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Mater."],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Ischemic stroke (IS) reperfusion induces neuronal damage through excessive reactive oxygen species (ROS) and neuroinflammation. Baicalin (Bai) shows antioxidant and anti-inflammatory effects but suffers from poor solubility and bioavailability. Metal-organic framework (MOF)-818, a zirconium-based framework with superoxide dismutase- and catalase-mimicking activity, efficiently scavenges ROS but lacks pharmacological versatility. Combining Bai with MOF-818 may offer multitarget neuroprotection in IS. To investigate the therapeutic efficacy and mechanisms of Bai-loaded MOF-818 (Bai@MOF-818) in IS.\n                    <jats:italic>In vitro<\/jats:italic>\n                    oxygen-glucose deprivation\/reperfusion models using PC-12 cells and BV-2 microglia were employed to assess ROS scavenging, mitochondrial protection, apoptosis, and microglial polarization.\n                    <jats:italic>In vivo<\/jats:italic>\n                    , Bai@MOF-818 was stereotactically delivered into the ischemic core of rats subjected to transient middle cerebral artery occlusion. Neurological function, infarct volume, oxidative stress, apoptosis, and microglial polarization were evaluated. Bai@MOF-818 markedly scavenged ROS, restored mitochondrial membrane potential, and promoted M1-to-M2 microglial polarization via NF-\n                    <jats:italic>\u03ba<\/jats:italic>\n                    B inhibition and PPAR\n                    <jats:italic>\u03b3<\/jats:italic>\n                    activation. This led to reduced TNF-\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \/IL-6 and increased IL-10\/Arg-1, alleviating neuroinflammation. Furthermore, Bai@MOF-818 inhibited neuronal apoptosis by suppressing Bax and cleaved caspase-3 while elevating the Bcl-2\/Bax ratio. Histological analyses revealed preserved tissue integrity, enhanced neuronal survival, reduced infarct size and edema, and improved motor and sensory recovery. Bai@MOF-818 exerts synergistic antioxidant and anti-inflammatory actions, attenuates neuronal apoptosis, and enhances neurological recovery, representing a promising multitarget therapeutic for cerebral ischemia-reperfusion injury.\n                  <\/jats:p>","DOI":"10.1088\/1748-605x\/ae96ef","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T22:52:13Z","timestamp":1786143133000},"page":"055016","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Baicalin-loaded MOF-818 nanozyme for ischemic stroke treatment via ROS scavenging and neuroinflammation suppression"],"prefix":"10.1088","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-6847-0665","authenticated-orcid":true,"given":"Wei","family":"Shen","sequence":"first","affiliation":[{"name":"Guangzhou University of Chinese Medicine"},{"name":"Department of Neurology"},{"name":"These authors contributed equally"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YuChen","family":"Wang","sequence":"additional","affiliation":[{"name":"Jinzhou Medical University"},{"name":"These authors contributed equally"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaosong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Shandong Second Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianjun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1278-5899","authenticated-orcid":true,"given":"Fengyuan","family":"Che","sequence":"additional","affiliation":[{"name":"Guangzhou University of Chinese Medicine"},{"name":"Department of Neurology"},{"name":"Linyi People\u2019s Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2026,10,1]]},"reference":[{"key":"bmmae96efbib1","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1038\/s41582-019-0208-y","type":"journal-article","article-title":"Global burden of neurological diseases highlights stroke","volume":"15","author":"Kaji","year":"2019","journal-title":"Nat. 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