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Mater."],"published-print":{"date-parts":[[2026,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Stress urinary incontinence (SUI) is associated with pelvic-floor extracellular-matrix (ECM) remodelling, including an imbalance between matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) that can weaken periurethral load-bearing connective tissue. This Review frames SUI as a clinically relevant ECM-failure niche and synthesises ECM-targeted biomaterials and nanocarriers designed to rebalance the MMP\/TIMP axis while enabling pragmatic pharmacodynamic readouts for early translation. We organise recent preclinical and early translational work across three modality classes: (i) protease-responsive injectable hydrogels that provide temporary mechanical support while tuning degradation and local protease inhibition; (ii) matrices functionalised with extracellular vesicles (EVs) carrying microRNAs and proteins that influence matrix turnover; and (iii) lipid nanoparticles delivering small interfering RNA to transiently suppress upstream drivers of ECM catabolism, including NF-\n                    <jats:italic>\u03ba<\/jats:italic>\n                    B\/MAPK signalling. For each class, we map controllable design variables to expected on-target effects and highlight concrete failure modes that often limit reproducibility and translation, such as potency and batch variability, placement sensitivity, viscoelastic fatigue, immune activation, and penetration\u2013retention trade-offs. We conclude with an assessment package linking tissue mechanics to molecular remodelling by combining transperineal shear-wave elastography with uEV microRNA panels to support context-of-use definition and cross-platform comparison under defined conditions.\n                  <\/jats:p>","DOI":"10.1088\/1748-605x\/ae62e4","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T22:56:29Z","timestamp":1776812189000},"page":"032005","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Extracellular matrix-targeted biomaterials and nanocarriers for pelvic-floor repair\/regeneration in stress urinary incontinence: local modulation of the MMP\/TIMP axis and NF-\n                    <i>\u03ba<\/i>\n                    B\/MAPK-linked remodelling programs"],"prefix":"10.1088","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-6733-698X","authenticated-orcid":true,"given":"Caizhi","family":"Lin","sequence":"first","affiliation":[{"name":"Science and Technology Experiment Center, Shanghai University of Traditional Chinese Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3752-9226","authenticated-orcid":true,"given":"Yan","family":"Ke","sequence":"additional","affiliation":[{"name":"Science and Technology Experiment Center, Shanghai University of Traditional Chinese Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2026,5,28]]},"reference":[{"key":"bmmae62e4bib1","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/s00192-009-0976-9","type":"journal-article","article-title":"An international urogynecological association (IUGA)\/international continence society (ICS) joint report on the terminology for female pelvic floor dysfunction","volume":"21","author":"Haylen","year":"2010","journal-title":"Int. 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