{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T12:11:02Z","timestamp":1778760662192,"version":"3.51.4"},"reference-count":27,"publisher":"IOP Publishing","issue":"3","license":[{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"},{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/questions\/alternative-author-rights-policies\/"},{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/questions\/alternative-author-rights-policies\/"}],"funder":[{"DOI":"10.13039\/100009110","name":"Natural Science Foundation of Xinjiang Uygur Autonomous Region","doi-asserted-by":"crossref","award":["2023D01E06"],"award-info":[{"award-number":["2023D01E06"]}],"id":[{"id":"10.13039\/100009110","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Xinjiang Medical University\/State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central cultivation project of National Science Foundation","award":["xyd2021Y005"],"award-info":[{"award-number":["xyd2021Y005"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["62035011"],"award-info":[{"award-number":["62035011"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Fundamental Research Funds for the Central Universities and State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia Fund","award":["SKL-HIDCA-2019-3"],"award-info":[{"award-number":["SKL-HIDCA-2019-3"]}]}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Biomed. Mater."],"published-print":{"date-parts":[[2026,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Triple-negative breast cancer (TNBC) is one of the most aggressive breast cancer subtypes with high metastatic and recurrence rates. However there is still a lack of effective targeting nanoprobes (NPs) which is leading to suboptimal targeted therapy. Cell membrane-encapsulation methods are one of the ideal targeting strategy, which could enhance the biocompatibility through endogenous membrane components while enabling functional integration of targeting and imaging capabilities. In this study, fluorescent dye-clinical indocyanine green (ICG) was successfully encapsulated by TNBC cell membranes via dual biolayer method to form M-ICG NPs. The M-ICG NPs exhibited well cellular uptake for TNBC tumor cells via active targeting capability after homologous cancer cell membrane coating. Meanwhile, strong near-infrared (NIR) fluorescence signals were detected at the tumor sites from mice post-injection of M-ICG NPs at 24 h, indicating that their effective targeted tumor accumulation enables good tumor-specific labeling with strong NIR fluorescence emission. Furthermore, the M-ICG NPs retain the excellent optical and photothermal properties of ICG. Under 808 nm laser irradiation, via infrared imaging, the process of temperature monitoring up to 55\u00b0C within 12 min was recorded, exhibiting a strong photothermal effect, which lays a foundation for constructing a multifunctional nanoplatform with tumor-specific targeting, excellent biocompatibility and structural stability.<\/jats:p>","DOI":"10.1088\/1748-605x\/ae65f5","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T22:54:46Z","timestamp":1777416886000},"page":"035011","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Tumor cell membrane modified clinical lCG nanoprobes for NIR fluorescence imaging of targeted triple negative breast cancer"],"prefix":"10.1088","volume":"21","author":[{"given":"Yuxiang","family":"Gao","sequence":"first","affiliation":[{"name":"Xinjiang Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1831-3002","authenticated-orcid":true,"given":"Siyu","family":"Huang","sequence":"additional","affiliation":[{"name":"Xinjiang Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaxing","family":"Li","sequence":"additional","affiliation":[{"name":"Xinjiang Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijun","family":"Zhu","sequence":"additional","affiliation":[{"name":"Xinjiang Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhong","family":"Du","sequence":"additional","affiliation":[{"name":"Xinjiang Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiabao","family":"Xiong","sequence":"additional","affiliation":[{"name":"Xinjiang Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1236-519X","authenticated-orcid":true,"given":"Nuernisha","family":"Alifu","sequence":"additional","affiliation":[{"name":"Xinjiang Medical University"},{"name":"Xinjiang Medical University"},{"name":"Xinjiang Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"266","published-online":{"date-parts":[[2026,5,14]]},"reference":[{"key":"bmmae65f5bib1","doi-asserted-by":"publisher","first-page":"450","DOI":"10.20892\/j.issn.2095-3941.2021.0676","type":"journal-article","article-title":"Breast cancer screening and early diagnosis in Chinese women","volume":"19","author":"Ding","year":"2022","journal-title":"Cancer Biol Med."},{"key":"bmmae65f5bib2","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2022.836417","type":"journal-article","article-title":"Triple-negative breast cancer: a brief review about epidemiology, risk factors, signaling pathways, treatment and role of artificial intelligence","volume":"9","author":"Almansour","year":"2022","journal-title":"Front. Mol. Biosci."},{"key":"bmmae65f5bib3","doi-asserted-by":"publisher","DOI":"10.1080\/15384047.2025.2472432","type":"journal-article","article-title":"The search for a TNBC vaccine: the guardian vaccine","volume":"26","author":"Fines","year":"2025","journal-title":"Cancer Biol. Ther."},{"key":"bmmae65f5bib4","doi-asserted-by":"publisher","first-page":"2661","DOI":"10.3390\/cancers15092661","type":"journal-article","article-title":"Endorsement of TNBC biomarkers in precision therapy by nanotechnology","volume":"15","author":"Chaudhuri","year":"2023","journal-title":"Cancers"},{"key":"bmmae65f5bib5","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1038\/s41523-022-00468-0","type":"journal-article","article-title":"Triple negative breast cancer: pitfalls and progress","volume":"8","author":"Zagami","year":"2022","journal-title":"NPJ Breast Cancer"},{"key":"bmmae65f5bib6","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1186\/s13045-022-01341-0","type":"journal-article","article-title":"Recent advances in therapeutic strategies for triple-negative breast cancer","volume":"15","author":"Li","year":"2022","journal-title":"J. Hematol. Oncol."},{"key":"bmmae65f5bib7","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2024.103712","type":"journal-article","article-title":"Platinum chemotherapy for early triple-negative breast cancer","volume":"75","author":"Mason","year":"2024","journal-title":"Breast"},{"key":"bmmae65f5bib8","doi-asserted-by":"publisher","first-page":"101","DOI":"10.2147\/BCTT.S516542","type":"journal-article","article-title":"Research progress on molecular biomarkers in the diagnosis and treatment of triple-negative breast cancer","volume":"29","author":"Ning","year":"2025","journal-title":"Chin. J. Lab. Diagn."},{"key":"bmmae65f5bib9","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.3892\/ijo.2020.5135","type":"journal-article","article-title":"Triple\u2010negative breast cancer therapy: Current and future perspectives (Review)","volume":"57","author":"Won","year":"2020","journal-title":"Int J Oncol."},{"key":"bmmae65f5bib10","doi-asserted-by":"publisher","first-page":"3428","DOI":"10.1158\/0008-5472.CAN-22-3432","type":"journal-article","article-title":"Development of a rare earth nanoprobe enables in vivo real-time detection of sentinel lymph node metastasis of breast cancer using NIR-IIb imaging","volume":"83","author":"Zhu","year":"2023","journal-title":"Cancer Res."},{"key":"bmmae65f5bib11","doi-asserted-by":"publisher","DOI":"10.1016\/j.matchemphys.2019.121860","type":"journal-article","article-title":"Heteroatom doped blue luminescent carbon dots as a nano-probe for targeted cell labeling and anticancer drug delivery vehicle","volume":"237","author":"Das","year":"2019","journal-title":"Mater. Chem. Phys."},{"key":"bmmae65f5bib12","doi-asserted-by":"publisher","first-page":"6762","DOI":"10.1039\/D1NA00447F","type":"journal-article","article-title":"Tailor made magnetic nanolights: fabrication to cancer theranostics applications","volume":"3","author":"Das","year":"2021","journal-title":"Nanoscale Adv."},{"key":"bmmae65f5bib13","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202309992","type":"journal-article","article-title":"Rare earth nanoprobes for targeted delineation of triple negative breast cancer and enhancement of radioimmunotherapy","volume":"11","author":"Ming","year":"2024","journal-title":"Adv. Sci."},{"key":"bmmae65f5bib14","doi-asserted-by":"publisher","first-page":"5141","DOI":"10.2147\/IJN.S417944","type":"journal-article","article-title":"Novel dual-mode NIR-II\/MRI nanoprobe targeting PD-L1 accurately evaluates the efficacy of immunotherapy for triple-negative breast cancer","volume":"8","author":"Liu","year":"2023","journal-title":"Int. J. Nanomed."},{"key":"bmmae65f5bib15","doi-asserted-by":"publisher","first-page":"5232","DOI":"10.1039\/d5bm00660k","type":"journal-article","article-title":"Advances in cell membrane-coated nanoparticles: multifunctional platforms for targeted drug delivery, precision phototherapy, and enhanced immunotherapy","volume":"13","author":"Sultana","year":"2023","journal-title":"Biomater Sci."},{"key":"bmmae65f5bib16","doi-asserted-by":"publisher","DOI":"10.1088\/1748-605X\/ad3311","type":"journal-article","article-title":"Current development of theragnostic nanoparticles for women\u2019s cancer treatment","volume":"19","author":"Kashyap","year":"2022","journal-title":"Biomed Mater."},{"key":"bmmae65f5bib17","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1038\/s41571-022-00699-x","type":"journal-article","article-title":"Targeting drugs to tumours using cell membrane-coated nanoparticles","volume":"20","author":"Fang","year":"2023","journal-title":"Nat Rev Clin Oncol."},{"key":"bmmae65f5bib18","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2023.100633","type":"journal-article","article-title":"Cell membrane-coated nanomaterials for cancer therapy","volume":"20","author":"Zeng","year":"2023","journal-title":"Mater. Today Bio"},{"key":"bmmae65f5bib19","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.844050","type":"journal-article","article-title":"engineered cell membrane-derived nanocarriers: the enhanced delivery system for therapeutic applications","volume":"10","author":"Yu","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"bmmae65f5bib20","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1007\/s13346-022-01252-0","type":"journal-article","article-title":"Cell membrane-coated nanoparticles: a novel multifunctional biomimetic drug delivery system","volume":"13","author":"Liu","year":"2023","journal-title":"Drug Deliv. Transl. Res."},{"key":"bmmae65f5bib21","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2024.2361169","type":"journal-article","article-title":"Advances in cell membrane-based biomimetic nanodelivery systems for natural products","volume":"31","author":"Zhang","year":"2024","journal-title":"Drug Deliv."},{"key":"bmmae65f5bib22","doi-asserted-by":"publisher","first-page":"837","DOI":"10.2147\/IJN.S346685","type":"journal-article","article-title":"Hybrid cell membrane-functionalized biomimetic nanoparticles for targeted therapy of osteosarcoma","volume":"17","author":"Cai","year":"2022","journal-title":"Int. J. Nanomed."},{"key":"bmmae65f5bib23","doi-asserted-by":"publisher","first-page":"10608","DOI":"10.1039\/d4ra01026d.","type":"journal-article","article-title":"Cancer cell membrane-coated nanoparticles: a promising anti-tumor bionic platform","volume":"14","author":"Guo","year":"2024","journal-title":"RSC Adv."},{"key":"bmmae65f5bib24","doi-asserted-by":"publisher","first-page":"157","DOI":"10.3390\/ph15020157","type":"journal-article","article-title":"Homotypic cancer cell membranes camouflaged nanoparticles for targeting drug delivery and enhanced chemo-photothermal therapy of glioma","volume":"15","author":"Ren","year":"2022","journal-title":"Pharmaceuticals"},{"key":"bmmae65f5bib25","doi-asserted-by":"publisher","DOI":"10.1177\/15330338241250244","type":"journal-article","article-title":"Advances in Composite Biofilm Biomimetic Nanodrug Delivery Systems for Cancer Treatment","volume":"23","author":"Meng","year":"2024","journal-title":"Technol Cancer Res Treat."},{"key":"bmmae65f5bib26","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2022.112895","type":"journal-article","article-title":"Red blood cell membrane nanoparticles for tumor phototherapy","volume":"220","author":"Zheng","year":"2022","journal-title":"Colloids Surf B Biointerfaces."},{"key":"bmmae65f5bib27","doi-asserted-by":"publisher","first-page":"669","DOI":"10.12307\/2023.983","type":"journal-article","article-title":"Preparation of a near-infrared photoresponsive biomimetic nanoprobe and its application in photothermal detection and treatment of breast cancer","volume":"28","author":"Li","year":"2024","journal-title":"Chin. J. Tissue Eng. Res."}],"container-title":["Biomedical Materials"],"original-title":[],"link":[{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ae65f5","content-type":"text\/html","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ae65f5\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ae65f5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ae65f5\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ae65f5\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ae65f5\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ae65f5\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"similarity-checking"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ae65f5\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T11:33:20Z","timestamp":1778758400000},"score":1,"resource":{"primary":{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ae65f5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,14]]},"references-count":27,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,5,14]]},"published-print":{"date-parts":[[2026,6,1]]}},"URL":"https:\/\/doi.org\/10.1088\/1748-605x\/ae65f5","relation":{},"ISSN":["1748-6041","1748-605X"],"issn-type":[{"value":"1748-6041","type":"print"},{"value":"1748-605X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,14]]},"assertion":[{"value":"Tumor cell membrane modified clinical lCG nanoprobes for NIR fluorescence imaging of targeted triple negative breast cancer","name":"article_title","label":"Article Title"},{"value":"Biomedical Materials","name":"journal_title","label":"Journal Title"},{"value":"paper","name":"article_type","label":"Article Type"},{"value":"\u00a9 2026 The Author(s). Published by IOP Publishing Ltd","name":"copyright_information","label":"Copyright Information"},{"value":"2025-12-09","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2026-04-28","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2026-05-14","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}