{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T07:05:57Z","timestamp":1784703957269,"version":"3.55.0"},"reference-count":56,"publisher":"IOP Publishing","issue":"4","license":[{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/iop-standard\/v1"},{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/questions\/alternative-author-rights-policies\/"},{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/questions\/alternative-author-rights-policies\/"},{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/questions\/alternative-author-rights-policies\/"},{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/questions\/alternative-author-rights-policies\/"}],"funder":[{"name":"Intramural Scientific Research Project of Gansu Provincial Hospital","award":["21GSSYB-21"],"award-info":[{"award-number":["21GSSYB-21"]}]},{"DOI":"10.13039\/501100004775","name":"Natural Science Foundation of Gansu Province of China","doi-asserted-by":"crossref","award":["21JR7RA631"],"award-info":[{"award-number":["21JR7RA631"]}],"id":[{"id":"10.13039\/501100004775","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Biomed. Mater."],"published-print":{"date-parts":[[2026,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Enterococcus faecalis<\/jats:italic>\n                    (\n                    <jats:italic>E. faecalis<\/jats:italic>\n                    ), a leading pathogen associated with severe nosocomial infections, poses a major control challenge owing to its widespread multidrug resistance. Current first-line therapies for\n                    <jats:italic>E. faecalis<\/jats:italic>\n                    infections combine ampicillin (Amp) with gentamicin or ceftriaxone, yet this approach is plagued by inherent toxicity and a tendency to promote drug-resistant strain colonization. To explore novel strategies against\n                    <jats:italic>E. faecalis<\/jats:italic>\n                    infections, we devised a combined treatment regimen consisting of methimazole (MMI) -melamine (Mel) co-functionalized gold nanoparticles (Au NPs, Mel-MMI@Au NPs) and Amp. Experiments demonstrated that Mel-MMI@Au NPs outperformed their single-ligand counterparts (Mel@Au NPs or MMI@Au NPs) in both stability and antibacterial activity. By disrupting bacterial cell membranes, Mel-MMI@Au NPs enhance Amp penetration across bacterial barriers for targeted inhibition, reducing Amp\u2019s minimum inhibitory concentration (MIC) by eightfold. The fractional inhibitory concentration index of the combination was determined to be 0.375 (below the synergism threshold of 0.5), confirming a robust synergistic antibacterial effect. This dual-modified Au NPs\u2013antibiotic strategy achieves low-dose synergistic bactericidal activity, delays resistance evolution, and ensures favorable biosafety, thereby overcoming the limitations of single antibiotics and representing a promising approach against multidrug-resistant\n                    <jats:italic>E. faecalis<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1088\/1748-605x\/ae859a","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T22:54:47Z","timestamp":1783032887000},"page":"045018","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Restoration of ampicillin susceptibility in drug-resistant\n                    <i>enterococcus faecalis<\/i>\n                    via synergistic therapy with co-functionalized gold nanoparticles"],"prefix":"10.1088","volume":"21","author":[{"given":"Qingqing","family":"Li","sequence":"first","affiliation":[{"name":"Department of Stomatology, Gansu Provincial Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingzhi","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Stomatology, Lanzhou University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8858-6011","authenticated-orcid":true,"given":"Peng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Gansu Provincial Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2026,7,22]]},"reference":[{"key":"bmmae859abib1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201901872)","type":"journal-article","article-title":"Considerations and caveats in combating ESKAPE pathogens against nosocomial infections","volume":"7","author":"Ma","year":"2019","journal-title":"Adv. Sci."},{"key":"bmmae859abib2","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.jcis.2024.11.163","type":"journal-article","article-title":"Bimetallic nanozymes for effectively removing, Enterococcus faecalis biofilms in pulp and periapical infection treatment","volume":"681","author":"Qiao","year":"2025","journal-title":"J. Colloid Interface Sci."},{"key":"bmmae859abib3","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.mib.2013.01.006","type":"journal-article","article-title":"Genomic transition of enterococci from gut commensals to leading causes of multidrug-resistant hospital infection in the antibiotic era","volume":"16","author":"Gilmore","year":"2013","journal-title":"Curr. Opin. Microbiol."},{"key":"bmmae859abib4","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1186\/s12879-020-05179-0","type":"journal-article","article-title":"Identification of Enterococcus faecalis in a patient with urinary-tract infection based on metagenomic next-generation sequencing: a case report","volume":"20","author":"Li","year":"2020","journal-title":"BMC Infect. Dis."},{"key":"bmmae859abib5","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1093\/cid\/ciz054","type":"journal-article","article-title":"Combination antimicrobial therapy for Enterococcus faecalis infective endocarditis","volume":"69","author":"Koehler","year":"2019","journal-title":"Clin. Infect. Dis."},{"key":"bmmae859abib6","doi-asserted-by":"publisher","first-page":"2173","DOI":"10.1093\/jac\/dkaa129","type":"journal-article","article-title":"In vivo synergism of ampicillin, gentamicin, ceftaroline and ceftriaxone against, Enterococcus faecalis assessed in the galleria mellonella infection model","volume":"75","author":"Thieme","year":"2020","journal-title":"J. Antimicrob. Chemother."},{"key":"bmmae859abib7","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1089\/mdr.2017.0049","type":"journal-article","article-title":"Occurrence of Enterococcus faecalis and Enterococcus faecium in various clinical infections: detection of their drug resistance and virulence determinants","volume":"24","author":"Jahansepas","year":"2018","journal-title":"Microb. Drug Resist."},{"key":"bmmae859abib8","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1038\/s41538-026-00790-y","type":"journal-article","article-title":"Extensively drug-resistant and heat-resistant Enterococcus faecalis and Enterococcus faecium in ready-to-eat meat products","volume":"10","author":"Sallam","year":"2026","journal-title":"npj Sci. Food."},{"key":"bmmae859abib9","doi-asserted-by":"publisher","first-page":"e00291","DOI":"10.1128\/AAC.00291-19","type":"journal-article","article-title":"Prospective observational study of the clinical prognoses of patients with bloodstream infections caused by ampicillin-susceptible but penicillin-resistant, Enterococcus faecalis","volume":"63","author":"Kim","year":"2019","journal-title":"Antimicrob. Agents Chemother."},{"key":"bmmae859abib10","doi-asserted-by":"publisher","first-page":"3075","DOI":"10.1714\/2214.23904","type":"journal-article","article-title":"ESC guidelines for the management of infective endocarditis: the task force for the management of infective endocarditis of the European society of cardiology (ESC) endorsed by: European association for cardio-thoracic surgery (EACTS), the European association of nuclear medicine (EANM)","volume":"36","author":"Habib","year":"2015","journal-title":"Eur. Heart J."},{"key":"bmmae859abib11","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1093\/cid\/ciy064","type":"journal-article","article-title":"A review of combination antimicrobial therapy for Enterococcus faecalis bloodstream infections and infective endocarditis","volume":"67","author":"Beganovic","year":"2018","journal-title":"Clin. Infect. Dis."},{"key":"bmmae859abib12","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1093\/cid\/cit052","type":"journal-article","article-title":"Ampicillin plus ceftriaxone is as effective as ampicillin plus gentamicin for treating Enterococcus faecalis infective endocarditis","volume":"56","author":"Fern\u00e1ndez-hidalgo","year":"2013","journal-title":"Clin. Infect. Dis."},{"key":"bmmae859abib13","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.1093\/jac\/dky051","type":"journal-article","article-title":"In vitro synergism and anti-biofilm activity of ampicillin, gentamicin, ceftaroline and ceftriaxone against Enterococcus faecalis","volume":"73","author":"Thieme","year":"2018","journal-title":"J. Antimicrob. Chemother."},{"key":"bmmae859abib14","doi-asserted-by":"publisher","first-page":"2162","DOI":"10.1086\/425580","type":"journal-article","article-title":"In vitro antienterococcal activity explains associations between exposures to antimicrobial agents and risk of colonization by multiresistant enterococci","volume":"190","author":"Rice","year":"2004","journal-title":"J. Infect. Dis."},{"key":"bmmae859abib15","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1007\/s11033-026-11786-y","type":"journal-article","article-title":"Phenotypic and genomic characterization of antimicrobial resistance in vancomycin-resistant Enterococcus faecalis","volume":"53","author":"Parmar","year":"2026","journal-title":"Mol. Biol. Rep."},{"key":"bmmae859abib16","doi-asserted-by":"publisher","first-page":"3030","DOI":"10.1021\/acsanm.1c03891","type":"journal-article","article-title":"Synergistic effects between metal nanoparticles and commercial antimicrobial agents a review","volume":"5","author":"Ribeiro","year":"2022","journal-title":"ACS Appl. Nano Mater."},{"key":"bmmae859abib17","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1080\/14686996.2021.1978801","type":"journal-article","article-title":"Current approaches for the exploration of antimicrobial activities of nanoparticles","volume":"22","author":"Rosli","year":"2021","journal-title":"Sci. Technol. Adv. Mater."},{"key":"bmmae859abib18","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2024.151257","type":"journal-article","article-title":"The impact of pistacia khinjuk plant gender on silver nanoparticle synthesis: are extracts of root obtained from female plants preferentially used?","volume":"746","author":"Tural","year":"2025","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"bmmae859abib19","doi-asserted-by":"publisher","DOI":"10.1002\/slct.202402117","type":"journal-article","article-title":"Comparative study on silver nanoparticle synthesis using male and female pistacia khinjuk leaf extracts: enhanced efficacy of female leaf extracts","volume":"9","author":"Tural","year":"2024","journal-title":"ChemistrySelect"},{"key":"bmmae859abib20","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1007\/s44445-025-00019-w","type":"journal-article","article-title":"Management of enterococcus faecalis associated endodontic infection using gold nanogel: an in-vitro study","volume":"37","author":"Sultan","year":"2025","journal-title":"Saudi Dent. J."},{"key":"bmmae859abib21","doi-asserted-by":"publisher","DOI":"10.1088\/2043-6262\/ada0b5)","type":"journal-article","article-title":"Antibacterial and antibiofilm activity of biogenic Se-Au nanoparticles against most prevalent pathogenic bacteria","volume":"16","author":"Hosseini","year":"2025","journal-title":"Adv. Nat. Sci.: Nanosci. Nanotechnol."},{"key":"bmmae859abib22","doi-asserted-by":"publisher","DOI":"10.1016\/j.rechem.2025.102323","type":"journal-article","article-title":"Green synthesis of gold nanoparticles supported over the myrtus communis L extract modified magnetic iron oxide as a novel antibacterial agent","volume":"15","author":"Moradi","year":"2025","journal-title":"Results Chem."},{"key":"bmmae859abib23","doi-asserted-by":"publisher","first-page":"3973","DOI":"10.1007\/s00253-022-12001-1","type":"journal-article","article-title":"Synergism between metallic nanoparticles and antibiotics","volume":"106","author":"Agreles","year":"2022","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"bmmae859abib24","doi-asserted-by":"publisher","first-page":"2885","DOI":"10.1007\/s40843-022-2459-3","type":"journal-article","article-title":"Leveraging bimetallic nanoparticles to synergistically enhance the efficacy of antibiotics against carbapenem-resistant bacteria","volume":"66","author":"Zhao","year":"2023","journal-title":"Sci. China Mater."},{"key":"bmmae859abib25","doi-asserted-by":"publisher","first-page":"8915","DOI":"10.3390\/ijms25168915","type":"journal-article","article-title":"Recent advances in the development of metal\/metal oxide nanoparticle and antibiotic conjugates (MNP-antibiotics) to address antibiotic resistance review and perspective","volume":"25","author":"Abdullah","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"bmmae859abib26","doi-asserted-by":"publisher","DOI":"10.1063\/5.0060299","type":"journal-article","article-title":"Metal-based nanoparticles for combating antibiotic resistance","volume":"8","author":"Altun","year":"2021","journal-title":"Appl. Phys. Rev."},{"key":"bmmae859abib27","doi-asserted-by":"publisher","first-page":"4029","DOI":"10.1021\/nl202559p","type":"journal-article","article-title":"Gold nanoparticles a revival inprecious metal administration to patients","volume":"11","author":"Thakor","year":"2011","journal-title":"Nano Lett."},{"key":"bmmae859abib28","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1038\/nnano.2007.223","type":"journal-article","article-title":"Immunological properties of engineered nanomaterials","volume":"2","author":"Dobrovolskaia","year":"2007","journal-title":"Nat. Nanotechnol."},{"key":"bmmae859abib29","doi-asserted-by":"publisher","first-page":"9425","DOI":"10.1021\/acsami.5c22655","type":"journal-article","article-title":"Repurposing a nonessential amino acid \u03b3-aminobutyric acid to treat multidrug-resistant bacteria","volume":"18","author":"Jia","year":"2026","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"bmmae859abib30","doi-asserted-by":"publisher","first-page":"9572","DOI":"10.1021\/acsnano.6c02349","type":"journal-article","article-title":"Gold nanoparticles regulate gut microbiota and immune responses for overcoming iron supplementation side effects in anemia therapy","volume":"20","author":"Zhang","year":"2026","journal-title":"ACS Nano"},{"key":"bmmae859abib31","doi-asserted-by":"publisher","author":"Iglesias","year":"2016","DOI":"10.1016\/j.infect.2014.02.003","type":"book"},{"key":"bmmae859abib32","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1038\/s41429-022-00513-x","type":"journal-article","article-title":"Methimazole and \u03b1-lipoic acid as metallo-\u03b2-lactamases inhibitors","volume":"75","author":"Zhang","year":"2022","journal-title":"J. Antibiot."},{"key":"bmmae859abib33","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1128\/JCM.05640-11","type":"journal-article","article-title":"Polyclonal diffusion of beta-lactamase-producing Enterococcus faecium","volume":"50","author":"Sarti","year":"2012","journal-title":"J. Clin. Microbiol."},{"key":"bmmae859abib34","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1089\/mdr.2019.0504","type":"journal-article","article-title":"Penicillin-resistant ampicillin-susceptible Enterococcus faecalis in Polish hospitals","volume":"27","author":"Gawryszewska","year":"2021","journal-title":"Microb. Drug Resist."},{"key":"bmmae859abib35","doi-asserted-by":"publisher","first-page":"12940","DOI":"10.1021\/ja4058635","type":"journal-article","article-title":"Synergy of non-antibiotic drugs and pyrimidinethiol on gold nanoparticles against superbugs","volume":"135","author":"Zhao","year":"2013","journal-title":"J. Am. Chem. Soc."},{"key":"bmmae859abib36","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1042\/bj2170027","type":"journal-article","article-title":"Effects of exogenous amines on mammalian cells with particular reference to membrane flow","volume":"217","author":"Dean","year":"1984","journal-title":"Biochem. J."},{"key":"bmmae859abib37","doi-asserted-by":"publisher","DOI":"10.1002\/smsc.202500632","type":"journal-article","article-title":"Drastic enhancement of activity and durability for oxygen reduction reaction by melamine modification for platinum nanocluster\u2010loaded electrocatalysts","volume":"6","author":"Kurosaki","year":"2026","journal-title":"Small Sci."},{"key":"bmmae859abib38","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1038\/s44259-024-00051-6","type":"journal-article","article-title":"Antibiotic susceptibility testing using minimum inhibitory concentration (MIC) assays","volume":"2","author":"Kade\u0159\u00e1bkov\u00e1","year":"2024","journal-title":"npj Antimicrob. Resist."},{"key":"bmmae859abib39","doi-asserted-by":"publisher","first-page":"3393","DOI":"10.2147\/IJN.S246310","type":"journal-article","article-title":"Comparative study of antibacterial effects of titanium dioxide nanoparticles alone and in combination with antibiotics on MDR pseudomonas aeruginosa","volume":"15","author":"Ahmed","year":"2020","journal-title":"Strains Int. J. Nanomed."},{"key":"bmmae859abib40","doi-asserted-by":"publisher","first-page":"3178","DOI":"10.1128\/AAC.03126-15","type":"journal-article","article-title":"Ampicillin in combination with ceftaroline, cefepime, or ceftriaxone demonstrates equivalent activities in a high-inoculum enterococcus faecalis infection model","volume":"60","author":"Luther","year":"2016","journal-title":"Antimicrob. Agents Chemother."},{"key":"bmmae859abib41","doi-asserted-by":"publisher","DOI":"10.1016\/j.rser.2023.113854","type":"journal-article","article-title":"A review on nanofluid stability preparation and application","volume":"2023","author":"Wang","year":"2023","journal-title":"Renew. Sustain. Energy Rev."},{"key":"bmmae859abib42","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1007\/s10562-011-0632-0","type":"journal-article","article-title":"Finite size effects in chemical bonding from small clusters to solids","volume":"141","author":"Kleis","year":"2011","journal-title":"Catal. Lett."},{"key":"bmmae859abib43","doi-asserted-by":"publisher","first-page":"5882","DOI":"10.1021\/la060045z","type":"journal-article","article-title":"Formation of gold nanoparticles using amine reducing agents","volume":"22","author":"Newman","year":"2006","journal-title":"Langmuir"},{"key":"bmmae859abib44","doi-asserted-by":"publisher","first-page":"29398","DOI":"10.1021\/acsami.8b11980","type":"journal-article","article-title":"Indole derivative-capped gold nanoparticles as an effective bactericide in vivo","volume":"10","author":"Zhao","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"bmmae859abib45","doi-asserted-by":"publisher","first-page":"7133","DOI":"10.1038\/s41598-021-86628-x","type":"journal-article","article-title":"Effect of 17\u03b2-estradiol on a human vaginal lactobacillus crispatus strain","volume":"11","author":"Clabaut","year":"2021","journal-title":"Sci. Rep."},{"key":"bmmae859abib46","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.pbiomolbio.2007.05.001","type":"journal-article","article-title":"Fluorescence polarization in studies of bacterial cytoplasmic membrane fluidity under environmental stress","volume":"95","author":"Mykytczuk","year":"2007","journal-title":"Prog. Biophys. Mol. Biol."},{"key":"bmmae859abib47","doi-asserted-by":"publisher","first-page":"47","DOI":"10.3390\/pathogens7020047","type":"journal-article","article-title":"Different dose-dependent modes of action of C-type natriuretic peptide on pseudomonas aeruginosa biofilm formation","volume":"7","author":"Desriac","year":"2018","journal-title":"Pathogens"},{"key":"bmmae859abib48","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241210226","type":"journal-article","article-title":"Effects of hydrophobic gold nanoparticles on structure and fluidity of SOPC lipid membranes","volume":"24","author":"Santhosh","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"bmmae859abib49","doi-asserted-by":"publisher","first-page":"10918","DOI":"10.1039\/d0cc03481a","type":"journal-article","article-title":"Bimetallic nanoparticles against multi-drug resistant bacteria","volume":"56","author":"Zhao","year":"2020","journal-title":"Chem. Commun."},{"key":"bmmae859abib50","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1016\/j.bbrc.2017.08.121","type":"journal-article","article-title":"Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) suppresses STING-mediated DNA sensing pathway through inducing mitochondrial fission","volume":"493","author":"Kwon","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"bmmae859abib51","doi-asserted-by":"publisher","first-page":"4963","DOI":"10.1021\/acsami.6b00161","type":"journal-article","article-title":"Antibacterial effects of biosynthesized silver nanoparticles on surface ultrastructure and nanomechanical properties of gram-negative bacteria viz Escherichia coli and Pseudomonas aeruginosa","volume":"8","author":"Ramalingam","year":"2016","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"bmmae859abib52","doi-asserted-by":"publisher","first-page":"1448","DOI":"10.1021\/acsnano.2c10203","type":"journal-article","article-title":"Self-driven electron transfer biomimetic enzymatic catalysis of bismuth-doped PCN-222 MOF for rapid therapy of bacteria-infected wounds","volume":"17","author":"Wu","year":"2023","journal-title":"ACS Nano"},{"key":"bmmae859abib53","doi-asserted-by":"publisher","first-page":"2307","DOI":"10.1007\/s12010-025-05561-1","type":"journal-article","article-title":"Eco-engineered gold nanoparticles via laurus nobilis at Native pH: toward multifunctional nanoformulations for in vitro cancer therapy","volume":"198","author":"Tural","year":"2026","journal-title":"Appl. Biochem. Biotechnol."},{"key":"bmmae859abib54","doi-asserted-by":"publisher","first-page":"2036","DOI":"10.1007\/s12010-022-03805-y","type":"journal-article","article-title":"Antimicrobial and antibiofilm activity of biosynthesized silver nanoparticles against beta-lactamase-resistant Enterococcus faecalis","volume":"194","author":"Fattah","year":"2022","journal-title":"Appl. Biochem. Biotechnol."},{"key":"bmmae859abib55","doi-asserted-by":"publisher","first-page":"4631","DOI":"10.2147\/IJN.S315067","type":"journal-article","article-title":"Nanosilver-decorated biodegradable mesoporous organosilica nanoparticles for GSH-responsive gentamicin release and synergistic treatment of antibiotic-resistant bacteria","volume":"16","author":"Li","year":"2021","journal-title":"Int. J. Nanomed."},{"key":"bmmae859abib56","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.54668","type":"journal-article","article-title":"Enhancing antimicrobial efficacy and synergistic effects of nano-silica-based combinations with doxycycline, metronidazole, and ciprofloxacin against Enterococcus faecalis biofilms","volume":"16","author":"Hameed","year":"2024","journal-title":"Cureus"}],"container-title":["Biomedical Materials"],"original-title":[],"link":[{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ae859a","content-type":"text\/html","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ae859a\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ae859a","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ae859a\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ae859a\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ae859a\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ae859a\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"similarity-checking"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ae859a\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T06:20:37Z","timestamp":1784701237000},"score":1,"resource":{"primary":{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/ae859a"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,22]]},"references-count":56,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,7,22]]},"published-print":{"date-parts":[[2026,8,1]]}},"URL":"https:\/\/doi.org\/10.1088\/1748-605x\/ae859a","relation":{},"ISSN":["1748-6041","1748-605X"],"issn-type":[{"value":"1748-6041","type":"print"},{"value":"1748-605X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,22]]},"assertion":[{"value":"Restoration of ampicillin susceptibility in drug-resistant\n                      enterococcus faecalis\n                      via synergistic therapy with co-functionalized gold nanoparticles","name":"article_title","label":"Article Title"},{"value":"Biomedical Materials","name":"journal_title","label":"Journal Title"},{"value":"paper","name":"article_type","label":"Article Type"},{"value":"\u00a9 2026 IOP Publishing Ltd. All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2026-01-30","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2026-07-01","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2026-07-22","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}