{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T03:21:27Z","timestamp":1768706487078,"version":"3.49.0"},"reference-count":18,"publisher":"IOP Publishing","issue":"43","license":[{"start":{"date-parts":[[2020,10,9]],"date-time":"2020-10-09T00:00:00Z","timestamp":1602201600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/iop-standard\/v1"},{"start":{"date-parts":[[2020,10,9]],"date-time":"2020-10-09T00:00:00Z","timestamp":1602201600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100007197","name":"U.S. Public Health Service","doi-asserted-by":"crossref","award":["GM34809"],"award-info":[{"award-number":["GM34809"]}],"id":[{"id":"10.13039\/100007197","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["J. Phys. A: Math. Theor."],"published-print":{"date-parts":[[2020,10,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    We introduce an analytical method to generate the pathway of a closed protein-bound DNA minicircle. We develop an analytical equation to connect two open curves smoothly and use the derived expressions to join the ends of two helical pathways and form models of nucleosome-decorated DNA minicircles. We find that the simplest smooth connector which satisfies the boundary conditions at the end points and the length requirement for such connections to be a quartic function on the\n                    <jats:italic>xy<\/jats:italic>\n                    -plane and linear along the\n                    <jats:italic>z<\/jats:italic>\n                    -direction. This is a general method which can be used to connect any two open curves with well defined mathematical definitions as well as pairs of discrete systems found experimentally. We used this method to describe the configurations of torsionally relaxed, 360-base pair DNA rings with two evenly-spaced, ideal nucleosomes. We considered superhelical nucleosomal pathways with different levels of DNA wrapping and allowed for different inter-nucleosome orientations. We completed the DNA circles with the smooth connectors and studied the associated bending and electrostatic energies for different configurations in the absence and presence of salt. The predicted stable states bear close resemblance to reconstituted minicircles observed under low and high salt conditions.\n                  <\/jats:p>","DOI":"10.1088\/1751-8121\/abb480","type":"journal-article","created":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T18:15:30Z","timestamp":1599070530000},"page":"435601","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["An analytical method to connect open curves for modeling protein-bound DNA minicircles"],"prefix":"10.1088","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6585-6465","authenticated-orcid":false,"given":"Seyed A","family":"Sabok-Sayr","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7803-1072","authenticated-orcid":false,"given":"Wilma K","family":"Olson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"266","published-online":{"date-parts":[[2020,10,9]]},"reference":[{"key":"aabb480bib1","first-page":"p 179","author":"Alberts","year":"2015","type":"book"},{"key":"aabb480bib2","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1146\/annurev.bi.49.070180.005343","type":"journal-article","volume":"49","author":"McGhee","year":"1980","journal-title":"Annu. 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All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2020-05-21","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2020-09-02","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2020-10-09","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}