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It was found that the extreme surface consisted of the polymer and external contaminants or organic products that had migrated from the core to the surface. Analysis of TPU showed that acetone was a suitable swelling agent. No significant change in the material was observed after hexane maceration. For silicone, the situation was reversed. We concluded that the solvents used were well suited for an extractables study of these two materials, and gained understanding of the phenomena that could lead to leaching during their medical use.<\/jats:p>","DOI":"10.1088\/1748-605x\/ae7523","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T22:53:47Z","timestamp":1780095227000},"page":"035034","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Contribution of biomaterials analysis to the study of extractables from neonatal central venous catheters"],"prefix":"10.1088","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5254-5163","authenticated-orcid":true,"given":"Yoann","family":"Le Basle","sequence":"first","affiliation":[{"name":"Universit\u00e9 Clermont Auvergne, CHU Clermont Ferrand, Clermont Auvergne INP, CNRS, ICCF"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3944-3752","authenticated-orcid":false,"given":"Val\u00e9rie","family":"Sautou","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Clermont Auvergne, CHU Clermont Ferrand, Clermont Auvergne INP, CNRS, ICCF"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1761-9817","authenticated-orcid":false,"given":"Sabine","family":"Sarraute","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Clermont Auvergne, ICCF"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2999-7644","authenticated-orcid":false,"given":"Christelle","family":"Blavignac","sequence":"additional","affiliation":[{"name":"Centre Imagerie Cellulaire Sant\u00e9, UCA PARTNER, UFR de M\u00e9decine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8086-7517","authenticated-orcid":true,"given":"Philip","family":"Chennell","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Clermont Auvergne, CHU Clermont Ferrand, Clermont Auvergne INP, CNRS, ICCF"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7573-9702","authenticated-orcid":false,"given":"B\u00e9n\u00e9dicte","family":"Mailhot-Jensen","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Clermont Auvergne, ICCF"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2026,6,23]]},"reference":[{"key":"bmmae7523bib1","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/s13020-018-0177-x","type":"journal-article","article-title":"Techniques for extraction and isolation of natural products: a comprehensive review","volume":"13","author":"Zhang","year":"2018","journal-title":"Chin. 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