{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T13:02:41Z","timestamp":1784984561543,"version":"3.55.0"},"reference-count":40,"publisher":"IOP Publishing","issue":"4","license":[{"start":{"date-parts":[[2017,9,27]],"date-time":"2017-09-27T00:00:00Z","timestamp":1506470400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/iop-standard\/v1"},{"start":{"date-parts":[[2017,9,27]],"date-time":"2017-09-27T00:00:00Z","timestamp":1506470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["J. Breath Res."],"published-print":{"date-parts":[[2017,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    : Recent studies have highlighted the possible involvement of leptin in inflammation. The leptin receptor is also expressed by alveolar macrophages, T lymphocytes and bronchial epitelial cells, suggesting a possible role in the cascade of airway inflammation.\n                    <jats:italic>Objectives<\/jats:italic>\n                    : The aim of the study was to evaluate the levels of leptin in exhaled breath condensate (EBC) from asthmatic, normal- and overweight children, in relationship with airway inflammation.\n                    <jats:italic>Methods<\/jats:italic>\n                    : 15 asthmatic non-obese children, 15 healthy non-asthmatic non-obese children, 11 obese children with asthma (OA) and 20 obese children without asthma (ONA) were enrolled. Body impedance of body weight, EBC collection, FeNO, spirometry and a blood sampling for serum leptin were assessed.\n                    <jats:italic>Results<\/jats:italic>\n                    : Leptin EBC levels were significantly higher (3.9 ng ml\n                    <jats:sup>\u22121<\/jats:sup>\n                    \u00b1 1.3) in overweight children than those obese with asthma (3.6 ng ml\n                    <jats:sup>\u22121<\/jats:sup>\n                    \u00b1 1.6;\n                    <jats:italic>p<\/jats:italic>\n                    = 0.97), non-owerweight asthmatics (2.2 ng ml\n                    <jats:sup>\u22121<\/jats:sup>\n                    \u00b1 1.2;\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.0001) and in healthy children (0.9 ng ml\n                    <jats:sup>\u22121<\/jats:sup>\n                    \u00b1 0.6;\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.001). Leptin EBC levels in asthmatic children were significantly higher than in healthy children (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.05). Leptin serum levels were significantly higher in the overweight children compared with the asthmatics (12.7 ng ml\n                    <jats:sup>\u22121<\/jats:sup>\n                    \u00b1 13.2;\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.001) and the healthy group (11.1 ng ml\n                    <jats:sup>\u22121<\/jats:sup>\n                    \u00b1 11.2;\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.001). We observed a significant correlation between EBC-leptin levels and the serum-leptin levels (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.001). No correlations were found between EBC-leptin levels, FeNO and lung function.\n                    <jats:italic>Conclusions<\/jats:italic>\n                    : This study shows that leptin is measurable in EBC in children and that EBC-leptin levels are significantly higher in the obese subjects and in asthmatic ones compared with healthy subjects. Leptin may therefore represent a non-invasive marker of non-specific airway inflammation in children.\n                  <\/jats:p>","DOI":"10.1088\/1752-7163\/aa61c5","type":"journal-article","created":{"date-parts":[[2017,9,27]],"date-time":"2017-09-27T08:15:16Z","timestamp":1506500116000},"page":"046005","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["Serum and exhaled breath condensate leptin levels in asthmatic and obesity children: a pilot study"],"prefix":"10.1088","volume":"11","author":[{"given":"A","family":"Bodini","sequence":"first","affiliation":[{"name":"University of Verona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Tenero","sequence":"additional","affiliation":[{"name":"University of Verona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Sandri","sequence":"additional","affiliation":[{"name":"University of Verona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Maffeis","sequence":"additional","affiliation":[{"name":"University of Verona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Piazza","sequence":"additional","affiliation":[{"name":"University of Verona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Zanoni","sequence":"additional","affiliation":[{"name":"University of Verona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Peroni","sequence":"additional","affiliation":[{"name":"University of Verona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Boner","sequence":"additional","affiliation":[{"name":"University of Verona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Piacentini","sequence":"additional","affiliation":[{"name":"University of Verona"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2017,9,27]]},"reference":[{"key":"jbraa61c5bib1","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1126\/science.7624778","type":"journal-article","article-title":"Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks","volume":"269","author":"Campfield","year":"1995","journal-title":"Science"},{"key":"jbraa61c5bib2","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1152\/japplphysiol.00781.2009","type":"journal-article","article-title":"Obesity and lung inflammation","volume":"108","author":"Mancuso","year":"2010","journal-title":"J. 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All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2016-11-27","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2017-02-21","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2017-09-27","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}