Minh","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anh Phuong","family":"Le","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minh Ngoc","family":"Khong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quang Khai","family":"Doan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6448-9794","authenticated-orcid":true,"given":"Phuong Nhi","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2082-4076","authenticated-orcid":true,"given":"Quang Thanh","family":"Ha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4303-0332","authenticated-orcid":true,"given":"Bich Kieu","family":"Pham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phuong Anh","family":"Lam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong Van","family":"Quyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1615-750X","authenticated-orcid":true,"given":"Won-Kyo","family":"Jung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2798-5968","authenticated-orcid":true,"given":"Phuong Thi Mai","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thi Hong Minh","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"266","published-online":{"date-parts":[[2026,4,7]]},"reference":[{"key":"bmmae56a7bib1","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1007\/s001980170135","type":"journal-article","article-title":"The incidence of hip fracture in four Asian countries: the Asian Osteoporosis Study (AOS)","volume":"12","author":"Lau","year":"2001","journal-title":"Osteoporos. 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All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2025-11-12","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2026-03-24","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2026-04-07","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}