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Furthermore, the coating demonstrated excellent cytocompatibility, and the aspirin-loaded AHTL8 significantly promoted the proliferation of mouse osteoblastic MC3T3-E1 cells. These findings indicate that the ZIF-L\/ZIF-8 composite coating serves as a highly efficient pH-triggered platform with high drug-loading and responsive release capacity, and its excellent cytocompatibility and MC3T3-E1 proliferation-promoting effect provide a preliminary basis for its potential application in promoting osseointegration.<\/jats:p>","DOI":"10.1088\/1748-605x\/ae60d7","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T22:55:01Z","timestamp":1776380101000},"page":"035002","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Synergistically enhanced aspirin loading and pH-triggered controlled release via a ZIF-L\/ZIF-8 hierarchical coating on titanium"],"prefix":"10.1088","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-2766-920X","authenticated-orcid":true,"given":"Shanchun","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyu","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingtong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunuo","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2026,4,29]]},"reference":[{"key":"bmmae60d7bib1","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.1177\/08853282231151230","type":"journal-article","article-title":"Effects of semiquinone-rich surface on the behaviors of vascular cells","volume":"37","author":"Wang","year":"2023","journal-title":"J. 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