{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:01:48Z","timestamp":1792785708929,"version":"4.5.0"},"reference-count":56,"publisher":"IOP Publishing","issue":"5","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/iop-standard\/v1"},{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"funder":[{"name":"Department of Science and Technology of Shaanxi Province","award":["2026JC-YBMS-1019"],"award-info":[{"award-number":["2026JC-YBMS-1019"]}]},{"name":"Science and Technology Bureau of Yu\u2019lin","award":["2024-CXY-189"],"award-info":[{"award-number":["2024-CXY-189"]}]},{"name":"National Natural Science Foundation of China","award":["31900965"],"award-info":[{"award-number":["31900965"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Biomed. Mater."],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The total flavonoids of Rhizoma Drynariae (TFRD) are traditionally used to repair bone defects. Magnesium phosphate cement (MPC) features high early strength, fast setting, good biocompatibility and osteoconductivity. Cobalt-doped hydroxyapatite (Co-HA) exerts a significant role in guiding the osteogenic and angiogenic differentiation of bone marrow stromal cells (BMSCs). We herein hypothesize that incorporating TFRD into MPC\/Co-HA yields composite scaffolds with sustained drug release and self-setting capacity, capable of inducing osteogenesis\n                    <jats:italic>In vitro<\/jats:italic>\n                    and accelerating bone repair in vivo. Accordingly, MPC\/Co-HA\/TFRD composites were fabricated with various TFRD loadings. The results showed that TFRD was uniformly dispersed in the MPC\/Co-HA matrix. It cleared that MPC\/Co-HA\/TFRD composites exhibited characteristic chemical constitution of MPC, Co-HA and TFRD, with no new phases formed. In addition, the weight loss ratio of the MPC\/Co-HA\/TFRD composites increased with increasing TFRD content, and the pH of the composite soaking solution remained within a range suitable for the human physiological environment throughout the immersion period. Drug release studies demonstrated that the MPC\/Co-HA\/TFRD composites exhibited an initial burst release within 48 h, followed by a sustained slow-release pattern.\n                    <jats:italic>In vitro<\/jats:italic>\n                    cellular experiments verified that the 5 wt% TFRD-loaded MPC\/Co-HA\/TFRD5 composite remarkably enhanced BMSCs proliferation. The incorporation of TFRD into MPC\/Co-HA enhanced alkaline phosphatase activity and accelerated calcium nodule formation, indicating that the composites effectively induced osteogenic differentiation of BMSCs. The introduction of TFRD into MPC\/Co-HA upregulated the expression of osteogenic-related proteins (IBSP, Runx2, and Osterix) and angiogenesis-related proteins (OPN, HIF-1\n                    <jats:italic>\u03b1<\/jats:italic>\n                    , and HO-1) in BMSCs.In vivo results revealed that the MPC\/Co-HA\/TFRD5 scaffold implanted into femoral condyle bone defects in New Zealand white rabbits significantly accelerated bone regeneration 8 weeks after surgery and exhibited favorable osteoconductivity. Hence, the MPC\/Co-HA\/TFRD composite represents a promising candidate scaffold for bone tissue regeneration applications.\n                  <\/jats:p>","DOI":"10.1088\/1748-605x\/aea50c","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T22:54:26Z","timestamp":1788994466000},"page":"055013","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Enhancement of osteogenic differentiation and bone regeneration by total flavonoids of Rhizoma Drynariae-loaded magnesium phosphate cement\/Co-doped hydroxyapatite composites"],"prefix":"10.1088","volume":"21","author":[{"given":"Ziyue","family":"Zhang","sequence":"first","affiliation":[{"name":"Yan\u2019an 716000"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"}]},{"given":"Yiming","family":"Qi","sequence":"additional","affiliation":[{"name":"Yan\u2019an 716000"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"data-curation","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8719-4192","authenticated-orcid":true,"given":"Lele","family":"Shang","sequence":"additional","affiliation":[{"name":"Yan\u2019an 716000"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"data-curation","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"}]},{"given":"Kangle","family":"Wang","sequence":"additional","affiliation":[{"name":"Yan\u2019an 716000"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"}]},{"given":"Hongqiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Yan\u2019an 716000"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7512-3537","authenticated-orcid":true,"given":"Xiaoxia","family":"Fan","sequence":"additional","affiliation":[{"name":"Yan\u2019an 716000"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]}],"member":"266","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"key":"bmmaea50cbib1","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1016\/S0140-6736(18)32112-3","type":"journal-article","article-title":"Osteoporosis","volume":"393","author":"Compston","year":"2019","journal-title":"Lancet"},{"key":"bmmaea50cbib2","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.bone.2016.02.020","type":"journal-article","article-title":"Inflammation, fracture and bone repair","volume":"86","author":"Loi","year":"2016","journal-title":"Bone"},{"key":"bmmaea50cbib3","first-page":"387","author":"Shimomura","year":"2016","type":"book"},{"key":"bmmaea50cbib4","doi-asserted-by":"publisher","first-page":"13614","DOI":"10.1073\/pnas.1003600107","type":"journal-article","article-title":"Osteoinductive ceramics as a synthetic alternative to autologous bone grafting","volume":"31","author":"Yuan","year":"2010","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"bmmaea50cbib5","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2025.115234","type":"journal-article","article-title":"Fabrication and characterization of ZnO\/HA scaffolds via spark plasma sintering at different temperatures for bone repair","volume":"258","author":"Zhu","year":"2026","journal-title":"Colloids Surf. B"},{"key":"bmmaea50cbib6","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1302\/2058-5241.3.170056","type":"journal-article","article-title":"Bioceramics and bone healing","volume":"3","author":"Ginebra","year":"2018","journal-title":"EFORT Open Rev."},{"key":"bmmaea50cbib7","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1016\/S1672-6529(14)60150-5","type":"journal-article","article-title":"Enhanced osteogenesis of nanosized cobalt-substituted hydroxyapatite","volume":"12","author":"Ignjatovic","year":"2015","journal-title":"J. Bionic Eng."},{"key":"bmmaea50cbib8","doi-asserted-by":"publisher","first-page":"39","DOI":"10.22068\/ijmse.16.1.39","type":"journal-article","article-title":"Hydrothermal synthesis of cobalt-doped hydroxyapatite nanoparticles: structure, magnetic behaviour, bioactivity and antibacterial activity (In Press)","volume":"16","author":"Yazdani","year":"2019","journal-title":"Iran. J. Mater. Sci. Eng."},{"key":"bmmaea50cbib9","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtcomm.2021.102392","type":"journal-article","article-title":"Cobalt content modulates characteristics and osteogenic properties of cobalt-containing hydroxyapatite in in-vitro milieu","volume":"27","author":"Khosrowshahi","year":"2021","journal-title":"Mater. Today Commun."},{"key":"bmmaea50cbib10","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtcomm.2024.108554","type":"journal-article","article-title":"Cobalt-doped hydroxyapatite for bone tissue engineering: synthesis, characterization and In vitro biocompatibility of real-time extract","volume":"38","author":"Yan","year":"2024","journal-title":"Mater. Today Commun."},{"key":"bmmaea50cbib11","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtcomm.2025.111532","type":"journal-article","article-title":"Enhancement of osteogenic differentiation and bone regeneration by poly (amino acid)\/cobalt-doped hydroxyapatite","volume":"42","author":"Fan","year":"2025","journal-title":"Mater. Today Commun."},{"key":"bmmaea50cbib12","doi-asserted-by":"publisher","first-page":"2387","DOI":"10.2147\/IJN.S58357","type":"journal-article","article-title":"Magnesium ion implantation on a micro\/nanostructured titanium surface promotes its bioactivity and osteogenic differentiation function","volume":"9","author":"Wang","year":"2014","journal-title":"Int. J. Nanomed."},{"key":"bmmaea50cbib13","doi-asserted-by":"publisher","first-page":"1278","DOI":"10.1111\/j.1600-0501.2010.01944.x","type":"journal-article","article-title":"Osteoblast response to magnesium ion-incorporated nanoporous titanium oxide surfaces","volume":"21","author":"Park","year":"2010","journal-title":"Clin. Oral Implants Res."},{"key":"bmmaea50cbib14","doi-asserted-by":"publisher","first-page":"1873","DOI":"10.1016\/j.actbio.2008.06.020","type":"journal-article","article-title":"Self-setting bioactive calcium-magnesium phosphate cement with high strength and degradability for bone regeneration","volume":"4","author":"Wu","year":"2008","journal-title":"Acta Biomater."},{"key":"bmmaea50cbib15","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1016\/j.colsurfb.2009.12.010","type":"journal-article","article-title":"Evaluation of inherent toxicology and biocompatibility of magnesium phosphate bone cement","volume":"76","author":"Yu","year":"2010","journal-title":"Colloids Surf. B"},{"key":"bmmaea50cbib16","doi-asserted-by":"publisher","first-page":"1260","DOI":"10.1016\/j.biomaterials.2009.11.005","type":"journal-article","article-title":"Hierarchically microporous\/macroporous scaffold of magnesium-calcium phosphate for bone tissue regeneration","volume":"31","author":"Wei","year":"2010","journal-title":"Biomaterials"},{"key":"bmmaea50cbib17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0317832","type":"journal-article","article-title":"Integrated metagenomic and metabolomic analyses of the effects of total flavonoids of Rhizoma Drynariae on reducing ovariectomized-induced osteoporosis by regulating gut microbiota and related metabolites","volume":"20","author":"Li","year":"2025","journal-title":"PLoS One"},{"key":"bmmaea50cbib18","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/S1383-5718(99)00010-8","type":"journal-article","article-title":"Inhibition of xenobiotic-induced genotoxicity in cultured precision-cut human and rat liver slices","volume":"440","author":"Lake","year":"1999","journal-title":"Mutat. Res."},{"key":"bmmaea50cbib19","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.nutres.2007.12.002","type":"journal-article","article-title":"Naringenin reduces tumor size and weight lost in N-methyl-N\u2019-nitro-N-nitrosoguanidine-induced gastric carcinogenesis in rats","volume":"28","author":"Ekambaram","year":"2008","journal-title":"Nutr. Res."},{"key":"bmmaea50cbib20","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.cbi.2007.02.012","type":"journal-article","article-title":"Flavanone and 2\u2019-OH flavanone inhibit metastasis of lung cancer cells via down-regulation of proteinases activities and MAPK pathway","volume":"167","author":"Hsiao","year":"2007","journal-title":"Chem. Biol. Interact."},{"key":"bmmaea50cbib21","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/S0009-8981(01)00778-1","type":"journal-article","article-title":"Comparison of antioxidant effects of naringin and probucol in cholesterol-fed rabbits","volume":"317","author":"Jeon","year":"2002","journal-title":"Clin. Chim. Acta"},{"key":"bmmaea50cbib22","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1016\/j.talanta.2006.06.015","type":"journal-article","article-title":"Determination of total antioxidant capacity by a new spectrophotometric method based on Ce(IV) reducing capacity measurement","volume":"71","author":"Ozyurt","year":"2007","journal-title":"Talanta"},{"key":"bmmaea50cbib23","doi-asserted-by":"publisher","first-page":"25103","DOI":"10.1074\/jbc.R109.041087","type":"journal-article","article-title":"Cellular and molecular mechanisms of bone remodeling","volume":"285","author":"Raggatt","year":"2010","journal-title":"J. Biol. Chem."},{"key":"bmmaea50cbib24","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/j.jep.2004.09.038","type":"journal-article","article-title":"Stimulative effects of Drynariae Rhizoma extracts on the proliferation and differentiation of osteoblastic MC3T3-E1cells","volume":"96","author":"Jeong","year":"2005","journal-title":"J. Ethnopharmacol."},{"key":"bmmaea50cbib25","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.3390\/molecules22071033","type":"journal-article","article-title":"Total flavonoids of Drynariae Rhizoma prevent bone loss induced by hindlimb unloading in rats","volume":"22","author":"Song","year":"2017","journal-title":"Molecules"},{"key":"bmmaea50cbib26","doi-asserted-by":"publisher","DOI":"10.1088\/1748-605X\/ad38ac","type":"journal-article","article-title":"Enhancing osteoblast proliferation and bone regeneration by poly (amino acid)\/selenium-doped hydroxyapatite","volume":"19","author":"Wei","year":"2024","journal-title":"Biomed. Mater."},{"key":"bmmaea50cbib27","doi-asserted-by":"publisher","DOI":"10.1088\/1748-6041\/3\/4\/044105","type":"journal-article","article-title":"Injectable bioactive calcium-magnesium phosphate cement for bone regeneration","volume":"3","author":"Wu","year":"2008","journal-title":"Biomed. Mater."},{"key":"bmmaea50cbib28","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.actbio.2015.04.012","type":"journal-article","article-title":"Novel tricalcium silicate\/magnesium phosphate composite bone cement having high compressive strength, In vitro bioactivity and cytocompatibility","volume":"21","author":"Liu","year":"2015","journal-title":"Acta Biomater."},{"key":"bmmaea50cbib29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ejphar.2009.01.035","type":"journal-article","article-title":"Effects of naringin on the proliferation and osteogenic differentiation of human bone mesenchymal stem cell","volume":"607","author":"Zhang","year":"2009","journal-title":"Eur. J. Pharmacol."},{"key":"bmmaea50cbib30","doi-asserted-by":"publisher","first-page":"403","DOI":"10.33549\/physiolres.932045","type":"journal-article","article-title":"Adhesion, growth and differentiation of osteoblasts on surface-modified materials developed for bone implants","volume":"60","author":"Vandrovcov\u00e1","year":"2011","journal-title":"Physiol. Res."},{"key":"bmmaea50cbib31","doi-asserted-by":"publisher","first-page":"9493","DOI":"10.3390\/ijms23169493","type":"journal-article","article-title":"Translating material science into bone regenerative medicine applications: state-of-the art methods and protocols","volume":"23","author":"Di Pietro","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"bmmaea50cbib32","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2022.998254","type":"journal-article","article-title":"Comparison of degradation behavior and osseointegration of 3D powder-printed calcium magnesium phosphate cement scaffolds with alkaline or acid post-treatment","volume":"10","author":"Kowalewicz","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"key":"bmmaea50cbib33","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.bej.2009.03.005","type":"journal-article","article-title":"Culture pH and osmolality influence proliferation and embryoid body yields of murine embryonic stem cells","volume":"45","author":"Chaudhry","year":"2009","journal-title":"Biochem. Eng. J."},{"key":"bmmaea50cbib34","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.susc.2004.06.178","type":"journal-article","article-title":"pH dependent growth of poly(L-lysine)\/poly(L-glutamic) acid multilayer films and their cell adhesion properties","volume":"570","author":"Richert","year":"2004","journal-title":"Surf. Sci."},{"key":"bmmaea50cbib35","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1208\/pt030326","type":"journal-article","article-title":"Intercalation compounds of hydrotalcite-like anionic clays with anti-inflammatory agents, II: uptake of diclofenac for a controlled release formulation","volume":"3","author":"Ambrogi","year":"2002","journal-title":"AAPS PharmSciTech"},{"key":"bmmaea50cbib36","doi-asserted-by":"publisher","first-page":"2342","DOI":"10.1039\/b106465g","type":"journal-article","article-title":"Intercalation and controlled release of pharmaceutically active compounds from a layered double hydroxide","volume":"37","author":"Khan","year":"2001","journal-title":"Chem. Commun."},{"key":"bmmaea50cbib37","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1080\/09205063.2013.878870","type":"journal-article","article-title":"Evaluation of the cytocompatibility hemocompatibility in vivo bone tissue regenerating capability of different PCL blends","volume":"25","author":"Padalhin","year":"2014","journal-title":"J. Biomater. Sci. Polym. Ed."},{"key":"bmmaea50cbib38","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1177\/0022034511435260","type":"journal-article","article-title":"Osteoinduction: a review of old concepts with new standards","volume":"91","author":"Miron","year":"2012","journal-title":"J. Dent. Res."},{"key":"bmmaea50cbib39","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-35454-9","type":"journal-article","article-title":"A novel fluorescein-bisphosphonate based diagnostic tool for the detection of hydroxyapatite in both cell and tissue models","volume":"8","author":"Sim","year":"2018","journal-title":"Sci. Rep."},{"key":"bmmaea50cbib40","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111480","type":"journal-article","article-title":"Total flavonoids of rhizoma drynariae ameliorates bone formation and mineralization in BMP-Smad signaling pathway induced large tibial defect rats","volume":"138","author":"Sun","year":"2021","journal-title":"Sci. Pharmacother."},{"key":"bmmaea50cbib41","doi-asserted-by":"publisher","first-page":"3004","DOI":"10.1002\/jbm.a.35841","type":"journal-article","article-title":"The effect of mesoporous bioglass on osteogenesis and adipogenesis of osteoporotic BMSCs","volume":"104","author":"Wu","year":"2016","journal-title":"J. Biomed. Mater. Res. A"},{"key":"bmmaea50cbib42","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1007\/s12011-016-0697-0","type":"journal-article","article-title":"Synthesis of trace element Si and Sr codoping hydroxyapatite with non-cytotoxicity and enhanced cell proliferation and differentiation","volume":"174","author":"Gao","year":"2016","journal-title":"Biol. Trace Elem. Res."},{"key":"bmmaea50cbib43","doi-asserted-by":"publisher","first-page":"1655","DOI":"10.1016\/j.archoralbio.2011.06.008","type":"journal-article","article-title":"Osteogenic effect of Drynariae rhizoma extracts and Naringin on MC3T3-E1cells and an induced rat alveolar bone resorption model","volume":"56","author":"Chen","year":"2011","journal-title":"Arch. Oral Biol."},{"key":"bmmaea50cbib44","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1002\/jbm.a.34356","type":"journal-article","article-title":"Enhanced osteogenesis by collagen-binding peptide from bone sialoprotein In vitro and in vivo","volume":"101A","author":"Choi","year":"2013","journal-title":"J. Biomed. Mater. Res. A"},{"key":"bmmaea50cbib45","doi-asserted-by":"publisher","first-page":"136","DOI":"10.4252\/wjsc.v5.i4.136","type":"journal-article","article-title":"Molecular mechanisms of mesenchymal stem cell differentiation towards osteoblasts World","volume":"5","author":"Fakhry","year":"2013","journal-title":"J. Stem Cells"},{"key":"bmmaea50cbib46","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.bone.2015.05.047","type":"journal-article","article-title":"Interactions between osteopontin and vascular endothelial growth factor: implications for skeletal disorders","volume":"81","author":"Ramchandani","year":"2015","journal-title":"Bone"},{"key":"bmmaea50cbib47","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1002\/jbm.a.31356","type":"journal-article","article-title":"Osteoblast differentiation In vitro and in vivo promoted by Osterix","volume":"83","author":"Fu","year":"2007","journal-title":"J. Biomed. Mater. Res. A"},{"key":"bmmaea50cbib48","doi-asserted-by":"publisher","first-page":"4685","DOI":"10.1210\/en.2003-1492","type":"journal-article","article-title":"Spaciotemporal association and bone morphogenetic protein regulation of sclerostin and osterix expression during embryonic osteogenesis","volume":"145","author":"Ohyama","year":"2004","journal-title":"Endocrinology"},{"key":"bmmaea50cbib49","doi-asserted-by":"publisher","first-page":"5445","DOI":"10.3390\/ijms22115445","type":"journal-article","article-title":"Regulation and role of transcription factors in osteogenesis","volume":"22","author":"Chan","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"bmmaea50cbib50","doi-asserted-by":"publisher","first-page":"269","DOI":"10.22203\/eCM.v028a19","type":"journal-article","article-title":"Role and regulation of RUNX2 in osteogenesis","volume":"28","author":"Bruderer","year":"2014","journal-title":"Eur. Cell Mater."},{"key":"bmmaea50cbib51","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1038\/s41580-020-00279-w","type":"journal-article","article-title":"Mechanisms of bone development and repair","volume":"21","author":"Salhotra","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"bmmaea50cbib52","doi-asserted-by":"publisher","first-page":"2097","DOI":"10.1016\/j.biomaterials.2011.11.053","type":"journal-article","article-title":"Blood vessel formation in the tissue-engineered bone with the constitutively active form of HIF-1\u03b1 mediated BMSCs","volume":"33","author":"Zou","year":"2012","journal-title":"Biomaterials"},{"key":"bmmaea50cbib53","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1016\/j.bone.2003.12.024","type":"journal-article","article-title":"Activation of the transcription factor HIF-1 and its target genes, VEGF, HO-1, iNOS, during fracture repair","volume":"34","author":"Komatsu","year":"2004","journal-title":"Bone"},{"key":"bmmaea50cbib54","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.jot.2015.05.002","type":"journal-article","article-title":"Bone defect animal models for testing efficacy of bone substitute biomaterials","volume":"3","author":"Li","year":"2015","journal-title":"J. Orthop. Transl."},{"key":"bmmaea50cbib55","doi-asserted-by":"publisher","first-page":"2615","DOI":"10.1016\/S0142-9612(00)00129-0","type":"journal-article","article-title":"Clinical biocompatibility of biodegradable orthopaedic implants for internal fixation: a review","volume":"21","author":"B\u00f6stman","year":"2000","journal-title":"Biomaterials"},{"key":"bmmaea50cbib56","doi-asserted-by":"publisher","first-page":"5058","DOI":"10.1016\/j.biomaterials.2007.07.049","type":"journal-article","article-title":"Bone bonding at natural and biomaterial surfaces","volume":"28","author":"Davies","year":"2007","journal-title":"Biomaterials"}],"container-title":["Biomedical Materials"],"original-title":[],"link":[{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/aea50c","content-type":"text\/html","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/aea50c\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/aea50c","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/aea50c\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/aea50c\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/aea50c\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/aea50c\/pdf","content-type":"application\/pdf","content-version":"am","intended-application":"similarity-checking"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/aea50c\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:02:14Z","timestamp":1790661734000},"score":1,"resource":{"primary":{"URL":"https:\/\/iopscience.iop.org\/article\/10.1088\/1748-605X\/aea50c"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,29]]},"references-count":56,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,9,29]]},"published-print":{"date-parts":[[2026,10,1]]}},"URL":"https:\/\/doi.org\/10.1088\/1748-605x\/aea50c","relation":{},"ISSN":["1748-6041","1748-605X"],"issn-type":[{"value":"1748-6041","type":"print"},{"value":"1748-605X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,29]]},"assertion":[{"value":"Enhancement of osteogenic differentiation and bone regeneration by total flavonoids of Rhizoma Drynariae-loaded magnesium phosphate cement\/Co-doped hydroxyapatite composites","name":"article_title","label":"Article Title"},{"value":"Biomedical Materials","name":"journal_title","label":"Journal Title"},{"value":"paper","name":"article_type","label":"Article Type"},{"value":"\u00a9 2026 IOP Publishing Ltd. All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2026-07-05","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2026-09-09","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2026-09-29","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}