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Despite their promise, challenges such as regulatory constraints, limited natural availability, and batch-to-batch variability associated with isolation-based production remain significant barriers. In this context, the integration of alternative synthetic and semi-synthetic approaches, alongside advances in biotechnology and chemical synthesis, offers viable strategies to enhance reproducibility, quality control, and scalability. Furthermore, emerging applications of marine-derived biomolecules in regenerative medicine and tissue engineering underscore their expanding therapeutic relevance. Looking ahead, the impact of climate change on marine biodiversity poses additional challenges to the availability and compositional consistency of marine resources, necessitating adaptive and sustainable sourcing strategies. Overall, this review underscores the critical importance of continued and responsible exploration of marine biodiversity to support innovative and effective therapeutic solutions for human health.<\/jats:p>","DOI":"10.1088\/1748-605x\/ae70e3","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T22:54:30Z","timestamp":1779317670000},"page":"032007","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Marine metabolites as biomedical resources: innovative sea-based strategies for human health"],"prefix":"10.1088","volume":"21","author":[{"given":"Sanjana","family":"Gaikwad","sequence":"first","affiliation":[{"name":"Vidya Pratishthan College of Arts, Science and Commerce"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mala","family":"Trivedi","sequence":"additional","affiliation":[{"name":"Amity Institute of Biotechnology, Amity University Uttar Pradesh, Lucknow Campus, Gomtinagar Extension"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh K","family":"Tiwari","sequence":"additional","affiliation":[{"name":"Amity Institute of Biotechnology, Amity University Uttar Pradesh, Lucknow Campus, Gomtinagar Extension"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5217-9039","authenticated-orcid":true,"given":"Manish","family":"Dwivedi","sequence":"additional","affiliation":[{"name":"Amity Institute of Biotechnology, Amity University Uttar Pradesh, Lucknow Campus, Gomtinagar Extension"},{"name":"Research Cell, Amity University Uttar Pradesh, Lucknow Campus"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2026,6,4]]},"reference":[{"key":"bmmae70e3bib1","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/s43141-021-00290-4","type":"journal-article","article-title":"Promising bioactive compounds from the marine environment and their potential effects on various diseases","volume":"20","author":"Karthikeyan","year":"2022","journal-title":"J. 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