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In hydrogen peroxide-challenged primary spinal cord neuron cultures and weight-drop contusion rat SCI models, locally injected DT NP\u2013Hydrogel significantly reduced oxidative stress marker 4-hydroxynonenal (4HNE), pro-apoptotic Caspase-3 (Casp3) expression, and gap junction protein connexin 43 (Cx43) levels, while simultaneously upregulating the neuron-specific marker class III\n                    <jats:italic>\u03b2<\/jats:italic>\n                    -tubulin (Tuj1). Collectively, our\n                    <jats:italic>in vitro<\/jats:italic>\n                    and\n                    <jats:italic>in vivo<\/jats:italic>\n                    data demonstrate that DT NP\u2013Hydrogel mitigates secondary spinal cord damage and delivers potent neuroprotective activity, establishing it as a promising therapeutic strategy for SCI.\n                  <\/jats:p>","DOI":"10.1088\/1748-605x\/aea1b3","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T22:53:46Z","timestamp":1788389626000},"page":"055011","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Reactive oxygen species-scavenging hydrogels loaded with tempol exert anti-oxidative effects in spinal cord injury rat models"],"prefix":"10.1088","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-4096-5196","authenticated-orcid":true,"given":"Gushang","family":"Xia","sequence":"first","affiliation":[{"name":"The People\u2019s Hospital of Chuxiong Yi Autonomous Prefecture"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renjie","family":"Shuai","sequence":"additional","affiliation":[{"name":"Tianjin Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ze","family":"Li","sequence":"additional","affiliation":[{"name":"Tianjin Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changlin","family":"Tang","sequence":"additional","affiliation":[{"name":"Tianjin Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaowen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Chongqing University of Chinese Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingli","family":"Kong","sequence":"additional","affiliation":[{"name":"The People\u2019s Hospital of Chuxiong Yi Autonomous Prefecture"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanyou","family":"Li","sequence":"additional","affiliation":[{"name":"The People\u2019s Hospital of Chuxiong Yi Autonomous Prefecture"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangfang","family":"Ma","sequence":"additional","affiliation":[{"name":"The People\u2019s Hospital of Chuxiong Yi Autonomous Prefecture"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianglin","family":"Li","sequence":"additional","affiliation":[{"name":"The People\u2019s Hospital of Chuxiong Yi Autonomous Prefecture"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9217-0336","authenticated-orcid":true,"given":"Yan","family":"Du","sequence":"additional","affiliation":[{"name":"Chongqing Key Laboratory of Emergency Medicine, Chongqing Emergency Medical Center"},{"name":"The Fourth People\u2019s Hospital of Chongqing, Chongqing University Central Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2026,9,18]]},"reference":[{"key":"bmmaea1b3bib1","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1038\/s41591-019-0475-6","type":"journal-article","article-title":"Spinal cord repair: advances in biology and technology","volume":"25","author":"Courtine","year":"2019","journal-title":"Nat. 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