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The synthesized NPs exhibited a uniform spherical morphology, with an average size of about 97 nm by SEM and a hydrodynamic diameter of 215 nm by DLS, confirming stability with a zeta potential of \u221230 mV. Incorporating NPs into chitosan hydrogels enhanced porosity, swelling response, and biodegradability, while rheological tests confirmed shear-thinning behavior and improved mechanical resilience\u2014features essential for injectability and mucosal retention. Drug release experiments demonstrated pH-responsive behavior: acidic environments yielded slow, controlled release, while physiological pH triggered faster release. Biological studies indicated that DOX-PLGA hydrogels effectively inhibited cancer cell growth by inducing apoptosis, disrupting mitochondrial function, increasing oxidative stress, and promoting inflammatory markers, alongside glutathione depletion. 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