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Mater."],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Airway barrier dysfunction is a hallmark of chronic lung diseases including cystic fibrosis, asthma, and chronic obstructive pulmonary disease, and is often shaped by polymicrobial rather than single-species interactions with the host tissue. However, extended host-microbe co-culture with rapid-colonizing airway pathogens such as Pseudomonas aeruginosa\n                    <jats:italic>(P. aeruginosa)<\/jats:italic>\n                    is difficult to sustain in accessible\n                    <jats:italic>in vitro<\/jats:italic>\n                    systems, limiting mechanistic study of polymicrobial barrier and inflammatory dynamics. Here we developed and validated an aqueous two-phase system (ATPS) that spatially confines bacterial communities over a human bronchial epithelial-endothelial transwell co-culture, extending the stable co-culture window to 24 h while preserving assayable barrier and cytokine readouts. Using a validation-by-recapitulation approach, the platform reproduced established\n                    <jats:italic>in vivo<\/jats:italic>\n                    phenomena:\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    -driven barrier disruption, attenuation of pathogenic effects by the commensals\n                    <jats:italic>Rothia mucilaginosa<\/jats:italic>\n                    and\n                    <jats:italic>Lactobacillus casei<\/jats:italic>\n                    with preserved junctional architecture, and\n                    <jats:italic>Streptococcus pneumoniae<\/jats:italic>\n                    exacerbation of barrier permeability accompanied by elevated IL-8 despite apparent junctional preservation. This accessible ATPS-based biomaterials platform requires no microfluidic or induced pluripotent stem cell-derived components and provides a tractable foundation for mechanistic studies of polymicrobial interactions at the airway epithelial barrier.\n                  <\/jats:p>","DOI":"10.1088\/1748-605x\/aea1cc","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T22:55:40Z","timestamp":1788389740000},"page":"055010","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Spatially controlled polymicrobial human airway model recapitulates complex interactions between\n                    <i>Pseudomonas aeruginosa<\/i>\n                    and lung commensals"],"prefix":"10.1088","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-1516-8548","authenticated-orcid":true,"given":"Sarah M","family":"Spencer","sequence":"first","affiliation":[{"name":"Dalhousie University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9549-8467","authenticated-orcid":true,"given":"Karla N","family":"Valenzuela-Valderas","sequence":"additional","affiliation":[{"name":"Dalhousie University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyu","family":"Cheng","sequence":"additional","affiliation":[{"name":"Dalhousie University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brendan M","family":"Leung","sequence":"additional","affiliation":[{"name":"Dalhousie University"},{"name":"Dalhousie University"},{"name":"Dalhousie University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2026,9,18]]},"reference":[{"key":"bmmaea1ccbib1","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1038\/s41579-022-00821-x","type":"journal-article","article-title":"The dynamic lung microbiome in health and disease","volume":"21","author":"Natalini","year":"2023","journal-title":"Nat. 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Published by IOP Publishing Ltd","name":"copyright_information","label":"Copyright Information"},{"value":"2026-06-01","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2026-09-02","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2026-09-18","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}