{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T13:02:40Z","timestamp":1784984560773,"version":"3.55.0"},"reference-count":51,"publisher":"IOP Publishing","issue":"2","license":[{"start":{"date-parts":[[2017,6,12]],"date-time":"2017-06-12T00:00:00Z","timestamp":1497225600000},"content-version":"vor","delay-in-days":11,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/iop-standard\/v1"},{"start":{"date-parts":[[2017,6,12]],"date-time":"2017-06-12T00:00:00Z","timestamp":1497225600000},"content-version":"tdm","delay-in-days":11,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"funder":[{"name":"Ohio Department of Development, Third Frontier Program","award":["BRCP 08-049"],"award-info":[{"award-number":["BRCP 08-049"]}]}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["J. Breath Res."],"published-print":{"date-parts":[[2017,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Many uremic solutes retained in chronic kidney disease are volatile, and can be detected by breath testing. We compared the exhaled breath of subjects with end stage renal disease (ESRD) to healthy volunteers to identify volatile compounds that can serve as a potential breathprint for renal failure. We analyzed the exhaled breath of 86 ESRD subjects and 25 healthy volunteers using selected-ion flow-tube mass spectrometry (SIFT-MS). Using a random forests classification model, we identified three known volatiles (2-propanol, ammonia, acetaldehyde) and two unknown volatiles (\n                    <jats:inline-formula>\n                      <jats:tex-math>\n                        \n                      <\/jats:tex-math>\n                      <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" overflow=\"scroll\">\n                        <mml:msup>\n                          <mml:msub>\n                            <mml:mrow>\n                              <mml:mi mathvariant=\"normal\">O<\/mml:mi>\n                            <\/mml:mrow>\n                            <mml:mrow>\n                              <mml:mn>2<\/mml:mn>\n                            <\/mml:mrow>\n                          <\/mml:msub>\n                          <mml:mo>+<\/mml:mo>\n                        <\/mml:msup>\n                        <mml:mn>50<\/mml:mn>\n                        <mml:mo>,<\/mml:mo>\n                      <\/mml:math>\n                    <\/jats:inline-formula>\n                    NO\n                    <jats:sup>+<\/jats:sup>\n                    76) that were highly significant for discriminating individuals with renal failure from individuals without renal failure (C statistic\u00a0&gt;\u00a00.99). This study provides preliminary support for the use of exhaled breath as a potential noninvasive screening tool in renal failure.\n                  <\/jats:p>","DOI":"10.1088\/1752-7163\/aa7143","type":"journal-article","created":{"date-parts":[[2017,5,5]],"date-time":"2017-05-05T04:15:09Z","timestamp":1493957709000},"page":"026009","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":21,"title":["Molecular breath analysis identifies the breathprint of renal failure"],"prefix":"10.1088","volume":"11","author":[{"given":"Sevag","family":"Demirjian","sequence":"first","affiliation":[{"name":"Department of Nephrology and Hypertension, Cleveland Clinic, Cleveland, OH,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly M","family":"Paschke","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Cleveland Clinic, Cleveland, OH,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Grove","sequence":"additional","affiliation":[{"name":"Department of Pulmonary, Allergy, and Critical Care Medicine, Respiratory Institute, Cleveland Clinic, Cleveland, OH,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J","family":"Heyka","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hypertension, Cleveland Clinic, Cleveland, OH,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raed A","family":"Dweik","sequence":"additional","affiliation":[{"name":"Department of Pulmonary, Allergy, and Critical Care Medicine, Respiratory Institute, Cleveland Clinic, Cleveland, OH,"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2017,6,12]]},"reference":[{"key":"jbraa7143bib1","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1038\/ki.1997.324","type":"journal-article","article-title":"Quantitative analysis of ammonia on the breath of patients in end-stage renal failure","volume":"52","author":"Davies","year":"1997","journal-title":"Kidney Int."},{"key":"jbraa7143bib2","doi-asserted-by":"publisher","first-page":"4617","DOI":"10.1073\/pnas.071057598","type":"journal-article","article-title":"Correlation of breath ammonia with blood urea nitrogen and creatinine during hemodialysis","volume":"98","author":"Narasimhan","year":"2001","journal-title":"Proc. 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