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Mater."],"published-print":{"date-parts":[[2026,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The growing crisis of bacterial resistance has prompted the development of novel antibacterial therapeutic systems to combat Methicillin-resistant\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    pneumonia. This study reports a nano-micelle system (RMLH-Ms) for the co-delivery of the antibiotic Linezolid and the traditional Chinese medicine monomer Honokiol. Antibacterial peptide Magainin II (Mag II) was employed to endow the micelles with bacterial targeting ability, and thioketal bond modification was used to confer ROS-responsive properties. Linezolid and Honokiol were successfully encapsulated into micelles with entrapment efficiencies (EE%&gt; 95%.) A low critical micelle concentration of 0.0138 mg ml\n                    <jats:sup>\u22121<\/jats:sup>\n                    and sustained colloidal stability over 21 d were observed. Mag II\u2010modified RMLH\u2010Ms appeared to show improved bacterial targeting ability compared with unmodified micelles. The ZIP score for Linezolid and Honokiol combination was 7.61, exhibiting a synergistic antibacterial effect. Micelles incorporated with honokiol (LH-Ms) reduced the MIC of L-Ms from 4 \u03bcg ml\n                    <jats:sup>\u22121<\/jats:sup>\n                    \u20132 \u03bcg ml\n                    <jats:sup>\u22121<\/jats:sup>\n                    . Furthermore, the incorporation of Honokiol also exhibited additional anti-inflammatory, macrophage polarization regulation immune microenvironment regulating activities\n                    <jats:italic>in vitro. In vivo<\/jats:italic>\n                    , The survival rates were 12.5%, 37.5%, 50%, 62.5%, and 75% for the model group, L-Ms, LH-Ms, MLH-Ms, and RMLH-Ms group, respectively. The survival rate of the RMLH-Ms group rose by 62.5% compared with the model group. RMLH-Ms induced mild decreases in lung bacterial burden, mitigated inflammatory responses and alleviated pathological lung damage, exhibiting favorable\n                    <jats:italic>in vivo<\/jats:italic>\n                    activity under experimental conditions.\n                  <\/jats:p>","DOI":"10.1088\/1748-605x\/aead3b","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:53:39Z","timestamp":1790636019000},"page":"065002","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["ROS responsive micelles coloaded with Linezolid and Honokiol for targeting and synergistic therapy of Methicillin-resistant Staphylococcus aureus pneumonia"],"prefix":"10.1088","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5661-8518","authenticated-orcid":true,"given":"Yuan","family":"Liu","sequence":"first","affiliation":[{"name":"Central Hospital of Dalian University of Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2282-971X","authenticated-orcid":false,"given":"Ying","family":"Bi","sequence":"additional","affiliation":[{"name":"Central Hospital of Dalian University of Technology"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"data-curation","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"}]},{"given":"Xiaofeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Central Hospital of Dalian University of Technology"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"}]},{"given":"Jian","family":"Xu","sequence":"additional","affiliation":[{"name":"Central Hospital of Dalian University of Technology"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"methodology","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"}]},{"given":"Meng","family":"Dai","sequence":"additional","affiliation":[{"name":"Central Hospital of Dalian University of Technology"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"methodology","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"}]},{"given":"Shuyan","family":"Wang","sequence":"additional","affiliation":[{"name":"Central Hospital of Dalian University of Technology"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"}]},{"given":"QianZi","family":"Ma","sequence":"additional","affiliation":[{"name":"Central Hospital of Dalian University of Technology"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"}]},{"given":"Lu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Liaoning University of Traditional Chinese Medicine"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"methodology","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Xuetao","family":"Li","sequence":"additional","affiliation":[{"name":"Liaoning University of Traditional Chinese Medicine"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"methodology","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2989-6309","authenticated-orcid":false,"given":"Ling","family":"Jiang","sequence":"additional","affiliation":[{"name":"Central Hospital of Dalian University of Technology"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]}],"member":"266","published-online":{"date-parts":[[2026,11,6]]},"reference":[{"key":"bmmaead3bbib1","doi-asserted-by":"publisher","first-page":"11692","DOI":"10.1021\/acsnano.3c02365","type":"journal-article","article-title":"Hybrid biomimetic membrane coated particles-mediated bacterial ferroptosis for acute MRSA pneumonia","volume":"17","author":"Hu","year":"2023","journal-title":"ACS Nano"},{"key":"bmmaead3bbib2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202403612","type":"journal-article","article-title":"Sono-triggered biomimetically nanoantibiotics mediate precise sequential therapy of MRSA-induced lung infection","volume":"36","author":"Ding","year":"2024","journal-title":"Adv. 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