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Mater."],"published-print":{"date-parts":[[2026,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Human tissues deteriorate over time and may not regenerate naturally, motivating the development of bioactive materials capable of stimulating tissue repair. Since the discovery of Bioglass 45S5\u00ae, this material has been widely recognized as a benchmark for bone regeneration due to its high bioactivity and ability to bond with living tissues. However, its tendency to crystallize during processing can compromise bioactivity and limit mechanical performance, posing a challenge for applications requiring both biological effectiveness and structural reliability. In this context, compositional modifications have emerged as a promising strategy to overcome these limitations. This study investigates the effect of adding magnesium oxide (MgO) and strontium oxide (SrO) to the Bioglass 45S5\u00ae composition, aiming to enhance mechanical properties while preserving bioactivity. Modified bioglass compositions were synthesized by the melt-quenching method, followed by controlled thermal treatments to obtain corresponding biovitroceramics. The materials were characterized using differential thermal analysis, x-ray diffraction, Raman spectroscopy to evaluate thermal behavior, phase transformations, and structural vibration. Mechanical properties were assessed through hardness and instrumented indentation tests, while biological performance was evaluated by\n                    <jats:italic>in vitro<\/jats:italic>\n                    assays, including cell viability and morphological analyses. The results demonstrate that the incorporation of MgO and SrO leads to improved mechanical properties compared to the reference Bioglass 45S5\u00ae, without inducing cytotoxic effects. These findings indicate that MgO and SrO modified bioglasses are promising candidates for biomedical applications, particularly in bone tissue engineering and regenerative medicine.\n                  <\/jats:p>","DOI":"10.1088\/1748-605x\/ae8ee9","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T22:55:32Z","timestamp":1784760932000},"page":"045031","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Structural, mechanical and biological evaluation of MgO and SrO modified bioglass 45S5\n                    <sup>\u00ae<\/sup>"],"prefix":"10.1088","volume":"21","author":[{"given":"Mariana Gunther","family":"Borges","sequence":"first","affiliation":[{"name":"High-pressure and Advanced Materials Laboratory (LAPMA), Institute of Physics, Federal University of Rio Grande do Sul (IF\/UFRGS)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicce","family":"Reis","sequence":"additional","affiliation":[{"name":"Graduate Program in Biosciences, Federal University of Health Sciences of Porto Alegre (UFCSPA)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9325-8139","authenticated-orcid":true,"given":"Paulo","family":"Soares","sequence":"additional","affiliation":[{"name":"Pontif\u00edcia Universidade Cat\u00f3lica do Paran\u00e1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9645-2412","authenticated-orcid":true,"given":"Liliana Ivet Sous","family":"Naasani","sequence":"additional","affiliation":[{"name":"Graduate Program in Health Sciences, Federal University of Health Sciences of Porto Alegre (UFCSPA)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7137-411X","authenticated-orcid":true,"given":"Tha\u00eds Casagrande","family":"Paim","sequence":"additional","affiliation":[{"name":"Graduate Program in Health Sciences, Federal University of Health Sciences of Porto Alegre (UFCSPA)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5987-3509","authenticated-orcid":false,"given":"M\u00e1rcia Ros\u00e2ngela","family":"Wink","sequence":"additional","affiliation":[{"name":"Graduate Program in Biosciences, Federal University of Health Sciences of Porto Alegre (UFCSPA)"},{"name":"Graduate Program in Health Sciences, Federal University of Health Sciences of Porto Alegre (UFCSPA)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7939-5938","authenticated-orcid":true,"given":"Silvio","family":"Buchner","sequence":"additional","affiliation":[{"name":"High-pressure and Advanced Materials Laboratory (LAPMA), Institute of Physics, Federal University of Rio Grande do Sul (IF\/UFRGS)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2026,8,10]]},"reference":[{"key":"bmmae8ee9bib1","doi-asserted-by":"publisher","first-page":"4457","DOI":"10.1016\/j.actbio.2012.08.023","type":"journal-article","article-title":"Review of bioactive glass: from Hench to hybrids","volume":"9","author":"Jones","year":"2013","journal-title":"Acta Biomater."},{"key":"bmmae8ee9bib2","doi-asserted-by":"publisher","first-page":"S53","DOI":"10.1016\/j.actbio.2015.07.019","type":"journal-article","article-title":"Reprint of: review of bioactive glass: from Hench to hybrids","volume":"23","author":"Jones","year":"2015","journal-title":"Acta Biomater."},{"key":"bmmae8ee9bib3","article-title":"Functional glasses and glass-ceramics: processing, properties and applications chapter 7","author":"Karmakar","year":"n.d.","type":"other"},{"key":"bmmae8ee9bib4","article-title":"Chapter 3: bioactive glasses","author":"Hench","year":"n.d.","type":"book"},{"key":"bmmae8ee9bib5","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.molstruc.2014.03.066","type":"journal-article","article-title":"Bioactive glasses: importance of structure and properties in bone regeneration","volume":"1073","author":"Hench","year":"2014","journal-title":"J. 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All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2026-04-17","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2026-07-22","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2026-08-10","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}