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The review protocol was prospectively registered on the Open Science Framework (OSF.IO\/NRZM7). Of 3217 studies, 41 were included in the analysis: 32 were\n                    <jats:italic>in vivo<\/jats:italic>\n                    studies, 8 were\n                    <jats:italic>in vitro<\/jats:italic>\n                    , and 1 was clinical. The main biomaterials used for OT culture and cryopreservation included fibrin, alginate, collagen, hyaluronic acid, and extracellular matrix. Key preservation strategies involve encapsulating OT within biomaterial-based systems and enriching culture media with biomaterials. Hydrogels have demonstrated advantages by providing structural scaffolding and facilitating the diffusion of oxygen, nutrients, and bioactive supplements, thereby promoting angiogenesis and supporting OT functional restoration. Growing interest has focused on combinatorial approaches that integrate multiple biomaterials with stem cells, plasma proteins, and growth or antioxidant factors to enhance folliculogenesis and restore oestrous cycles. Despite progress, critical challenges persist, including capsule disintegration and the associated risk of immune sensitisation, as well as limited understanding of long-term tissue revascularisation and OT-biomaterial interactions. Overall, biobased materials strategies, particularly hydrogels, show promise for improving OT preservation and functionality, but further research is needed to optimise these materials and understand their long-term implications for fertility outcomes. Among the included studies, only one was a clinical study; the rest consisted of\n                    <jats:italic>in vivo<\/jats:italic>\n                    animal models and\n                    <jats:italic>in vitro<\/jats:italic>\n                    experiments. This limitation should be recognised, as it prevents direct application of the results to clinical practice. Consequently, further clinical research is crucial to confirm these strategies and facilitate their safe and effective implementation in fertility preservation protocols.\n                  <\/jats:p>","DOI":"10.1088\/1748-605x\/ae98cf","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T22:54:17Z","timestamp":1786575257000},"page":"052004","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The role of biomaterials in ovarian tissue cryopreservation and transplantation: a scoping review"],"prefix":"10.1088","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5237-3883","authenticated-orcid":true,"given":"In\u00eas","family":"Dias","sequence":"first","affiliation":[{"name":"Univ Coimbra"},{"name":"Univ Coimbra"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4948-2325","authenticated-orcid":false,"given":"Gabriela","family":"Correia-Barros","sequence":"additional","affiliation":[{"name":"Univ Coimbra"},{"name":"Univ Coimbra"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9269-5417","authenticated-orcid":true,"given":"Carlos Miguel","family":"Marto","sequence":"additional","affiliation":[{"name":"Univ Coimbra"},{"name":"Univ Coimbra"},{"name":"Clinical Academic Center of Coimbra (CACC)"},{"name":"Univ Coimbra"},{"name":"Univ Coimbra"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3634-859X","authenticated-orcid":false,"given":"Beatriz","family":"Serambeque","sequence":"additional","affiliation":[{"name":"Univ Coimbra"},{"name":"Univ Coimbra"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7202-1650","authenticated-orcid":false,"given":"Maria Filomena","family":"Botelho","sequence":"additional","affiliation":[{"name":"Univ Coimbra"},{"name":"Univ Coimbra"},{"name":"Clinical Academic Center of Coimbra (CACC)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7423-2996","authenticated-orcid":false,"given":"Teresa Almeida","family":"Santos","sequence":"additional","affiliation":[{"name":"Unidade Local de Sa\u00fade de Coimbra"},{"name":"Univ Coimbra"},{"name":"Univ Coimbra"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1977-5258","authenticated-orcid":false,"given":"Ana Sofia","family":"Pais","sequence":"additional","affiliation":[{"name":"Univ Coimbra"},{"name":"Univ Coimbra"},{"name":"Unidade Local de Sa\u00fade de Coimbra"},{"name":"Univ Coimbra"},{"name":"Univ Coimbra"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0689-6007","authenticated-orcid":true,"given":"Mafalda","family":"Laranjo","sequence":"additional","affiliation":[{"name":"Univ Coimbra"},{"name":"Univ Coimbra"},{"name":"Clinical Academic Center of Coimbra (CACC)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"key":"bmmae98cfbib1","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3322\/caac.21834","type":"journal-article","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. 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