{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T06:45:41Z","timestamp":1785739541506,"version":"3.56.0"},"reference-count":160,"publisher":"IOP Publishing","issue":"4","license":[{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"vor","delay-in-days":2,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/iop-standard\/v1"},{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"tdm","delay-in-days":2,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"funder":[{"name":"Long-gang District Medical and Health Technology Research Project","award":["LGKCYLWS2022021"],"award-info":[{"award-number":["LGKCYLWS2022021"]}]},{"name":"Research Project of the Fundamental Research Funds for Provincial Universities of Heilongjiang Province","award":["2018-KYYWF-0135"],"award-info":[{"award-number":["2018-KYYWF-0135"]}]},{"name":"Shenzhen Science and Technology Program","award":["JCYJ20230807114504009"],"award-info":[{"award-number":["JCYJ20230807114504009"]}]},{"name":"Institutional Research Talent Development Fund of Longgang Central Hospital","award":["YN2024B002"],"award-info":[{"award-number":["YN2024B002"]}]}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Biomed. Mater."],"published-print":{"date-parts":[[2026,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cancer remains a major global health burden, with conventional monotherapies often limited by recurrence, therapeutic resistance, and systemic toxicity. Natural products, derived from diverse sources and characterized by distinct chemical structures, exhibit broad anticancer potential by modulating multiple molecular pathways. However, their clinical application is frequently constrained by poor solubility, low bioavailability, and chemical instability. Nano-delivery systems (NDS) have emerged as a promising strategy to address these limitations by improving pharmacokinetic properties, stabilizing labile compounds, and enabling co-delivery with conventional therapeutics, thereby supporting multimodal and synergistic interventions. This review provides a comprehensive overview of natural product-based NDS in cancer therapy, beginning with classification strategies and mechanistic frameworks, followed by an analysis of how NDS enhance pharmacological performance and facilitate integration into combination regimens. Finally, it highlights key translational challenges and opportunities, offering a foundation for the future development and clinical translation of natural product-based NDS.<\/jats:p>","DOI":"10.1088\/1748-605x\/ae7ee2","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T22:54:38Z","timestamp":1781736878000},"page":"042005","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Advances in nano-delivery of natural products for cancer therapy: mechanisms and translational strategies"],"prefix":"10.1088","volume":"21","author":[{"given":"Xiang","family":"Chen","sequence":"first","affiliation":[{"name":"Mudanjiang Medical University"},{"name":"Guangzhou University of Chinese Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huibin","family":"Wu","sequence":"additional","affiliation":[{"name":"Mudanjiang Medical University"},{"name":"Guangzhou University of Chinese Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Pan","sequence":"additional","affiliation":[{"name":"Mudanjiang Medical University"},{"name":"Guangzhou University of Chinese Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiqun","family":"Li","sequence":"additional","affiliation":[{"name":"Longgang Central Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibing","family":"Dai","sequence":"additional","affiliation":[{"name":"Longgang Central Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Wang","sequence":"additional","affiliation":[{"name":"Mudanjiang Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Mao","sequence":"additional","affiliation":[{"name":"Longgang Central Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6617-6006","authenticated-orcid":true,"given":"Jianbo","family":"Yu","sequence":"additional","affiliation":[{"name":"Mudanjiang Medical University"},{"name":"Longgang Central Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2026,8,3]]},"reference":[{"key":"bmmae7ee2bib1","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1200\/JCO.23.02328","type":"journal-article","article-title":"Expanding research in cancer epidemiology in journal of clinical oncology","volume":"42","author":"Cheng","year":"2024","journal-title":"J. Clin. Oncol."},{"key":"bmmae7ee2bib2","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1016\/j.ccell.2023.02.016","type":"journal-article","article-title":"The evolving tumor microenvironment: from cancer initiation to metastatic outgrowth","volume":"41","author":"De Visser","year":"2023","journal-title":"Cancer Cell"},{"key":"bmmae7ee2bib3","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1038\/s41577-024-01111-8","type":"journal-article","article-title":"Cancer immune evasion, immunoediting and intratumour heterogeneity Nat.","volume":"25","author":"Roerden","year":"2025","journal-title":"Rev. Immunol."},{"key":"bmmae7ee2bib4","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2024.217116","type":"journal-article","article-title":"Natural products reverse cisplatin resistance in the hypoxic tumor microenvironment","volume":"598","author":"Yang","year":"2024","journal-title":"Cancer Lett."},{"key":"bmmae7ee2bib5","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2024.148976","type":"journal-article","article-title":"A natural product-derived nanozyme regulator induced chemo-ferroptosis dual therapy in remodeling of the tumor immune microenvironment of hepatocellular carcinoma","volume":"482","author":"Lai","year":"2024","journal-title":"Chem. Eng. J."},{"key":"bmmae7ee2bib6","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1016\/j.apsb.2021.08.020","type":"journal-article","article-title":"Emerging role of natural products in cancer immunotherapy","volume":"12","author":"Dong","year":"2022","journal-title":"Acta. Pharm. Sin. B"},{"key":"bmmae7ee2bib7","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2024.122513","type":"journal-article","article-title":"Ultrasound-augmented enzyodynamic-Ca2+ overload synergetic tumor nanotherapy","volume":"307","author":"Chang","year":"2024","journal-title":"Biomaterials"},{"key":"bmmae7ee2bib8","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2024.2361169","type":"journal-article","article-title":"Advances in cell membrane-based biomimetic nanodelivery systems for natural products","volume":"31","author":"Zhang","year":"2024","journal-title":"Drug Deliv."},{"key":"bmmae7ee2bib9","doi-asserted-by":"crossref","first-page":"4011","DOI":"10.1016\/j.apsb.2022.08.022","type":"journal-article","article-title":"New opportunities and challenges of natural products research: when target identification meets single-cell multiomics","volume":"12","author":"Zhu","year":"2022","journal-title":"Acta. Pharm. Sin. B"},{"key":"bmmae7ee2bib10","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-025-03378-y","type":"journal-article","article-title":"Integration of active ingredients from traditional chinese medicine with nano-delivery systems for tumor immunotherapy","volume":"23","author":"Zheng","year":"2025","journal-title":"J. Nanobiotechnol."},{"key":"bmmae7ee2bib11","doi-asserted-by":"publisher","first-page":"4311","DOI":"10.1007\/s10311-021-01276-x","type":"journal-article","article-title":"Recent strategies in nanodelivery systems for natural products: a review","volume":"19","author":"Vanti","year":"2021","journal-title":"Environ. Chem. Lett."},{"key":"bmmae7ee2bib12","doi-asserted-by":"publisher","first-page":"24593","DOI":"10.1021\/acsnano.3c10212","type":"journal-article","article-title":"Advanced generation therapeutics: biomimetic nanodelivery system for tumor immunotherapy","volume":"17","author":"Li","year":"2023","journal-title":"ACS Nano"},{"key":"bmmae7ee2bib13","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2025.102307","type":"journal-article","article-title":"A novel folate receptor-targeted curcumin nano-delivery system: a dual therapeutic strategy for precise inhibition of MRCK\u03b2 to suppress ovarian cancer proliferation and immune escape Mater.","volume":"35","author":"Shi","year":"2025","journal-title":"Today Bio"},{"key":"bmmae7ee2bib14","first-page":"10781","type":"journal-article","article-title":"Engineering therapeutic scaffolds: integrating drug delivery with tissue regeneration","volume":"13","author":"Moghaddam","year":"2025","journal-title":"J. Mater. Chem. B"},{"key":"bmmae7ee2bib15","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/s12951-025-03092-9","type":"journal-article","article-title":"Recent advances in self-targeting natural product-based nanomedicines","volume":"23","author":"Liu","year":"2025","journal-title":"J. Nanobiotechnol."},{"key":"bmmae7ee2bib16","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2025.101726","type":"journal-article","article-title":"Recent advances in biomimetic nanodelivery systems for cancer immunotherapy","volume":"32","author":"Yang","year":"2025","journal-title":"Mater. Today Bio"},{"key":"bmmae7ee2bib17","doi-asserted-by":"publisher","first-page":"26296","DOI":"10.1021\/acsnano.5c04463","type":"journal-article","article-title":"Tissue-resident macrophage membrane-coated nanomedicine for targeted tumor therapy","volume":"19","author":"Su","year":"2025","journal-title":"ACS Nano"},{"key":"bmmae7ee2bib18","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2024.107099","type":"journal-article","article-title":"Natural products for combating multidrug resistance in cancer","volume":"202","author":"Chen","year":"2024","journal-title":"Pharmacol. Res."},{"key":"bmmae7ee2bib19","doi-asserted-by":"publisher","first-page":"4934","DOI":"10.1021\/acs.chemrev.2c00763","type":"journal-article","article-title":"Strategies and lessons learned from total synthesis of taxol","volume":"123","author":"Min","year":"2023","journal-title":"Chem. Rev."},{"key":"bmmae7ee2bib20","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.jare.2023.11.016","type":"journal-article","article-title":"HIF-1\u03b1 inhibition by MO-2097, a novel chiral-free benzofuran targeting hnRNPA2B1","volume":"64","author":"Han","year":"2024","journal-title":"J. Adv. Res."},{"key":"bmmae7ee2bib21","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2024.108752","type":"journal-article","article-title":"New drug discovery and development from natural products: advances and strategies","volume":"264","author":"Wang","year":"2024","journal-title":"Pharmacol. Ther."},{"key":"bmmae7ee2bib22","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1039\/D3NP00017F","type":"journal-article","article-title":"From plant to cancer drug: lessons learned from the discovery of taxol","volume":"40","author":"Cech","year":"2023","journal-title":"Nat. Prod. Rep."},{"key":"bmmae7ee2bib23","doi-asserted-by":"publisher","first-page":"1904","DOI":"10.1038\/s41467-025-57280-0","type":"journal-article","article-title":"A concise enzyme cascade enables the manufacture of natural and halogenated protoberberine alkaloids","volume":"16","author":"Fei","year":"2025","journal-title":"Nat. Commun."},{"key":"bmmae7ee2bib24","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2025.101238","type":"journal-article","article-title":"Role of the sulfur-containing amino acid-ROS axis in cancer chemotherapeutic drug resistance","volume":"81","author":"Wu","year":"2025","journal-title":"Drug Resist. Updat"},{"key":"bmmae7ee2bib25","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202413122","type":"journal-article","article-title":"Berberine derivative B68 promotes tumor immune clearance by dual-targeting BMI1 for senescence induction and CSN5 for PD-L1 degradation","volume":"12","author":"Hu","year":"2024","journal-title":"Adv. Sci."},{"key":"bmmae7ee2bib26","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2023.100903","type":"journal-article","article-title":"Morphologically transformable peptide nanocarriers coloaded with doxorubicin and curcumin inhibit the growth and metastasis of hepatocellular carcinoma","volume":"24","author":"Liu","year":"2024","journal-title":"Mater. Today Bio"},{"key":"bmmae7ee2bib27","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2022.114445","type":"journal-article","article-title":"Opportunities and challenges for co-delivery nanomedicines based on combination of phytochemicals with chemotherapeutic drugs in cancer treatment","volume":"188","author":"Gao","year":"2022","journal-title":"Adv. Drug Deliv. Rev."},{"key":"bmmae7ee2bib28","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2020.107686","type":"journal-article","article-title":"The strategies and techniques of drug discovery from natural products","volume":"216","author":"Zhang","year":"2020","journal-title":"Pharmacol. Ther."},{"key":"bmmae7ee2bib29","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1186\/s12951-022-01703-3","type":"journal-article","article-title":"Review targeted drug delivery systems for norcantharidin in cancer therapy","volume":"20","author":"Zhai","year":"2022","journal-title":"J. Nanobiotechnol."},{"key":"bmmae7ee2bib30","doi-asserted-by":"publisher","first-page":"3838","DOI":"10.1039\/D1TB00029B","type":"journal-article","article-title":"A hybrid membrane coating nanodrug system against gastric cancer via the VEGFR2\/STAT3 signaling pathway","volume":"9","author":"Long","year":"2021","journal-title":"J. Mater. Chem. B"},{"key":"bmmae7ee2bib31","doi-asserted-by":"publisher","first-page":"4093","DOI":"10.3390\/molecules30204093","type":"journal-article","article-title":"Pro-apoptotic and cytotoxic effects of melittin on HL-60 acute promyelocytic leukemia cells: implications for retinoid-independent therapy","volume":"30","author":"Stela","year":"2025","journal-title":"Molecules"},{"key":"bmmae7ee2bib32","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1161\/CIRCRESAHA.123.323346","type":"journal-article","article-title":"Exercise inhibits doxorubicin-induced cardiotoxicity via regulating B cells","volume":"134","author":"Wang","year":"2024","journal-title":"Circ. Res."},{"key":"bmmae7ee2bib33","doi-asserted-by":"publisher","first-page":"6532","DOI":"10.1038\/s41467-025-61675-4","type":"journal-article","article-title":"Living therapeutics of nonpathogenic bacteria as biosynthesis factory and active carriers for enhancing tumor-targeted therapy","volume":"16","author":"Dong","year":"2025","journal-title":"Nat. Commun."},{"key":"bmmae7ee2bib34","doi-asserted-by":"publisher","first-page":"6347","DOI":"10.1093\/nar\/gkae308","type":"journal-article","article-title":"Structural and biochemical characterization of the mitomycin C repair exonuclease MrfB","volume":"52","author":"Manthei","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"bmmae7ee2bib35","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1146\/annurev-micro-040824-022431","type":"journal-article","article-title":"Roles of marine microbial natural products","volume":"79","author":"Svendsen","year":"2025","journal-title":"Annu. Rev. Microbiol."},{"key":"bmmae7ee2bib36","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2025.101412","type":"journal-article","article-title":"Pharmacological reprogramming of plitidepsin as a SARS-CoV-2 inhibitor","volume":"106","author":"Jimeno","year":"2025","journal-title":"Mol. Aspects Med."},{"key":"bmmae7ee2bib37","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1039\/d5np00031a","type":"journal-article","article-title":"Natural product-derived compounds in clinical trials and drug approvals","volume":"43","author":"Butler","year":"2026","journal-title":"Nat. Prod. Rep."},{"key":"bmmae7ee2bib38","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2024.118097","type":"journal-article","article-title":"Marine specialized metabolites: unveiling nature\u2019s chemical treasures from the deep blue","volume":"183","author":"Jayawardena","year":"2025","journal-title":"TRAC Trends Anal. Chem."},{"key":"bmmae7ee2bib39","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1038\/s41392-023-01667-2","type":"journal-article","article-title":"Microcolin H, a novel autophagy inducer, exerts potent antitumour activity by targeting PITP\u03b1\/\u03b2","volume":"8","author":"Yang","year":"2023","journal-title":"Signal Transducer Target. Ther."},{"key":"bmmae7ee2bib40","doi-asserted-by":"publisher","first-page":"1556","DOI":"10.1038\/s41467-025-68279-y","type":"journal-article","article-title":"Binary mineral nanoparticles enable intravascular delivery of metal ions to tumors for metalloimmunotherapy","volume":"17","author":"Nguyen","year":"2026","journal-title":"Nat. Commun."},{"key":"bmmae7ee2bib41","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/s13020-022-00577-9","type":"journal-article","article-title":"Mineral medicine: from traditional drugs to multifunctional delivery systems","volume":"17","author":"Zhong","year":"2022","journal-title":"Chin. Med."},{"key":"bmmae7ee2bib42","doi-asserted-by":"publisher","DOI":"10.1002\/smtd.202500665","type":"journal-article","article-title":"Dynamic shielding of arsenic-loaded transferrin with calcium manganese carbonate potentiates antitumor effects via self-enhanced synergistic therapy","volume":"9","author":"Gao","year":"2025","journal-title":"Small Methods"},{"key":"bmmae7ee2bib43","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2025.159943","type":"journal-article","article-title":"Nanodelivery of arsenic trioxide induces macrophage-governed cGAS-STING signaling to remodel immune microenvironment in hepatocellular carcinoma","volume":"506","author":"Li","year":"2025","journal-title":"Chem. Eng. J."},{"key":"bmmae7ee2bib44","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202502404","type":"journal-article","article-title":"The chemistry and biology of the tetrodotoxin natural product family","volume":"64","author":"Ni\u00dfl","year":"2025","journal-title":"Angew. Chem., Int. Ed."},{"key":"bmmae7ee2bib45","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.133871","type":"journal-article","article-title":"Development of a RNA-protein complex based smart drug delivery system for 9-hydroxycamptothecin","volume":"276","author":"Zhang","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"bmmae7ee2bib46","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2024.101144","type":"journal-article","article-title":"An intratumor bacteria-targeted DNA nanocarrier for multifaceted tumor microenvironment intervention","volume":"27","author":"Wang","year":"2024","journal-title":"Mater. Today Bio"},{"key":"bmmae7ee2bib47","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202518753","type":"journal-article","article-title":"Design, synthesis, and structural evolution of pseudo-natural product IDO1 inhibitors and degraders","volume":"65","author":"Cheng","year":"2026","journal-title":"Angew. Chem., Int. Ed."},{"key":"bmmae7ee2bib48","doi-asserted-by":"publisher","first-page":"43488","DOI":"10.1021\/acsami.0c13164","type":"journal-article","article-title":"Bioactive natural small molecule-tuned coassembly of photosensitive drugs for highly efficient synergistic and enhanced type I photochemotherapy","volume":"12","author":"Cheng","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"bmmae7ee2bib49","doi-asserted-by":"publisher","first-page":"22968","DOI":"10.1021\/acsnano.5c02492","type":"journal-article","article-title":"Biomimetic ginsenoside Rb1 and probucol co-assembled nanoparticles for targeted atherosclerosis therapy via inhibition of oxidative stress, inflammation, and lipid deposition","volume":"19","author":"Zeng","year":"2025","journal-title":"ACS Nano"},{"key":"bmmae7ee2bib50","doi-asserted-by":"publisher","first-page":"27557","DOI":"10.1021\/acsnano.4c08508","type":"journal-article","article-title":"Co-assembled binary polyphenol natural products for the prevention and treatment of radiation-induced skin injury","volume":"18","author":"Hu","year":"2024","journal-title":"ACS Nano"},{"key":"bmmae7ee2bib51","doi-asserted-by":"publisher","first-page":"61647","DOI":"10.1021\/acsami.5c10705","type":"journal-article","article-title":"Dual-enzyme nanoassemblies of carbon dots and gold for tumor microenvironment-responsive immunotherapy in hepatocellular carcinoma","volume":"17","author":"Lai","year":"2025","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"bmmae7ee2bib52","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1041138","type":"journal-article","article-title":"Tumor immunomodulatory effects of polyphenols","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Immunol."},{"key":"bmmae7ee2bib53","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1016\/j.tibtech.2020.01.008","type":"journal-article","article-title":"Microbial coculture for flavonoid synthesis","volume":"38","author":"Xu","year":"2020","journal-title":"Trends Biotechnol."},{"key":"bmmae7ee2bib54","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.124508","type":"journal-article","article-title":"Flavonoids nanostructures promising therapeutic efficiencies in colorectal cancer","volume":"241","author":"Hassani","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"bmmae7ee2bib55","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1007\/s11030-025-11202-w","type":"journal-article","article-title":"In silico and in vitro analysis of diethyl phthalate as a quorum sensing inhibitor and its antitumor evaluation against MDA-MB-231 cell lines","volume":"30","author":"Rashiya","year":"2026","journal-title":"Mol. Divers"},{"key":"bmmae7ee2bib56","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202200038","type":"journal-article","article-title":"Intelligent nanodelivery system-generated 1O2 mediates tumor vessel normalization by activating endothelial TRPV4-eNOS signaling","volume":"18","author":"Zhang","year":"2022","journal-title":"Small"},{"key":"bmmae7ee2bib57","doi-asserted-by":"publisher","first-page":"9031","DOI":"10.1021\/acsnano.3c12796","type":"journal-article","article-title":"Microfluidic synthesis of CuH nanoparticles for antitumor therapy through hydrogen-enhanced apoptosis and cuproptosis","volume":"18","author":"He","year":"2024","journal-title":"ACS Nano"},{"key":"bmmae7ee2bib58","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1186\/s12951-023-01959-3","type":"journal-article","article-title":"Metal-organic framework-encapsulated dihydroartemisinin nanoparticles induces apoptotic cell death in ovarian cancer by blocking ROMO1-mediated ROS production","volume":"21","author":"Yan","year":"2023","journal-title":"J. Nanobiotechnol."},{"key":"bmmae7ee2bib59","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1016\/j.jconrel.2022.05.057","type":"journal-article","article-title":"Nano co-delivery of plumbagin and dihydrotanshinone I reverses immunosuppressive TME of liver cancer","volume":"348","author":"Han","year":"2022","journal-title":"J. Control. Release"},{"key":"bmmae7ee2bib60","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1186\/s13046-025-03531-3","type":"journal-article","article-title":"Bufalin inhibits hepatocellular carcinoma progression by blocking EGFR-mediated RAS-RAF-MEK-ERK pathway activation","volume":"44","author":"Liu","year":"2025","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"bmmae7ee2bib61","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2024.110614","type":"journal-article","article-title":"Application of mitochondrial miRNA-204 nanoprobes in alzheimer\u2019s disease treatment by clearing reactive oxygen species-mediated autophagy","volume":"36","author":"Li","year":"2024","journal-title":"Chin. Chem. Lett."},{"key":"bmmae7ee2bib62","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.119907","type":"journal-article","article-title":"Sequential delivery of nanoformulated \u03b1-mangostin and triptolide overcomes permeation obstacles and improves therapeutic effects in pancreatic cancer","volume":"241","author":"Feng","year":"2020","journal-title":"Biomaterials"},{"key":"bmmae7ee2bib63","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.155468","type":"journal-article","article-title":"The mechanism of curcumin to protect mouse ovaries from oxidative damage by regulating AMPK\/mTOR mediated autophagy","volume":"128","author":"Duan","year":"2024","journal-title":"Phytomedicine"},{"key":"bmmae7ee2bib64","doi-asserted-by":"publisher","first-page":"4008","DOI":"10.1039\/D2BM00595F","type":"journal-article","article-title":"Cascade nanozymes based on the \u2018butterfly effect\u2019 for enhanced starvation therapy through the regulation of autophagy","volume":"10","author":"Yao","year":"2022","journal-title":"Biomater. Sci."},{"key":"bmmae7ee2bib65","first-page":"337","type":"journal-article","article-title":"Gasdermins and pyroptosis in the kidney Nat.","volume":"19","author":"Elias","year":"2023","journal-title":"Rev. Nephrol."},{"key":"bmmae7ee2bib66","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.116644","type":"journal-article","article-title":"Zhuidu formula suppresses the migratory and invasive properties of triple-negative breast cancer cells via dual signaling pathways of RhoA\/ROCK and CDC42\/MRCK","volume":"315","author":"Wu","year":"2023","journal-title":"J. Ethnopharmacol"},{"key":"bmmae7ee2bib67","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/s13046-025-03301-1","type":"journal-article","article-title":"Integrative analysis of immunogenic PANoptosis and experimental validation of cinobufagin-induced activation to enhance glioma immunotherapy","volume":"44","author":"Cai","year":"2025","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"bmmae7ee2bib68","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2020.614419","type":"journal-article","article-title":"Anti-glioblastoma activity of kaempferol via programmed cell death induction: involvement of autophagy and pyroptosis","volume":"8","author":"Chen","year":"2020","journal-title":"Front Bioeng. Biotechnol."},{"key":"bmmae7ee2bib69","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202407153","type":"journal-article","article-title":"Tumor microenvironment\u2010activatable metal\u2010phenolic nanoformulations for ultrasound\u2010boosted ferroptosis through triple regulatory pathways","volume":"34","author":"Liu","year":"2024","journal-title":"Adv. Funct. Mater."},{"key":"bmmae7ee2bib70","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2025.138203","type":"journal-article","article-title":"Engineering an advanced multicomponent pentacyclic triterpenoid nanoplatform for synergistic co-delivery of cyclin-dependent kinase 4\/6 inhibitors to enhance cancer chemoimmunotherapy","volume":"699","author":"Zhou","year":"2025","journal-title":"J. Colloid Interface Sci."},{"key":"bmmae7ee2bib71","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2025.101914","type":"journal-article","article-title":"IL-15 functionalized biomimetic hybrid mRNA vaccine for enhanced NSCLC immunotherapy via synergistic activation of T cells and NK cells","volume":"32","author":"Guo","year":"2025","journal-title":"Mater. Today Bio"},{"key":"bmmae7ee2bib72","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2019.123228","type":"journal-article","article-title":"Enhanced cancer therapy of celastrol in vitro and in vivo by smart dendrimers delivery with specificity and biosafety","volume":"383","author":"Ge","year":"2020","journal-title":"Chem. Eng. J."},{"key":"bmmae7ee2bib73","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2023.144692","type":"journal-article","article-title":"Ginsenoside Rg3-engineered exosomes as effective delivery platform for potentiated chemotherapy and photoimmunotherapy of glioblastoma","volume":"471","author":"Li","year":"2023","journal-title":"Chem. Eng. J."},{"key":"bmmae7ee2bib74","doi-asserted-by":"publisher","first-page":"1292","DOI":"10.1016\/j.ijbiomac.2021.05.073","type":"journal-article","article-title":"Astragalus membranaceus polysaccharides potentiate the growth-inhibitory activity of immune checkpoint inhibitors against pulmonary metastatic melanoma in mice","volume":"182","author":"Hwang","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"bmmae7ee2bib75","doi-asserted-by":"publisher","first-page":"7183","DOI":"10.1021\/acsabm.4c00682","type":"journal-article","article-title":"Nucleus-targeted sonosensitizer activates the cGAS-STING pathway for tumor sonodynamic immunotherapy","volume":"7","author":"Chen","year":"2024","journal-title":"ACS Appl. Bio Mater."},{"key":"bmmae7ee2bib76","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.774440","type":"journal-article","article-title":"Platycodon grandiflorum triggers antitumor immunity by restricting PD-1 expression of CD8 T cells in local tumor microenvironment","volume":"13","author":"Yang","year":"2022","journal-title":"Front. Pharmacol."},{"key":"bmmae7ee2bib77","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2024.151437","type":"journal-article","article-title":"Nano-assemblies overcome cancer multidrug resistance for effectively synergistic chemo-immuno-oncotherapy","volume":"490","author":"Liu","year":"2024","journal-title":"Chem. Eng. J."},{"key":"bmmae7ee2bib78","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.jare.2022.09.007","type":"journal-article","article-title":"Paclitaxel-loaded ginsenoside Rg3 liposomes for drug-resistant cancer therapy by dual targeting of the tumor microenvironment and cancer cells","volume":"49","author":"Zhu","year":"2023","journal-title":"J. Adv. Res."},{"key":"bmmae7ee2bib79","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2020.105325","type":"journal-article","article-title":"Astragaloside IV enhances cisplatin chemosensitivity in hepatocellular carcinoma by suppressing MRP2","volume":"148","author":"Qu","year":"2020","journal-title":"Eur. J. Pharm. Sci."},{"key":"bmmae7ee2bib80","doi-asserted-by":"publisher","first-page":"1464","DOI":"10.1021\/acsnano.2c10219","type":"journal-article","article-title":"Immune exosomes loading self-assembled nanomicelles traverse the blood-brain barrier for chemo-immunotherapy against glioblastoma","volume":"17","author":"Cui","year":"2023","journal-title":"ACS Nano"},{"key":"bmmae7ee2bib81","doi-asserted-by":"publisher","first-page":"6409","DOI":"10.7150\/thno.99033","type":"journal-article","article-title":"Genetically engineered cellular nanoparticles loaded with curcuminoids for cancer immunotherapy","volume":"14","author":"Liao","year":"2024","journal-title":"Theranostics"},{"key":"bmmae7ee2bib82","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1186\/s12951-022-01628-9","type":"journal-article","article-title":"Exosome-liposome hybrid nanoparticle codelivery of TP and miR497 conspicuously overcomes chemoresistant ovarian cancer","volume":"20","author":"Li","year":"2022","journal-title":"J. Nanobiotechnol."},{"key":"bmmae7ee2bib83","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2024.216622","type":"journal-article","article-title":"Triptolide induces apoptosis and cytoprotective autophagy by ROS accumulation via directly targeting peroxiredoxin 2 in gastric cancer cells","volume":"587","author":"Chen","year":"2024","journal-title":"Cancer Lett."},{"key":"bmmae7ee2bib84","doi-asserted-by":"publisher","first-page":"5961","DOI":"10.1182\/blood-2023-184408","type":"journal-article","article-title":"Dihydroartemisinin synergistically promotes the antileukemic activity of venetoclax by downregulating mcl-1 in acute myeloid leukemia cells","volume":"142","author":"Zhuang","year":"2023","journal-title":"Blood"},{"key":"bmmae7ee2bib85","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2024.157231","type":"journal-article","article-title":"Sensitizing sorafenib to hepatocellular carcinoma with dual-targeted and pH-responsive nanodrugs via overcoming the hypoxia tumor microenvironment","volume":"500","author":"Li","year":"2024","journal-title":"Chem. Eng. J."},{"key":"bmmae7ee2bib86","doi-asserted-by":"publisher","first-page":"2077","DOI":"10.1016\/j.apsb.2024.02.003","type":"journal-article","article-title":"Targeting PKM2 signaling cascade with salvianic acid a normalizes tumor blood vessels to facilitate chemotherapeutic drug delivery","volume":"14","author":"Qian","year":"2024","journal-title":"Acta. Pharm. Sin. B"},{"key":"bmmae7ee2bib87","doi-asserted-by":"publisher","first-page":"1579","DOI":"10.1002\/ptr.6350","type":"journal-article","article-title":"Gambogic acid impairs tumor angiogenesis by targeting YAP\/STAT3 signaling axis","volume":"33","author":"Wan","year":"2019","journal-title":"Phytother. Res."},{"key":"bmmae7ee2bib88","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2024.158682","type":"journal-article","article-title":"Immunomodulatory pd-FePorP nanozyme for inhibition of tumor invasion and metastasis by reinforced ferroptosis and specific epithelial-mesenchymal reversal","volume":"504","author":"Zhai","year":"2025","journal-title":"Chem. Eng. J."},{"key":"bmmae7ee2bib89","doi-asserted-by":"publisher","first-page":"4092","DOI":"10.1002\/ptr.7871","type":"journal-article","article-title":"Honokiol inhibits epithelial-mesenchymal transition and hepatic fibrosis via activation of ecadherin\/GSK3\u03b2\/JNK and inhibition of AKT\/ERK\/p38\/\u03b2-catenin\/TMPRSS4 signaling axis","volume":"37","author":"Seo","year":"2023","journal-title":"Phytother. Res."},{"key":"bmmae7ee2bib90","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2023.216596","type":"journal-article","article-title":"Dihydroartemisinin inhibits the development of colorectal cancer by GSK-3\u03b2\/TCF7\/MMP9 pathway and synergies with capecitabine","volume":"582","author":"Dai","year":"2024","journal-title":"Cancer Lett."},{"key":"bmmae7ee2bib91","doi-asserted-by":"publisher","first-page":"774","DOI":"10.3390\/ph16050774","type":"journal-article","article-title":"Rutin gel with bone graft accelerates bone formation in a rabbit model by inhibiting MMPs and enhancing collagen activities","volume":"16","author":"Albaqami","year":"2023","journal-title":"Pharmaceuticals"},{"key":"bmmae7ee2bib92","doi-asserted-by":"publisher","first-page":"8365","DOI":"10.7150\/thno.45395","type":"journal-article","article-title":"Emodin reduces breast cancer lung metastasis by suppressing macrophage-induced breast cancer cell epithelial-mesenchymal transition and cancer stem cell formation","volume":"10","author":"Liu","year":"2020","journal-title":"Theranostics"},{"key":"bmmae7ee2bib93","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2022.154597","type":"journal-article","article-title":"Magnolol regulates miR-200c-3p to inhibit epithelial-mesenchymal transition and retinoblastoma progression by modulating the ZEB1\/E-cadherin axis in vitro and in vivo","volume":"110","author":"Lai","year":"2023","journal-title":"Phytomedicine"},{"key":"bmmae7ee2bib94","doi-asserted-by":"publisher","first-page":"4702","DOI":"10.7150\/thno.126209","type":"journal-article","article-title":"Nanobiomaterial-enabled boron delivery systems and innovative strategies for revolutionizing BNCT","volume":"16","author":"Yang","year":"2026","journal-title":"Theranostics"},{"key":"bmmae7ee2bib95","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202411930","type":"journal-article","article-title":"Paclitaxel\/luteolin coloaded dual\u2010functional liposomes for esophageal cancer therapy","volume":"12","author":"Sun","year":"2025","journal-title":"Adv. Sci."},{"key":"bmmae7ee2bib96","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2025.102509","type":"journal-article","article-title":"Preparation of hierarchically targetable astragalus polysaccharide lipid nanoparticles and study on their therapeutic effect on orthotopic colon cancer","volume":"35","author":"Hou","year":"2025","journal-title":"Mater. Today Bio"},{"key":"bmmae7ee2bib97","doi-asserted-by":"publisher","first-page":"61676","DOI":"10.1021\/acsami.5c13198","type":"journal-article","article-title":"Dual-targeted biomimetic nanoparticles for enhanced delivery of polyphyllin B synergistically induce ferroptosis and immunogenic cell death in gastric cancer","volume":"17","author":"Zu","year":"2025","journal-title":"ACS Appl Mater Interfaces"},{"key":"bmmae7ee2bib98","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202412953","type":"journal-article","article-title":"Icaritin represses autophagy to promote colorectal cancer cell apoptosis and sensitized low-temperature photothermal therapy via targeting HSP90-TXNDC9 interactions","volume":"12","author":"He","year":"2025","journal-title":"Adv. Sci."},{"key":"bmmae7ee2bib99","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1016\/j.actbio.2023.01.049","type":"journal-article","article-title":"Small-size Ti3C2Tx MXene nanosheets coated with metal-polyphenol nanodots for enhanced cancer photothermal therapy and anti-inflammation","volume":"159","author":"Liao","year":"2023","journal-title":"Acta Biomater."},{"key":"bmmae7ee2bib100","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2024.121897","type":"journal-article","article-title":"Hyaluronic acid\/dextran-based polymeric micelles co-delivering ursolic acid and doxorubicin to mitochondria for potentiating chemotherapy in MDR cancer","volume":"332","author":"Guo","year":"2024","journal-title":"Carbohydr. Polym."},{"key":"bmmae7ee2bib101","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2025.102710","type":"journal-article","article-title":"pH-responsive nanocomplex for active transport of aPD-1 and PTX to enhance cancer chemoimmunotherapy","volume":"62","author":"Qin","year":"2025","journal-title":"Nano Today"},{"key":"bmmae7ee2bib102","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202500446","type":"journal-article","article-title":"RBC membrane-camouflaged nanosystem-mediated synergistic drug combination for enhanced anti-tumor therapy","volume":"14","author":"Cheng","year":"2025","journal-title":"Adv. Healthcare Mater."},{"key":"bmmae7ee2bib103","doi-asserted-by":"publisher","first-page":"10455","DOI":"10.2147\/IJN.S479438","type":"journal-article","article-title":"Bio-inspired nanodelivery platform: platelet membrane-cloaked genistein nanosystem for targeted lung cancer therapy","volume":"19","author":"Gao","year":"2024","journal-title":"Int. J. Nanomed."},{"key":"bmmae7ee2bib104","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2020.117180","type":"journal-article","article-title":"Pectin co-functionalized dual layered solid lipid nanoparticle made by soluble curcumin for the targeted potential treatment of colorectal cancer","volume":"252","author":"Mohamed","year":"2021","journal-title":"Carbohydr. Polym."},{"key":"bmmae7ee2bib105","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.jconrel.2022.01.002","type":"journal-article","article-title":"Mitochondria-targeted polymer-celastrol conjugate with enhanced anticancer efficacy","volume":"342","author":"Geng","year":"2022","journal-title":"J. Control. Release"},{"key":"bmmae7ee2bib106","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2024.155709","type":"journal-article","article-title":"Mechanism of self-assembled celastrol-erianin nanomedicine for treatment of breast cancer","volume":"499","author":"Tian","year":"2024","journal-title":"Chem. Eng. J."},{"key":"bmmae7ee2bib107","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.jconrel.2023.11.033","type":"journal-article","article-title":"Targeted delivery of hybrid nanovesicles for enhanced brain penetration to achieve synergistic therapy of glioma","volume":"365","author":"Wang","year":"2024","journal-title":"J. Control. Release"},{"key":"bmmae7ee2bib108","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1186\/s12951-021-00922-4","type":"journal-article","article-title":"Biomimetic nanotherapy: core\u2013shell structured nanocomplexes based on the neutrophil membrane for targeted therapy of lymphoma","volume":"19","author":"Zhao","year":"2021","journal-title":"J Nanobiotechnol"},{"key":"bmmae7ee2bib109","doi-asserted-by":"publisher","first-page":"3643","DOI":"10.1016\/j.apsb.2024.04.010","type":"journal-article","article-title":"Endoplasmic reticulum-targeted delivery of celastrol and PD-L1 siRNA for reinforcing immunogenic cell death and potentiating cancer immunotherapy","volume":"14","author":"Wang","year":"2024","journal-title":"Acta Pharm Sin B"},{"key":"bmmae7ee2bib110","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.114750","type":"journal-article","article-title":"Iron deficiency in hepatocellular carcinoma cells induced sorafenib resistance by upregulating HIF-1\u03b1 to inhibit apoptosis","volume":"163","author":"Gao","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"bmmae7ee2bib111","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.810565","type":"journal-article","article-title":"Native endophytes of tripterygium wilfordii-mediated biotransformation reduces toxicity of celastrol","volume":"13","author":"Ma","year":"2022","journal-title":"Front. Microbiol."},{"key":"bmmae7ee2bib112","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1038\/s41392-020-0149-3","type":"journal-article","article-title":"Erianin, a novel dibenzyl compound in dendrobium extract, inhibits lung cancer cell growth and migration via calcium\/calmodulin-dependent ferroptosis","volume":"5","author":"Chen","year":"2020","journal-title":"Signal Transducer Target. Ther."},{"key":"bmmae7ee2bib113","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113993","type":"journal-article","article-title":"Disorders of cancer metabolism: the therapeutic potential of cannabinoids","volume":"157","author":"Sun","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"bmmae7ee2bib114","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2025.102278","type":"journal-article","article-title":"Carrier-free nanoparticles based on natural products trigger dual \u2018synergy and attenuation\u2019 for enhanced phototherapy of liver cancer","volume":"35","author":"Wang","year":"2025","journal-title":"Mater. Today Bio"},{"key":"bmmae7ee2bib115","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110820","type":"journal-article","article-title":"Anti-tumor activities and mechanisms of traditional Chinese medicines formulas: a review","volume":"132","author":"Fan","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"bmmae7ee2bib116","doi-asserted-by":"publisher","first-page":"5837","DOI":"10.2147\/IJN.S466042","type":"journal-article","article-title":"Tumor cell-targeting and tumor microenvironment-responsive nanoplatforms for the multimodal imaging-guided photodynamic\/photothermal\/chemodynamic treatment of cervical cancer","volume":"19","author":"Wang","year":"2024","journal-title":"Int. J. Nanomed."},{"key":"bmmae7ee2bib117","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1038\/nnano.2007.387","type":"journal-article","article-title":"Nanocarriers as an emerging platform for cancer therapy","volume":"2","author":"Peer","year":"2007","journal-title":"Nat. Nanotechnol."},{"key":"bmmae7ee2bib118","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2019.119701","type":"journal-article","article-title":"Structure-based design of charge-conversional drug self-delivery systems for better targeted cancer therapy","volume":"232","author":"Xiao","year":"2020","journal-title":"Biomaterials"},{"key":"bmmae7ee2bib119","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1186\/s12951-022-01628-x","type":"journal-article","article-title":"The anti-tumor and renoprotection study of E-[c(RGDfK)2]\/folic acid co-modified nanostructured lipid carrier loaded with doxorubicin hydrochloride\/salvianolic acid A","volume":"20","author":"Zhang","year":"2022","journal-title":"J. Nanobiotechnol."},{"key":"bmmae7ee2bib120","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2020.124418","type":"journal-article","article-title":"pH and glutathione dual responsive nanoparticles based on ganoderma lucidum polysaccharide for potential programmable release of three drugs","volume":"389","author":"Zheng","year":"2020","journal-title":"Chem. Eng. J."},{"key":"bmmae7ee2bib121","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1038\/s41467-023-35957-8","type":"journal-article","article-title":"Reprogramming systemic and local immune function to empower immunotherapy against glioblastoma","volume":"14","author":"Zhou","year":"2023","journal-title":"Nat. Commun."},{"key":"bmmae7ee2bib122","doi-asserted-by":"publisher","first-page":"5074","DOI":"10.1038\/s41467-025-60448-3","type":"journal-article","article-title":"Neoantigens combined with in situ cancer vaccination induce personalized immunity and reshape the tumor microenvironment","volume":"16","author":"Feng","year":"2025","journal-title":"Nat. Commun."},{"key":"bmmae7ee2bib123","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1016\/j.ajps.2022.08.003","type":"journal-article","article-title":"pH-activatable oxidative stress amplifying dissolving microneedles for combined chemo-photodynamic therapy of melanoma","volume":"17","author":"Huang","year":"2022","journal-title":"Asian J. Pharm. Sci."},{"key":"bmmae7ee2bib124","doi-asserted-by":"publisher","first-page":"29827","DOI":"10.1021\/acsami.3c03068","type":"journal-article","article-title":"ROS responsive nanoparticles encapsulated with natural medicine remodel autophagy homeostasis in breast cancer","volume":"15","author":"Zhang","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"bmmae7ee2bib125","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/s12951-023-01806-5","type":"journal-article","article-title":"Biomimetic retractable DNA nanocarrier with sensitive responsivity for efficient drug delivery and enhanced photothermal therapy","volume":"21","author":"Yang","year":"2023","journal-title":"J. Nanobiotechnol."},{"key":"bmmae7ee2bib126","doi-asserted-by":"publisher","first-page":"4073","DOI":"10.1016\/j.apsb.2024.05.015","type":"journal-article","article-title":"An iron-based metal-organic framework nanoplatform for enhanced ferroptosis and oridonin delivery as a comprehensive antitumor strategy","volume":"14","author":"Cai","year":"2024","journal-title":"Acta. Pharm. Sin. B"},{"key":"bmmae7ee2bib127","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2024.122851","type":"journal-article","article-title":"Gamabufotalin loaded micro-nanocomposites for multimodal therapy of metastatic TNBC by efficiently inducing ICD","volume":"314","author":"Fan","year":"2025","journal-title":"Biomaterials"},{"key":"bmmae7ee2bib128","doi-asserted-by":"publisher","first-page":"58041","DOI":"10.1021\/acsami.3c08071","type":"journal-article","article-title":"Gold-crowned bismuth-based nanocomposites for sonodynamic, photothermal, and chemotherapeutic cancer therapy","volume":"15","author":"Meng","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"bmmae7ee2bib129","doi-asserted-by":"publisher","first-page":"5128","DOI":"10.1039\/D5RA08728G","type":"journal-article","article-title":"Engineering combination nanomedicines to overcome cancer resistance","volume":"16","author":"Singh","year":"2026","journal-title":"RSC Adv."},{"key":"bmmae7ee2bib130","doi-asserted-by":"publisher","first-page":"35933","DOI":"10.1021\/acsnano.5c13350","type":"journal-article","article-title":"Photosynthetic plant-derived nanovesicles precisely amplify photodynamic effect by light-activated oxygen generation for enhanced cancer photoimmunotherapy","volume":"19","author":"Mei","year":"2025","journal-title":"ACS Nano"},{"key":"bmmae7ee2bib131","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2023.108184","type":"journal-article","article-title":"Targeting self-enhanced ROS-responsive artesunatum prodrug nanoassembly potentiates gemcitabine activity by down-regulating CDA expression in cervical cancer","volume":"34","author":"Wang","year":"2023","journal-title":"Chin. Chem. Lett."},{"key":"bmmae7ee2bib132","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2026.102772","type":"journal-article","article-title":"Nanomaterial-enabled rheumatoid arthritis treatment: an advanced investigation into photonic - acoustic - gaseous multimodal therapy","volume":"37","author":"Chen","year":"2026","journal-title":"Mater. Today Bio"},{"key":"bmmae7ee2bib133","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202502617","type":"journal-article","article-title":"Artesunate nanoplatform targets the serine\u2013MAPK axis in cancer-associated fibroblasts to reverse photothermal resistance in triple-negative breast cancer","volume":"37","author":"Zheng","year":"2025","journal-title":"Adv. Mater."},{"key":"bmmae7ee2bib134","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1007\/s40005-025-00731-z","type":"journal-article","article-title":"Disulfide bond-driven nanoassembly of lipophilic epirubicin prodrugs for breast cancer therapy","volume":"55","author":"Yuan","year":"2025","journal-title":"J. Pharm. Investig."},{"key":"bmmae7ee2bib135","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2024.107100","type":"journal-article","article-title":"Novel nano-drug delivery system for natural products and their application","volume":"201","author":"Huang","year":"2024","journal-title":"Pharmacol. Res."},{"key":"bmmae7ee2bib136","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtnano.2021.100115","type":"journal-article","article-title":"Supramolecular PEGylation of camptothecin for cancer therapy","volume":"14","author":"Sun","year":"2021","journal-title":"Mater. Today Nano"},{"key":"bmmae7ee2bib137","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202505173","type":"journal-article","article-title":"Oxaliplatin\/norcantharidin prodrug co-loaded nanoparticles: synergistic DNA-repair blockade plus PD-L1 downregulation for inhibit tumor growth and metastasis","volume":"15","author":"Chen","year":"2026","journal-title":"Adv. Healthcare Mater."},{"key":"bmmae7ee2bib138","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1007\/s10856-026-07012-7","type":"journal-article","article-title":"Smart nanoparticle delivery systems for curcumin: a targeted strategy to enhance anticancer efficacy and bioavailability","volume":"37","author":"Fu","year":"2026","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"bmmae7ee2bib139","doi-asserted-by":"publisher","first-page":"1356","DOI":"10.3390\/ijms27031356","type":"journal-article","article-title":"Recent advancements in bioactive natural products and nanoparticle-mediated drug delivery in cancer therapy","volume":"27","author":"Bhajan","year":"2026","journal-title":"Int. J. Mol. Sci."},{"key":"bmmae7ee2bib140","doi-asserted-by":"publisher","first-page":"1767","DOI":"10.1007\/s10311-020-01038-1","type":"journal-article","article-title":"Conventional and nanomaterial-based techniques to increase the bioavailability of therapeutic natural products: A review","volume":"18","author":"Paroha","year":"2020","journal-title":"Environ. Chem. Lett."},{"key":"bmmae7ee2bib141","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1080\/17425247.2025.2506830","type":"journal-article","article-title":"Nano-drug delivery system of natural products for disease prevention and treatment","volume":"22","author":"Gao","year":"2025","journal-title":"Expert Opin. Drug Deliv."},{"key":"bmmae7ee2bib142","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1021\/acs.molpharmaceut.2c00882","type":"journal-article","article-title":"The integration of nanomedicine with traditional Chinese medicine: Drug delivery of natural products and other opportunities","volume":"20","author":"Zeng","year":"2023","journal-title":"Mol. Pharm."},{"key":"bmmae7ee2bib143","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201704307","type":"journal-article","article-title":"Biodistribution, clearance, and long-term fate of clinically relevant nanomaterials","volume":"30","author":"Bourquin","year":"2018","journal-title":"Adv. Mater."},{"key":"bmmae7ee2bib144","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1208\/s12249-021-02000-2","type":"journal-article","article-title":"Tumor-targeted delivery of bufalin-loaded modified albumin-polymer hybrid for enhanced antitumor therapy and attenuated hemolysis toxicity and cardiotoxicity","volume":"22","author":"Xu","year":"2021","journal-title":"AAPS Pharm. Sci. Tech."},{"key":"bmmae7ee2bib145","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1007\/s13659-025-00432-1","type":"journal-article","article-title":"Nature meets machine: The AI renaissance in natural product drug discovery","volume":"16","author":"Muthuraj","year":"2026","journal-title":"Nat. Prod. Bioprospect."},{"key":"bmmae7ee2bib146","doi-asserted-by":"publisher","DOI":"10.2174\/0115680266359804251111113649","type":"journal-article","article-title":"A novel perspective on using artificial intelligence and nanoinformatics to develop nanomedicines","volume":"26","author":"Tyagi","year":"2026","journal-title":"Curr. Top Med. Chem."},{"key":"bmmae7ee2bib147","doi-asserted-by":"publisher","first-page":"1258","DOI":"10.3390\/pharmaceutics17101258","type":"journal-article","article-title":"Formulation strategies for immunomodulatory natural products in 3D tumor spheroids and organoids: current challenges and emerging solutions","volume":"17","author":"Hong","year":"2025","journal-title":"Pharmaceutics"},{"key":"bmmae7ee2bib148","doi-asserted-by":"publisher","first-page":"27151","DOI":"10.1039\/D5NR02611C","type":"journal-article","article-title":"Nanotechnologies for traditional chinese medicine research: quality control and therapeutic applications","volume":"17","author":"Fan","year":"2025","journal-title":"Nanoscale"},{"key":"bmmae7ee2bib149","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1021\/acsmeasuresciau.6c00007","type":"journal-article","article-title":"Liquid chromatography\u2013charged aerosol detection for characterization of natural toxin reference materials","volume":"6","author":"Wright","year":"2026","journal-title":"ACS Meas. Sci. Au"},{"key":"bmmae7ee2bib150","doi-asserted-by":"publisher","first-page":"4485","DOI":"10.7150\/ijbs.114373","type":"journal-article","article-title":"Cancer patient-derived organoids: Novel models for the study of natural products","volume":"21","author":"Liu","year":"2025","journal-title":"Int. J. Biol. Sci."},{"key":"bmmae7ee2bib151","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/s12943-026-02601-0","type":"journal-article","article-title":"Beyond the mouse: 3R-guided alternative animal models transforming cancer research","volume":"25","author":"Faehling","year":"2026","journal-title":"Mol. Cancer"},{"key":"bmmae7ee2bib152","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202204335","type":"journal-article","article-title":"Targeted cancer immunotherapy: Nanoformulation engineering and clinical translation","volume":"9","author":"Yu","year":"2022","journal-title":"Adv. Sci."},{"key":"bmmae7ee2bib153","doi-asserted-by":"publisher","DOI":"10.2174\/0115748928377734250731191700","type":"journal-article","article-title":"Nano-carriers based approaches loaded with herbal bioactive compounds for the treatment of cancer: recent updates and future prospects","volume":"20","author":"Zafar","year":"2025","journal-title":"Recent Pat. Anti-Cancer Drug Discov."},{"key":"bmmae7ee2bib154","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2025.111743","type":"journal-article","article-title":"Unravelling the epigenetic based mechanism in discovery of anticancer phytomedicine: Evidence based studies","volume":"131","author":"Bashir","year":"2025","journal-title":"Cell. Signal"},{"key":"bmmae7ee2bib155","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2025.107733","type":"journal-article","article-title":"Traditional Chinese medicine and natural products in management of hepatocellular carcinoma: Biological mechanisms and therapeutic potential","volume":"215","author":"Xun","year":"2025","journal-title":"Pharmacol. Res."},{"key":"bmmae7ee2bib156","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2025.157582","type":"journal-article","article-title":"Nanosized natural products for immune dysregulation: A systematic review of mechanisms, therapeutic applications, and translational challenges","volume":"150","author":"Guo","year":"2026","journal-title":"Phytomedicine"},{"key":"bmmae7ee2bib157","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.144032","type":"journal-article","article-title":"RGD peptide\/dextran sulfate-based nanocarriers loaded with triptolide for double-targeted apoptosis of both tumor cells and M2-like TAMs in pancreatic cancer therapy","volume":"311","author":"Ge","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"bmmae7ee2bib158","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2025.12.030","type":"journal-article","article-title":"Revolutionizing drug discovery from natural products: the roles of artificial intelligence and multi-omics in accelerating innovation","author":"Wang","year":"2025","journal-title":"Acta. Pharm. Sin. B"},{"key":"bmmae7ee2bib159","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1186\/s13020-025-01194-y","type":"journal-article","article-title":"Advancing the modernization of traditional chinese medicine through artificial intelligence and multimodal data integration","volume":"21","author":"Guo","year":"2026","journal-title":"Chin. Med."},{"key":"bmmae7ee2bib160","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1186\/s12943-025-02357-z","type":"journal-article","article-title":"Precision nanomedicine: Navigating the tumor microenvironment for enhanced cancer immunotherapy and targeted drug delivery","volume":"24","author":"Sabit","year":"2025","journal-title":"Mol. Cancer"}],"container-title":["Biomedical Materials"],"original-title":[],"link":[{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ae7ee2","content-type":"text\/html","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ae7ee2\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ae7ee2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ae7ee2\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ae7ee2\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ae7ee2\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ae7ee2\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"similarity-checking"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ae7ee2\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T06:03:16Z","timestamp":1785736996000},"score":1,"resource":{"primary":{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ae7ee2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,1]]},"references-count":160,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,8,3]]},"published-print":{"date-parts":[[2026,8,1]]}},"URL":"https:\/\/doi.org\/10.1088\/1748-605x\/ae7ee2","relation":{},"ISSN":["1748-6041","1748-605X"],"issn-type":[{"value":"1748-6041","type":"print"},{"value":"1748-605X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,1]]},"assertion":[{"value":"Advances in nano-delivery of natural products for cancer therapy: mechanisms and translational strategies","name":"article_title","label":"Article Title"},{"value":"Biomedical Materials","name":"journal_title","label":"Journal Title"},{"value":"paper","name":"article_type","label":"Article Type"},{"value":"\u00a9 2026 IOP Publishing Ltd. All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2025-10-24","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2026-06-17","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2026-08-03","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}