{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T07:14:46Z","timestamp":1783322086416,"version":"3.54.6"},"reference-count":34,"publisher":"IOP Publishing","issue":"4","license":[{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["32300978"],"award-info":[{"award-number":["32300978"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the Shaanxi University joint project","award":["2020GXLH-Y-015"],"award-info":[{"award-number":["2020GXLH-Y-015"]}]},{"name":"the Scientific Research Development Fund of the First Affiliated Hospital of Xi\u2019an Jiaotong University in China","award":["2022MS-22"],"award-info":[{"award-number":["2022MS-22"]}]}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Biomed. Mater."],"published-print":{"date-parts":[[2026,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Extracorporeal membrane oxygenation (ECMO) represents the most advanced modalit\n                    <jats:underline>y<\/jats:underline>\n                    of extracorporeal life support. The centrifugal pump head, a key component in direct contact with blood, demands excellent blood compatibility to ensure optimal performance. To address this requirement, a self-lubricating anticoagulant surface (SLACS) was fabricated on a roughened stainless steel substrate through physical adhesion and chemical bonding using a dimethylsiloxane gel (S-PDMS). In the blood slidin\n                    <jats:underline>g<\/jats:underline>\n                    experiment, blood remained on 316 l stainless steel for 6 s but slid off the SLACS in just 0.64 s, demonstrating exceptional resistance to blood adhesion and superior blood compatibility. Applying SLACS to the ECMO centrifugal pump head significantly enhanced its anticoagulant and antibacterial properties, while also exhibiting excellent safety, stability and durability. The feasibility of SLACS as a novel coating was validated through static tests, computational simulations and dynamic experiments, offering a promising solution for improving the safety of ECMO therapy.\n                  <\/jats:p>","DOI":"10.1088\/1748-605x\/ae7e2f","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T22:52:52Z","timestamp":1781650372000},"page":"045002","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Self-lubricating anticoagulant surface (SLACS) mimicking heart valve tissue for improving biocompatibility of artificial blood pumps"],"prefix":"10.1088","volume":"21","author":[{"given":"Shiyu","family":"Cui","sequence":"first","affiliation":[{"name":"The First Affiliated Hospital of Xi\u2019an Jiaotong University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0335-3673","authenticated-orcid":true,"given":"Yaoyao","family":"Chen","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Xi\u2019an Jiaotong University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zhong","sequence":"additional","affiliation":[{"name":"Xi\u2019an Jiaotong University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Xi\u2019an Jiaotong University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Xi\u2019an Jiaotong University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhua","family":"Ren","sequence":"additional","affiliation":[{"name":"Xi \u2018an Gaoling District Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodan","family":"Gou","sequence":"additional","affiliation":[{"name":"Xi\u2019an Jiaotong University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Cheng","sequence":"additional","affiliation":[{"name":"Xi\u2019an Jiaotong University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Yang","sequence":"additional","affiliation":[{"name":"Xi\u2019an Jiaotong University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7031-7404","authenticated-orcid":true,"given":"Feng","family":"Chen","sequence":"additional","affiliation":[{"name":"Xi\u2019an Jiaotong University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0110-8497","authenticated-orcid":true,"given":"Ying","family":"He","sequence":"additional","affiliation":[{"name":"Xi\u2019an Jiaotong University Health Science Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7520-6665","authenticated-orcid":true,"given":"Lihong","family":"Fan","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Xi\u2019an Jiaotong University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2026,7,6]]},"reference":[{"key":"bmmae7e2fbib1","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1161\/CIRCULATIONAHA.122.062371","type":"journal-article","article-title":"Unloading the left ventricle in venoarterial ECMO: in whom, when, and How?","volume":"147","author":"Ezad","year":"2023","journal-title":"Circulation"},{"key":"bmmae7e2fbib2","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.tmrv.2014.12.001","type":"journal-article","article-title":"Extracorporeal membrane oxygenation-hemostatic complications","volume":"29","author":"Murphy","year":"2015","journal-title":"Transfus. Med. Rev."},{"key":"bmmae7e2fbib3","doi-asserted-by":"publisher","first-page":"99","DOI":"10.3389\/fbioe.2018.00099","type":"journal-article","article-title":"Blood-contacting biomaterials: in vitro evaluation of the hemocompatibility","volume":"6","author":"Weber","year":"2018","journal-title":"Front. Bioeng. Biotechnol."},{"key":"bmmae7e2fbib4","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1097\/01.MAT.0000085672.42122.49","type":"journal-article","article-title":"What price support? Ventricular assist device induced systemic response","volume":"49","author":"Thompson","year":"2003","journal-title":"ASAIO J."},{"key":"bmmae7e2fbib5","doi-asserted-by":"publisher","first-page":"1162","DOI":"10.1016\/j.athoracsur.2009.06.028","type":"journal-article","article-title":"Incidence and patterns of adverse event onset during the first 60 days after ventricular assist device implantation","volume":"88","author":"Genovese","year":"2009","journal-title":"Ann. Thorac. Surg."},{"key":"bmmae7e2fbib6","doi-asserted-by":"publisher","first-page":"1809","DOI":"10.1097\/CCM.0000000000005673","type":"journal-article","article-title":"Complications associated with venovenous extracorporeal membrane oxygenation\u2014what can go wrong?","volume":"50","author":"Teijeiro-Paradis","year":"2022","journal-title":"Crit. Care Med."},{"key":"bmmae7e2fbib7","doi-asserted-by":"publisher","first-page":"226","DOI":"10.3390\/jfb16060226","type":"journal-article","article-title":"What are the best biocompatible materials for extracorporeal membrane oxygenation","volume":"16","author":"Hagiwara","year":"2025","journal-title":"J. Funct. Biomater."},{"key":"bmmae7e2fbib8","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1097\/MAT.0000000000002116","type":"journal-article","article-title":"Multi-method investigation of blood damage induced by blood pumps in different clinical support modes","volume":"70","author":"Li","year":"2024","journal-title":"ASAIO J."},{"key":"bmmae7e2fbib9","doi-asserted-by":"publisher","first-page":"4974","DOI":"10.1039\/D2TB00379A","type":"journal-article","article-title":"Investigation of heparin-loaded poly(ethylene glycol)-based hydrogels as anti-thrombogenic surface coatings for extracorporeal membrane oxygenation","volume":"10","author":"Zhang","year":"2022","journal-title":"J. Mater. Chem. B"},{"key":"bmmae7e2fbib10","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.actbio.2024.07.058","type":"journal-article","article-title":"An endothelium membrane mimetic antithrombotic coating enables safer and longer extracorporeal membrane oxygenation application","volume":"186","author":"Li","year":"2024","journal-title":"Acta Biomater."},{"key":"bmmae7e2fbib11","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-22520-2","type":"journal-article","article-title":"Hydrogel nanocomposite-based breathable non-adhesive coating for oxygen sensing film used within extracorporeal perfusion system","volume":"15","author":"Parshad","year":"2025","journal-title":"Sci. Rep."},{"key":"bmmae7e2fbib12","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.37953","type":"journal-article","article-title":"Biological responses and hemocompatibility of diamond-like carbon thin films on different PEO interlayers for potential cardiovascular stent applications","volume":"113","author":"Shahin","year":"2025","journal-title":"J. Biomed. Mater. Res. A"},{"key":"bmmae7e2fbib13","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2021.129702","type":"journal-article","article-title":"A starch-based zwitterionic hydrogel coating for blood-contacting devices with durability and bio-functionality","volume":"421","author":"Yao","year":"2021","journal-title":"Chem. Eng. J."},{"key":"bmmae7e2fbib14","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2023.145358","type":"journal-article","article-title":"Heart valve-inspired self-lubricating anticoagulant surfaces","volume":"474","author":"Cheng","year":"2023","journal-title":"Chem. Eng. J."},{"key":"bmmae7e2fbib15","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.matlet.2019.03.110","type":"journal-article","article-title":"Self-assembled phase-transited lysozyme\/heparin coating on titanium surfaces for improved hemocompatibility","volume":"247","author":"Xu","year":"2019","journal-title":"Mater. Lett."},{"key":"bmmae7e2fbib16","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1213\/00000539-199909000-00006","type":"journal-article","article-title":"The effects of heparin coating of oxygenator fibers on platelet adhesion and protein adsorption","volume":"89","author":"Niimi","year":"1999","journal-title":"Anesth. Analg."},{"key":"bmmae7e2fbib17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.143048","type":"journal-article","article-title":"Enhancing vascular implants with heparin-polylysine-copper nanozyme coating for synergistic anticoagulation and antirestenotic activity","volume":"309","author":"Zeng","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"bmmae7e2fbib18","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1016\/j.bioactmat.2025.09.009","type":"journal-article","article-title":"Hydrodynamic-derived centrifugal blood pump design for stable-low-flow-rate rate performance: from surface to structure","volume":"54","author":"Jiang","year":"2025","journal-title":"Bioact. Mater."},{"key":"bmmae7e2fbib19","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.actbio.2025.10.006","type":"journal-article","article-title":"Silk-based multilayer coatings for anticoagulation and durability improvement in ECMO hollow fiber membranes","volume":"207","author":"Zhang","year":"2025","journal-title":"Acta Biomater."},{"key":"bmmae7e2fbib20","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1186\/s12959-024-00624-5","type":"journal-article","article-title":"Heparin-induced thrombocytopenia in extracorporeal membrane oxygenation-supported patients: a systematic review and meta-analysis","volume":"22","author":"Song","year":"2024","journal-title":"Thromb. J."},{"key":"bmmae7e2fbib21","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1016\/j.ccrj.2024.10.003","type":"journal-article","article-title":"Anticoagulation and associated complications in veno-arterial extracorporeal membrane oxygenation in adult patients: a systematic review and meta-analysis","volume":"26","author":"Vlok","year":"2024","journal-title":"Crit. Care Resuscitation"},{"key":"bmmae7e2fbib22","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2026.1767978","type":"journal-article","article-title":"Efficacy of reduced-intensity or no heparin versus standard heparin anticoagulation in patients on extracorporeal membrane oxygenation: a systematic review and meta-analysis","volume":"13","author":"Zhang","year":"2026","journal-title":"Front. Med."},{"key":"bmmae7e2fbib23","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2025.123486","type":"journal-article","article-title":"Metal-phenolic networks assisted construction of multi-layered endothelium-mimetic polyelectrolyte coating with nitric oxide generation and glycocalyx functionalization","volume":"324","author":"Chen","year":"2026","journal-title":"Biomaterials"},{"key":"bmmae7e2fbib24","doi-asserted-by":"publisher","first-page":"2342","DOI":"10.3390\/ma14092342","type":"journal-article","article-title":"Anti-thrombogenicity study of a covalently-attached monolayer on stent-grade stainless Steel","volume":"14","author":"Yang","year":"2021","journal-title":"Materials"},{"key":"bmmae7e2fbib25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.mser.2014.10.001","type":"journal-article","article-title":"Metallic implant biomaterials","volume":"87","author":"Chen","year":"2015","journal-title":"Mater. Sci. Eng. R"},{"key":"bmmae7e2fbib26","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1177\/0267659120931307","type":"journal-article","article-title":"Haemolysis induced by mechanical circulatory support devices: unsolved problems","volume":"35","author":"Khne","year":"2020","journal-title":"Perfusion"},{"key":"bmmae7e2fbib27","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1111\/j.1525-1594.1995.tb02397.x","type":"journal-article","article-title":"Development of an axial flow ventricular assist device: in vitro and in vivo evaluation","volume":"19","author":"Mizuguchi","year":"1995","journal-title":"Artif. Organs"},{"key":"bmmae7e2fbib28","doi-asserted-by":"publisher","first-page":"M858","DOI":"10.1097\/00002480-199609000-00113","type":"journal-article","article-title":"Effect of surface roughness on hemolysis in a centrifugal blood pump","volume":"42","author":"Takami","year":"1996","journal-title":"ASAIO J."},{"key":"bmmae7e2fbib29","article-title":"Standard practice for assessment of hemolytic properties of materials (F04.16)","author":"ASTM F756-17","year":"2017","type":"other"},{"key":"bmmae7e2fbib30","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1086\/668439","type":"journal-article","article-title":"Infections acquired by adults who receive extracorporeal membrane oxygenation: risk factors and outcome","volume":"34","author":"Aubron","year":"2013","journal-title":"Infection Control Hosp. Epidemiol."},{"key":"bmmae7e2fbib31","doi-asserted-by":"publisher","first-page":"1633","DOI":"10.1093\/cid\/cis783","type":"journal-article","article-title":"Nosocomial infections in adult cardiogenic shock patients supported by venoarterial extracorporeal membrane oxygenation","volume":"55","author":"Schmidt","year":"2012","journal-title":"Clin. Infect. Dis."},{"key":"bmmae7e2fbib32","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1016\/j.jtcvs.2010.07.017","type":"journal-article","article-title":"Infections occurring during extracorporeal membrane oxygenation use in adult patients","volume":"140","author":"Sun","year":"2010","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"bmmae7e2fbib33","doi-asserted-by":"publisher","first-page":"259","DOI":"10.3390\/mi16030259","type":"journal-article","article-title":"Mechanical stimulation of red blood cells aging: focusing on the microfluidics application","volume":"16","author":"Gural","year":"2025","journal-title":"Micromachines"},{"key":"bmmae7e2fbib34","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1177\/039139889001300507","type":"journal-article","article-title":"Estimation of shear stress-related blood damage in heart valve prostheses\u2013in vitro comparison of 25 aortic valves","volume":"13","author":"Giersiepen","year":"1990","journal-title":"Int. J. Artif. Organs"}],"container-title":["Biomedical Materials"],"original-title":[],"link":[{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ae7e2f","content-type":"text\/html","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ae7e2f\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ae7e2f","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ae7e2f\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ae7e2f\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ae7e2f\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ae7e2f\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"similarity-checking"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ae7e2f\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T06:32:04Z","timestamp":1783319524000},"score":1,"resource":{"primary":{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ae7e2f"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,6]]},"references-count":34,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,7,6]]},"published-print":{"date-parts":[[2026,8,1]]}},"URL":"https:\/\/doi.org\/10.1088\/1748-605x\/ae7e2f","relation":{},"ISSN":["1748-6041","1748-605X"],"issn-type":[{"value":"1748-6041","type":"print"},{"value":"1748-605X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,6]]},"assertion":[{"value":"Self-lubricating anticoagulant surface (SLACS) mimicking heart valve tissue for improving biocompatibility of artificial blood pumps","name":"article_title","label":"Article Title"},{"value":"Biomedical Materials","name":"journal_title","label":"Journal Title"},{"value":"paper","name":"article_type","label":"Article Type"},{"value":"\u00a9 2026 The Author(s). Published by IOP Publishing Ltd","name":"copyright_information","label":"Copyright Information"},{"value":"2025-04-13","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2026-06-16","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2026-07-06","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}