{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T07:00:53Z","timestamp":1784876453194,"version":"3.55.0"},"reference-count":236,"publisher":"IOP Publishing","issue":"4","license":[{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/iop-standard\/v1"},{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"funder":[{"name":"ICMR-DHR","award":["R.12014\/27\/2022-HR"],"award-info":[{"award-number":["R.12014\/27\/2022-HR"]}]}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Biomed. Mater."],"published-print":{"date-parts":[[2026,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Leukaemia, a widespread haematological cancer, possesses particular challenges in theranostics despite the availability of traditional and modern approaches. This article addresses a significant gap in the literature: a lack of focus on polymeric and hybrid nanoparticles (P&amp;HNP) in advancing leukaemia therapy. It explores how to overcome limitations of conventional therapeutic approaches. The rationale for this study stems from several considerations, including the fact that while polymeric nanoparticles show promise in leukaemia theranostics, a comprehensive assessment of how biomaterial choices influence therapeutic efficacy remains lacking. This article briefly describes conventional challenges in leukaemia theranostics, followed by the properties of P&amp;HNP that make them potential candidates for leukaemia management. In addition, an understanding of the distinctions between natural (e.g. chitosan) and synthetic polymers (e.g. polyethene glycol), as well as their capacity to integrate targeting ligands, imaging agents, and therapeutic payloads, is essential for the rational design of next-generation treatments. Indeed, hybrid nanosystems that combine polymers with metallic nanoparticles (e.g. Au, Ag, Fe, and Zn) represent an emerging frontier, as noted. Next, the current status and clinical outcomes of P&amp;HNP-based formulations are presented, along with their limitations and solutions to advance them as advanced therapies. Finally, challenges or obstacles that limit the translation perspective of laboratory-designed nanomedicine were addressed. This review identifies promising directions, including innovative nanoparticle designs and combination therapies, that may transform leukaemia treatment paradigms and improve patient survival.<\/jats:p>","DOI":"10.1088\/1748-605x\/ae83f7","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T22:53:08Z","timestamp":1782773588000},"page":"042004","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["A review on assessment of advances in polymers and their hybrid nanosystem for leukaemia theranostics applications"],"prefix":"10.1088","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-8983-9185","authenticated-orcid":false,"given":"Soni","family":"Prajapati","sequence":"first","affiliation":[{"name":"King George\u2019s Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0493-1991","authenticated-orcid":true,"given":"Akash","family":"Kumar","sequence":"additional","affiliation":[{"name":"Academy of Scientific and Innovative Research (AcSIR)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9674-8093","authenticated-orcid":true,"given":"Ranjana","family":"Singh","sequence":"additional","affiliation":[{"name":"King George\u2019s Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2026,7,24]]},"reference":[{"key":"bmmae83f7bib1","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1186\/s40001-023-01539-z","type":"journal-article","article-title":"Nanotechnology in leukemia: diagnosis, efficient-targeted drug delivery, and clinical trials","volume":"28","author":"Salama","year":"2023","journal-title":"Eur. J. Med. Res."},{"key":"bmmae83f7bib2","article-title":"Leukemia: AML, CML, ALL and CLL","author":"Lockwood, W","year":"2024","type":"web-resource"},{"key":"bmmae83f7bib3","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1109\/INFOP.2015.7489422","type":"conference-proceedings","article-title":"Detection of leukemia in microscopic white blood cell images","author":"Khobragade","year":"2015"},{"key":"bmmae83f7bib4","author":"Bain","year":"2017","type":"book"},{"key":"bmmae83f7bib5","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.70193","type":"journal-article","article-title":"Minimal residual disease detection: implications for clinical diagnosis and cancer patient treatment","volume":"6","author":"Song","year":"2025","journal-title":"MedComm"},{"key":"bmmae83f7bib6","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/B978-0-443-18770-4.00017-2","type":"book","article-title":"Liposome-based nanomedicines for cancer immunotherapy","author":"Alam","year":"2024"},{"key":"bmmae83f7bib7","doi-asserted-by":"publisher","first-page":"1652","DOI":"10.3390\/biomedicines13071652","type":"journal-article","article-title":"Advances and challenges in targeted therapy and its combination strategies for leukemia","volume":"13","author":"Zhong","year":"2025","journal-title":"Biomedicines"},{"key":"bmmae83f7bib8","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-04139-5","type":"journal-article","article-title":"Early replacement of re-induction therapy following failed intensive induction treatment enhances the therapeutic efficacy of newly diagnosed AML","volume":"15","author":"Sui","year":"2025","journal-title":"Sci. Rep."},{"key":"bmmae83f7bib9","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1177068","type":"journal-article","article-title":"Application of iron oxide nanoparticles in the diagnosis and treatment of leukemia","volume":"14","author":"Wang","year":"2023","journal-title":"Front. Pharmacol."},{"key":"bmmae83f7bib10","doi-asserted-by":"publisher","first-page":"6478","DOI":"10.1021\/acsbiomaterials.0c01040","type":"journal-article","article-title":"Advances of nanoparticles for leukemia treatment","volume":"6","author":"Shen","year":"2020","journal-title":"ACS Biomater. Sci. Eng."},{"key":"bmmae83f7bib11","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1208\/s12249-023-02670-0","type":"journal-article","article-title":"Nanoparticle-based approaches for treatment of hematological malignancies: a comprehensive review","volume":"24","author":"Hani","year":"2023","journal-title":"AAPS Pharm. Sci. Tech."},{"key":"bmmae83f7bib12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jksus.2022.102182","type":"journal-article","article-title":"An overview on therapeutic efficacy and challenges of nanoparticles in blood cancer therapy","volume":"34","author":"Wang","year":"2022","journal-title":"J. King Saud Univ. Sci."},{"key":"bmmae83f7bib13","doi-asserted-by":"publisher","first-page":"276","DOI":"10.3390\/nano10020276","type":"journal-article","article-title":"Nanocarriers as magic bullets in the treatment of leukemia","volume":"10","author":"Houshmand","year":"2020","journal-title":"Nanomaterials"},{"key":"bmmae83f7bib14","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1002\/JLB.5MR0620-063RR","type":"journal-article","article-title":"Research advances in nanomedicine, immunotherapy, and combination therapy for leukemia","volume":"109","author":"Wan","year":"2021","journal-title":"J. Leucocyte Biol."},{"key":"bmmae83f7bib15","doi-asserted-by":"publisher","first-page":"2376","DOI":"10.1039\/D0BM00129E","type":"journal-article","article-title":"Nanomedicine\u2013a promising therapy for hematological malignancies","volume":"8","author":"Huang","year":"2020","journal-title":"Biomater. Sci."},{"key":"bmmae83f7bib16","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e34951","type":"journal-article","article-title":"Targeted therapy for leukemia based on nanomaterials","volume":"10","author":"Qian","year":"2024","journal-title":"Heliyon"},{"key":"bmmae83f7bib17","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1007\/s10238-025-01686-z","type":"journal-article","article-title":"Nanotechnology in leukemia therapy: revolutionizing targeted drug delivery and immune modulation","volume":"25","author":"Bishoyi","year":"2025","journal-title":"Clin. Exp. Med."},{"key":"bmmae83f7bib18","doi-asserted-by":"publisher","first-page":"278","DOI":"10.3390\/nano11020278","type":"journal-article","article-title":"Review of contemporary self-assembled systems for the controlled delivery of therapeutics in medicine","volume":"11","author":"Osorno","year":"2021","journal-title":"Nanomaterials"},{"key":"bmmae83f7bib19","doi-asserted-by":"publisher","DOI":"10.3390\/ijms252010910","type":"journal-article","article-title":"Assessing the toxicity of metal-and carbon-based nanomaterials in vitro: impact on respiratory, intestinal, skin, and immune cell lines","volume":"25","author":"Carrillo-romero","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"bmmae83f7bib20","doi-asserted-by":"publisher","first-page":"8210","DOI":"10.1038\/s41598-021-87560-w","type":"journal-article","article-title":"Chemical characterization (LC\u2013MS\u2013ESI), cytotoxic activity and intracellular localization of PAMAM G4 in leukemia cells","volume":"11","author":"Flores-mej\u00eda","year":"2021","journal-title":"Sci. Rep."},{"key":"bmmae83f7bib21","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1080\/00914037.2019.1685516","type":"journal-article","article-title":"Targeted delivery of DOX by transferrin conjugated DSPE-PEG nanoparticles in leukemia therapy","volume":"70","author":"Fang","year":"2021","journal-title":"Int. J. Polym. Mater. Polym. Biomater."},{"key":"bmmae83f7bib22","doi-asserted-by":"publisher","first-page":"8662","DOI":"10.1073\/pnas.1307152110","type":"journal-article","article-title":"Transcytosis and brain uptake of transferrin-containing nanoparticles by tuning avidity to transferrin receptor","volume":"110","author":"Wiley","year":"2013","journal-title":"Proc. Natl Acad. Sci."},{"key":"bmmae83f7bib23","doi-asserted-by":"publisher","first-page":"4119","DOI":"10.3390\/ijms21114119","type":"journal-article","article-title":"Ruthenium dendrimers against human lymphoblastic leukemia 1301 cells","volume":"21","author":"Michlewska","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"bmmae83f7bib24","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/484963","type":"journal-article","article-title":"Bypassing P\u2010glycoprotein drug efflux mechanisms: possible applications in Pharmacoresistant schizophrenia therapy","volume":"2015","author":"Hoosain","year":"2015","journal-title":"Biomed. Res. Int."},{"key":"bmmae83f7bib25","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/3408318","type":"journal-article","article-title":"Successes and challenges for diagnosis and therapy of acute leukemia","volume":"2019","author":"Lonetti","year":"2019","journal-title":"J. Oncol."},{"key":"bmmae83f7bib26","doi-asserted-by":"publisher","first-page":"e26","DOI":"10.1017\/S1463423623000129","type":"journal-article","article-title":"What causes delays in diagnosing blood cancers? A rapid review of the evidence","volume":"24","author":"Black","year":"2023","journal-title":"Primary Health Care Res. Dev."},{"key":"bmmae83f7bib27","author":"Chennamadhavuni","year":"2023","type":"report"},{"key":"bmmae83f7bib28","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1016\/j.jmoldx.2025.05.001","type":"journal-article","article-title":"Analytical performance of the NCI-myeloMATCH assay\u2013a rapid turnaround genomic profiling assay for myeloid disorders","volume":"27","author":"Yeung","year":"2025","journal-title":"J. Mol. Diagn."},{"key":"bmmae83f7bib29","doi-asserted-by":"publisher","first-page":"4006","DOI":"10.1182\/bloodadvances.2022007378","type":"journal-article","article-title":"High-sensitivity next-generation sequencing MRD assessment in ALL identifies patients at very low risk of relapse","volume":"6","author":"Short","year":"2022","journal-title":"Blood Adv."},{"key":"bmmae83f7bib30","doi-asserted-by":"publisher","first-page":"860","DOI":"10.3390\/children12070860","type":"journal-article","article-title":"False-positive and false-negative MRD results in children with acute lymphoblastic leukemia: navigating between scylla and charybdis (brief review and clinical experience)","volume":"12","author":"Korkina","year":"2025","journal-title":"Children"},{"key":"bmmae83f7bib31","doi-asserted-by":"publisher","first-page":"11","DOI":"10.3978\/j.issn.2306-9759.2014.04.01","type":"journal-article","article-title":"MicroRNAs as biomarkers in leukemia","volume":"1","author":"Wang","year":"2014","journal-title":"Stem Cell Invest."},{"key":"bmmae83f7bib32","doi-asserted-by":"publisher","first-page":"801","DOI":"10.2217\/fon-2018-0812","type":"journal-article","article-title":"Why have microRNA biomarkers not been translated from bench to clinic?","volume":"15","author":"Saliminejad","year":"2019","journal-title":"Future Oncol."},{"key":"bmmae83f7bib33","doi-asserted-by":"publisher","first-page":"3469","DOI":"10.3390\/ijms23073469","type":"journal-article","article-title":"MicroRNAs in leukemias: a clinically annotated compendium","volume":"23","author":"Turk","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"bmmae83f7bib34","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1186\/s40364-025-00839-2","type":"journal-article","article-title":"Emerging strategies and novel therapeutic targets in acute myeloid leukemia: current advances and future directions","volume":"13","author":"Cao","year":"2025","journal-title":"Biomarker Res."},{"key":"bmmae83f7bib35","doi-asserted-by":"publisher","first-page":"46","DOI":"10.3322\/caac.21873","type":"journal-article","article-title":"Acute myeloid leukemia management and research in 2025","volume":"75","author":"Kantarjian","year":"2025","journal-title":"Cancer J. Clin."},{"key":"bmmae83f7bib36","doi-asserted-by":"publisher","first-page":"6345","DOI":"10.1182\/bloodadvances.2025017584","type":"journal-article","article-title":"Challenges and opportunities for improvement in the practical management of adults with acute lymphoblastic leukemia","volume":"9","author":"Cassaday","year":"2025","journal-title":"Blood Adv."},{"key":"bmmae83f7bib37","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1007\/s11899-012-0150-1","type":"journal-article","article-title":"Signal transduction in the chronic leukemias: implications for targeted therapies","volume":"8","author":"Ahmed","year":"2013","journal-title":"Curr. Hematol. Malignancy Rep."},{"key":"bmmae83f7bib38","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1200\/JCO.23.01075","type":"journal-article","article-title":"Long-term results of the dasatinib-blinatumomab protocol for adult Philadelphia-positive ALL","volume":"42","author":"Fo\u00e0","year":"2024","journal-title":"J. Clin. Oncol."},{"key":"bmmae83f7bib39","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1016\/j.ccell.2019.08.004","type":"journal-article","article-title":"Combining the allosteric inhibitor asciminib with ponatinib suppresses emergence of and restores efficacy against highly resistant BCR-ABL1 mutants","volume":"36","author":"Eide","year":"2019","journal-title":"Cancer Cell"},{"key":"bmmae83f7bib40","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2021.174633","type":"journal-article","article-title":"Simvastatin potentiates the cell-killing activity of imatinib in imatinib-resistant chronic myeloid leukemia cells mainly through PI3K\/AKT pathway attenuation and Myc downregulation","volume":"913","author":"Ding","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"bmmae83f7bib41","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1111\/ijd.13852","type":"journal-article","article-title":"Long\u2010term mucocutaneous adverse effects of imatinib in Indian chronic myeloid leukemia patients","volume":"57","author":"Vinay","year":"2018","journal-title":"Int. J. Dermatol."},{"key":"bmmae83f7bib42","doi-asserted-by":"publisher","DOI":"10.1136\/esmoopen-2019-000606","type":"journal-article","article-title":"European Medicines Agency review of midostaurin (Rydapt) for the treatment of adult patients with acute myeloid leukaemia and systemic mastocytosis","volume":"4","author":"Tzogani","year":"2019","journal-title":"ESMO Open"},{"key":"bmmae83f7bib43","doi-asserted-by":"publisher","first-page":"e879","DOI":"10.1016\/S2352-3026(21)00307-0","type":"journal-article","article-title":"Zanubrutinib, obinutuzumab, and venetoclax with minimal residual disease-driven discontinuation in previously untreated patients with chronic lymphocytic leukaemia or small lymphocytic lymphoma: a multicentre, single-arm, phase 2 trial","volume":"8","author":"Soumerai","year":"2021","journal-title":"Lancet Haematol."},{"key":"bmmae83f7bib44","doi-asserted-by":"publisher","first-page":"oyaf237","DOI":"10.1093\/oncolo\/oyaf237","type":"journal-article","article-title":"Considerations for the practical management of cardiovascular risk with Bruton\u2019s tyrosine kinase inhibitors for patients with chronic lymphocytic leukemia","volume":"30","author":"Lenihan","year":"2025","journal-title":"Oncologist"},{"key":"bmmae83f7bib45","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2024.104243","type":"journal-article","article-title":"Efficacy and challenges involving combination therapies in CLL","volume":"29","author":"Alanazi","year":"2024","journal-title":"Drug Discovery Today"},{"key":"bmmae83f7bib46","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1002\/hon.3126","type":"journal-article","article-title":"Predictors of ibrutinib\u2010associated atrial fibrillation: 5\u2010year follow\u2010up of a prospective study","volume":"41","author":"Mattiello","year":"2023","journal-title":"Hematol. Oncol."},{"key":"bmmae83f7bib47","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3390\/cells10010010","type":"journal-article","article-title":"Molecular remission using low-dose immunotherapy with minimal toxicities for poor prognosis IGHV\u2014unmutated chronic lymphocytic leukemia","volume":"10","author":"Maharaj","year":"2020","journal-title":"Cells"},{"key":"bmmae83f7bib48","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1038\/s41392-021-00578-4","type":"journal-article","article-title":"FLT3 tyrosine kinase inhibitors synergize with BCL-2 inhibition to eliminate FLT3\/ITD acute leukemia cells through BIM activation","volume":"6","author":"Zhu","year":"2021","journal-title":"Signal Transduction Targeted Ther."},{"key":"bmmae83f7bib49","doi-asserted-by":"publisher","first-page":"1198","DOI":"10.1182\/blood.2021012775","type":"journal-article","article-title":"Clonal hematopoiesis, myeloid disorders and BAX-mutated myelopoiesis in patients receiving venetoclax for CLL","volume":"139","author":"Blombery","year":"2022","journal-title":"Blood J. Am. Soc. Hematol."},{"key":"bmmae83f7bib50","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1106\/UJQK-83T8-KACC-0AUY","type":"journal-article","article-title":"Current trends in the treatment of acute and chronic myelogenous leukemia","volume":"15","author":"Stull","year":"2002","journal-title":"J. Pharm. Pract."},{"key":"bmmae83f7bib51","doi-asserted-by":"publisher","first-page":"S83","DOI":"10.1016\/j.cmi.2018.03.022","type":"journal-article","article-title":"ESCMID Study Group for Infections in Compromised Hosts (ESGICH) Consensus Document on the safety of targeted and biological therapies: an infectious diseases perspective (Agents targeting lymphoid or myeloid cells surface antigens [II]: CD22, CD30, CD33, CD38, CD40, SLAMF-7 and CCR4)","volume":"24","author":"Drgona","year":"2018","journal-title":"Clin. Microbiol. Infection"},{"key":"bmmae83f7bib52","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/j.htct.2023.07.007","type":"journal-article","article-title":"Toxicity and outcome of adults with acute myeloid leukemia receiving consolidation with high-dose cytarabine","volume":"46","author":"Lopes","year":"2024","journal-title":"Hematol. Transfusion Cell Ther."},{"key":"bmmae83f7bib53","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1080\/09205063.2023.2294541","type":"journal-article","article-title":"Advantages of nanomedicine over the conventional treatment in Acute myeloid leukemia","volume":"35","author":"Janani","year":"2024","journal-title":"J. Biomater. Sci. Polym. Ed."},{"key":"bmmae83f7bib54","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1002\/hon.2828","type":"journal-article","article-title":"Obinutuzumab\u2010related adverse events: a systematic review and meta\u2010analysis","volume":"39","author":"Amitai","year":"2021","journal-title":"Hematol. Oncol."},{"key":"bmmae83f7bib55","doi-asserted-by":"publisher","first-page":"4246","DOI":"10.1200\/JCO.24.00272","type":"journal-article","article-title":"Results of the simultaneous combination of ponatinib and blinatumomab in Philadelphia chromosome-positive ALL","volume":"42","author":"Kantarjian","year":"2024","journal-title":"J. Clin. Oncol."},{"key":"bmmae83f7bib56","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1007\/s10238-025-01795-9","type":"journal-article","article-title":"The AML immune paradox: decoding escape pathways and pioneering checkpoint, vaccine, and combination strategies","volume":"25","author":"Soleimani Samarkhazan","year":"2025","journal-title":"Clin. Exp. Med."},{"key":"bmmae83f7bib57","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1080\/17474086.2019.1647778","type":"journal-article","article-title":"Novel therapies in low-and high-risk myelodysplastic syndrome","volume":"12","author":"Germing","year":"2019","journal-title":"Exp. Rev. Hematol."},{"key":"bmmae83f7bib58","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241914964","type":"journal-article","article-title":"Epigenetic modulators as therapeutic agents in cancer","volume":"24","author":"Patnaik","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"bmmae83f7bib59","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.112804","type":"journal-article","article-title":"Stromal-induced epithelial-mesenchymal transition induces targetable drug resistance in acute lymphoblastic leukemia","volume":"42","author":"Park","year":"2023","journal-title":"Cell Rep."},{"key":"bmmae83f7bib60","doi-asserted-by":"publisher","first-page":"2142","DOI":"10.1002\/jbm.b.34862","type":"journal-article","article-title":"TiO2 nanoparticle coatings on glass surfaces for the selective trapping of leukemia cells from peripheral blood","volume":"109","author":"Garcia Diosa","year":"2021","journal-title":"J. Biomed. Mater. Res. B"},{"key":"bmmae83f7bib61","doi-asserted-by":"publisher","first-page":"394","DOI":"10.3390\/polym18030394","type":"journal-article","article-title":"Co-release of cytarabine and polyphenol-rich extract from polycaprolactone microparticles towards leukemia therapy","volume":"18","author":"Leyva Castro","year":"2026","journal-title":"Polymers"},{"key":"bmmae83f7bib62","doi-asserted-by":"publisher","first-page":"992","DOI":"10.1161\/ATVBAHA.108.165506","type":"journal-article","article-title":"Nanotechnology in medical imaging: probe design and applications","volume":"29","author":"Cormode","year":"2009","journal-title":"Arteriosclerosis Thrombosis Vascular Biol."},{"key":"bmmae83f7bib63","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.freeradbiomed.2021.02.044","type":"journal-article","article-title":"Nanodelivery of natural isothiocyanates as a cancer therapeutic","volume":"167","author":"Wang","year":"2021","journal-title":"Free Radical Biol. Med."},{"key":"bmmae83f7bib64","doi-asserted-by":"publisher","first-page":"15344","DOI":"10.1073\/pnas.1411499111","type":"journal-article","article-title":"Investigating the optimal size of anticancer nanomedicine","volume":"111","author":"Tang","year":"2014","journal-title":"Proc. Natl Acad. Sci."},{"key":"bmmae83f7bib65","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1186\/s11671-018-2688-x","type":"journal-article","article-title":"Antiproliferative and apoptosis triggering potential of paclitaxel-based targeted-lipid nanoparticles with enhanced cellular internalization by transferrin receptors\u2014A study in leukemia cells","volume":"13","author":"Dai","year":"2018","journal-title":"Nanoscale Res. Lett."},{"key":"bmmae83f7bib66","first-page":"131","type":"journal-article","article-title":"Effect of size on the biodistribution and blood clearance of etoposide-loaded PLGA nanoparticles","volume":"65","author":"Yadav","year":"2011","journal-title":"PDA J. Pharm. Sci. Technol."},{"key":"bmmae83f7bib67","doi-asserted-by":"publisher","first-page":"457","DOI":"10.4155\/tde.12.21","type":"journal-article","article-title":"Size matters: gold nanoparticles in targeted cancer drug delivery","volume":"3","author":"Dreaden","year":"2012","journal-title":"Ther. Deliv."},{"key":"bmmae83f7bib68","doi-asserted-by":"publisher","first-page":"3047","DOI":"10.3390\/cancers14133047","type":"journal-article","article-title":"Theranostic potentials of gold nanomaterials in hematological malignancies","volume":"14","author":"Shakil","year":"2022","journal-title":"Cancers"},{"key":"bmmae83f7bib69","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.ijpharm.2010.02.014","type":"journal-article","article-title":"Biophysical characterization of a liposomal formulation of cytarabine and daunorubicin","volume":"391","author":"Dicko","year":"2010","journal-title":"Int. J. Pharm."},{"key":"bmmae83f7bib70","doi-asserted-by":"publisher","first-page":"4550","DOI":"10.1021\/jacs.1c00850","type":"journal-article","article-title":"Nanoparticle shape determines dynamics of targeting nanoconstructs on cell membranes","volume":"143","author":"Choo","year":"2021","journal-title":"J. Am. Chem. Soc."},{"key":"bmmae83f7bib71","doi-asserted-by":"publisher","first-page":"2043","DOI":"10.2147\/DDDT.S202818","type":"journal-article","article-title":"In vitro and in vivo effect of hyaluronic acid modified, doxorubicin and gallic acid co-delivered lipid-polymeric hybrid nano-system for leukemia therapy","volume":"13","author":"Shao","year":"2019","journal-title":"Drug Des. Devel. Ther."},{"key":"bmmae83f7bib72","doi-asserted-by":"publisher","first-page":"5406","DOI":"10.1038\/s41467-019-13263-6","type":"journal-article","article-title":"Anisotropic polymer nanoparticles with controlled dimensions from the morphological transformation of isotropic seeds","volume":"10","author":"Hua","year":"2019","journal-title":"Nat. Commun."},{"key":"bmmae83f7bib73","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1117\/12.878802","type":"journal-article","article-title":"Photothermal therapy of acute leukemia cells in the near-infrared region using gold nanorods CD-33 conjugates","volume":"7897","author":"Liopo","year":"2011","journal-title":"Proc. SPIE"},{"key":"bmmae83f7bib74","doi-asserted-by":"publisher","first-page":"7884","DOI":"10.1016\/j.biomaterials.2013.07.015","type":"journal-article","article-title":"Anti-leukemia activity of PVP-coated silver nanoparticles via generation of reactive oxygen species and release of silver ions","volume":"34","author":"Guo","year":"2013","journal-title":"Biomaterials"},{"key":"bmmae83f7bib75","doi-asserted-by":"publisher","first-page":"2199","DOI":"10.1021\/mp300350e","type":"journal-article","article-title":"Dexamethasone-loaded block copolymer nanoparticles induce leukemia cell death and enhance therapeutic efficacy: a novel application in pediatric nanomedicine","volume":"10","author":"Krishnan","year":"2013","journal-title":"Mol. Pharm."},{"key":"bmmae83f7bib76","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2020.104601","type":"journal-article","article-title":"Targeted dendrimers for antagonizing the migration and viability of NALM-6 lymphoblastic leukemia cells","volume":"107","author":"Chittasupho","year":"2021","journal-title":"Bioorg. Chem."},{"key":"bmmae83f7bib77","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.biomaterials.2009.09.030","type":"journal-article","article-title":"Self-assembled hyaluronic acid nanoparticles for active tumor targeting","volume":"31","author":"Choi","year":"2010","journal-title":"Biomaterials"},{"key":"bmmae83f7bib78","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1080\/10717544.2018.1435747","type":"journal-article","article-title":"Transferrin and octaarginine modified dual-functional liposomes with improved cancer cell targeting and enhanced intracellular delivery for the treatment of ovarian cancer","volume":"25","author":"Deshpande","year":"2018","journal-title":"Drug Deliv."},{"key":"bmmae83f7bib79","doi-asserted-by":"publisher","first-page":"3435","DOI":"10.1016\/j.biomaterials.2011.01.021","type":"journal-article","article-title":"The effect of surface charge on in vivo biodistribution of PEG-oligocholic acid based micellar nanoparticles","volume":"32","author":"Xiao","year":"2011","journal-title":"Biomaterials"},{"key":"bmmae83f7bib80","doi-asserted-by":"publisher","first-page":"381","DOI":"10.3390\/md17060381","type":"journal-article","article-title":"Recent advances in chitosan-based carriers for gene delivery","volume":"17","author":"Cao","year":"2019","journal-title":"Mar. Drugs"},{"key":"bmmae83f7bib81","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.ijpharm.2014.01.015","type":"journal-article","article-title":"Polyethylene glycol-modified arachidyl chitosan-based nanoparticles for prolonged blood circulation of doxorubicin","volume":"464","author":"Termsarasab","year":"2014","journal-title":"Int. J. Pharm."},{"key":"bmmae83f7bib82","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1186\/s12964-023-01213-1","type":"journal-article","article-title":"Targeted Silencing of NRF2 by rituximab-conjugated nanoparticles increases the sensitivity of chronic lymphoblastic leukemia cells to Cyclophosphamide","volume":"21","author":"Khodakarami","year":"2023","journal-title":"Cell Commun. Signaling"},{"key":"bmmae83f7bib83","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1002\/ajh.27730","type":"journal-article","article-title":"CPX\u2010351 (Vyxeos) in Acute Myeloid Leukemia: Time to Move On?","volume":"100","author":"Gangat","year":"2025","journal-title":"Am. J. Hematol."},{"key":"bmmae83f7bib84","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1007\/s11051-022-05404-8","type":"journal-article","article-title":"pH-sensitive chitosan-PEG-decorated hollow mesoporous silica nanoparticles could be an effective treatment for acute myeloid leukemia (AML)","volume":"24","author":"Ultav","year":"2022","journal-title":"J. Nanopart. Res."},{"key":"bmmae83f7bib85","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2024.105415","type":"journal-article","article-title":"Enhanced therapeutic efficacy of asparaginase and chloroquine co-loaded ZIF-8 nanoparticles for overcoming l-asparaginase resistance in leukemia treatment","volume":"93","author":"Shama","year":"2024","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"bmmae83f7bib86","doi-asserted-by":"publisher","first-page":"439","DOI":"10.3390\/md16110439","type":"journal-article","article-title":"Folate receptor-targeted and GSH-responsive carboxymethyl chitosan nanoparticles containing covalently entrapped 6-mercaptopurine for enhanced intracellular drug delivery in leukemia","volume":"16","author":"Wei","year":"2018","journal-title":"Mar. Drugs"},{"key":"bmmae83f7bib87","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2022.121796","type":"journal-article","article-title":"Co-encapsulation of l-asparaginase and etoposide in dextran nanoparticles for synergistic effect in chronic myeloid leukemia cells","volume":"622","author":"Konh\u00e4user","year":"2022","journal-title":"Int. J. Pharm."},{"key":"bmmae83f7bib88","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.colsurfb.2016.08.022","type":"journal-article","article-title":"Nanomedicine-based paclitaxel induced apoptotic signaling pathways in A562 leukemia cancer cells","volume":"149","author":"Wang","year":"2017","journal-title":"Colloids Surf. B"},{"key":"bmmae83f7bib89","doi-asserted-by":"publisher","first-page":"670","DOI":"10.3390\/cancers13040670","type":"journal-article","article-title":"Recent advancements in stimuli responsive drug delivery platforms for active and passive cancer targeting","volume":"13","author":"Rahim","year":"2021","journal-title":"Cancers"},{"key":"bmmae83f7bib90","doi-asserted-by":"publisher","DOI":"10.1016\/j.surfin.2025.106153","type":"journal-article","article-title":"Development of a pH\/NIR\/temperature-responsive drug delivery system using AuNRs@ ZnO@ mPDA nanoparticles for synergistic cancer therapy","volume":"61","author":"Ma","year":"2025","journal-title":"Surf. Interfaces"},{"key":"bmmae83f7bib91","doi-asserted-by":"publisher","first-page":"1354","DOI":"10.3390\/pharmaceutics17101354","type":"journal-article","article-title":"Advances in PCL, PLA, and PLGA-based technologies for anticancer drug delivery","volume":"17","author":"Kim","year":"2025","journal-title":"Pharmaceutics"},{"key":"bmmae83f7bib92","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1016\/j.biopha.2016.11.121","type":"journal-article","article-title":"Novel transferrin modified and doxorubicin loaded Pluronic 85\/lipid-polymeric nanoparticles for the treatment of leukemia: in vitro and in vivo therapeutic effect evaluation","volume":"86","author":"Zhu","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"bmmae83f7bib93","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.33263\/LIANBS93.12251238","type":"journal-article","article-title":"Influence of surface charge on the functional properties of silica nanoparticles and cellular toxicity","volume":"9","author":"Chunduri","year":"2020","journal-title":"Lett. Appl. NanoBioSci."},{"key":"bmmae83f7bib94","doi-asserted-by":"publisher","first-page":"349","DOI":"10.31083\/j.fbl2910349","type":"journal-article","article-title":"Nanoengineered platform-based microenvironment-triggered immunotherapy in cancer treatment","volume":"29","author":"Dhas","year":"2024","journal-title":"Front. Biosci.-Landmark"},{"key":"bmmae83f7bib95","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1186\/s12967-026-07792-0","type":"journal-article","article-title":"Overcoming therapeutic challenges in acute myeloid leukemia: active targeting strategies by nano-drug delivery systems","volume":"24","author":"Tang","year":"2026","journal-title":"J. Transl. Med."},{"key":"bmmae83f7bib96","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1586\/ehm.11.30","type":"journal-article","article-title":"The bone marrow microenvironment and leukemia: biology and therapeutic targeting","volume":"4","author":"Sison","year":"2011","journal-title":"Expert Rev. Hematol."},{"key":"bmmae83f7bib97","doi-asserted-by":"publisher","first-page":"248","DOI":"10.3390\/ijms27010248","type":"journal-article","article-title":"Hybrid nanocarriers for cancer therapy: advancements in co-delivery of gene therapy and immunotherapy","volume":"27","author":"Berikkhanova","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"bmmae83f7bib98","doi-asserted-by":"publisher","first-page":"61","DOI":"10.3390\/cells14020061","type":"journal-article","article-title":"Hyaluronic acid-based drug delivery systems for cancer therapy","volume":"14","author":"Pashkina","year":"2025","journal-title":"Cells"},{"key":"bmmae83f7bib99","doi-asserted-by":"publisher","first-page":"ojaf108","DOI":"10.1093\/asjof\/ojaf108","type":"journal-article","article-title":"Effectiveness of hyaluronidase on hyaluronic acid degradation: an experimental study","volume":"7","author":"Oliveira","year":"2025","journal-title":"Proc. Aesthetic Surg. J. Open Forum"},{"key":"bmmae83f7bib100","doi-asserted-by":"publisher","first-page":"e2968","DOI":"10.1002\/jgm.2968","type":"journal-article","article-title":"In vitro and in vivo gene delivery using chitosan\/hyaluronic acid nanoparticles: influences of molecular mass of hyaluronic acid and lyophilization on transfection efficiency","volume":"19","author":"Sato","year":"2017","journal-title":"J. Gene Med."},{"key":"bmmae83f7bib101","doi-asserted-by":"publisher","first-page":"195","DOI":"10.15171\/apb.2019.023","type":"journal-article","article-title":"Current advances in chitosan nanoparticles based drug delivery and targeting","volume":"9","author":"Garg","year":"2019","journal-title":"Adv. Pharm. Bull."},{"key":"bmmae83f7bib102","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1016\/j.eurpolymj.2017.04.021","type":"journal-article","article-title":"Penetration and toxicity of chitosan and its derivatives","volume":"93","author":"Zubareva","year":"2017","journal-title":"Eur. Polym. J."},{"key":"bmmae83f7bib103","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2023.123495","type":"journal-article","article-title":"Aptamer-modified chitosan-capped mesoporous silica nanoparticles for co-delivery of cytarabine and daunorubicin in leukemia","volume":"646","author":"Heydari","year":"2023","journal-title":"Int. J. Pharm."},{"key":"bmmae83f7bib104","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.3390\/ijms24021040","type":"journal-article","article-title":"A novel form of arginine-chitosan as nanoparticles efficient for siRNA delivery into mouse leukemia cells","volume":"24","author":"Luo","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"bmmae83f7bib105","doi-asserted-by":"publisher","first-page":"1592","DOI":"10.1039\/C8BM00263K","type":"journal-article","article-title":"Systemic delivery of CRISPR\/Cas9 with PEG-PLGA nanoparticles for chronic myeloid leukemia targeted therapy","volume":"6","author":"Liu","year":"2018","journal-title":"Biomater. Sci."},{"key":"bmmae83f7bib106","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.ijbiomac.2016.03.021","type":"journal-article","article-title":"Dendrimer-based nanoparticles for potential personalized therapy in chronic lymphocytic leukemia: targeting the BCR-signaling pathway","volume":"88","author":"Franiak-pietryga","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"key":"bmmae83f7bib107","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1329636","type":"journal-article","article-title":"GP60 and SPARC as albumin receptors: key targeted sites for the delivery of antitumor drugs","volume":"15","author":"Ji","year":"2024","journal-title":"Front. Pharmacol."},{"key":"bmmae83f7bib108","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1093\/annonc\/mdl104","type":"journal-article","article-title":"Abraxane\u00ae, a novel Cremophor\u00ae-free, albumin-bound particle form of paclitaxel for the treatment of advanced non-small-cell lung cancer","volume":"17","author":"Green","year":"2006","journal-title":"Ann. Oncol."},{"key":"bmmae83f7bib109","doi-asserted-by":"publisher","first-page":"6945","DOI":"10.2147\/IJN.S467876","type":"journal-article","article-title":"Albumin nanoparticle-based drug delivery systems","volume":"19","author":"Qu","year":"2024","journal-title":"Int. J. Nanomed."},{"key":"bmmae83f7bib110","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.2217\/nnm.16.32","type":"journal-article","article-title":"Fibronectin-modified surfaces for evaluating the influence of cell adhesion on sensitivity of leukemic cells to siRNA nanoparticles","volume":"11","author":"Valencia-Serna","year":"2016","journal-title":"Nanomedicine"},{"key":"bmmae83f7bib111","doi-asserted-by":"publisher","first-page":"471","DOI":"10.3390\/pharmaceutics15020471","type":"journal-article","article-title":"Casein-based nanoparticles: a potential tool for the delivery of daunorubicin in acute lymphocytic leukemia","volume":"15","author":"Zahariev","year":"2023","journal-title":"Pharmaceutics"},{"key":"bmmae83f7bib112","doi-asserted-by":"publisher","first-page":"10703","DOI":"10.3168\/jds.2018-14915","type":"journal-article","article-title":"Immunoreactive properties of \u03b1-casein and \u03ba-casein: ex vivo and in vivo studies","volume":"101","author":"Fuc","year":"2018","journal-title":"J. Dairy Sci."},{"key":"bmmae83f7bib113","doi-asserted-by":"publisher","first-page":"942","DOI":"10.3390\/pharmaceutics14050942","type":"journal-article","article-title":"Chitosan-hyaluronan nanoparticles for vinblastine sulfate delivery: characterization and internalization studies on K-562 cells","volume":"14","author":"Cannav\u00e0","year":"2022","journal-title":"Pharmaceutics"},{"key":"bmmae83f7bib114","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s40846-024-00911-6","type":"journal-article","article-title":"A pH-sensitive curcumin\/crocetin-loaded chitosan nanoparticles for treating acute myeloid leukemia: an in vitro study","volume":"44","author":"Jiao","year":"2024","journal-title":"J. Med. Biol. Eng."},{"key":"bmmae83f7bib115","doi-asserted-by":"publisher","first-page":"466","DOI":"10.3390\/pharmaceutics14020466","type":"journal-article","article-title":"Hyaluronic acid nanoparticles for immunogenic chemotherapy of leukemia and T-cell lymphoma","volume":"14","author":"Krishnan","year":"2022","journal-title":"Pharmaceutics"},{"key":"bmmae83f7bib116","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.ejpb.2023.07.008","type":"journal-article","article-title":"Quality by design endorsed fabrication of Ibrutinib-loaded human serum albumin nanoparticles for the management of leukemia","volume":"190","author":"Famta","year":"2023","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"bmmae83f7bib117","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1186\/s12951-024-02460-1","type":"journal-article","article-title":"Targeted delivery of HSP90 inhibitors for efficient therapy of CD44-positive acute myeloid leukemia and solid tumor-colon cancer","volume":"22","author":"Jia","year":"2024","journal-title":"J. Nanobiotechnol."},{"key":"bmmae83f7bib118","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12668-025-01878-7","type":"journal-article","article-title":"Bone marrow delivery of nilotinib hydrochloride through nanoparticles for therapy of chronic myeloid leukemia","volume":"15","author":"Arpitha","year":"2025","journal-title":"BioNanoScience"},{"key":"bmmae83f7bib119","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2024.109779","type":"journal-article","article-title":"Red blood cell membrane-coated FLT3 inhibitor nanoparticles to enhance FLT3-ITD acute myeloid leukemia treatment","volume":"35","author":"Liu","year":"2024","journal-title":"Chin. Chem. Lett."},{"key":"bmmae83f7bib120","doi-asserted-by":"publisher","DOI":"10.1016\/j.jafr.2024.101332","type":"journal-article","article-title":"Avocado seed extract encapsulated in zein nanoparticles as a functional ingredient","volume":"18","author":"Chuacharoen","year":"2024","journal-title":"J. Agric. Food Res."},{"key":"bmmae83f7bib121","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2024.102474","type":"journal-article","article-title":"CD13-targeting and TRAIL-displaying protein nanoparticles effectively induce apoptotic cell death of acute myeloid leukemia, prolonging survival in mouse models","volume":"59","author":"Jun","year":"2024","journal-title":"Nano Today"},{"key":"bmmae83f7bib122","doi-asserted-by":"publisher","first-page":"4045","DOI":"10.2147\/IJN.S210057","type":"journal-article","article-title":"Cholate-modified polymer-lipid hybrid nanoparticles for oral delivery of quercetin to potentiate the antileukemic effect","volume":"14","author":"Yin","year":"2019","journal-title":"Int. J. Nanomed."},{"key":"bmmae83f7bib123","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s11671-016-1512-8","type":"journal-article","article-title":"Aptamer-functionalized fluorescent silica nanoparticles for highly sensitive detection of leukemia cells","volume":"11","author":"Tan","year":"2016","journal-title":"Nanoscale Res. Lett."},{"key":"bmmae83f7bib124","doi-asserted-by":"publisher","first-page":"14","DOI":"10.3390\/biomedicines8010014","type":"journal-article","article-title":"Aptamer-conjugated Tb (III)-doped silica nanoparticles for luminescent detection of leukemia cells","volume":"8","author":"Grechkin","year":"2020","journal-title":"Biomedicines"},{"key":"bmmae83f7bib125","doi-asserted-by":"publisher","first-page":"4099","DOI":"10.2147\/IJN.S78995","type":"journal-article","article-title":"Targeted tumor imaging of anti-CD20-polymeric nanoparticles developed for the diagnosis of B-cell malignancies","volume":"10","author":"Capolla","year":"2015","journal-title":"Int. J. Nanomed."},{"key":"bmmae83f7bib126","doi-asserted-by":"publisher","first-page":"454","DOI":"10.3390\/ph16030454","type":"journal-article","article-title":"Properties of poly (lactic-co-glycolic acid) and progress of poly (lactic-co-glycolic acid)-based biodegradable materials in biomedical research","volume":"16","author":"Lu","year":"2023","journal-title":"Pharmaceuticals"},{"key":"bmmae83f7bib127","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11095-018-2482-6","type":"journal-article","article-title":"Radiolabeled PLGA nanoparticles for effective targeting of bendamustine in tumor bearing mice","volume":"35","author":"Khan","year":"2018","journal-title":"Pharm. Res."},{"key":"bmmae83f7bib128","doi-asserted-by":"publisher","first-page":"2103","DOI":"10.3390\/molecules24112103","type":"journal-article","article-title":"Novel targeted nano-parthenolide molecule against NF-kB in acute myeloid leukemia","volume":"24","author":"Darwish","year":"2019","journal-title":"Molecules"},{"key":"bmmae83f7bib129","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1021\/mp100455h","type":"journal-article","article-title":"Coformulation of doxorubicin and curcumin in poly (D, L-lactide-co-glycolide) nanoparticles suppresses the development of multidrug resistance in K562 cells","volume":"8","author":"Misra","year":"2011","journal-title":"Mol. Pharm."},{"key":"bmmae83f7bib130","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1007\/s12668-025-02233-6","type":"journal-article","article-title":"A comparative review of polylactic acid and poly (Lactic-co-Glycolic Acid) biomaterials: optimizing drug delivery","volume":"16","author":"Jumadi","year":"2026","journal-title":"BioNanoScience"},{"key":"bmmae83f7bib131","doi-asserted-by":"publisher","first-page":"1713","DOI":"10.1007\/s12247-023-09753-2","type":"journal-article","article-title":"Development and statistical optimization of polymer-based nanoparticulate delivery system for enhancing cytarabine efficacy in leukemia treatment","volume":"18","author":"Jan","year":"2023","journal-title":"J. Pharm. Innov."},{"key":"bmmae83f7bib132","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2022.102627","type":"journal-article","article-title":"Polylactic acid based polymeric nanoparticle mediated co-delivery of navitoclax and decitabine for cancer therapy","volume":"47","author":"Mehrotra","year":"2023","journal-title":"Nanomed. Nanotechnol. Biol. Med."},{"key":"bmmae83f7bib133","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1007\/s13205-021-03105-y","type":"journal-article","article-title":"Emerging uses of PLA\u2013PEG copolymer in cancer drug delivery","volume":"12","author":"Mundel","year":"2022","journal-title":"3 Biotech"},{"key":"bmmae83f7bib134","first-page":"125","type":"journal-article","article-title":"Preparation and characterization of PLA-PEG-PLA\/PEI\/DNA nanoparticles for improvement of transfection efficiency and controlled release of DNA in gene delivery systems","volume":"18","author":"Amani","year":"2019","journal-title":"Iran J. Pharm. Res."},{"key":"bmmae83f7bib135","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.jconrel.2019.08.018","type":"journal-article","article-title":"siRNA-mediated BCR-ABL silencing in primary chronic myeloid leukemia cells using lipopolymers","volume":"310","author":"Valencia-Serna","year":"2019","journal-title":"J. Control. Release"},{"key":"bmmae83f7bib136","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1016\/j.leukres.2014.08.008","type":"journal-article","article-title":"Polymeric nanoparticle-mediated silencing of CD44 receptor in CD34+ acute myeloid leukemia cells","volume":"38","author":"Gul-uluda\u011f","year":"2014","journal-title":"Leukemia Res."},{"key":"bmmae83f7bib137","doi-asserted-by":"publisher","first-page":"3167","DOI":"10.3390\/nano13243167","type":"journal-article","article-title":"Exploring the potential of siRNA delivery in acute myeloid leukemia for therapeutic silencing","volume":"13","author":"Ubeda Gutierrez","year":"2023","journal-title":"Nanomaterials"},{"key":"bmmae83f7bib138","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1016\/j.jconrel.2023.09.001","type":"journal-article","article-title":"Polyethylenimine (PEI) in gene therapy: current status and clinical applications","volume":"362","author":"Casper","year":"2023","journal-title":"J. Control. Release"},{"key":"bmmae83f7bib139","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1038\/s41417-019-0095-9","type":"journal-article","article-title":"Use of polymeric CXCR4 inhibitors as siRNA delivery vehicles for the treatment of acute myeloid leukemia","volume":"27","author":"Wang","year":"2020","journal-title":"Cancer Gene Ther."},{"key":"bmmae83f7bib140","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.118971","type":"journal-article","article-title":"In vitro anti-leukemic assessment and sustained release behaviour of cytarabine loaded biodegradable polymer based nanoparticles","volume":"267","author":"Jan","year":"2021","journal-title":"Life Sci."},{"key":"bmmae83f7bib141","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2025.101727","type":"journal-article","article-title":"Poloxamer-based drug delivery systems: frontiers for treatment of solid tumors","volume":"32","author":"Pourbakhsh","year":"2025","journal-title":"Mater. Today Bio"},{"key":"bmmae83f7bib142","doi-asserted-by":"publisher","first-page":"3645","DOI":"10.1016\/j.xphs.2016.09.010","type":"journal-article","article-title":"Development and characterization of FLT3-specific curcumin-loaded polymeric micelles as a drug delivery system for treating FLT3-overexpressing leukemic cells","volume":"105","author":"Tima","year":"2016","journal-title":"J. Pharm. Sci."},{"key":"bmmae83f7bib143","doi-asserted-by":"publisher","first-page":"3961","DOI":"10.1021\/acs.langmuir.7b04335","type":"journal-article","article-title":"Microfluidic assisted nanoprecipitation of PLGA nanoparticles for curcumin delivery to leukemia jurkat cells","volume":"34","author":"Leung","year":"2018","journal-title":"Langmuir"},{"key":"bmmae83f7bib144","doi-asserted-by":"publisher","first-page":"6503","DOI":"10.1021\/acs.biomac.4c00672","type":"journal-article","article-title":"Development of CD33-targeted dual drug-loaded nanoparticles for the treatment of pediatric acute myeloid leukemia","volume":"25","author":"Carvalho","year":"2024","journal-title":"Biomacromolecules"},{"key":"bmmae83f7bib145","doi-asserted-by":"publisher","first-page":"543","DOI":"10.2147\/IJN.S190027","type":"journal-article","article-title":"Idarubicin-loaded methoxy poly (ethylene glycol)-b-poly (l-lactide-co-glycolide) nanoparticles for enhancing cellular uptake and promoting antileukemia activity","volume":"14","author":"Liang","year":"2019","journal-title":"Int. J. Nanomed."},{"key":"bmmae83f7bib146","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2025.107043","type":"journal-article","article-title":"Enhancement of the in vitro anti-leukemic effect of the histone deacetylase inhibitor Romidepsin using Poly-(D, L-lactide-co-glycolide) nanoparticles as a drug carrier","volume":"207","author":"Aroonthongsawat","year":"2025","journal-title":"Eur. J. Pharm. Sci."},{"key":"bmmae83f7bib147","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2025.e42450","type":"journal-article","article-title":"Clofarabine-loaded aptamer-conjugated biodegradable nanoparticle successfully targeted CD117 overexpressed HL60 cells and potentially induced apoptosis","volume":"11","author":"Ray","year":"2025","journal-title":"Heliyon"},{"key":"bmmae83f7bib148","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2021.121296","type":"journal-article","article-title":"Repurposing chlorpromazine for anti-leukaemic therapy by nanoparticle encapsulation","volume":"612","author":"Gundersen","year":"2022","journal-title":"Int. J. Pharm."},{"key":"bmmae83f7bib149","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2024.123971","type":"journal-article","article-title":"Fisetin nanoparticles based on cells cycle and apoptosis intervention for the treatment of lymphoma and leukemia","volume":"654","author":"Yang","year":"2024","journal-title":"Int. J. Pharm."},{"key":"bmmae83f7bib150","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1080\/03639045.2019.1569036","type":"journal-article","article-title":"In vitro activity of resorcinarene\u2013chlorambucil conjugates for therapy in human chronic myelogenous leukemia cells","volume":"45","author":"Mendoza-cardozo","year":"2019","journal-title":"Drug Dev. Ind. Pharm."},{"key":"bmmae83f7bib151","doi-asserted-by":"publisher","first-page":"12297","DOI":"10.2147\/IJN.S477597","type":"journal-article","article-title":"Aptamer sgc8-modified PAMAM nanoparticles for targeted siRNA delivery to inhibit BCL11B in T-cell acute lymphoblastic leukemia","volume":"19","author":"Zeng","year":"2024","journal-title":"Int. J. Nanomed."},{"key":"bmmae83f7bib152","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1021\/acs.bioconjchem.5c00065","type":"journal-article","article-title":"Aptamer-vs fab-conjugated liposomes: a comparative study in targeting acute myeloid leukemia cells","volume":"36","author":"Jin","year":"2025","journal-title":"Bioconjugate Chem."},{"key":"bmmae83f7bib153","doi-asserted-by":"publisher","first-page":"115","DOI":"10.3390\/biom15010115","type":"journal-article","article-title":"Lipopolymers as the basis of non-viral delivery of therapeutic siRNA nanoparticles in a leukemia (MOLM-13) model","volume":"15","author":"Yotsomnuk","year":"2025","journal-title":"Biomolecules"},{"key":"bmmae83f7bib154","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1038\/s41375-023-01854-8","type":"journal-article","article-title":"Nanoparticle-mediated targeting of the fusion gene RUNX1\/ETO in t (8; 21)-positive acute myeloid leukaemia","volume":"37","author":"Issa","year":"2023","journal-title":"Leukemia"},{"key":"bmmae83f7bib155","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.exphem.2022.05.001","type":"journal-article","article-title":"RUNX1 inhibition using lipid nanoparticle-mediated silencing RNA delivery as an effective treatment for acute leukemias","volume":"112","author":"Iida","year":"2022","journal-title":"Exp. Hematol."},{"key":"bmmae83f7bib156","doi-asserted-by":"publisher","first-page":"2015","DOI":"10.1021\/acs.molpharmaceut.0c01243","type":"journal-article","article-title":"Evaluation of the anticancer activity of pH-sensitive polyketal nanoparticles for acute myeloid leukemia","volume":"18","author":"Rajagopal","year":"2021","journal-title":"Mol. Pharm."},{"key":"bmmae83f7bib157","doi-asserted-by":"publisher","DOI":"10.1002\/adtp.202100100","type":"journal-article","article-title":"Nanoparticle\u2010mediated delivery of micheliolide analogs to eliminate leukemic stem cells in the bone marrow","volume":"5","author":"Ackun\u2010farmmer","year":"2022","journal-title":"Adv. Ther."},{"key":"bmmae83f7bib158","doi-asserted-by":"publisher","first-page":"2101","DOI":"10.1021\/acs.molpharmaceut.5b00071","type":"journal-article","article-title":"CD19-Targeted nanodelivery of doxorubicin enhances therapeutic efficacy in B-cell acute lymphoblastic leukemia","volume":"12","author":"Krishnan","year":"2015","journal-title":"Mol. Pharm."},{"key":"bmmae83f7bib159","doi-asserted-by":"publisher","first-page":"9791","DOI":"10.3390\/ijms23179791","type":"journal-article","article-title":"Co-formulation of amphiphilic cationic and anionic cyclodextrins forming nanoparticles for siRNA delivery in the treatment of acute myeloid leukaemia","volume":"23","author":"Kont","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"bmmae83f7bib160","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.117543","type":"journal-article","article-title":"Dual-aptamer-decorated reduction-activated dimeric-prodrug nanoparticles for broad-spectrum treatment of leukemia","volume":"180","author":"Yang","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"bmmae83f7bib161","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/j.actbio.2022.04.005","type":"journal-article","article-title":"Lipase-triggered drug release from BCL2 inhibitor ABT-199-loaded nanoparticles to elevate anti-leukemic activity through enhanced drug targeting on the mitochondrial membrane","volume":"145","author":"Liang","year":"2022","journal-title":"Acta Biomater."},{"key":"bmmae83f7bib162","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.bioelechem.2017.12.010","type":"journal-article","article-title":"A new composite consisting of electrosynthesized conducting polymers, graphene sheets and biosynthesized gold nanoparticles for biosensing acute lymphoblastic leukemia","volume":"121","author":"Mazloum-ardakani","year":"2018","journal-title":"Bioelectrochemistry"},{"key":"bmmae83f7bib163","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioelechem.2022.108176","type":"journal-article","article-title":"Electrochemical DNA biosensor for chronic myelocytic leukemia based on hybrid nanostructure","volume":"147","author":"Avelino","year":"2022","journal-title":"Bioelectrochemistry"},{"key":"bmmae83f7bib164","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1509322","type":"journal-article","article-title":"DNA-loaded targeted nanoparticles as a safe platform to produce exogenous proteins in tumor B cells","volume":"15","author":"Grimaldi","year":"2025","journal-title":"Front. Immunol."},{"key":"bmmae83f7bib165","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.matpr.2023.10.158","type":"journal-article","article-title":"In-house glutamine based compound loaded poly-(DL-lactide-coglycolide) nanoparticles as a possible candidate for the management of chronic myeloid leukemia","volume":"126","author":"Das","year":"2023","journal-title":"Mater. Today Proc."},{"key":"bmmae83f7bib166","doi-asserted-by":"publisher","first-page":"3960","DOI":"10.3390\/ma15113960","type":"journal-article","article-title":"Reduced cardiotoxicity of ponatinib-loaded PLGA-PEG-PLGA nanoparticles in zebrafish xenograft model","volume":"15","author":"Al-thani","year":"2022","journal-title":"Materials"},{"key":"bmmae83f7bib167","doi-asserted-by":"publisher","first-page":"8025","DOI":"10.2147\/IJN.S146875","type":"journal-article","article-title":"Cooperation of IRAK1\/4 inhibitor and ABT-737 in nanoparticles for synergistic therapy of T cell acute lymphoblastic leukemia","volume":"12","author":"Wu","year":"2017","journal-title":"Int. J. Nanomed."},{"key":"bmmae83f7bib168","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2147\/DDDT.S387246","type":"journal-article","article-title":"Binary nanodrug-delivery system designed for leukemia therapy: aptamer-and transferrin-codecorated daunorubicin-and luteolin-coloaded nanoparticles","volume":"17","author":"Zhu","year":"2023","journal-title":"Drug Des. Devel. Ther."},{"key":"bmmae83f7bib169","doi-asserted-by":"publisher","first-page":"142","DOI":"10.4103\/RPS.RPS_197_24","type":"journal-article","article-title":"Synthesis and in vitro evaluation of self-assembling biocompatible heparin-based targeting polymeric micelles for delivery of doxorubicin to leukemic cells","volume":"20","author":"Emami","year":"2025","journal-title":"Res. Pharm. Sci."},{"key":"bmmae83f7bib170","doi-asserted-by":"publisher","first-page":"52","DOI":"10.3390\/pharmaceutics10020052","type":"journal-article","article-title":"Wool-like hollow polymeric nanoparticles for CML chemo-combinatorial therapy","volume":"10","author":"Cortese","year":"2018","journal-title":"Pharmaceutics"},{"key":"bmmae83f7bib171","doi-asserted-by":"publisher","first-page":"8363","DOI":"10.2147\/IJN.S134756","type":"journal-article","article-title":"Encapsulation of Piper cabralanum (Piperaceae) nonpolar extract in poly (methyl methacrylate) by miniemulsion and evaluation of increase in the effectiveness of antileukemic activity in K562 cells","volume":"12","author":"Mendes","year":"2017","journal-title":"Int. J. Nanomed."},{"key":"bmmae83f7bib172","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.1021\/acs.bioconjchem.2c00232","type":"journal-article","article-title":"Role of common cell culture media supplements on citrate-stabilized gold nanoparticle protein corona formation, aggregation state, and the consequent impact on cellular uptake","volume":"33","author":"Barbero","year":"2022","journal-title":"Bioconjugate Chem."},{"key":"bmmae83f7bib173","doi-asserted-by":"publisher","first-page":"7173","DOI":"10.2147\/IJN.S221021","type":"journal-article","article-title":"Chitosan gold nanoparticles induce different ROS-dependent cell death modalities in leukemic cells","volume":"14","author":"Mart\u00ednez-torres","year":"2019","journal-title":"Int. J. Nanomed."},{"key":"bmmae83f7bib174","doi-asserted-by":"publisher","first-page":"399","DOI":"10.3390\/jfb14080399","type":"journal-article","article-title":"Optimization of tyrosine kinase inhibitor-loaded gold nanoparticles for stimuli-triggered antileukemic drug release","volume":"14","author":"Tatar","year":"2023","journal-title":"J. Funct. Biomater."},{"key":"bmmae83f7bib175","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1016\/j.colsurfb.2013.07.070","type":"journal-article","article-title":"Synthesis and characterization of jacalin-gold nanoparticles conjugates as specific markers for cancer cells","volume":"112","author":"Marangoni","year":"2013","journal-title":"Colloids Surf. B"},{"key":"bmmae83f7bib176","doi-asserted-by":"publisher","first-page":"6205","DOI":"10.2147\/IJN.S312752","type":"journal-article","article-title":"Chlorambucil-iron oxide nanoparticles as a drug delivery system for leukemia cancer cells","volume":"16","author":"Hussein-al-ali","year":"2021","journal-title":"Int. J. Nanomed."},{"key":"bmmae83f7bib177","doi-asserted-by":"publisher","first-page":"21346","DOI":"10.1021\/am5063025","type":"journal-article","article-title":"Poly (2-vinyl-4, 4-dimethylazlactone)-functionalized magnetic nanoparticles as carriers for enzyme immobilization and its application","volume":"6","author":"Mu","year":"2014","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"bmmae83f7bib178","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2021.118017","type":"journal-article","article-title":"Starch-based magnetic nanocomposite for targeted delivery of hydrophilic bioactives as anticancer strategy","volume":"264","author":"Sousa","year":"2021","journal-title":"Carbohydr. Polym."},{"key":"bmmae83f7bib179","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1186\/s12951-021-00921-5","type":"journal-article","article-title":"Self-assembling ferritin-dendrimer nanoparticles for targeted delivery of nucleic acids to myeloid leukemia cells","volume":"19","author":"Palombarini","year":"2021","journal-title":"J. Nanobiotechnol."},{"key":"bmmae83f7bib180","doi-asserted-by":"publisher","first-page":"1868","DOI":"10.1039\/D1NA00880C","type":"journal-article","article-title":"ZnO nanostructured materials and their potential applications: progress, challenges and perspectives","volume":"4","author":"Raha","year":"2022","journal-title":"Nanoscale Adv."},{"key":"bmmae83f7bib181","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1016\/j.msec.2015.11.063","type":"journal-article","article-title":"Synthesis of ZnPc loaded poly (methyl methacrylate) nanoparticles via miniemulsion polymerization for photodynamic therapy in leukemic cells","volume":"60","author":"Feuser","year":"2016","journal-title":"Mater. Sci. Eng. C"},{"key":"bmmae83f7bib182","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1007\/s12010-023-04590-y","type":"journal-article","article-title":"Polyamidoamine dendrimers functionalized with ZnO-chitosan nanoparticles as an efficient surface for l-asparaginase immobilization","volume":"196","author":"Iraninasab","year":"2024","journal-title":"Appl. Biochem. Biotechnol."},{"key":"bmmae83f7bib183","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15204","type":"journal-article","article-title":"Prolonged intracellular accumulation of light-inducible nanoparticles in leukemia cells allows their remote activation","volume":"8","author":"Boto","year":"2017","journal-title":"Nat. Commun."},{"key":"bmmae83f7bib184","doi-asserted-by":"publisher","first-page":"5245","DOI":"10.1039\/D1TB00548K","type":"journal-article","article-title":"Zwitterion-functionalized hollow mesoporous Prussian blue nanoparticles for targeted and synergetic chemo-photothermal treatment of acute myeloid leukemia","volume":"9","author":"Bai","year":"2021","journal-title":"J. Mater. Chem. B"},{"key":"bmmae83f7bib185","doi-asserted-by":"publisher","first-page":"33","DOI":"10.46235\/1028-7221-16996-IOG","type":"journal-article","article-title":"Influence of graphene oxide nanoparticles on functional activity of Jurkat cell line","volume":"28","author":"Usanina","year":"2025","journal-title":"Russ. J. Immunol."},{"key":"bmmae83f7bib186","doi-asserted-by":"publisher","first-page":"3618","DOI":"10.3390\/cancers15143618","type":"journal-article","article-title":"Therapeutic targeting potential of novel silver nanoparticles coated with anti-CD20 antibody against chronic lymphocytic leukemia","volume":"15","author":"Adamo","year":"2023","journal-title":"Cancers"},{"key":"bmmae83f7bib187","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2022.121163","type":"journal-article","article-title":"Utilization of novel lectin-conjugated Au nanoparticles as Thomsen-Friedenreich onco-antigen target for in vitro cytotoxicity and apoptosis induction in leukemic cell line","volume":"311","author":"Akram","year":"2022","journal-title":"Life Sci."},{"key":"bmmae83f7bib188","doi-asserted-by":"publisher","first-page":"2007","DOI":"10.3390\/cells11132007","type":"journal-article","article-title":"Some preliminary results to eradicate leukemic cells in extracorporeal circulation by actuating doxorubicin-loaded nanochains of Fe3O4 nanoparticles","volume":"11","author":"Zheng","year":"2022","journal-title":"Cells"},{"key":"bmmae83f7bib189","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.actbio.2022.03.030","type":"journal-article","article-title":"Glycyrrhetinic acid nanoparticles combined with ferrotherapy for improved cancer immunotherapy","volume":"144","author":"Li","year":"2022","journal-title":"Acta Biomater."},{"key":"bmmae83f7bib190","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2022.103572","type":"journal-article","article-title":"A combined arsenic trioxide\/tetrandrine nanoparticle formulation with improved inhibitory effect against promyelocytic leukemia","volume":"74","author":"Xu","year":"2022","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"bmmae83f7bib191","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1016\/j.bioactmat.2022.03.022","type":"journal-article","article-title":"A biomimetic nanocomposite with enzyme-like activities and CXCR4 antagonism efficiently enhances the therapeutic efficacy of acute myeloid leukemia","volume":"18","author":"Kong","year":"2022","journal-title":"Bioact. Mater."},{"key":"bmmae83f7bib192","doi-asserted-by":"publisher","first-page":"108","DOI":"10.5530\/pres.20251946","type":"journal-article","article-title":"Green synthesis of gold nanoparticles using sphaeranthus amaranthoides: drug loading and anticancer properties in nanomedicine","volume":"17","author":"Khan","year":"2025","journal-title":"Pharmacogn. Res."},{"key":"bmmae83f7bib193","doi-asserted-by":"publisher","first-page":"262","DOI":"10.34172\/PS.2024.4","type":"journal-article","article-title":"Biogenic zinc oxide nanoparticles attenuate Acute Lymphoblastic Leukemia Cell Proliferation through oxidative stress and DNA damage","volume":"30","author":"Sujatha","year":"2024","journal-title":"Pharm. Sci."},{"key":"bmmae83f7bib194","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-66650-5","type":"journal-article","article-title":"Anticancer efficacy of biosynthesized silver nanoparticles loaded with recombinant truncated parasporin-2 protein","volume":"14","author":"Srisaisap","year":"2024","journal-title":"Sci. Rep."},{"key":"bmmae83f7bib195","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1177\/07482337241227244","type":"journal-article","article-title":"Toxicity evaluation of silver nanoparticles synthesized from naringin flavonoid on human promyelocytic leukemic cells and human blood cells","volume":"40","author":"Soni","year":"2024","journal-title":"Toxicol. Ind. Health"},{"key":"bmmae83f7bib196","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-43978-y","type":"journal-article","article-title":"Synthesis of halloysite nanotubes decorated with green silver nanoparticles to investigate cytotoxicity, lipid peroxidation and induction of apoptosis in acute leukemia cells","volume":"13","author":"Zhang","year":"2023","journal-title":"Sci. Rep."},{"key":"bmmae83f7bib197","doi-asserted-by":"publisher","first-page":"437","DOI":"10.3390\/bioengineering10040437","type":"journal-article","article-title":"Green synthesis and antiproliferative activity of gold nanoparticles of a controlled size and shape obtained using shock wave extracts from amphipterygium adstringens","volume":"10","author":"Torres-ortiz","year":"2023","journal-title":"Bioengineering"},{"key":"bmmae83f7bib198","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2022.103342","type":"journal-article","article-title":"Green fabrication of copper oxide nanoparticles by Tragopogon collinus leaf extract: characterization and exploring their selective anticancer effects against human leukemia cell line","volume":"72","author":"Xie","year":"2022","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"bmmae83f7bib199","doi-asserted-by":"publisher","first-page":"404","DOI":"10.52547\/umj.33.6.404","type":"journal-article","article-title":"Effect of cytotoxicity of silver nanoparticles synthesized with thymus vulgaris extract on molt-4 leukemia cell line","volume":"33","author":"Shirmardi","year":"2022","journal-title":"Stud. Med. Sci."},{"key":"bmmae83f7bib200","doi-asserted-by":"publisher","first-page":"e5498","DOI":"10.1002\/aoc.5498","type":"journal-article","article-title":"Introducing a novel chemotherapeutic drug formulated by iron nanoparticles for the clinical trial studies","volume":"36","author":"Ma","year":"2022","journal-title":"Appl. Organomet. Chem."},{"key":"bmmae83f7bib201","doi-asserted-by":"publisher","first-page":"4697","DOI":"10.1007\/s12011-023-03574-7","type":"journal-article","article-title":"Investigating the effects of biogenic zinc oxide nanoparticles produced using papaver somniferum extract on oxidative stress, cytotoxicity, and the induction of apoptosis in the THP-1 cell line","volume":"201","author":"Kadhim","year":"2023","journal-title":"Biol. Trace Element Res."},{"key":"bmmae83f7bib202","doi-asserted-by":"publisher","first-page":"7323","DOI":"10.2147\/IJN.S467733","type":"journal-article","article-title":"Fe3O4-Coated CNTs-gum Arabic nano-hybrid composites exhibit enhanced anti-leukemia potency against AML cells via ROS-mediated signaling","volume":"19","author":"Abdel Halim","year":"2024","journal-title":"Int. J. Nanomed."},{"key":"bmmae83f7bib203","doi-asserted-by":"publisher","DOI":"10.1016\/j.inoche.2022.110171","type":"journal-article","article-title":"Green synthesis, chemical characterization of gold nanoparticles decorated on biodegradable arabic gum modified magnetic nanoparticles for the treatment of leukemia","volume":"146","author":"Lin","year":"2022","journal-title":"Inorg. Chem. Commun."},{"key":"bmmae83f7bib204","doi-asserted-by":"publisher","DOI":"10.1016\/j.jorganchem.2025.123657","type":"journal-article","article-title":"Ultrasound assisted green synthesis of lignosulfonate-copper nanocomposite: investigation of its application in the Ullmann type CN coupling reactions followed by study of anti-leukemia cancer effects","volume":"1034","author":"El-kott","year":"2025","journal-title":"J. Organomet Chem."},{"key":"bmmae83f7bib205","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1007\/s10904-023-02751-4","type":"journal-article","article-title":"Synthesis of gold nanoparticles encapsulated chitosan\/gelatin polymers for the treatment of several types of leukemia","volume":"34","author":"Ma","year":"2024","journal-title":"J. Inorg. Organomet Polym. Mater."},{"key":"bmmae83f7bib206","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1016\/j.jconrel.2024.03.022","type":"journal-article","article-title":"STING-activating cyclic dinucleotide-manganese nanoparticles evoke robust immunity against acute myeloid leukemia","volume":"368","author":"Aikins","year":"2024","journal-title":"J. Control. Release"},{"key":"bmmae83f7bib207","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.1016\/j.jcis.2024.07.075","type":"journal-article","article-title":"An investigation of quantum dot theranostic probes for prostate and leukemia cancer cells using a CdZnSeS QD-based nanoformulation","volume":"675","author":"Tan","year":"2024","journal-title":"J. Colloid Interface Sci."},{"key":"bmmae83f7bib208","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1007\/s11033-024-09914-7","type":"journal-article","article-title":"Development of mesoporous magnetic nanoparticles supported idarubicin and investigation of apoptotic and cytotoxic effects on cancer cell lines","volume":"51","author":"Ulusal","year":"2024","journal-title":"Mol. Biol. Rep."},{"key":"bmmae83f7bib209","doi-asserted-by":"publisher","first-page":"402","DOI":"10.3390\/pharmaceutics16030402","type":"journal-article","article-title":"Combined delivery of miR-15\/16 through humanized ferritin nanocages for the treatment of chronic lymphocytic leukemia","volume":"16","author":"Liberati","year":"2024","journal-title":"Pharmaceutics"},{"key":"bmmae83f7bib210","doi-asserted-by":"publisher","first-page":"22128","DOI":"10.1021\/acsanm.3c04297","type":"journal-article","article-title":"Hollow mesoporous Prussian blue nanoparticles loaded with daunorubicin for acute myeloid leukemia treatment","volume":"6","author":"Li","year":"2023","journal-title":"ACS Appl. Nano Mater."},{"key":"bmmae83f7bib211","doi-asserted-by":"publisher","first-page":"140","DOI":"10.18502\/ijhoscr.v16i3.10136","type":"journal-article","article-title":"Anticancer effects of ZnO\/CNT@ Fe3O4 in AML-derived KG1 cells: shedding light on promising potential of metal nanoparticles in acute leukemia","volume":"16","author":"Yousefi","year":"2022","journal-title":"Int. J. Hematol.-Oncol. Stem Cell Res."},{"key":"bmmae83f7bib212","doi-asserted-by":"publisher","first-page":"2811","DOI":"10.1182\/blood.V110.11.2811.2811","type":"journal-article","article-title":"Toxicities of Intravenous (IV) Pegasparaginase (ONCASPAR\u00ae) in Adults with Acute Lymphoblastic Leukemia (ALL)","volume":"110","author":"Advani","year":"2007","journal-title":"Blood"},{"key":"bmmae83f7bib213","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/j.ijrobp.2013.02.009","type":"journal-article","article-title":"Preclinical evaluation of Genexol-PM, a nanoparticle formulation of paclitaxel, as a novel radiosensitizer for the treatment of non-small cell lung cancer","volume":"86","author":"Werner","year":"2013","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"bmmae83f7bib214","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1634\/theoncologist.12-8-991","type":"journal-article","article-title":"FDA drug approval summary: pegaspargase (Oncaspar\u00ae) for the first-line treatment of children with acute lymphoblastic leukemia (ALL)","volume":"12","author":"Dinndorf","year":"2007","journal-title":"Oncologist"},{"key":"bmmae83f7bib215","doi-asserted-by":"publisher","first-page":"774","DOI":"10.3390\/pharmaceutics15030774","type":"journal-article","article-title":"Approved nanomedicine against diseases","volume":"15","author":"Jia","year":"2023","journal-title":"Pharmaceutics"},{"key":"bmmae83f7bib216","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3390\/pharmaceutics9020012","type":"journal-article","article-title":"Liposomal formulations in clinical use: an updated review","volume":"9","author":"Bulbake","year":"2017","journal-title":"Pharmaceutics"},{"key":"bmmae83f7bib217","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2024.122615","type":"journal-article","article-title":"Oncology\u2019s trial and error: analysis of the FDA withdrawn accelerated approvals","volume":"346","author":"Preziosi","year":"2024","journal-title":"Life Sci."},{"key":"bmmae83f7bib218","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2025.2494781","type":"journal-article","article-title":"Biomaterial-based drug delivery: evaluating the safety profiles of liposomal Vyxeos","volume":"32","author":"Liu","year":"2025","journal-title":"Drug Deliv."},{"key":"bmmae83f7bib219","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.sajce.2023.08.009","type":"journal-article","article-title":"An overview of nanoparticles in drug delivery: properties and applications","volume":"46","author":"Hsu","year":"2023","journal-title":"South Afr. J. Chem. Eng."},{"key":"bmmae83f7bib220","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1208\/s12248-012-9339-4","type":"journal-article","article-title":"Challenges in development of nanoparticle-based therapeutics","volume":"14","author":"Desai","year":"2012","journal-title":"AAPS J."},{"key":"bmmae83f7bib221","doi-asserted-by":"publisher","first-page":"2219","DOI":"10.3390\/polym15092219","type":"journal-article","article-title":"Design and application of hybrid polymer-protein systems in cancer therapy","volume":"15","author":"Sun","year":"2023","journal-title":"Polymers"},{"key":"bmmae83f7bib222","doi-asserted-by":"publisher","DOI":"10.1016\/j.onano.2022.100048","type":"journal-article","article-title":"Scale-up polymeric-based nanoparticles drug delivery systems: development and challenges","volume":"7","author":"Herdiana","year":"2022","journal-title":"OpenNano"},{"key":"bmmae83f7bib223","doi-asserted-by":"publisher","first-page":"e5369","DOI":"10.1002\/aoc.5369","type":"journal-article","article-title":"Green formulation and chemical characterization of Lens culinaris seed aqueous extract conjugated gold nanoparticles for the treatment of acute myeloid leukemia in comparison to mitoxantrone in a leukemic mouse model","volume":"34","author":"Ahmeda","year":"2020","journal-title":"Appl. Organomet. Chem."},{"key":"bmmae83f7bib224","doi-asserted-by":"publisher","DOI":"10.1016\/j.omto.2023.100751","type":"journal-article","article-title":"Bispecific CD33\/CD123 targeted chimeric antigen receptor T cells for the treatment of acute myeloid leukemia","volume":"31","author":"Boucher","year":"2023","journal-title":"Mol. Ther.-Oncol."},{"key":"bmmae83f7bib225","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s40580-019-0193-2","type":"journal-article","article-title":"Current trends and challenges in cancer management and therapy using designer nanomaterials","volume":"6","author":"Navya","year":"2019","journal-title":"Nano Convergence"},{"key":"bmmae83f7bib226","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1080\/10717544.2017.1333170","type":"journal-article","article-title":"Anti-CD123 antibody-modified niosomes for targeted delivery of daunorubicin against acute myeloid leukemia","volume":"24","author":"Liu","year":"2017","journal-title":"Drug Deliv."},{"key":"bmmae83f7bib227","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1177\/0885328217712111","type":"journal-article","article-title":"Identification and imaging of leukemia cells using dual-aptamer-functionalized graphene oxide complex","volume":"32","author":"Bahreyni","year":"2017","journal-title":"J. Biomater. Appl."},{"key":"bmmae83f7bib228","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/j.apsb.2019.01.011","type":"journal-article","article-title":"Red blood cell membrane-camouflaged nanoparticles: a novel drug delivery system for antitumor application","volume":"9","author":"Xia","year":"2019","journal-title":"Acta Pharm. Sin. B"},{"key":"bmmae83f7bib229","doi-asserted-by":"publisher","first-page":"8474","DOI":"10.1021\/ja2120234","type":"journal-article","article-title":"Trehalose glycopolymers for stabilization of protein conjugates to environmental stressors","volume":"134","author":"Mancini","year":"2012","journal-title":"J. Am. Chem. Soc."},{"key":"bmmae83f7bib230","doi-asserted-by":"publisher","first-page":"5609","DOI":"10.3390\/molecules26185609","type":"journal-article","article-title":"Biomimetic cascade polymer nanoreactors for starvation and photodynamic cancer therapy","volume":"26","author":"Liu","year":"2021","journal-title":"Molecules"},{"key":"bmmae83f7bib231","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1038\/s41565-021-01017-9","type":"journal-article","article-title":"The ancillary effects of nanoparticles and their implications for nanomedicine","volume":"16","author":"Stater","year":"2021","journal-title":"Nat. Nanotechnol."},{"key":"bmmae83f7bib232","doi-asserted-by":"publisher","first-page":"99","DOI":"10.3109\/1547691X.2013.821564","type":"journal-article","article-title":"Immunogenicity of therapeutic proteins: influence of aggregation","volume":"11","author":"Ratanji","year":"2014","journal-title":"J. Immunotoxicol."},{"key":"bmmae83f7bib233","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/j.colsurfa.2014.01.043","type":"journal-article","article-title":"PEGylation of surfacted magnetite core\u2013shell nanoparticles for biomedical application","volume":"460","author":"Ill\u00e9s","year":"2014","journal-title":"Colloids Surf. A"},{"key":"bmmae83f7bib234","doi-asserted-by":"publisher","first-page":"e5378","DOI":"10.1002\/aoc.5378","type":"journal-article","article-title":"Preparation, formulation, and chemical characterization of silver nanoparticles using Melissa officinalis leaf aqueous extract for the treatment of acute myeloid leukemia in vitro and in vivo conditions","volume":"34","author":"Ahmeda","year":"2020","journal-title":"Appl. Organomet. Chem."},{"key":"bmmae83f7bib235","doi-asserted-by":"publisher","first-page":"4563","DOI":"10.2147\/IJN.S112204","type":"journal-article","article-title":"D-\u03b1-Tocopheryl polyethylene glycol succinate\/Solutol HS 15 mixed micelles for the delivery of baohuoside I against non-small-cell lung cancer: optimization and in vitro, in vivo evaluation","volume":"11","author":"Yan","year":"2016","journal-title":"Int. J. Nanomed."},{"key":"bmmae83f7bib236","doi-asserted-by":"publisher","first-page":"2684","DOI":"10.1200\/JCO.2017.77.6112","type":"journal-article","article-title":"CPX-351 (cytarabine and daunorubicin) liposome for injection versus conventional cytarabine plus daunorubicin in older patients with newly diagnosed secondary acute myeloid leukemia","volume":"36","author":"Lancet","year":"2018","journal-title":"J. Clin. Oncol."}],"container-title":["Biomedical Materials"],"original-title":[],"link":[{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ae83f7","content-type":"text\/html","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ae83f7\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ae83f7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ae83f7\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ae83f7\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ae83f7\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ae83f7\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"similarity-checking"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ae83f7\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T06:07:44Z","timestamp":1784873264000},"score":1,"resource":{"primary":{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ae83f7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,24]]},"references-count":236,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,7,24]]},"published-print":{"date-parts":[[2026,8,1]]}},"URL":"https:\/\/doi.org\/10.1088\/1748-605x\/ae83f7","relation":{},"ISSN":["1748-6041","1748-605X"],"issn-type":[{"value":"1748-6041","type":"print"},{"value":"1748-605X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,24]]},"assertion":[{"value":"A review on assessment of advances in polymers and their hybrid nanosystem for leukaemia theranostics applications","name":"article_title","label":"Article Title"},{"value":"Biomedical Materials","name":"journal_title","label":"Journal Title"},{"value":"paper","name":"article_type","label":"Article Type"},{"value":"\u00a9 2026 IOP Publishing Ltd. All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2026-02-19","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2026-06-29","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2026-07-24","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}