{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T08:14:12Z","timestamp":1788423252282,"version":"build-2803163510"},"reference-count":37,"publisher":"IOP Publishing","issue":"5","license":[{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/iop-standard\/v1"},{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"funder":[{"name":"JiangXi Provincial Natural Science Foundation of China","award":["20224ACB204013"],"award-info":[{"award-number":["20224ACB204013"]}]},{"name":"Open Project of Jiangxi University of Science and Technology","award":["2024ZCZZSZ03"],"award-info":[{"award-number":["2024ZCZZSZ03"]}]},{"name":"Jiangxi Provincial Key Laboratory of Additive Manufacturing of Implantable Medical Device","award":["20244BCE52188"],"award-info":[{"award-number":["20244BCE52188"]}]},{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"crossref","award":["52365046"],"award-info":[{"award-number":["52365046"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Key Research and Development Program of China","award":["2023YFB4605800"],"award-info":[{"award-number":["2023YFB4605800"]}]}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Biomed. Mater."],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Intestinal inflammation caused by achalasia of the cardia is often accompanied by the production of reactive oxygen species (ROS) and lipid peroxides (LPO). ROS result from the excessive accumulation after the stimulation of inflammatory factors, and lipid peroxides are generated by the oxidation of polyunsaturated fatty acids. This study developed a nanocomposite (PB@Se) by loading selenium (Se) onto Prussian blue (PB) through\n                    <jats:italic>in situ<\/jats:italic>\n                    growth, which was subsequently incorporated into poly-L-lactic acid to fabricate intestinal stents via selective laser sintering for sustained PB@Se release. Notably, PB mimicked multi-enzyme activity to eliminate inflammation-induced ROS. Meanwhile, Se upregulated key intracellular antioxidant enzyme, GPx4 which could decrease lipid peroxides through catalyzing the reduction of lipid hydroperoxide, the main active intermediate of LPO. Results demonstrated that PLLA\/PB@Se stents exhibited the higher ROS and lipid peroxide scavenging efficiency. The scavenging efficiency of PLLA\/PB@Se stents for superoxide anion radicals (O\n                    <jats:sub>2<\/jats:sub>\n                    <jats:sup>\u2212<\/jats:sup>\n                    \u00b7) and hydroxyl radicals (\u00b7OH) was approximately 50% and 58% respectively, while decomposition ability for hydrogen peroxide (H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    ) increased to 1.9 times that of the initial state in 20 min. This work presents a feasible dual strategy to combat intestinal inflammation by simultaneously eliminating ROS and LPO.\n                  <\/jats:p>","DOI":"10.1088\/1748-605x\/ae9d1f","type":"journal-article","created":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T22:48:17Z","timestamp":1787438897000},"page":"055002","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Anti-inflammatory intestinal stents based on biomaterials composed of poly-L-lactic acid loaded with selenium-functionalized Prussian blue"],"prefix":"10.1088","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2029-5112","authenticated-orcid":true,"given":"Cijun","family":"Shuai","sequence":"first","affiliation":[{"name":"Jiangxi University of Science and Technology"},{"name":"Central South University"},{"name":"College of Mechanical Engineering, Xinjiang University"},{"name":"School of Sino-German Robotics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Gao","sequence":"additional","affiliation":[{"name":"Jiangxi University of Science and Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2286-2004","authenticated-orcid":true,"given":"Xiong","family":"Shuai","sequence":"additional","affiliation":[{"name":"Jiangxi University of Science and Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gao","family":"Pan","sequence":"additional","affiliation":[{"name":"Jiangxi University of Science and Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9567-9295","authenticated-orcid":true,"given":"Shuping","family":"Peng","sequence":"additional","affiliation":[{"name":"Central South University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiantian","family":"He","sequence":"additional","affiliation":[{"name":"Jiangxi University of Science and Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2026,9,3]]},"reference":[{"key":"bmmae9d1fbib1","doi-asserted-by":"publisher","first-page":"1456","DOI":"10.1053\/j.gastro.2022.01.024","type":"journal-article","article-title":"Disease monitoring in inflammatory bowel disease: evolving principles and possibilities","volume":"162","author":"Plevris","year":"2022","journal-title":"Gastroenterology"},{"key":"bmmae9d1fbib2","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.14309\/ajg.0000000000000731","type":"journal-article","article-title":"ACG clinical guidelines: diagnosis and management of achalasia","volume":"115","author":"Vaezi","year":"2020","journal-title":"Am. 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All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2026-05-07","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2026-08-21","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2026-09-03","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}