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Mater."],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The clinical management of methicillin-resistant\n                    <jats:italic>S. aureus<\/jats:italic>\n                    (MRSA) pneumonia is hindered by biofilm infections and cytokine storms. A key challenge is the lack of real-time monitoring tools for the inflammatory microenvironment during treatment. In this study, we developed a theranostic platform (CS@EAgNP) using TPP-modified chitosan to load silver sodium nitroprusside nano-aggregates (AgNP) and epigallocatechin gallate (EGCG). This system combines ultrasound (US) imaging with US-activated therapy. The CS@EAgNP nano-aggregates can act as an excellent US contrast enhancer.\n                    <jats:italic>In vivo<\/jats:italic>\n                    US imaging indicated that AgNP generated significantly enhanced echo signals at the infection site, providing real-time and high-contrast visualization of the inflammatory foci that was unattainable with normal lung tissue. Moreover, these nano-aggregates release NO, silver and EGCG under US. The NO and silver penetrate biofilms to kill MRSA, while EGCG scavenges reactive oxygen species and modulates inflammation. This reduces pro-inflammatory cytokines like IL-6 and TNF-\n                    <jats:italic>\u03b1<\/jats:italic>\n                    , mitigating the cytokine storm.\n                    <jats:italic>In vivo<\/jats:italic>\n                    results further confirm that this image-guided strategy achieves significant bacterial clearance and promotes lung tissue regeneration without detectable toxicity to major organs. This integrated approach bridges diagnosis and treatment, offering a promising solution for managing MRSA pneumonia.\n                  <\/jats:p>","DOI":"10.1088\/1748-605x\/aeb215","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:52:21Z","timestamp":1791499941000},"page":"055021","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Silver sodium nitroprusside nano-aggregates for ultrasound-activated immunomodulatory therapy of MRSA pneumonia"],"prefix":"10.1088","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-6799-8226","authenticated-orcid":true,"given":"Minxian","family":"Ji","sequence":"first","affiliation":[{"name":"The Affiliated Guangdong Second Provincial General Hospital of Jinan University"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"data-curation","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"software","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"}]},{"given":"Guanxue","family":"Li","sequence":"additional","affiliation":[{"name":"Zhujiang Hospital, Southern Medical University"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"},{"role":"software","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"}]},{"given":"Lihua","family":"Xie","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Guangdong Medical University"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"data-curation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7087-4622","authenticated-orcid":true,"given":"Guanhai","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Guangdong Medical University"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"funding-acquisition","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]}],"member":"266","published-online":{"date-parts":[[2026,10,20]]},"reference":[{"key":"bmmaeb215bib1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2025.102603","type":"journal-article","article-title":"Non-antibiotic nanoplatform based CuS\/AuNCs@Lip NPs for inhibition pneumonia caused by MRSA and its mechanism exploration","volume":"35","author":"Fan","year":"2025","journal-title":"Mater. 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