{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T08:07:03Z","timestamp":1784016423034,"version":"3.55.0"},"reference-count":31,"publisher":"IOP Publishing","issue":"4","license":[{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/iop-standard\/v1"},{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/questions\/alternative-author-rights-policies\/"},{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/questions\/alternative-author-rights-policies\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["32271377"],"award-info":[{"award-number":["32271377"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Biomed. Mater."],"published-print":{"date-parts":[[2026,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Drug-eluting stents effectively reduce restenosis but are hampered by delayed re-endothelialization and chronic inflammation, which can trigger late thrombosis. Addressing this requires a surface that simultaneously promotes rapid endothelial repair, inhibits thrombosis, and modulates the local immune environment. Herein, we report a rationally designed dual-peptide coating on a titanium stent material, fabricated via a sequential orthogonal chemical coupling strategy. An antifouling polyethylene glycol (PEG) layer was first immobilized on a polydopamine base, followed by the controlled, stepwise grafting of the endothelial progenitor cell (EPC)-specific TPS peptide and the bifunctional DGEA peptide. This approach allows for precise tuning of the peptide ratio. The resulting TPS\/DGEA coating demonstrated a temporal synergy in promoting endothelialization: the TPS moiety was responsible for the specific and efficient capture of EPCs, while the DGEA moiety subsequently enhanced the spreading and proliferation of both captured EPCs and mature endothelial cells, accelerating the formation of a confluent endothelium. Crucially, leveraging the intrinsic bifunctionality of the immobilized DGEA peptide, the coating significantly suppressed M1 macrophage polarization and reduced pro-inflammatory TNF-\n                    <jats:italic>\u03b1<\/jats:italic>\n                    secretion, demonstrating potent immunomodulatory effects. Furthermore, the coating exhibited superior hemocompatibility through a dual-mechanism anticoagulation approach, combining the passive protein resistance of the PEG layer with the active molecular antagonism of the DGEA peptide against platelet integrin\n                    <jats:italic>\u03b1<\/jats:italic>\n                    <jats:sub>2<\/jats:sub>\n                    <jats:italic>\u03b2<\/jats:italic>\n                    <jats:sub>1<\/jats:sub>\n                    , which collectively inhibited platelet adhesion\/activation and prolonged coagulation times. In an\n                    <jats:italic>ex vivo<\/jats:italic>\n                    circulation model, the dual-peptide coating dramatically reduced thrombus formation. This integrated strategy, which combines precise control over peptide presentation with the synergistic functions of EPC recruitment, immune modulation, and multi-mechanism anticoagulation, presents a promising and versatile platform for engineering the next generation of advanced cardiovascular stents.\n                  <\/jats:p>","DOI":"10.1088\/1748-605x\/ae8599","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T22:54:41Z","timestamp":1783032881000},"page":"045011","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["A sequentially orthogonal dual-peptide (TPS\/DGEA) coating with synergistic anticoagulant, anti-inflammatory and pro-endothelialization functions for vascular stents"],"prefix":"10.1088","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-6924-4343","authenticated-orcid":true,"given":"Huaishi","family":"Chen","sequence":"first","affiliation":[{"name":"Key Laboratory of Advanced Technology of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qihao","family":"Bian","sequence":"additional","affiliation":[{"name":"Key Laboratory of Advanced Technology of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Pei","sequence":"additional","affiliation":[{"name":"Key Laboratory of Advanced Technology of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyu","family":"Su","sequence":"additional","affiliation":[{"name":"School of Life Science and Engineering, Southwest Jiaotong University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyuan","family":"Xue","sequence":"additional","affiliation":[{"name":"Key Laboratory of Advanced Technology of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kangli","family":"Lei","sequence":"additional","affiliation":[{"name":"Key Laboratory of Advanced Technology of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenzhai","family":"Cao","sequence":"additional","affiliation":[{"name":"Zigong first people\u2019s hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8882-6912","authenticated-orcid":true,"given":"Junying","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Advanced Technology of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2026,7,14]]},"reference":[{"key":"bmmae8599bib1","doi-asserted-by":"publisher","first-page":"1705","DOI":"10.3390\/diagnostics15131705","type":"journal-article","article-title":"The big data era in cardiology and cardiovascular medicine: advanced analytics for truly personalized care","volume":"15","author":"Ambrosino","year":"2025","journal-title":"Diagnostics"},{"key":"bmmae8599bib2","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2025.109914","type":"journal-article","article-title":"Patient-specific coronary angioplasty simulations\u2014a mixed-dimensional finite element modeling approach","volume":"189","author":"Datz","year":"2025","journal-title":"Comput. 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All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2026-03-21","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2026-07-02","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2026-07-14","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}