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Although these five classes of materials differ in chemical composition, they all combine intrinsic bioactivity with abundant modifiable sites, making them an ideal platform for constructing multifunctional periodontal regeneration scaffolds. Based on this, this review focuses on the microstructural characteristics and structure-activity relationships of marine polysaccharide, systematically summarizing their applications and research progress in the design of periodontal tissue regeneration scaffolds.<\/jats:p>","DOI":"10.1088\/1748-605x\/ae98ce","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T22:54:14Z","timestamp":1786575254000},"page":"042008","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Applications of natural marine polysaccharide scaffold materials in periodontal tissue regeneration"],"prefix":"10.1088","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-4631-6310","authenticated-orcid":true,"given":"Xinyu","family":"Li","sequence":"first","affiliation":[{"name":"School of Stomatology of Qingdao University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7733-0090","authenticated-orcid":true,"given":"Jian","family":"Li","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital of Qingdao University"},{"name":"School of Stomatology of Qingdao University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhibin","family":"Xiao","sequence":"additional","affiliation":[{"name":"School of Stomatology of Qingdao University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haichuan","family":"Ma","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital of Qingdao University"},{"name":"School of Stomatology of Qingdao University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Fan","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital of Qingdao University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4031-4173","authenticated-orcid":true,"given":"Ye","family":"Liang","sequence":"additional","affiliation":[{"name":"Medical Research Centre, The Affiliated Hospital of Qingdao University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2026,8,26]]},"reference":[{"key":"bmmae98cebib1","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1177\/0022034514552491","type":"journal-article","article-title":"Global burden of severe periodontitis in 1990\u20132010: a systematic review and meta-regression","volume":"93","author":"Kassebaum","year":"2014","journal-title":"J. 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