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Mater."],"published-print":{"date-parts":[[2026,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Peri-implantitis is a biofilm-associated infectious disorder marked by progressive peri-implant bone loss and remains a major cause of late implant failure. To achieve simultaneous antibacterial treatment and bone regeneration, an injectable charge-complementary hydrogel (BMP-2@HA\/\n                    <jats:italic>\u03f5<\/jats:italic>\n                    -PL) was fabricated using anionic hyaluronic acid (HA), cationic\n                    <jats:italic>\u03f5<\/jats:italic>\n                    -poly-L-lysine (\n                    <jats:italic>\u03f5<\/jats:italic>\n                    -PL), and positively charged bone morphogenetic protein-2 (BMP-2). Its structural and physicochemical features were examined by Fourier-transform infrared spectroscopy, scanning electron microscopy (SEM), rheological testing, compression analysis, and swelling-degradation behavior assessments. BMP-2 release was quantified by enzyme-linked immunosorbent assay.\n                    <jats:italic>In vitro<\/jats:italic>\n                    , cytocompatibility of the BMP-2@HA\/\n                    <jats:italic>\u03f5<\/jats:italic>\n                    -PL hydrogel with rat bone marrow mesenchymal stem cells (BMSCs) was evaluated by CCK-8 and live\/dead staining, whereas osteogenic differentiation was assessed by alkaline phosphatase activity, calcium deposition, and expression of osteogenesis-related genes. Antibacterial activity\n                    <jats:italic>in vitro<\/jats:italic>\n                    was evaluated against\n                    <jats:italic>S. aureus<\/jats:italic>\n                    (\n                    <jats:italic>S. aureus<\/jats:italic>\n                    ) and\n                    <jats:italic>E. coli<\/jats:italic>\n                    (\n                    <jats:italic>E. coli<\/jats:italic>\n                    ). The results demonstrated the successful synthesis of the hydrogels, and BMP\u20102 incorporation optimized the physicochemical properties (a densely packed network, higher compressive strength, and slower degradation) of the BMP\u20102@HA\/\n                    <jats:italic>\u03f5<\/jats:italic>\n                    \u2010PL hydrogel, which also showed effective BMP\u20102 release.\n                    <jats:italic>In vitro<\/jats:italic>\n                    evaluation further indicated that the BMP\u20102@HA\/\n                    <jats:italic>\u03f5<\/jats:italic>\n                    \u2010PL hydrogel exhibited favorable cytocompatibility, enhanced osteogenic differentiation of BMSCs due to the synergistic effect of HA and BMP\u20102, and robust antibacterial effects against both\n                    <jats:italic>S. aureus<\/jats:italic>\n                    and\n                    <jats:italic>E. coli<\/jats:italic>\n                    . These findings indicate that the injectable BMP\u20102@HA\/\n                    <jats:italic>\u03f5<\/jats:italic>\n                    \u2010PL hydrogel features dual antibacterial and osteoinductive functions, offering a promising minimally invasive strategy for peri-implantitis treatment.\n                  <\/jats:p>","DOI":"10.1088\/1748-605x\/ae9231","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T22:52:33Z","timestamp":1785365553000},"page":"045029","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Injectable charge-complementary hyaluronic acid\/\n                    <i>\u03f5<\/i>\n                    -Poly-L-lysine hydrogel loaded with BMP-2 for potential antibacterial and osteogenic management of peri-implantitis"],"prefix":"10.1088","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-9091-8567","authenticated-orcid":true,"given":"Siqi","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Stomatology, General Hospital of Southern Theater Command"},{"name":"School of Stomatology, Southern Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3373-6797","authenticated-orcid":true,"given":"Xiao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Stomatology, General Hospital of Southern Theater Command"},{"name":"School of Stomatology, Southern Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2026,8,7]]},"reference":[{"key":"bmmae9231bib1","doi-asserted-by":"publisher","first-page":"522","DOI":"10.4014\/jmb.2111.11024","type":"journal-article","article-title":"Physicochemical, antibacterial properties, and compatibility of ZnO-NP\/chitosan\/\u03b2-glycerophosphate composite hydrogels","volume":"32","author":"Huang","year":"2022","journal-title":"J. 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