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However, current multi-channel microfluidic chips confront challenges such as the unintended absorption of molecules, dependence on complex multi-material and multi-step fabrication processes, and instability in confining liquids. To address these challenges, we propose a multi-channel microfluidic chip with bilateral stripe structures, which can be mass-produced using single cyclic olefin copolymer material through injection molding. The bilateral stripe structures can effectively confine liquids with different wettabilities within the central channel by leveraging the edge effect. To demonstrate the versatility of the microfluidic platform, we successfully constructed tubular endothelial and renal tubule barriers on this chip, showcasing its potential for high-throughput, standardized organoid culture. This innovative microfluidic platform enables the construction of various\n                    <jats:italic>in vitro<\/jats:italic>\n                    organ models, offering a powerful tool for preclinical research and drug development.\n                  <\/jats:p>","DOI":"10.1088\/1748-605x\/ae722d","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T22:54:52Z","timestamp":1779490492000},"page":"035023","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Multi-channel microfluidic chip with bilateral stripe for reconstruction of tissue barrier models in vitro"],"prefix":"10.1088","volume":"21","author":[{"given":"Zhejun","family":"Chong","sequence":"first","affiliation":[{"name":"Southeast University"},{"name":"Southeast University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaqi","family":"Tang","sequence":"additional","affiliation":[{"name":"Jiangsu Avatarget Biotechnology Co., Ltd"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zhang","sequence":"additional","affiliation":[{"name":"Jiangsu Avatarget Biotechnology Co., Ltd"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Ouyang","sequence":"additional","affiliation":[{"name":"Jiangsu Avatarget Biotechnology Co., Ltd"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianfeng","family":"Zhu","sequence":"additional","affiliation":[{"name":"Jiangsu Avatarget Biotechnology Co., Ltd"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8922-370X","authenticated-orcid":true,"given":"Zaozao","family":"Chen","sequence":"additional","affiliation":[{"name":"Southeast University"},{"name":"Southeast University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Southeast University"},{"name":"Southeast University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8926-7710","authenticated-orcid":true,"given":"Zhongze","family":"Gu","sequence":"additional","affiliation":[{"name":"Southeast University"},{"name":"Southeast University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2026,6,4]]},"reference":[{"key":"bmmae722dbib1","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1038\/nrd.2017.226","type":"journal-article","article-title":"Drug development in the era of precision medicine","volume":"17","author":"Dugger","year":"2018","journal-title":"Nat. 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