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Recent studies have demonstrated that ES can significantly promote osteoblast differentiation and bone formation, making piezoelectric hydrogels a critical factor in facilitating bone tissue regeneration. By integrating piezoelectric materials into hydrogels, they not only support cell growth but also actively promote bone healing through mechanoelectrical signaling. Specifically, this review (i) quantifies the range of piezoelectric coefficients and electrical outputs reported for hydrogels, (ii) critically compares fabrication methods with their scalability limitations, and (iii) outlines design guidelines for achieving stable, clinically translatable piezoelectric systems. By bridging materials science and bioelectric medicine, this review provides a roadmap for developing next-generation bone repair scaffolds. Unlike previous narrative reviews, our work provides a critical comparative assessment\u2014quantitatively comparing piezoelectric coefficients, fabrication scalability, and translational bottlenecks.\n                  <\/jats:p>","DOI":"10.1088\/1748-605x\/ae9b56","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T22:53:27Z","timestamp":1787093607000},"page":"042009","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Research progress on the application of piezoelectric hydrogel materials in bone tissue engineering"],"prefix":"10.1088","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-3967-7729","authenticated-orcid":true,"given":"Shuang","family":"Deng","sequence":"first","affiliation":[{"name":"Shanghai Pudong Hospital, Fudan University Pudong Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqing","family":"Di","sequence":"additional","affiliation":[{"name":"Shanghai Pudong Hospital, Fudan University Pudong Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanliang","family":"Meng","sequence":"additional","affiliation":[{"name":"Shanghai Pudong Hospital, Fudan University Pudong Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianbo","family":"Jia","sequence":"additional","affiliation":[{"name":"Shanghai Pudong Hospital, Fudan University Pudong Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawen","family":"He","sequence":"additional","affiliation":[{"name":"Shanghai Pudong Hospital, Fudan University Pudong Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3537-9180","authenticated-orcid":true,"given":"Dejian","family":"Li","sequence":"additional","affiliation":[{"name":"Shanghai Pudong Hospital, Fudan University Pudong Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2026,9,1]]},"reference":[{"key":"bmmae9b56bib1","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1186\/s13287-024-03745-w","type":"journal-article","article-title":"Osteoinductive micro-nano guided bone regeneration membrane for in situ bone defect repair","volume":"15","author":"Wang","year":"2024","journal-title":"Stem Cell Res. 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